JOURNAL OF FOOD SCIENCE
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2019
·Vol. 84
·期 6
·1447-1455
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IF 2.081
Jingdong Xiao,Ming Zhang,Wenhang Wang,Anguo Teng,Anjun Liu,Ran Ye,Yaowei Liu,Kun Wang,Junsheng Ding,Xiaomeng Wu
Oleogel with tailored viscoelasticity is a great interest for food structuring, while its potential benefits for edible film performance are not clear. In this study, β-sitosterol (0, 5, 10, 15, and 20 wt%)-corn oil oleogel was developed and used in the formation of gelatin-based films. Importantly, adding oleogel significantly decreased water vapor permeability of the gelatin films, however, it had little negative influence on film strength. In addition, the results of this study demonstrated that increasing the sitosterol in oleogels led to an increasing number of ordered crystals formed in the oleogel, which contributed to compact and smooth surface of the film. Moreover, the incorporation of oleogel also caused some changes in molecule conformation and film barrier property. Therefore, the superior mechanical performance and moisture resistance properties of the film were obtained when 15% β-sitosterol was used to prepare oleogel. Practical Application Corn oil oleogels β-sitosterol was incorporated with gelatin to prepare the gelatin film aiming to improve the water resistance of the films for its variety of practical production. The enhanced vapor permeability and accepted strength of the emulsion film indicated the potential application of it with a variety of edible packaging forms, such as films, pouch and sachet in medium and high humid condition.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2019
·
IF 2.931
Xia Lu,Zhefeng Fan
An easy, dependable, and sensitive cholic acid activity experiment was designed based on β‑cyclodextrin-modified carbon dot (β‑CD-CD) nanoprobes with specific host–guest recognizing ability and photoelectron transfer capability. The β‑CD-CD nanoprobes were characterized by infrared, ultraviolet-visible, and fluorescence spectroscopy and transmission electron microscopy . The fluorescence of the probes under optimized conditions linearly responded to cholic acid concentration from 0 to 650 μmol·L −1 with a detection limit of 25 nmol·L −1 . The probes also performed well in detecting cholic acid in serum and urine samples with an average recovery rate of 97.1%–103.4%. Thus, this study provides a reliable, rapid, and easy method of cholic acid detection in body fluids that can be potentially applied in medical studies.
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Soft Matter
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2019
·Vol. 15
·期 15
·3198-3207
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IF 3.399
Bo Zhu,Lihua Jia,Xiangfeng Guo,Jianxin Yin,Zhenlong Zhao,Nannan Chen,Shuxuan Chen,Yue Jia
A novel cationic gemini surfactant (C12NDDA) with a spacer containing naphthalene and amides was successfully synthesized. The assembly of C12NDDA with β-cyclodextrin (β-CD) was investigated using various techniques including transmission electron microscopy, proton nuclear magnetic resonance (1H NMR), and scanning electron microscopy. Tuning the C12NDDA concentration and the C12NDDA/β-CD molar ratio allowed the production of different assembled aggregate morphologies such as micelles, vesicles, nanowires, nanorods, and hydrogels. Investigation of the inclusion mechanisms of C12NDDA and β-CD by 1H NMR revealed that hydrophobic interactions, hydrogen bonding, π–π stacking, and electrostatic forces play key roles in the assembly process. The antimicrobial activities of the C12NDDA/xβ-CD (x = 0–4) inclusion complexes were tested against Gram-negative bacteria (Escherichia coli and Salmonella) and Gram-positive bacteria (Staphylococcus aureus and Streptococcus), and very low minimum inhibitory concentrations of 0.078–0.31 μg mL−1 were observed. Thus, this newly synthesized gemini surfactant and its inclusion complexes exhibit potential as superior broad-spectrum disinfectants for various biomedical and biotechnological applications.
