ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Qi Chen,Yue Zhou,Xudong Zhu,Lei Xu,Ge Bai,Yaru Zhou,Nannan Zhang,Hongwen Liu,Yani Pan,Yu Liu,Lishan Wang,Xueni Fu,Jingjing Wei,Lina Zhou,Lu Xu,Yuxiang Sun,Zhangding Wang,Shanshan Shen,Yun Zhu,Lei Wang
Tumor-associated neutrophils (TANs), particularly the N2 phenotype, contribute to T cell exhaustion in cholangiocarcinoma (CCA), leading to low response rates to PD-1 inhibitor therapy. To address this issue, cancer-associated fibroblast (CAF)-derived extracellular vesicles loaded with ruxolitinib (CEVs@Ru) are developed to selectively target and reprogram N2 TANs, thereby modulating the immunosuppressive tumor microenvironment (TME). The combination of CEVs@Ru with anti-PD-1 antibody therapy significantly enhanced antitumor efficacy, reducing tumor weight by 89.86% and normalizing liver weight, without significant adverse effects. This approach improved the local concentration of ruxolitinib, increased CD8+ T cell infiltration, and reduced regulatory T cells, indicating a remodeled TME conducive to effective antitumor immunity. The findings provide a promising strategy for enhancing PD-1 inhibitor efficacy and improving patient outcomes in CCA and potentially other solid tumors.
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高影响因子
Exploration
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2025
·
IF 22.5
Qi Lu,Hao Ye,Jian Zhao,Xiaoyuan Fan,Kaiyuan Wang,Zeyu Han,Tian Liu,Lili Du,Jiaxuan Song,Helin Wang,Haotian Zhang,Zhonggui He,Jin Sun
The tumor microenvironment is characterized by immunosuppression and compromised intratumoral perfusion, which impairs the effectiveness of immune checkpoint inhibitors and nanomedicines. A significant challenge is the role of activated platelets, as they increase transfer-mediated PD-L1 expression from tumor cells and maintain the integrity of tumor vasculature. These platelets support tumor growth by stabilizing the vasculature and enabling immune evasion, as well as shielding tumor cells from immune detection. To address these platelet-mediated negative antitumor effects, we have developed bioengineered platelets (PTNPs) with surface-anchored ticagrelor-loaded gelatin nanoparticles. This study utilizes the natural tendency of platelets to localize their activated counterparts into tumors. Upon binding to tumor-associated activated platelets, the PTNPs release ticagrelor in response to the secreted matrix metalloproteinases by activated platelet, inhibiting further platelet activation. This reduction in platelet activation lessens platelet-facilitated immunosuppression and diminishes the transferred-PD-L1 expression from cancer cells to platelets, thus enhancing the immune response of anti-PD-L1 therapy. Additionally, this strategy weakens the activated platelets’ contribution to tumor vascular integrity, improving the extravasation and chemotherapeutic efficacy of nanomedicines. Our findings highlight the crucial role of platelet activation in tumor biology and introduce PTNPs as an effective approach to disrupt tumor-supporting platelet activities and enhance anticancer treatments efficacy.
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
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IF 8.3
Jiming Zeng,Hanyu Shi,Qian Wang,Chengchen Wang,Yukun Wang,YaXin Zhou,Guobin Yang,Jun Li,Giuseppe Mele,Chen Wang
Photocatalytic water splitting for hydrogen production and the degradation of organic pollutants are regarded as promising strategies to address the current energy crisis and environmental issues. As a wide-bandgap metal oxide, TiO 2 is characterized by low catalytic activity and a narrow range of light absorption when used alone, whereas its combination with narrow-bandgap semiconductors has been shown to lead to a significant enhancement in catalytic performance. In this study, CdS–TiO 2 composites were synthesized via a ball-milling method, after which Pt–Pd nanoparticles were deposited by photodeposition. The noble metals were found to interact with CdS and TiO 2 respectively, while a synergistic catalytic effect between Pd and Pt was also observed. The photocatalytic efficiency was further extended by the formation of CdS–TiO 2 heterojunctions, resulting in a significantly enhanced hydrogen production rate of 4656.99 μmol h −1 g cat −1 in the ternary system. Moreover, the composite demonstrated significantly enhanced performance in the photocatalytic reduction of 4-NP, The Pt–Pd NPs/CdS-Vo-TiO 2 photocatalyst achieved a 95.2 % conversion rate for 4-NP within 2 min, also demonstrating high photocatalytic activity.
