Stress Biology
·
2025
·Vol. 5
·期 1
·1-15
·
IF 5.8
Hao Xinchang,Li Yiwen,Hang Zhaoyue,Chen Yue,Tang Yidong,Miao Jianqiang,Peng Qin,Liu Xili
Cucumber target spot, a major disease that threatens cucumber production, is caused by Corynespora cassiicola . Cyclobutrifluram, a novel succinate dehydrogenase inhibitor (SDHI) developed by Syngenta, has demonstrated strong inhibitory activity against various plant pathogenic fungi and nematodes. However, its antifungal spectrum, resistance risk as well as underlying mechanisms of resistance in C. cassiicola remain poorly understood. In this study, cyclobutrifluram exhibited potent inhibitory activity against anamorphic fungi and selected ascomycetes, with the mean sensitivity of C. cassiicola isolates to the fungicide being 0.98 ± 1.26 μg/mL. Additionally, five laboratory-derived cyclobutrifluram-resistant mutants showed comparable or lower biological fitness than their respective parental isolates. The resistant mutants and field isolates were also found to possess nine distinct point mutations in the CcSdhB , CcSdhC or CcSdhD genes. Finally, cyclobutrifluram exhibited positive cross-resistance with other SDHIs, with the resistance levels varying depending on the specific mutations present. In conclusion, cyclobutrifluram was found to be effective against anamorphic fungi and selected ascomycetes. C. cassiicola ’s risk of resistance development to cyclobutrifluram was assessed as moderate to high and was primarily associated with mutations in CcSdh genes.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yumei Zhang,Yunqi Song,Kemin Xie,Yujie Tang,Yao Yao
A novel chemical sensor featuring an In 2 O 3 -O v /In-nIm heterostructure was facilely fabricated through the in-situ growth of In 2 O 3 -O v on an In 3+ ions-based 2-nitroimidazole metal-organic material (In-nIm MOM). The proposed synthetic strategy effectively enhances the sensing performance. The oxygen vacancies provided by In 2 O 3 -O v can increase the number of reaction centers and active sites, and the abundant porous channels offered by the In-nIm are very beneficial for gas interaction and diffusion. As expected, the In 2 O 3 -O v /In-nIm gas sensor demonstrates outstanding performance, including ultrahigh sensitivity (9853) to 200 ppm ethanol at 230℃, rapid response/recovery speeds (2 s/6 s), an extremely low detection limit (0.003 ppb), superior selectivity, and robust stability. This work provides a potential strategy for fabricating advanced sensing materials by synergistically integrating the merits of metal oxide semiconductors and metal-organic materials, rendering the heterostructure a promising candidate for high-performance chemical sensors.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Shengqiang Zhang,Tengdiao Zhang,Miao Huang,Razium Ali Soomro,Xiaojie Liu
Microporous carbons are promising sulfur hosts for room temperature sodium–sulfur (RT Na–S) batteries. Yet, most designs primarily focus on confining small S 2 – 4 molecules and overlook the sluggish redox of short-chain polysulfides (Na 2 S ₙ , n ≤ 4), which accumulate as insulating Na 2 S/Na 2 S 2 . Herein, we report a Cu-MOF-derived microporous carbon bearing both carboxyl ( COOH) and amide ( CONH 2 ) groups (denoted MPC-Cu). The unique 0.5–0.8 nm uniform pores effectively physically lock S 2 – 4 molecules, eliminating long-chain polysulfides (Na 2 S ₙ , 4 < n ≤ 8) shuttling. Density functional theory (DFT) calculations and electrochemical analysis confirm that COOH groups enhances Na 2 S ₙ adsorption (binding energy −1.51 eV for Na 2 S 4 ) and promotes Na + diffusion (ranging from 10 −9 –10 −11 cm 2 s −1 ), whereas CONH 2 groups lower the Na 2 S oxidation barrier from 1.16 eV to 0.70 eV. Consequently, S/MPC-Cu cathode delivers long-term cycle performance (571.5 mAh g −1 at 2 A g −1 with a capacity retention of 83 % over 1000 cycles) and outstanding rate performance (504.1 mAh g −1 at 5 A g −1 ). This work provides a novel strategy in designing microporous carbon catalysts for cathodes of high-capacity, long-life RT Na S batteries.