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Advanced Composites and Hybrid Materials
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2019
·Vol. 2
·期 2
·330-338
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IF 0
Wang Jin,Wu Zongchao,Xie Ruihong,Zhu Yuanyuan,Liu Xueting
Nanocomposites of MoS 2 and conjugated polymers are excellent candidates for optical limiters, solid electrodes, electrolytes, and other purposes. The ordered layered structures of nanocomposites are essential. A strategy to prepare the regular two-dimensional (2D) layered MoS 2 /conjugated polymer nanocomposites was developed based on the β -cyclodextrin ( β -CD) template. The complete intercalation nanocomposites of molybdenum disulfide (MoS 2 ) with poly(3,4-ethylenedioxythiophene) (PEDOT), poly(3-methylthiophene) (P3MT), and polypyrrole (PPy) were prepared successfully. MoS 2 is in the form of a monolayer or no more than trilayer with conjugated polymers inserted into the interlayers. In comparison with that of β -CD, sulfonated β -CD ( β -CDSO 3 ) has better water-soluble and act as dopants to improve the electrical and electrochemical performances of these nanocomposites simultaneously. The conductivities of nanocomposites based on β -CDSO 3 template increase by one to three orders of magnitude, and their capacitance performances are superior. As an innovative route to prepare the regular 2D layered MoS 2 /polymer nanocomposites, the methodology is expected to be applicable to a wide range of layered materials and hydrophobic monomers.
A strategy to prepare regular 2D layered MoS 2 /conjugated polymer composites with high conductivity was developed via β -CDSO 3 template.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2019
·Vol. 136
·期 25
·47683
·
IF 2.188
Bin Guo,Huimin Wang,Danan Lan,Xiaomin Pang,Yiming Li,Haiyan Liu,Hongyuan Yan,Ligai Bai
Three temperature-sensitive monolithic columns were prepared by atom transfer radical polymerization and oxidation–reduction method using the initiator systems of CCl 4 /FeCl 2 , BPO/DMA, and APS/TEMED, respectively. The three monoliths were characterized by scanning electron microscopy, nitrogen adsorption, and thermogravimetric analysis. The obtained monolithic columns were used as on-line solid phase extraction sorbent coupled with high-performance liquid chromatography for the enrichment of β-sitosterol. By comparing some influencing factors on the adsorption, the optimum temperature-sensitive monolithic column which was initiated by CCl 4 /FeCl 2 was selected for enrichment of β-sitosterol from plant oil. The maximum adsorption capacity of the monolith for β-sitosterol was 10.0031 mg/g. The limit of detection and limit of quantitation were 0.039 and 0.13 mg/mL, respectively. The recovery was in the range of 90.21–98.26%. The results showed that the monolith had better selectivity for β-sitosterol and could be used for enrichment of β-sitosterol in food samples. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47683.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
·
IF 3.973
Xiufang Li,Jian Chen,Hui Liu,Zhiwei Deng,Jianbing Li,Tao Ren,Ling Huang,Wenqing Chen,Yanjing Yang,Shian Zhong
The study developed a simple, effective and inexpensive strategy for capturing, enriching and detecting circulating tumor cells (CTCs) by using folic acid (FA) as the targeting molecule instead of antibodies. This work constructed magnetic halloysite nanotubes (MHNTs) coated with biocompatible β-cyclodextrin (CD), and conjugated to FA via a PEG-Ad linker, to specifically capture the FA receptor (FR)-overexpressing cancer cells. The capture efficiencies of [email protected] β [email protected] for the Skov3, Hela and A549 cancer cells were 96.3%, 97.0% and 95.6% respectively. In addition, the nanoparticles were able to capture very low numbers of the cancer cells (25–500 cells/mL) from PBS and whole blood, as well as selectively capture the cancer cells over normal HEK 293 T cells. Furthermore, the captured cells were viable and grew normally in vitro , indicating the future potential of downstream analyses. This approach can be adapted for different CTCs, once the tumor-specific surface markers are identified and the efficacy of targeting ligands is established. Taken together, FA-conjugated MHNTs nanoparticles are a highly promising tool for isolating CTCs for the diagnosis and treatment of cancer.
