Nature Communications
·
2025
·Vol. 16
·期 1
·1-19
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IF 15.7
Tang Yizhang,Yu Xujiang,He Liangrui,Tang Meng,Yue Wenji,Chen Ruitong,Zhao Jie,Pan Qi,Li Wanwan
Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous excitation and/or endogenous H 2 O 2 and O 2 . Here we report a versatile oxidizing pentavalent bismuth(V) nanoplatform (NaBi V O 3 -PEG) can generate reactive oxygen species in an excitation-free and H 2 O 2 - and O 2 -independent manner. Upon exposure to the tumor microenvironment, NaBi V O 3 -PEG undergoes continuous H + -accelerated hydrolysis with •OH and 1 O 2 generation through electron transfer-mediated Bi V -to-Bi III conversion and lattice oxygen transformation. The simultaneous release of sodium counterions after endocytosis triggers caspase-1-mediated pyroptosis. NaBi V O 3 -PEG intratumorally administered initiates robust therapeutic efficacies against both primary and distant tumors and activates systemic immune responses to combat tumor metastasis. NaBi V O 3 -PEG intravenously administered can efficiently accumulate at the tumor site for further real-time computed tomography monitoring, immunotherapy, or alternative synergistic immune-radiotherapy. Overall, this work offers a nanomedicine based on high-valence bismuth(V) nanoplatform and underscores its great potential for cancer immunotherapy.
研究领域:
纳米医学
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癌症免疫疗法
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肿瘤学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2020
·
IF 3.408
Tao Guo,Ting Xu,Wentao Xia,Andrew J. Carrier,Li Wang,Xu Zhang
We report herein, double quantum dot composites of graphene oxide and CuO (GOQD-q-CuO), formed by a low-temperature solution process, possess enhanced haloperoxidase (HPO)-like catalytic activity, which catalyze the oxidation of Cl − by H 2 O 2 to generate reactive chlorine species (RCS). A sensitive and selective colorimetric sensor was then developed via the oxidation of 3,3ʹ,5,5ʹ-tetramethylbenzidine (TMB) by the GOQD-q-CuO catalytic system through the generation of RCS for H 2 O 2 and glucose detection, with detection limits of 0.5 and 2.5 μM and linear ranges between 2.5–200 and 5–400 μM, respectively. This sensor was further applied to glucose detection in clinical serum samples showing no significant differences with the hexokinase method. Additionally, we demonstrate that the GOQD modulates the catalytic activity of q-CuO by reversing its zeta potential , producing an overall negatively charged surface, therefore GOQD-q-CuO has much higher affinity than CuO to the positively charged chromogenic substrate TMB, yielding higher HPO-like activity. Moreover, the presence of Cl − accelerates electron transfer to facilitate Cu 2+ reduction to Cu + on the GOQD-q-CuO surface, speeding up the overall catalytic reaction for the RCS generation, therefore, higher detection sensitivity was achieved.
研究领域:
生物化学
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材料科学
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分析化学
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高影响因子
Food Analytical Methods
·
2014
·Vol. 8
·期 6
·1556-1564
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IF 1.802
Liu Tao,Zhang Xiao,Hao Jianpeng,Zhu Wenxin,Liu Wei,Zhang Daohong,Wang Jianlong
Herein, we for the first time report an acetylcholinesterase (AChE)-free colorimetric method for the detection of chlorpyrifos (CP), which is based on the oxidation reaction of H 2 O 2 with CP and 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS 2− ) catalyzed by hemin/G-quadruplex DNAzyme. In the absence of CP, ABTS 2− is directly oxidized by H 2 O 2 with hemin/G-quadruplex DNAzyme as a biocatalyst to produce the blue-green-colored free radical anion (ABTS ·− ), accompanied with an obvious UV-visible absorbance at 418 nm. However, the amount of H 2 O 2 used in H 2 O 2 -DNAzyme-ABTS 2− system will be decreased if CP is first reacted with H 2 O 2 , leading to the decrease of the amount of ABTS ·− and a change in the UV-visible absorbance of ABTS ·− at 418 nm. Thus, an indirect dependence relation between CP concentration and the absorbance of ABTS ·− at 418 nm could be constructed and used for CP detection. Under optimal conditions, the detection range of the method is 0.04–1 μg/mL, with a detection limit of 0.01 μg/mL. Application of the method in real juice samples shows good analytical features in terms of recoveries (95–107.5 %), the relative standard deviation (RSD) (0.6–4.7 %), rendering it as an attractive candidate to current methodologies for the determination of CP.