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LIPIDS
·
2025
·
IF 1.6
Xu Haixia,Chen Hui
Energy metabolism manipulation strategy, enhancing fat metabolism while reducing the dependence on glucose, is beneficial to improve exercise performance. The multi-ingredient supplements (MIS) mixed with valine, isoleucine, leucine, β-alanine, creatine, L-carnitine, quercetin, and betaine were found to be able to improve the endurance performance of mice, which was associated with a shift of energy substrates from glucose to fatty acids. Thus, we hypothesized that the MIS regulating lipid metabolism contributes to enhancing exercise endurance in mice. The present study aimed to explore the alterations in the biochemical composition of mice treated with the MIS using a metabolomics strategy after they were subjected to endurance exercise. The serum metabolite profile was investigated using ultrahigh performance liquid chromatography tandem mass spectrometry. Results showed that significant changes in lipid metabolism were observed in the MIS-treated mice during endurance exercise compared with the vehicle control. Specifically, the MIS treatment reduced glycerophospholipids, glycerolipids, long-chain fatty acids, and inflammatory signaling arachidonic acid derivatives, and increased medium-long-chain acylcarnitine levels relative to the exercised group. Furthermore, the levels of dimethylglycine (DMG), citrate (CA), glycerol, creatine, and corticosterone were also increased after the MIS supplementation, which was associated with the changes in the pathways of serotoninergic synapses, CA cycles, and amino acid metabolisms. In conclusion, the MIS tested in this study effectively alters serum metabolomics profiles, which provides further evidence to support a shift in energy substrate utilization contributing to the ability of the MIS to improve exercise performance.
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IMMUNITY
·
2021
·
IF 31.745
Ling-jie Huang,Xin-tao Mao,Yi-yuan Li,Dan-dan Liu,Ke-qi Fan,Rong-bei Liu,Ting-ting Wu,Hao-li Wang,Yu Zhang,Bing Yang,Cun-qi Ye,Jiang-yan Zhong,Ren-jie Chai,Qian Cao,Jin Jin
Summary Inflammatory bowel disease (IBD) mainly includes Crohn’s disease (CD) and ulcerative colitis (UC). Immune disorders play an essential role in the pathogenesis of these two IBDs, but the differences in the immune microenvironment of the colon and their underlying mechanisms remain poorly investigated. Here we examined the immunological features and metabolic microenvironment of untreated individuals with IBD by multiomics analyses. Modulation of CD-specific metabolites, particularly reduced selenium, can obviously shape type 1 T helper (Th1) cell differentiation, which is specifically enriched in CD. Selenium supplementation suppressed the symptoms and onset of CD and Th1 cell differentiation via selenoprotein W (SELW)-mediated cellular reactive oxygen species scavenging. SELW promoted purine salvage pathways and inhibited one-carbon metabolism by recruiting an E3 ubiquitin ligase, tripartite motif-containing protein 21, which controlled the stability of serine hydroxymethyltransferase 2. Our work highlights selenium as an essential regulator of T cell responses and potential therapeutic targets in CD.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Thao Pham Manh,Dinh Son Le,Ky Nguyen Van,Lan Ngo Thi,Tien Phat Doan,Dinh Thao Vu,Tuan Nguyen Van,Thu Hoa Nguyen Thi,Nguyen Vo Anh Duy,Minh Triet Dang,Nguyen To Van
s The present study demonstrates a successful synthesis of manganese-doped nickel cobalt sulfides (Mn-NiCo 2 S 4 ), which deliver marked improvements in electrochemical properties compared to pristine NiCo 2 S 4 . Comprehensive structural, morphological, compositional, surface, and electronic characterizations provide clear insights into the enhanced performance. Specifically, we identify three primary factors contributing to the superior electrochemical behaviors of Mn-NiCo 2 S 4 : ( i ) the appearance of hollow nanorods, which facilitates electrolyte access and improves ionic transport; ( ii ) the synergistic effects arising from the Faradaic reactions, which play a crucial role in boosting the electrochemical performance of Mn-NiCo 2 S 4 compared to the unmodified NiCo 2 S 4 ; and ( iii ) the enhances electronic conductivity from increased electron density and effective charge redistribution due to Mn doping confirmed by density functional theory simulations and experimental observations, leading to reduced internal resistance and improved electrochemical kinetics. Remarkably, Mn-NiCo 2 S 4 achieves an exceptional specific capacity of 470 C g -1 at a current density of 1 A g -1 . Additionally, the Mn-NiCo 2 S 4 //AC asymmetric supercapacitor delivers impressive energy densities ranging from 37.09 to 84.85 Wh kg -1 , corresponding to power densities decreasing from 7.09 to 0.79 kW kg -1 ; maintaining 50.52% capacity retention after 10,000 cycles at 2 mA cm -2 . These results underscore the potential of Mn-NiCo 2 S 4 and related doped materials as next-generation electrodes for advanced, high-performance supercapacitors, paving the way for significant advancements in energy storage technology.