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高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Tianyi Huang,Ke Liang,Danyang Zhao,Zhiyuan Yu,Zhiqiang Zhao,Shafqat Ullah,Jiajia Wu,Yong Chen,Shuliang Lu,Jun Huang,Sibudjing Kawi,Qiangqiang Xue,Yujun Wang,Guangsheng Luo
Low-temperature and highly selective hydrogenation of 2-ethylanthraquinone (EAQ) is still challenging, owing to the high energy barrier for hydrogen dissociation and the lack of multifunctional active sites. Herein, alumina supports with specific crystal planes were synthesized via the modified sol–gel approach using octanol as the crystal growth directing agent. The layered γ-alumina support characterized (100) crystal planes materialized atomic dispersion of palladium species (Pd dispersion 66.3%), comprising Pd single atoms and subnanometer clusters. The dual-site catalyst with a low Pd loading (0.1%) achieved a H2O2 space-time yield of 1273.7 g·H2O2/g·Pd/h and selectivity of 99.4% at room temperature (25 °C) in a fluidized reactor. Moreover, the apparent activation energy for EAQ hydrogenation of the dual-site structure is significantly lower than those of the single-site structures. Systematically, in situ spectroscopic techniques confirmed that Pd single atoms enabled effective hydrogen adsorption and dissociation and the effective anchoring subnanometer Pd clusters endowed moderate adsorption intensity of intermediates and inhibited overhydrogenation. We posit that these results provide guidance for the design and synthesis of supported metal catalyst featuring synergistic single atom and subnanometer cluster active sites for practically selective hydrogenation processes.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Danhong Gao,Shang Li,Xianjie Xu,Hongwei Liu,Hanling Deng,Qianyao Lu,Dusong Hou,Sheng Huang,Mingzhi Jiao,Xiaowei Li,Xinjian He
Rapid and reliable detection of methane (CH 4 ), a key clean energy source and potent greenhouse gas, is of great importance for industrial safety and environmental protection. In this work, a high-performance CH 4 gas sensor is developed based on hollow ZnO nanobowls decorated with Pd nanoparticles, synthesized via a template-assisted strategy followed by mild impregnation. The hollow nanobowl architecture features a uniform particle size (~350 nm), ordered mesopores (~3.4 nm), and a high specific surface area of 104.06 m 2 g −1 , which effectively enhances gas diffusion and surface reaction kinetics without relying on complex heterojunctions or bimetallic systems. The introduction of Pd increases the oxygen vacancy content from 29.41% to 41.48%, provides additional active sites, and facilitates electron transport. Moreover, Pd catalyzes O 2 dissociation via a spillover effect and lowers the activation energy for C H bond cleavage in CH 4 , while the work function difference between Pd and ZnO induces a Schottky barrier at the interface, dynamically modulating the sensor conductivity. Benefiting from the synergistic effects of morphological regulation and interfacial electronic modulation, the sensor exhibits a high response of 67% to 1000 ppm CH₄ at an operating temperature of 253.5 °C, along with an ultrafast response/recovery time of 2/10.5 s and a wide detection range of 20–10,000 ppm. In addition, the sensor demonstrates good selectivity and excellent long-term stability, with less than 10% signal fluctuation over 30 days. Building upon the reliable concentration discrimination validated by CNN-1D models, an LSTM-based short-term dynamic prediction framework was further introduced to evaluate temporal early-warning performance under rapid methane concentration variations. The results demonstrate that the proposed sensor–algorithm integration can effectively capture dynamic concentration evolution and accurately predict the 5000 ppm alarm threshold across multiple diffusion rates, highlighting its potential for early-warning applications in confined spaces.
