APPLIED OPTICS
·
2021
·Vol. 60
·期 22
·6659-6664
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IF 1.98
Pingping Teng,Danheng Gao,Xinghua Yang,Meng Luo,Depeng Kong,Shuai Gao,Zhihai Liu,Zhanao Li,Xingyue Wen,Libo Yuan,Libo Yuan,Kang Li,Mark Bowkett,Nigel Copner
In this paper, we present a microstructured optofluidic in-fiber Raman sensor for the detection of quinolone antibiotic residue in a water environment based on Ag surface-enhanced Raman scattering (SERS) substrate grown on the surface of the suspended core of micro-hollow optical fiber (MHF). Here, MHF has a special structure with a suspended core and a microchannel inside, which can become a natural in-fiber optofluidic device. Meanwhile, the self-assembled Ag SERS substrate can be grown on the suspended core’s surface through chemical bonds, forming a microstructured optofluidic device with a Raman enhancement effect. Therefore, it can effectively detect the Raman signal of unlabeled trace quinolone antibiotic residue (ciprofloxacin and norfloxacin) inside the optical fiber. The results show that the ciprofloxacin and norfloxacin detection limits (LOD) are ${{10}^{- 10}}\;{\rm{M}}$ and ${{10}^{- 11}}\;{\rm{M}}$, respectively. Compared with the maximum residue limit (${3.01} \times {{10}^{- 7}}\;{\rm{mol}}/{\rm{L}}$) stipulated by the European Union, the results are much lower, and an ideal quantitative relationship can be obtained within the detection range. Significantly, this study provides an in-fiber microstructured optofluidic Raman sensor for the label-free detection of quinolone antibiotic residue, which will have good development prospects in the field of antibiotic water pollution environmental detection.
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Nanoscale
·
2019
·Vol. 12
·期 7
·4359-4365
·
IF 6.97
Zhen Wang,Chunxue Zheng,Peng Zhang,Zhulin Huang,Chuhong Zhu,Xiujuan Wang,Xiaoye Hu,Jian Yan
Herein, we report a facile strategy of combined SERS measurements based on a split-type SERS substrate, which exhibits excellent SERS activity, detection signal reproducibility and chemical stability. The SERS substrate consists of an ordered Al2O3@Ag@Si nanocone array and Ag nanoparticles (Ag-NPs), both of which are fabricated individually. The Al2O3@Ag@Si nanocone array is obtained by ion-sputtering Ag on an Si nanocone array and then coating an ultrathin (∼2 nm) Al2O3 dielectric layer via atomic layer deposition (ALD). Ag-NPs are synthesized via the liquid phase method and then immersed in an organic solvent for liquid seal. For the SERS measurement, Ag-NPs are dispersed in a liquid containing the probe molecules and then, they self-assemble on the surface of the Al2O3@Ag@Si nanocones. Subsequently, the ultrathin Al2O3 dielectric layer separates Ag-NPs from the Ag@Si nanocones, forming massive gap-introduced hot spots. This substrate is sensitive to 1 pM Rhodamine R6G with an average enhancement factor of up to 109, exhibiting excellent SERS activity. Moreover, due to the protection of the Al2O3 dielectric layer and the organic solvent for the Ag@Si nanocones and Ag-NPs against oxidation, the split-type SERS substrate achieves an SERS signal with almost no attenuation after five months, indicating its good chemical stability.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Yongfeng Zhou,Pei Liang,De Zhang,Lisha Tang,Qianmin Dong,Shangzhong Jin,Dejiang Ni,Zhi Yu,Jiaming Ye
A stable substrate is extraordinarily important for the trace detection of Surface Enhanced Raman Scattering technique. We have designed in this paper a simple seed growth method to prepare Ag@ZrO 2 core-shell nanoparticles as well as regulate the core-shell ratio by adjusted concentration of zirconium propoxides added. The shell thickness effect and spacing on SERS activities have been simulated in different finite time domains, which goes perfectly with those previous experiment results. With Ag@ZrO 2 core-shell nanoparticles adopted as the SERS substrate and R6G as molecular probe , the detection range could reach as great as 10 -8 M. The regression model, obtained through principal component analysis, is adopted for some rapid and precise detection; and the determination coefficient (R 2 ) is going up to 0.9743, proving that the SERS substrate we have prepared has extremely high detection accuracy. To explore the stability of core-shell nanoparticles, we have taken both two different cases of strong acid solution as well as strong alkali solution for the core-shell nanoparticle etching, and this is how a SERS test could be carried out. These experimental results have indicated that the outer zirconia layer could keep the silver surface from oxidation and its stability is ensured, quite crucial for the applied SERS.