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JOURNAL OF MICROENCAPSULATION
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2019
·
IF 2.04
Ran Li,Rui Bao,Qiu-Xuan Yang,Qi-Long Wang,Michael Adu-Frimpong,Qiu-Yu Wei,Toreniyazov Elmurat,Hao Ji,Jiang-Nan Yu,Xi-Ming Xu
Aims: The aim was to improve the absorption and bioavailability of [6]-shogaol with β-cyclodextrin (β-CD) prior to in vitro and in vivo evaluation.Methods: [6]-Shogaol/β-CDs inclusion complexes (6-S-β-CDs) were developed using saturated aqueous solution method and characterised with appropriate techniques. The absorption and bioavailability potential of [6]-shogaol was evaluated via in vivo pharmacokinetics and in situ intestinal perfusion.Results: The results of characterisation showed that 6-S-β-CDs (drug loading, 7.15%) were successfully formulated. In vitro release study indicated significantly improved [6]-shogaol release. Pharmacokinetic parameters such as Cmax, AUC0–36 h, and oral relative bioavailability (about 685.36%) were substantially enhanced. The in situ intestinal perfusion study revealed that [6]-shogaol was markedly absorbed via passive diffusion in the intestinal segments, and duodenum followed by ileum and jejunum.Conclusions: Cyclodextrin inclusion technology could enhance the intestinal absorption and oral bioavailability of hydrophobic drugs like [6]-shogaol.
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CATALYSIS TODAY
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2018
·
IF 4.667
Jing Peng,Sheng Wang,Hai-Jian Yang,Binru Ban,Zidong Wei,Lihua Wang,Lei Bo
In present work, three amino-bridged biomass bis-β-cyclodextrins (bis-β-CDs) and eight bifunctionalized bis-β-CDs derivatives were designed and synthesized as environmental friendly catalysts to fix CO 2 . Both the bridged bis-β-CDs 1a - 3a /potassium halide and haloalkane functionalized bis-β-CDs 1b - 8b were poven to be efficient catalytic systems for the solvent-free coupling reaction of CO 2 and epoxides. After systematic investigation, the optimized conditions of (120 °C, 4 MPa, 0.14mol% 1a , 1.25mol% KI, 2 h) have been established for dual catalytic system 1a /KI and the excellent yield (94%) with high selectivity (99%) can be achieved for the cycloaddition of CO 2 and propylene oxide. Furthermore, after functionalization with alkyl halides, bis-β-CD derivative 1b-8b as sigle bifunctional catalyst exhibited better activity under milder optimal conditions of (110 °C, 2 MPa, 0.125mol% 1b and 4 h). Moreover, these bifunctional catalysts are also applicable to a variety of epoxides (including diepoxides) and good catalytic performances were abtained for producing the corresponding cyclic carbonates in most cases. Furthermore, this catalyst can be reused at least for five times without significant activity decrease. Finally, a possible mechanism including the activation of both epoxide and CO 2 was proposed based on the literatures and experimental results.
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INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
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2018
·
IF 1.372
Hui Wang,Bo Qu,He Liu,Jie Ding,Nanqi Ren
A magnetic solid-phase extraction method for the preconcentration of three organochlorine pesticides (OCPs) from water samples has been proposed, based on magnetic phosphatidylcholine (MPC) as adsorbents. The extraction procedure was carried out in a single step by stirring the mixture of MPC and water samples. Subsequently, the MPC was collected by an external magnetic field without additional centrifugation or filtration. The analytes were desorbed from the MPC and finally analysed by gas chromatography–tandem mass spectrometry. The influence of various parameters on OCPs recoveries was studied. Results show that phosphatidylcholine amount and extraction time were critical in enhancing extraction performance, and the presence of humic acid was shown to significantly reduce the extraction efficiency. The limits of detection obtained were in the range of 0.1–0.15 ng L−1. Recoveries of spiked water samples ranged from 76.2% to 101.5% with relative standard deviations varying from 3.8% to 7.7%. The proposed method was employed for analysis of pentachlorobenzene, α-hexachlorocyclohexane and β-endosulfan in the surface water from two rivers in northeast China.