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高影响因子
Materials Today Energy
·
2026
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IF 8.1
Yipeng Nie,Longquan Deng,Zipei Cui,Zhao Jiang,Wenchao Sheng
Coupling hydrogen evolution reaction (HER) with glycerol oxidation reaction (GOR) in a hybrid electrolyzer represents a highly promising approach for green hydrogen production and glycerol upgrading. However, the limited activity and stability of existing GOR catalysts restrict the energy efficiency of the coupled system. In this study, Pd/C and Pd 4 Ag x /C catalysts were synthesized to investigate the impact of Ag on the activity and stability of Pd-based catalysts for GOR. The optimized Pd 4 Ag 8 /C demonstrated a specific activity of 17.4 ± 0.1 mA cm −2 Pd and a mass activity of 13.2 ± 0.3 A mg −1 Pd , both being more than 10 times higher than those of Pd/C. Combined results of ultra-performance liquid chromatography and density functional theory calculations revealed that the introduction of Ag promotes C−C cleavage in glyceric acid on Pd sites, facilitating electron transfer in GOR and thereby enhancing the GOR activity. The GOR coupled HER hybrid electrolyzer using Pd 4 Ag 8 /C as the GOR catalyst achieved a significant reduction of ∼1.07 V in cell voltage compared to conventional water electrolysis system at a current density of 10 mA cm −2 with a favorable operational stability, and realized the production of high-value-added chemicals, demonstrating the promising potential in both hydrogen production and upgrade of glycerol.
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高影响因子
MOLECULAR PHARMACEUTICS
·
2026
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IF 4.5
Wanyu Jin,Shujun Xu,Hongyan Zhang,Yujie Li,Mengna Shi,Ninghui Ma,Xin Zhang,Lujia Zhu,Yang Xiong
The limited efficacy of programmed death-ligand-1 (PD-L1) monoclonal antibodies (aPD-L1) in triple-negative breast cancer (TNBC) is largely attributable to the immunosuppressive tumor microenvironment (TME). Notably, the abundance of cancer-associated adipocytes (CAAs) constitutes a distinctive feature of the TNBC microenvironment, contributing significantly to its immunosuppressive nature. CAAs upregulate cluster of differentiation 36 (CD36), a fatty acid translocase on tumor cells, thereby promoting excessive fatty acids (FAs) uptake and lipid droplet (LD) accumulation, which starve immune cells and reinforce immunosuppression through this metabolic adaptation. Berberine (BBR), a bioactive alkaloid derived from Rhizoma coptidis, has previously been shown to ameliorate lipid metabolism disorders through downregulation of CD36 in metabolic diseases such as hepatic steatosis. We therefore hypothesize that BBR inhibits CD36-mediated FAs uptake and reduces LD accumulation in tumor cells, representing a novel mechanism that remains unexplored in the context of TNBC. In this study, we demonstrated that BBR counteracts the tumor-promoting effects of CAAs in 4T1 cells by inhibiting CD36 upregulation and its mediated FAs uptake, thereby reducing CAA-induced LD accumulation and ultimately suppressing tumor cell proliferation. Furthermore, BBR remodeled the TME by enhancing CD8+ T cell recruitment and activity, while reducing immunosuppressive factors. In order to improve the sustained release of BBR at the tumor site and overcome its poor aqueous solubility, we created a thermosensitive hydrogel-based nanoparticle system (BBR-NPs-GEL). This injectable hydrogel demonstrated favorable thermosensitive gelation and shear-thinning behavior, making it suitable for localized administration. It exhibited a gelation temperature of 35.3 ± 0.2 °C and a sustained release profile with 52% of BBR released within 48 h. In 4T1Fluc tumor-bearing mice, BBR-NPs-GEL significantly suppressed tumor growth and remodeled the TME, as evidenced by increased infiltration of CD8+ T cells (+8.49%), activation of dendritic cells (+8.39%), and a shift toward M1-macrophages (+39.9%), accompanied by a reduction in M2-macrophages (−19.13%). Importantly, when combined with aPD-L1 therapy, the treatment elicited synergistic antitumor effects, resulting in enhanced tumor regression. This combination strategy effectively overcame metabolic immunosuppression and reversed immune resistance in TNBC.