研究领域:
分析化学
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环境科学
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食品安全
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DOI
高影响因子
TALANTA
·
2016
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IF 4.035
Hongyu Chen,Aijin Fang,Li He,Youyu Zhang,Shouzhuo Yao
Diabetes mellitus is an epidemic disease that it has became a worldwide public health problem. Thus, blood glucose monitoring has attracted extensive attention. Here, we report a nanosensor based on inner filter effect (IFE) between upconversion nanoparticles (UCNPs) and squaric acid (SQA)-iron(III) for the highly sensitive and selective detection of glucose levels in human serum. In this assay, GOx-catalyzed oxidization of glucose produces gluconic acid and hydrogen peroxide (H 2 O 2 ). The latter can catalytically oxidize iron(II) to iron(III) which can rapidly (<1 min) coordinate with the SQA to produce (SQA)-iron(III). The absorption band of (SQA)-iron(III) largely covered the emission band of UCNPs, resulting the fluorescence emission of UCNPs was effectively quenched. Therefore, the glucose can be monitored based on the formation of SQA-iron(III). Under the optimal condition, the fluorescence quenching efficiency shows a good linear response to glucose concentration in the ranges of 7–340 μmol/L with a detection limit of 2.3 μmol/L. The developed method has been further applied to monitor glucose levels in human serum with satisfactory results. Compared with other fluorescence methods , current method displayed high sensitivity and signal-to-noise ratio. Meanwhile, this nanosystem is also generalizable and can be easily expanded to the detection of various H 2 O 2 -involved analytes.
研究领域:
生物化学
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医学诊断
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纳米技术
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2023
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IF 9.5
Yanqing Cong,Xinyue Li,Shiyi Zhang,Qiuang Zheng,Yi Zhang,Shi-Wen Lv
Photocatalytic technique is regarded as the cleanest approach for producing H2O2. Herein, two kinds of novel polyimide COFs decorated with CQDs (namely, MPa-COFs/CQDs and MNd-COFs/CQDs) were constructed by using the one-pot hydrothermal method. Due to the electron donor role of CQDs, the recombination of photoinduced electrons and holes was suppressed after the combination of polyimide COFs with CQDs. Importantly, the introduction of CQDs not only boosted the absorbing ability of polyimide COFs toward visible light but also reduced the impedance and improved the charge transfer efficiency. After CQDs were embedded into polyimide COFs, the surface hydrophilicity of catalysts was significantly improved, which provided convenience for the water oxidation reaction. Benefiting from the electron donor–acceptor interaction between polyimide COFs and CQDs, a step-by-step two-electron oxygen reduction reaction over polyimide COFs was enhanced. More interestingly, the embedding of CQDs can create a direct two-electron water oxidation reaction pathway, which played an important role in photocatalytic H2O2 generation. Meanwhile, H+ generated from water oxidation can also be used for the reduction of oxygen to form H2O2. Under the synergistic effects of water oxidation and oxygen reduction, as-prepared MPa-COFs/CQDs-2 displayed excellent performance in photocatalytic H2O2 generation, and its yield was as high as 540 μmol/g within 60 min. In short, the current work shared an effective strategy to improve the performance of polyimide COFs in photocatalytic H2O2 production.