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ENERGY & FUELS
·
2020
·
IF 3.421
Mingjie Du,Xiaoqing Tian,Ran Ran,Wei Zhou,Kaiming Liao,Zongping Shao
The cycling performance of lithium–sulfur (Li–S) batteries, which is a major parameter determining the practical application of such an advanced high-energy-density battery system (1675 mA h g–1), is strongly affected by the properties of the cathodic sulfur hosts. As a desirable sulfur host, it should possess high surface area, good electronic conductivity, and superior physisorption and chemisorption to polysulfides. Here, by taking advantage of the magnesiothermic denitriding technology, the graphitic carbon nitride (GCN) with a tunable nitrogen content, surface area, and pore volume has been designed as a sulfur host for high-performance Li–S batteries. With a nitrogen content of ∼6%, a surface area of 594 m2 g–1, and a pore volume of about 2 cm3 g–1, the GCN-based host can retain sulfur and allow its reversible convention within cathodic region, thereby delivering a high capacity of 852.2 mA h g–1 at 0.5 C with a low capacity decay of 0.12% per cycle within 300 cycles. This work provides a feasible way to design nitrogen-doped carbon materials with tunable nitrogen content and enlightens the host material design for practical Li–S batteries.
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ELECTROCHIMICA ACTA
·
2014
·
IF 4.086
Wenjuan Liu,Fahe Cao,Yan Xia,Linrong Chang,Jianqing Zhang
Corrosion of magnesium is initiated from film-free region where the pit corrosion is the main corrosion form. The incubation and growth of active spots in film-free region is affected by the concentration of Cl − and the composition of surface film. Application of scanning electrochemical microscopy (SECM) in feedback mode for corrosion study of AM60 and AMCe1 (AM60 with additional Ce) magnesium alloy in different NaCl solutions is presented. SECM mapping mode was also used to monitor the electrochemical processes on AM60 and AMCe1 alloys immersed in NaCl solutions. The results indicate that the electrochemical behavior of magnesium alloy is different depending on chloride ion concentration and its surface film. Enhanced localized corrosion of magnesium alloy with chloride ions concentration shows that higher concentrated chloride ions results in the rapid initiation and quick growth of active spots, facilitates breakdown and high hydration of surface film. Meanwhile, scratch tests were performed on magnesium alloy, known to develop an artificial defect to monitor variation of electrochemical activity. In the proximity of the local defect, the accelerated electrochemistry activity originating from the high-hydration of surface film is observed when chloride ions are concentrated in the environment. Furthermore, the addition of rare earth element Ce is advantage of reducing the tendency of incubation and growth of active spots due to its more complete and protective surface film.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2018
·
IF 4.229
Dandan Li,Congcong Wei,Qiang Wang,Lin Liu,Dazhong Zhong,Genyan Hao,Jinping Li,Qiang Zhao
Silver-based catalysts with an adjustable structure are promising as efficient oxygen evolution catalysts. Four types of silver-oxide (AgO) morphologies were obtained by potentiostatic deposition in situ in organic carboxylate by altering the amount of ammonia as the complexing agent. AgO films can be used in the oxygen-evolution reaction; AgO that is formed by using potassium acetate that contains 1.32 mM ammonia as an electrolyte exhibits preferable performance. Catalyzed water oxidation occurs in 0.1 mol/L potassium phosphate solution (pH 12.3) with an average activity of 3.5 mA/cm 2 , and persists for at least 10 h at 2.03 V (vs. Reversible Hydrogen Electrode, RHE). Overpotential is 438 mV at a current density of 1 mA/cm 2 . The Faradaic efficiency is 94.4%. Samples were well characterized by X-ray powder diffraction, scanning electron microscopy and X-ray photoelectron spectroscopy.