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JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Xia Zhou,Guangqiang Liu,Hongwen Zhang,Yue Li,Weiping Cai
A core–shell configuration of the zeolite imidazole framework (ZIF-8) wrapped urchin-like Au-Ag alloyed nanocrystals (UAANs) were designed and fabricated via adding the pre-formed plasmonic nanoparticles into the ZIF-8 precursor solution with hexadecyltrimethyl ammonium bromide (CTAB). The UAANs are about 100 nm in size with high-density tips. The ZIF-8 shell layer is nanoporous and can be controlled in thickness from 10 nm to 40 nm by the CTAB concentration. Importantly, such ZIF-8 wrapped UAANs can be used as the highly efficient surface enhanced Raman scattering (SERS) substrates for detection of the trace hexachlorocyclohexane (HCH) molecules. The ZIF-8 shell layer with an appropriate thickness (-∼20 nm) can evidently increase the SERS performance of the UAANs to the trace γ-HCH and α-HCH. Such wrapping-enhanced SERS effect significantly increases, by a power function, with the decreasing HCH concentration, especially in the concentration below 10 −6 M, which is attributed to the ever-increasing enrichment effect to the HCH molecules. The detection limit is down below 1.5 ppb. This work presents a highly efficient substrate for the SERS-based detection of the trace HCH, and also displays the potential application in the SERS detection of volatile small molecules.
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TALANTA
·
2019
·
IF 4.916
Jie Chang,Amin Zhang,Zhicheng Huang,Yunsheng Chen,Qian Zhang,Daxiang Cui
The rapid identification of living cancer cells is highly crucial for cancer diagnosis, prognosis, and treatment monitoring. However, it is a great challenge to develop an effective way for rapid identification and imaging of cancer cells in a living state. Moreover, synthesis of monodisperse nanoparticles (NPs) with high sensitive surface-enhanced Raman scattering (SERS) activity is also a tough work. Herein, we creatively reported a convenient method to synthesize the novel NPs as the substrate of SERS sensors, which possessed a gold nanobipyramid core and silver nanorod shell. These gold nanobipyramid core and silver nanorod shell NPs (Au NBP@Ag NRs) were further modified with 4-mercaptobenzoicacid (4-MBA, Raman reporter molecule) and then conjugated with reduced bovine serum albumin (rBSA) and folic acid (FA) on their surfaces, to finally acquire Au NBP@Ag NR-MBA-rBSA-FA nanoprobes. In this system, With the enhancement factor (EF) of Au NBP@Ag NRs was about 4 × 10 7 , it could significantly enhance Raman signal for Raman reporter molecules, and 4-MBA molecules performed high SERS signals based on their structures; the nanoprobes have favorable specificity and biocompatibility owing to the modification of rBSA which effectively avoided the nonspecific attachment of non-targeted cells. Moreover, the obtained SERS nanoprobes have excellent sensitivity for gastric cancer cells (MGC-803 cells) due to the conjugation of folic acid. Thus, the finally obtained Au NBP@Ag NR-MBA-rBSA-FA nanoprobes possess excellent detection efficiency for living MGC-803 cells. Therefore, our synthesized nanoprobes exhibit ultrasensitive SERS-activity, excellent specificity and superior cancer cells targeting ability, which could be applied for rapid identification and Raman imaging of living cancer cells via the SERS signal detection of the nanoprobes.