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高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 11
·e202204286
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IF 2.1
Yating Zeng,Hanping Fu,Liran Liu,Li Feng,Tianxiang Zhang,Qingshuang Liang,Xiufeng Xiao
Graphical A novel 2D/1D/-2D RP/BP-MBWO composed of in situ junction and Z-scheme system has been successfully synthesized. Benefiting from this favourable interfacial and structural characteristics, the fabricated BP/RP-MBWO photocatalyst shows a sharply improved photocatalytic H 2 and H 2 O 2 evolution performance. Exploring multifunctional photocatalysts with rational design and construction of unique transport channels is of great significance for the value-added chemicals production and environmental remediation. In this work, a novel 2D/1D/-2D RP/BP-MBWO dual heterostructure photocatalyst has been successfully synthesized by loading the in-situ grown 2D/1D RP/BP heterostructure on the 2D Bi 2 WO 6 nanosheets. through simple ultrasonic agitation.Benefiting from this favourable interfacial and structural characteristics, the fabricated BP/RP-MBWO photocatalyst shows a sharply improved photocatalytic H 2 and H 2 O 2 evolution performance. Excitingly, the optimal of H 2 O 2 production rate of the BP/RP-Bi 2 WO 6 composites is as high as 622.5 μmol g −1 h −1 under visible light irradiation, which is approximately 15 times as that of pure MBWO. The hydrogen production performance of the complexes was significantly improved compared to the pure MBWO samples. When the BP/RP loading was 20 %, the prepared nanocomposites showed the highest photocatalytic hydrogen evolution efficiency with the hydrogen production rate of about 0.77 μmol ⋅ g −1 ⋅ h −1 . This work is expected to offer a new inspiration for the rational design and construction of effcient photocatalyst systems toward solar energy capture and conversion.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Shaolong Wang,Hao Liu,Dingding Ye,Qiao Lan,Xun Zhu,Yang Yang,Rong Chen,Qiang Liao
Both sustainable storage of renewable energy using H 2 O 2 as energy carrier and wastewater treatment by electro-Fenton are highly dependent on the efficiency of H 2 O 2 electrosynthesis via 2-electron reduction of O 2 . Rational design of high-performance and cost-effective electrocatalysts with facile preparation is bear the brunt of scalable H 2 O 2 electrosynthesis. Herein, for the first time, we synthesize a pitaya peel-derived formicary-like electrocatalyst employing facile pyrolysis and KOH activation. At the optimal mass ratio of biochar to KOH (1:3), the electrocatalyst exhibits prominent H 2 O 2 activity and selectivity owing to its rich self-doped oxygen-containing functional groups as well as structural defects and sp 3 -C bonds serving as reactive sites, rational hierarchical pores boosting mass transfer of reactants and products, and ultrahigh specific surface area facilitating the exposure of reactive sites. Under natural air diffusion, the pitaya peel-derived catalyst-coated cathode achieves surprising H 2 O 2 productivity of 41.6 mg h −1 cm −2 with current efficiency of 65.5% at large current density of 100 mA cm −2 , meeting the near-industrial requirements for sustainable H 2 O 2 production. Long-term operation stability at large current and rapid degradation of multiple high-concentration organic pollutants demonstrate tremendous potential of the pitaya peel-derived catalysts for H 2 O 2 -based renewable energy storage and environmental remediation.