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Desalination and Water Treatment
·
2024
·
IF 1
Zhineng Liu,Hongwei Rong,Zhaorui Chu,Huayong Luo,Meihua Zhao,Randeng Wang,Chaosheng Zhang
The combination of qualitative methods with quantitative analysis of pharmaceuticals and their metabolites in wastewater treatment plants using liquid chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry is presented. The selected pharmaceuticals were found at a low or medium level in raw wastewater, compared with previous studies around the world. The removal efficiencies of sulfamethoxazole in the four parallel biological treatment processes were similar. Data-independent and data-dependent mass spectrometry acquisition methods (All Ions MS/MS and auto MS/MS) were employed for qualitative analysis. Five of the 18 tentatively identified compounds resulted from data-independent acquisition mode were confirmed with standards. Thirty-nine pharmaceuticals and seven metabolites were tentatively identified using data-dependent acquisition mode. The parent pharmaceuticals and their metabolites, such as caffeine and its three metabolites (3-methylxanthine, 1,7-dimethyluric acid, and paraxanthine), were detected in wastewater. Irbesartan and valsartan were tentatively identified in both positive and negative modes. The present study demonstrates that both data-dependent and data- independent acquisitions are suitable and reliable for tentative determination of pharmaceuticals and their metabolites in municipal wastewater.
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DYES AND PIGMENTS
·
2022
·
IF 5.122
Jun Hou,Xiaoqing Xiong,Chengqi Jiao,Xinyao Huang,Deyang Fu,Hongjuan Zhao,Yixuan Li
Supercritical carbon dioxide (scCO 2 ) is commonly used as an excellent solvent in chemical reactions and dyeing fields because of its advantages. In this work, three coumarin and 1,8-naphthalimide fluorescent dyes ( DAMC , NP-NH , and NP-dimethyl ) were successfully constructed on the basis of the Au/titanium dioxide (Au/TiO 2 ) catalytic reduction of nitro in scCO 2 instead of SnCl 2 /hydrochloric acid solution, and their structures were confirmed correctly by mass spectrometry (MS) and nuclear magnetic resonance (NMR). The cleaner synthesis and dyeing polyester fabrics of coumarin derivative ( DAMC ) in the presence or absence of N-methyl-pyrrolidone (NMP) were first studied by employing stepwise and synchronous methods. All results for DAMC indicated that the synchronous synthesis and dyeing method is more beneficial. Here, the synchronous synthesis and dyeing polyester fabrics of 1,8-naphthalimide derivatives ( NP–NH and NP-dimethyl ) in scCO 2 were also investigated. Through the comprehensive analysis of color strength ( K/S ) value and fixation rate, the optimal temperatures and pressures of synthesis and dyeing for NP-NH and NP-dimethyl were obtained in the absence or presence of NMP. The dyed fabrics with NP-NH and NP-dimethyl exhibited yellow or yellowish-brown in daylight and bright fluorescent yellowish-green in ultraviolet light. All results showed that the clean production of fluorescent dyes ( DAMC , NP-NH , and NP-dimethyl ) can be realized by the hydrogenation of nitro with efficient Au/TiO 2 catalyst in scCO 2 , meanwhile, the synchronous synthesis and dyeing method was proposed for the synthesized dyes. The realization of synchronous synthesis and dyeing fabrics for fluorescent dyes in scCO 2 is an effective way to prevent environment pollution brought by the processes of synthesis and dyeing. Thus, the constructing and dyeing strategy of fluorescent dyes will be beneficial to the sustainable development of environment.
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JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Ruiyun You,Jie Li,Haonan Wang,Yaling Wu,Jingzheng Weng,Yudong Lu
Label-free surface-enhanced Raman scattering (SERS) technology is used to screen for colon cancer for its rapid identification, high specificity and non-invasiveness. Here, we have developed a high-performance SERS biosensor that has combined concentration, separation and detection for effective screening of colon cancer. This SERS biosensor is equipped with a centrifuge tube and a filter that consists of two ultrafiltration membranes (UFMs). First, silver nanoparticles (Ag NPs) are uniformly reduced in-situ on the UFM using a controlled “silver mirror reaction”, then the filter and centrifuge tube are assembled into an ultrafiltration centrifuge tube containing Ag NPs (Ag NPs/UFT biosensor). And finally, the Ag NPs/UFT biosensor is applied to concentrate and separate colon cancer serum. The biosensor reduces signal fluctuations in the detection of liquid phase substrates (Ag NPs colloids), which are prone to aggregation and instability, more importantly minimizes the interference of large amounts of small molecule proteins and also concentrates and retains molecular weight proteins of high diagnostic value. Furthermore, we employed SERS spectroscopy by portable Raman, combined with principal component analysis-linear discriminant analysis (PCA-LDA) models, to further assess the screening diagnosis of colon cancer. As a proof of concept, we achieved 100% specificity and 87.5% accuracy with our sensors. This study will contribute to the field of non-invasive, rapid and practical screening for colon cancer together with the ultrafiltration system.
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