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Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 32
·9856-9864
·
IF 6.641
Di Yin,Ming-Liang Wang,Ying-Zi Wang,Xun Hu,Bo Liu,Hong Liu,Lulu Ma,Guang-Gang Gao
A ternary nanocomposite containing ZnO, ZnS and MoS2 (ZnMoNCs) has been firstly synthesized by Keggin-type polyoxomolybdate and ZIF-8 as starting materials to provide Mo and Zn sources simultaneously. As compared to the mono- or bi-component complex, ZnMoNCs present more sensitive and stable surface-enhanced Raman scattering (SERS) activity. When rhodamine 6G is used as a probing molecule, the detection limit of 10−9 mol L−1 can be achieved on the ZnMoNC substrate with the enhancement factor (EF) of 1.4 × 108, which is the highest sensitivity among the known semiconductor SERS substrates. The increased adsorption sites and the synergistically improved charge transfer are conducive to the large enhancement of the SERS activity. It was also proved that the ZnMoNC substrate possesses high stability and self-cleaning properties, and can be reused in SERS detection without losing its activity even after 5 cycles. This work paves a new way to the design of new semiconductor SERS substrates by the utility of a multicomponent complex.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2019
·Vol. 21
·期 7
·1-14
·
IF 2.009
Chen Xiao-Hong,Zhu Jian,Li Jian-Jun,Zhao Jun-Wu
In this paper, we report plasmonic spectra and surface-enhanced Raman scattering (SERS) dual-mode iodide ions (I − ) detecting probe based on Ag-coated tetrapod Au nanostars (Au@Ag tetrapod nanostars). This probe depends on the fact that I − can etch the silver layer of Au@Ag tetrapod nanostars in the presence of Cu 2+ , which leads to the red shift of in-plane localized surface plasmon resonance (LSPR) peak and decrease of SERS intensity. Indeed, our regular morphologies of Au@Ag tetrapod nanostars provide a uniform response space for the plasmonic spectral probe. The red shift caused by both the silver layer etching and gold tips exposing make the in-plane LSPR peak more sensitive to the changes of I − concentration, which results in an extremely wide linear range of 0.5–280 μM. Meanwhile, when the four Au tips are not fully coated by silver layer but still exposed to outsides, the strong SERS enhancement effect from Ag coating and tip effect together leads to the lower limit of detection (LOD) of 26 nM. Furthermore, this proposed method exhibits a good selectivity for I − over other ions and is well applied in dried kelp and drinking water.
The proposed plasmonic spectrum and SERS dual-mode probe based on the Ag-coated tetrapod gold nanostars exhibits extremely wide linear range and relatively low LOD
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JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2019
·
IF 2.752
Hongji Li,Yan Wang,Yue Li,Jinyue Zhang,Yu Qiao,Qingwei Wang,Guangbo Che
As a sensitive analytical technique, surface-enhanced Raman scattering (SERS) is widely used in spectral analysis, single molecule detection and biological/chemical sensors. Noble-metal nanostructures have sensitive SERS properties and usually act as SERS substrates. Moreover, semiconductors also possess SERS properties and when the semiconductors are combined with noble metals this can not only enhance the SERS signal but also introduce additional properties. Therefore, in this investigation, SiO 2 @TiO 2 @Ag composite materials are selected as SERS substrates, which not only increase the SERS property of substrates but also introduce the property of self-cleaning under conditions of UV light . The molecularly imprinted technique (MIT) is combined with SERS in this investigation to improve the disadvantage of traditional SERS substrates having low selectivity . Molecularly imprinted polymers (MIPs) have specific adsorption properties that can enrich the templates on the surface of SiO 2 @TiO 2 @Ag composites. Importantly, the MIPs can prevent the SERS substrate being oxidized, which effectively protects the core materials. Hence, SiO 2 @TiO 2 @Ag@MIPs is synthesized based on SERS and MIT for used in pyrethroid detection. The Raman intensity and fenvalerate concentration show a good linear relationship in the FE range of 1.0–100 nmol l −1 and the detection limit is 0.2 nmol l −1 . Furthermore, the SiO 2 @TiO 2 @Ag@MIPs present good selectivity and self-cleaning. This investigation provides a novel approach to pyrethroid detection.
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Analytical Methods
·
2018
·Vol. 10
·期 38
·4655-4664
·
IF 2.073
Yadan Ma,Yuhong Wang,Yong Luo,Huazhen Duan,Dan Li,Hu Xu,Essy Kouadio Fodjo
Ideal SERS substrates and rapid sampling are crucial for on-site detection of pesticide residues. In this work, silver nanoparticles and graphene oxide were successfully prepared on cellulose paper (Ag NPs/GO paper) using a screen printing technique. The screen printing ink containing graphene oxide and silver nanoparticles was orderly printed onto cellulose paper substrates by controlling the printing cycles to fabricate controllable SERS substrates in large batches for the detection of pesticide residues. It was found that for up to four cycles, the SERS effect increased with the number of Ag NP printing cycles and no obvious change was observed. The prepared Ag NPs/GO paper may exhibit a high enrichment ability due to the π–π stacking and electrostatic interactions of GO toward pesticide molecules. The results suggest that the high density of Ag NPs/GO on the prepared paper is enough for ultrasensitive SERS detection of thiram, thiabendazole and methyl parathion in complex surfaces with a low limit of detection of 0.26 ng cm−2, 28 ng cm−2, and 7.4 ng cm−2, which are much lower than the maximal residue limits in fruit prescribed by the U.S. Environmental Protection Agency. Thus, the sensitive SERS detection of pesticide residues based on Ag NPs/GO paper offers great potential for its practical application in environmental analysis and food safety.