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高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Chao-Qing Li,Meng-Wen Ma,Bin Zhang,Wei Chen,Zhong-Yuan Yin,Xiao-Ting Xie,Xiao-Lin Hou,Yuan-Di Zhao,Bo Liu
A nanoplatform based on Ag 2 S quantum dots (QDs) and tellurium nanorods (TeNRs) was developed for combined chemo-photothermal therapy guided by H 2 O 2 -activated near-infrared (NIR)-II fluorescence imaging. Polypeptide PC 10 AGRD-modified TeNRs and Ag 2 S QDs were co-encapsulated in 4T1 cell membrane to prepare a nanoplatform ( [email protected] ). Ag 2 S QDs and TeNRs in the [email protected] were used as a fluorescence probe and photosensitizer , and a chemotherapeutic prodrug and quenching agent to quench the fluorescence of Ag 2 S QDs, respectively. After the [email protected] was specifically targeted to the tumor site, the TeNRs were dissolved by the high concentration of H 2 O 2 at the tumor site to light up the fluorescence of Ag 2 S QDs for NIR-II fluorescence imaging. In addition, the generated toxic TeO 6 6− molecules decreased ATP production by selective cancer chemotherapy, which is beneficial for photothermal therapy. The elevated temperature due to photothermal therapy in turn promoted the chemical reaction in chemotherapy. In vitro and in vivo toxicity results showed that the [email protected] possesses high biocompatibility. Compared to single photothermal therapy and chemotherapy, the synergistic chemo-photothermal therapy can effectively suppress the growth of 4T1 tumor. This all-in-one nanoplatform provides a boulevard for the combination therapy of tumors guided by NIR-II fluorescence imaging. Statement of significance NIR-II fluorescence imaging shows the characteristics of low tissue absorption, reflection, and scattering, which can greatly reduce the influence of autofluorescence in vivo . However, the non-negligible effect of autofluorescence is still observed in fluorescence imaging in vivo . Therefore, there is an urgent need to develop a strategy of controlled release of fluorescence for accurate imaging and tumor therapy. Here, Ag 2 S quantum dots (QDs) with NIR-II fluorescence emission and good photothermal conversion efficiency are used as a fluorescence probe and photosensitizer, and tellurium nanorods (TeNRs) are used as a chemotherapeutic prodrug and quenching agent to quench the fluorescence of Ag 2 S QDs. This multiple nanoplatform provides an inspiration for the combination therapy of tumor guided by NIR-II fluorescence imaging.
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PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Xinyao Liu,Sheng Li,Zhitong Wang,Xinyuan Wang,Yang He,Liankui Wen
We explored the effects of ultrahigh-pressure technology and chlorogenic acid on the color stability and structure–activity relationship of malvidin (MV). Experimental conditions were optimized through single-factor experiments and response surface analysis at a pressure of 300 MPa, mass ratio of MV to chlorogenic acid of 1:3.64 (w/w), and time of 5 min. Compared with MV, MV derivatives showed higher stability and in vitro antioxidant activity. X-ray diffraction analysis, UV–vis spectroscopy, Fourier transform infrared spectroscopy, high-performance liquid chromatography, and mass spectrometry were conducted to determine the structures of MV derivatives for the first time. Ultrahigh pressure facilitated acylation of chlorogenic acid and MV and produced four new MV derivatives. Analysis of the effect of malvidin-3-O-6-(acrylic acid-(2-hydroxy, 4-carboxy-cyclohexanol) ester)-guaiacol (Mv3ACEC) on ARPE-19 cells exposed to H2O2 by RNA transcriptome sequencing showed that Mv3ACEC simultaneously inhibited various inflammatory and apoptotic signal transduction pathways, exerted a synergistic effect, and partly inhibited cell apoptosis through the MAPK signaling pathway. Therefore, the results show that ultrahigh pressure will cause acylation of chlorogenic acid and MV to produce four new MV derivatives, and MV derivatives protect ARPE-19 cells from H2O2-induced oxidative stress.
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PubMed
高影响因子
CNS Neuroscience & Therapeutics
·
2024
·
IF 4.8
Lu Wang,Yingjuan Wei,Zhenzhou Sun,Wenya Tai,Hui Li,Yaling Yin,Lin‐Hua Jiang,Jian‐Zhi Wang
Background Oxidative stress is a well‐known pathological factor driving neuronal loss and age‐related neurodegenerative diseases. Melatonin, coenzyme Q10 and lecithin are three common nutrients with an antioxidative capacity. Here, we examined the effectiveness of them administrated individually and in combination in protecting against oxidative stress‐induced neuronal death in vitro, and neurodegenerative conditions such as Alzheimer's disease and associated deficits in vivo. Methods Mouse neuroblastoma Neuro‐2a (N2a) cells were exposed with H 2 O 2 for 6 h, and subsequently treated with melatonin, coenzyme Q10, and lecithin alone or in combination for further 24 h. Cell viability was assessed using the CCK ‐8 assay. Eight‐week‐old male mice were intraperitoneally injected with D‐(+)‐galactose for 10 weeks and administrated with melatonin, coenzyme Q10 , lecithin, or in combination for 5 weeks starting from the sixth week, followed by behavioral tests to assess the effectiveness in mitigating neurological deficits, and biochemical assays to explore the underlying mechanisms. Results Exposure to H 2 O 2 significantly reduced the viability of N2a cells and increased oxidative stress and tau phosphorylation, all of which were alleviated by treatment with melatonin, coenzyme Q10, lecithin alone, and, most noticeably, by combined treatment. Administration of mice with D‐(+)‐galactose‐induced oxidative stress and tau phosphorylation, brain aging, impairments in learning and memory, anxiety‐ and depression‐like behaviors, and such detrimental effects were mitigated by melatonin, coenzyme Q10, lecithin alone, and, most consistently, by combined treatment. Conclusions These results suggest that targeting oxidative stress via supplementation of antioxidant nutrients, particularly in combination, is a better strategy to alleviate oxidative stress‐mediated neuronal loss and brain dysfunction due to age‐related neurodegenerative conditions.