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PubMed
高影响因子
Small
·
2018
·Vol. 14
·期 14
·1703613
·
IF 9.598
Yanxia Ma,Lisi Yin,Guojian Cao,Qingli Huang,Maoshuai He,Wenxian Wei,Hong Zhao,Dongen Zhang,Mingyan Wang,Tao Yang
Exploration of highly efficient electrocatalysts is significantly urgent for the extensive adoption of the fuel cells. Because of their high activity and super stability, Pt-Pd bimetal nanocrystals have been widely recognized as one class of promising electrocatalysts for oxygen reduction. This article presents the synthesis of popcorn-shaped Pt-Pd bimetal nanoparticles with a wide composition range through a facile hydrothermal strategy. The hollow-centered nanoparticles are surrounded by several petals and concave surfaces. By exploring the oxygen reduction reaction on the carbon supported Pt-Pd popcorns in perchloric acid solution, it is found that compared with the commercial Pt/C catalyst the present catalysts display superior catalytic performances in aspects of catalytic activity and stability. More importantly, the Pt-Pd popcorns display minor performance degradations through prolonged potential cycling. The enhanced performances can be mainly attributed to the unique popcorn structure of the Pt-Pd components, which allows the appearance and long existence of the high active sites with more accessibility. The present work highlights the key roles of accessible high active sites in the oxygen reduction reaction, which will ultimately guide the design of highly durable Pt-Pd catalysts.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Tianhang Liu,Kaisheng Yao,Shuaibo Li,Hang Li,Qi Wang,Tianhang Han,Aozhou Wang,Haili Zhao
Concave nanomaterials possess superior properties, but their synthesis usually requires complicated steps, specific conditions and additional reagents (surfactants, capping agents, seeds, etc.). Herein, the well-defined Au@Pd concave nanocubes (CNCs) is facile one-step fabricated in a deep eutectic solvent (DES, named reline) composed of choline chloride (ChCl) and urea. It is found that the reline is crucial to the formation of Au@Pd CNCs. Owing to the concave core-shell structures, and electronic effects between Au core and Pd shell, Au@Pd CNCs exhibited excellent catalytic performance, and recovery convenience in the selective hydrogenation of 4-nitrostyrene. Specifically, under normal temperature and pressure conditions (25°C, 0.1 MPa), 4-nitrostyrene can be completely hydrogenated to 4-nitroethylbenzene within 7.0 min. After five cycles, Au@Pd CNCs still maintain the highly catalytic activity and 100 % selectivity toward 4-nitroethylbenzene. It is expected that well-constructed Au@Pd CNCs also display advanced potentials in other applications.
研究领域:
纳米材料
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催化化学
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绿色化学
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无机合成
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加氢反应
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高影响因子
JOURNAL OF CATALYSIS
·
2026
·
IF 6.5
Yuyong Zhang,Yuanjun Zhao,Yuanyuan Zhu,Yudi Wu,Zhaozhan Wang,Jinglin Mu,Yong Yang
The integration of superior homogeneous catalytic activity with the practical advantages of facile separation and robust recyclability of heterogeneous systems remains a grand challenge. Here, we report a heterogenized bidentate phosphine ligand, constructed by integrating commercial Xantphos into a hypercrosslinked porous polymer, as a versatile platform for Pd-catalyzed alkoxycarbonylation. The tailored polymer, featuring a high surface area, hierarchical pores, and chemical robustness, provides privileged coordination microenvironments. It empowers highly efficient alkoxycarbonylation of diverse alkenes with various alcohols, including monoalcohols, diols, and polyols, to produce valuable esters with activity and selectivity comparable to its homogeneous molecular counterpart. Moreover, the catalytic system enables the in-situ formation of a robust Pd catalyst, wherein Pd nanoparticles are stabilized and uniformly dispersed via strong Pd-P coordination. This resulting catalyst demonstrates exceptional durability, being readily recycled over ten times without significant degradation in performance. This work pioneers a versatile platform for ligand immobilization that effectively bridges homogeneous efficiency with heterogeneous durability, unlocking efficient and sustainable pathways for carbonylation and other ligand-mediate transformations.