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Nanomaterials
·
2018
·Vol. 8
·期 5
·289
·
IF 3.504
Mingli Wang,Guochao Shi,Yanying Zhu,Yuhong Wang,Wanli Ma
Rapid sampling and multicomponent analysis are vital in pesticide residue detection. In this work, we proposed a SERS platform to detect three kinds of pesticides on apple peels simultaneously by a straightforward “press and peel off” method. The flexible Au/dragonfly wing (Au/DW) substrate was obtained from sputtering Au nanoislands on DW bioscaffold arrays by a simple direct current (DC) magnetron sputtering system. The high-performance substrate exhibited a low limit of detection (LOD) to 4-aminothiophenol (4-ATP) (10−9M), outstanding reproducibility (less than 12.15%), good stability and suitability in multifold pesticide residues detection. Considering its excellent sample collection efficiency, the Au/DW substrate was employed to solve critical pesticide residue problems for detection of acephate (APT), cypermethrin (CPT), tsumacide (MTMC) and their multiple components on apple peels. The results show that the LOD was 10−3ng/cm2for APT obtained on the apple surface with a calculation equation of y = 0.26x + 6.68 and a determination coefficient (R2) of 0.970. Additionally, the LOD values for CPT and MTMC were 10−3ng/cm2and 10−4ng/cm2, respectively. The finding in this work may provide a promising biomimetic SERS platform for on-spot detection of other organic pollutants in the food industry and inenvironmental protection.Keywords:SERS;dragonfly wing;magnetron sputtering;pesticide residue
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Nanomaterials
·
2018
·Vol. 8
·期 7
·560
·
IF 3.504
Xia Zhou,Qian Zhao,Guangqiang Liu,Hongwen Zhang,Yue Li,Weiping Cai
A modified seed growth route was developed to fabricate the Au nanocrystals with high-density tips based on kinetically-controlled growth via adjusting the adding rate of Au seeds into growth solution. The obtained Au nanostructures were chestnut-like in morphology and about 100 nm in size. They were built of the radial [111]-oriented nanoneedles and were 30–50 nm in length. There were about 120–150 tips in each nanocrystal. The formation of chestnut-like Au nanocrystals is ascribed to surfactant-induced preferential growth of seeds along direction [111]. Importantly, the chestnut-like Au configuration displayed powerful surface enhanced Raman scattering (SERS) performance (enhance factor > 107), owing to the high density of tips. Further, such film was used as a SERS substrate for the detection of lindane (γ-666) molecules (the typical organochlorine pesticide). The detection limit was about 10 ppb, and the relationship between SERS intensityIand concentrationCof 666 accords with the double logarithm linear. This work presents a simple approach to Au nanocrystal with high-density tips, and provides a highly efficacious SERS-substrate for quantitative and trace recognition of toxic chlorinated pesticides.Keywords:kinetically-controlled seed growth;chestnut-like Au nanocrystals;high-density tips;SERS performances;chlorinated pesticide residues
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Food Analytical Methods
·
2019
·Vol. 12
·期 9
·2094-2105
·
IF 2.413
Yaseen Tehseen,Pu Hongbin,Sun Da-Wen
The sensitivity of surface-enhanced Raman spectroscopy (SERS) extremely relies on experimental parameters including pH and aggregating agents. Using Au@Ag nanoparticles (NPs) with 26 nm Au core size and 6 nm Ag shell thickness as the substrate, the effect of cationic (Ca 2+ , K + , Na + ) and anionic (Cl − , Br − ) aggregating agents was investigated on the SERS detection of phosalone. The optimum concentrations of the aggregating agents in relation to the maximum SERS intensity differed broadly from 1 × 10 −2 mol/L for CaBr 2 to 1 × 10 1 mol/L for KCl. Both anions and cations greatly affected the SERS enhancement. With employing Br − as the anion, Ca 2+ and K + showed the maximum SERS intensities for phosalone, while using Ca 2+ as the cation, Br − produced the maximum SERS enhancement. Among these aggregating agent combinations, the maximum SERS enhancement was achieved by employing 1 × 10 −2 mol/L CaBr 2 at pH 3.0. The detection limits of phosalone in standard solution and peach were 0.02 mg/L and 0.2 mg/kg, respectively. This study demonstrated that the Au@Ag NP-based SERS approach could be used as a sensitive, rapid, and simple method for detecting trace contaminants in food matrices.
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