研究领域:
神经科学
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药理学
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细胞生物学
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衰老研究
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PubMed
高影响因子
SYNTHETIC METALS
·
2014
·
IF 2.222
Fang Liao,Siwei Yang,Xiubing Li,Lijun Yang,Zhihui Xie,Chenshu Hu,Shuai Yan,Tongyan Ren,Zhiduo Liu
Tunable fluorescent nanomaterials are of great significance. In this paper, the poly(o-phenylenediamine) (PoPD) nanospheres were synthesized via chemical oxidation polymerization of o-phenylenediamine (oPD) monomers by (NH 4 ) 2 S 2 O 8 (APS) at room temperature. It is interesting that when this fluorescent nanosphere was doped by F, S and Se via a simple hydrothermal progress, the fluorescence spectrum remarkably changed. The emission peak of F-doped and S-doped PoPD nanosphere was at 411 nm and 530 nm, the spectrum blue shift can be attributed to the electron-withdrawing effect of F and S. On the other side, the emission peak of Se-doped PoPD nanospheres were at 594 nm and can be attributed to the electronic donor effect of Se. These nanomaterials can be used as ultra-sensitive fluorescent detection system (ppb level) for Cu 2+ , Ca 2+ , Hg 2+ and H 2 O 2 . The tunable spectrum and sensing performance of this system is interesting and significant.
研究领域:
材料科学
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纳米技术
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分析化学
·
荧光光谱
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DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Yibing Feng,Kun Qiao,Xiaohan Jiang,Huiling Ji,Jiang Meng,Jigang Wang
A photocatalysis–self-Fenton system (PSFs) offers a viable solution to the continuous hydrogen peroxide (H 2 O 2 ) dosing and insufficient Fe 2 + regeneration challenges in conventional Fenton chemistry. An oxygen-doped g-C 3 N 4 microrod (OCNT)-based PSFs was synthesized via a facile oxalic acid-mediated supramolecular self-assembly route, enabling efficient pollutant degradation. In situ H 2 O 2 production was achieved through a two-electron oxygen reduction reaction (2e − -ORR), with photogenerated electrons accelerating Fe 2+ /Fe 3+ cycling and enhancing H 2 O 2 utilization. The system exhibited an apparent rate constant of 0.071 min −1 for tetracycline (TC) removal, 12.2- and 4.2-fold higher than pristine g-C 3 N 4 and a photo-Fenton system, respectively. Density functional theory (DFT) calculations and experimental results indicated that oxygen heteroatom doping increased the molecular dipole moment and optimized the band structure, while the one-dimensional microrod morphology exposed abundant active sites. These synergistic effects facilitated charge-carrier separation, improved interfacial mass transfer, and promoted the two-electron oxygen-reduction pathway, thereby accelerating Fe 2+ /Fe 3+ cycling and hole oxidation. The platform demonstrated broad pH adaptability, strong anti-interference capability, and long-term operational stability. This work provides an effective strategy for on-site H 2 O 2 generation and utilization in photocatalytic–Fenton systems for the degradation of organic contaminants.
研究领域:
环境化学
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材料科学
·
催化
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水处理技术
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物理化学
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纳米技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）