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FOOD RESEARCH INTERNATIONAL
·
2019
·
IF 3.579
Qianyu Dan,Wenfei Xiong,Hongshan Liang,Di Wu,Fuchao Zhan,Yutong Chen,Shuang Ding,Bin Li
Nobiletin (Nob) is a major component among the most reported polymethoxyflavones (PMFs), which possesses multiple efficacious healthcare activities. Owing to its high melting point and poor water solubility, the oral bioavailability of Nob needs to be improved via loading Nob on carriers. To take full advantage of Nob, the interaction mechanism between Nob and vehicles should be clarified. Herein, β-lactoglobulin (β-LG) was selected as the vehicle and further investigated the binding mechanism between Nob and β-LG. The binding stoichiometry of complex was found to be 1:1 by analysis of intrinsic fluorescence experiment. The results also confirmed by isothermal titration calorimetry (ITC) measurement that the binding behavior between β-LG and Nob was a spontaneously endothermic process driving mainly by hydrophobic interaction. Moreover, competitive binding and molecular docking method indicated the Nob was primary bound to internal calyx of β-LG at neutral pH. UV spectrophotometry revealed that the solubility of Nob was enhanced to 3 times by forming complex. Furthermore, Nob could alter secondary structure of β-LG by a transition from α-helix to β-sheet and lead to small increase on surface hydrophobicity of β-LG. This work will provide some valuable information on clarifying the interaction between protein and PMFs, which contributing to improve the poor bioavailability of PMFs.
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ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Hongjie Huang,Xiaoqing Hu,Xin Zhang,Xiaoning Duan,Jiying Zhang,Xin Fu,Linghui Dai,Lan Yuan,Chunyan Zhou,Yingfang Ao
Synovium-derived mesenchymal stem cells (SMSCs) are attractive tissue-specific cells for cartilage regeneration because of their easy availability, higher chondrogenic potential, and joint specificity. In the present study, we established a hybrid scaffold to codeliver SMSCs and transforming growth factor beta (TGF-β), which can integrate the scaffolds, the growth factor, and the autogenous cells within rabbit cartilage defects. A chitosan hydrogel and a decellularized bone matrix were used to fabricate the gel–solid duplex phase biomaterials, which were proven to retain more cells, promote tissue integration, and provide mechanical support. In vitro experiments demonstrated that this hybrid scaffold could release TGF-β in a controlled biphasic pattern, which can promote cell proliferation and chondrogenic differentiation of loaded rabbit SMSCs. For in vivo experiments, we filled cartilage defects with the hybrid materials, delivering autogenous SMSCs and TGF-β simultaneously via chitosan’s sol–gel transition. Histological analysis, magnetic resonance imaging, and nanoindentation assessment indicated superior cartilage regeneration using this codelivery system compared with that from routine microfracture or control delivery scaffolds. Beyond cartilage regeneration, the easy preparation, favorable biophysical properties, and controlled release ability make this codelivery system applicable to transport other tissue-specific cells or biofactors for tissue engineering.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2018
·
IF 2.196
Dexia Han,Zhengang Zhao,Zhengming Xu,Yuan Li,Pingling Zhang,Xiaoming Guo
β-FeOOH-coupled activated carbon (FAC) was prepared and used to remove bromate from an aqueous phase. SEM, XRD, and FTIR analyses indicated that a larger number of β-FeOOH particles were anchored on the AC surface, which greatly enhanced the bromate adsorption and reduction rates. The influences of the pH, contact time, temperature, and competitive anions on bromate removal by FAC were evaluated. FAC can be used over a wide pH range (3–8) for bromate adsorption and reduction, and competing anions inhibit bromate uptake. The adsorption kinetics agreed well with the pseudo-second-order model (R2 ≥ 0.99), and the adsorption isotherms were well fitted by the Langmuir model. The thermodynamic analysis suggested that bromate removal by FAC was a spontaneous and endothermic process. Bromate was adsorbed and then reduced to bromide; Fe3+ acted as a catalyst to accelerate the reductive reaction. The results of this study indicate that FAC is a stable and promising material for bromate removal.
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