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高影响因子
ACS Catalysis
·
2026
·
IF 13.6
Shunwu Wang,Zhenbo Guo,Bing Tang,Jinglin Du,Qianling Zou,Ligang Wang,Xiaohui Li,Xiaodong Zhou,Lang Liu,Yadong Li
Developing chemoselective hydrogenation of alkynes into alkenes is one of the major strategies of the fine chemical industry; however, it presents significant challenges in achieving the semi-hydrogenation of carbon−carbon triple bond (C=C) to carbon−carbon double bond (C=C) without further hydrogenation. Herein, it is proposed that d−p orbital hybridization between the Pd single-atom-cluster sites and the bismuth species can serve as a descriptor for revealing the catalytic activity. Guided by DFT simulation, the well-dispersed Pd clusters and single-atom Pd−O4 sites on Bi-doped hydroxyapatite (PdSA+C/HAP-Bi) are fabricated for semi-hydrogenation of phenylacetylene, realizing the trade-off between activity and selectivity with a robust turnover frequency of 10,140 h−1, surpassing those of the commercial Pd/C catalyst and most of the reported catalysts. It also displays good stability for enduring six cycles with minimal declines in conversion and selectivity. Notably, this catalyst offers a general platform, showcasing broad substrate compatibility across at least 30 types of alkynes. Particularly, the introduction of well-dispersed Bi and PdC can induce prominent electron redistribution at the Pd−O4 sites and adjust the hybridization between the central Pd 3d and Bi 4f orbitals. Simultaneously, the strong electronic coupling in Pd−O−Bi pairs facilitated the d-electron domination near the Fermi level, boosted the activation of H2 and phenylacetylene at PdC sites, and improved the desorption capacity of styrene at Pd−O4 sites. This synergy ultimately lowers the energy barrier for the phenylacetylene semi-hydrogenation.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 10
·679
·
IF 5.4
Wu Siying,Du Tianmei,Ma Mengyun,Pu Fang,Zhang Yanli,Men Xue,Wang Hongbin,Yang Wenrong,Pang Pengfei
The development of a novel molecularly imprinted electrochemical sensor for the sensitive and selective detection of bisphenol A (BPA) is reported, based on a nanocomposite comprising dendritic Pt–Pd bimetallic nanoparticles and graphitic carbon nitride (Pt–Pd NPs/g-C 3 N 4 ). The molecularly imprinted polymer (MIP) was fabricated via electrochemical polymerization on Pt–Pd NPs/g-C 3 N 4 nanocomposite modified screen-printed electrode (Pt–Pd NPs/g-C 3 N 4 /SPE) surface. The synergistic integration of porous Pt–Pd NPs and ultrathin g-C 3 N 4 nanosheets provides a larger effective surface and enhances catalytic activity for BPA determination. The MIP film was fabricated via cyclic voltammetry on the modified electrode, employing BPA as the template molecule and pyrrole as the functional monomer. Following template removal, the resulting molecularly imprinted cavities within the MIP demonstrated high specificity for BPA recognition. The fabricated MIP-based electrochemical sensor exhibited an excellent linear response and high sensitivity for BPA detection over a broad concentration range of 2–100 ng/mL, achieving a limit of detection (LOD) of 0.2 ng/mL (3 σ/S ) and a limit of quantification (LOQ) of 0.6 ng/mL. The MIP-based sensor exhibits outstanding specificity, reproducibility, and operational stability, thereby providing a versatile platform for rapid and ultrasensitive BPA detection—a critical capability for ensuring environmental safety and protecting public health. Graphical
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高影响因子
危险品化学品经营许可证（带存储）