MICROPOROUS AND MESOPOROUS MATERIALS
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2026
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IF 4.5
Rui Feng,Runxi Zhang,Dejun Shi,Hongyue Yu,Kebin Chi,Peng Peng,Xinlong Yan,Shijian Lu
Seed type controls the physiochemical properties of template-free DGC ZSM-5. • S1 seeding affords mesoporous nanocrystallite aggregates with moderate acidity. • S2 seeding favors Al occupation at straight and intersecting channels. • S2-derived catalyst achieves 94.1% conversion with >90% stability after 36 h. • S1-derived catalyst exhibits ultralow coking rate (0.056 h −1 ) and coke content (∼2.2 wt%). The template-free dry gel conversion (DGC) synthesis of zeolites typically suffers from poor crystallinity and limited structural tunability. In this study, we demonstrated that these limitations can be effectively overcome through a seed-assisted DGC strategy, employing colloidal S1, self-synthesized S2, and commercial ZSM-5 as seeds to direct ZSM-5 crystallization. Comprehensive characterization revealed that seed type critically influences crystallite size, mesoporosity, framework silica-to-alumina ratio (SAR), aluminum siting, and the distribution of Brønsted and Lewis acid sites. Specifically, S1 seeding afforded nanocrystallite aggregates with abundant mesopores, moderate acidity, and the highest SAR (106). S2 seeding resulted in intermediate crystallite dimensions, preferential Al occupation at straight and intersecting channels, and the highest Brønsted/Lewis ratio (6.1). In contrast, the seed-free system yielded dense, large-block crystallites with a lower SAR (65). In n-hexane cracking at 550 °C, the S2-derived catalyst (S2-DG-Z5) achieved the highest initial conversion (94.1%) and light olefin selectivity, while maintaining >90% conversion after 36 h, whereas the seed-free counterpart (DG-Z5) dropped from 90% to <80%. Meanwhile, the S1-derived catalyst (S1-DG-Z5) exhibited the lowest coking rate (0.056 h −1 ) and coke content (∼2.2 wt%), attributable to its moderate acidity, nanocrystallite morphology, and mesoporosity, which synergistically suppress coking and enhance mass transport. Collectively, these findings establish seed type as a pivotal parameter for tuning Al siting and acidity in template-free DG-synthesized ZSM-5, and highlight this seed-assisted route as an effective strategy for producing high-crystallinity, stable zeolite catalysts for hydrocarbon cracking. Download: Download high-res image (288KB) Download: Download full-size image
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Translational Pediatrics
·
2025
·Vol. 14
·期 6
·1213
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IF 1.7
Zihong Shan,Chenghui He,Qingyao Yang,Jingjing Xiong,Meng Li,Mingyao Meng,Yongkun Huang
Background Previous research has indicated that chenodeoxycholic acid (CDCA) plays a significant role in intestinal motility and is implicated in some gastrointestinal (GI) disorders. However, the impact of CDCA on defecation patterns in infants, particularly those who are breastfed, remains unclear. This study explored the relationship between CDCA and defecation frequency in breastfed infants, focusing on the underlying mechanisms. Methods We measured CDCA levels in stool samples of infants with varying defecation frequencies using metabolomics, along with studies to explore the impact of CDCA on murine colonic transit and with in vitro cellular studies to elucidate the underlying physiological mechanisms. Results In our murine model, CDCA treatment increased GI transit distance, enhanced fecal water content, and reduced transit time, without causing significant colonic damage. Additionally, CDCA treatment enhanced 5-hydroxytryptamine (5-HT) secretion and upregulated signaling molecules such as tryptophan hydroxylase 1 (Tph1), G protein-coupled bile acid receptor 1 (TGR5), and transient receptor potential ankyrin 1 (TRPA1). Selective inhibition of these pathways suppressed 5-HT secretion and normalized intestinal motility parameters, confirming their mechanistic role. Moreover, CDCA treatment of rat insulinoma-derived RIN-14B cells also resulted in increased 5-HT secretion. Conclusions These findings reveal that CDCA significantly correlates with defecation frequency in breastfed infants and likely influences intestinal motility through the TGR5/TRPA1-5-HT signaling axis.
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ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Yuehan Zhang,Panpan Zhao,Zhixuan Yu,Jianguo Zhao,Junfeng Zhai,Shaojun Dong
The efficient conversion of renewable biomass into value-added products is essential for sustainable development. In this work, we report a two-chamber photocatalytic fuel cell (PFC) consisting of a NiFe-LDH/BiVO4/FTO photoanode and a BOD/TCPP/BP/ITO biocathode, which allows for the simultaneous accomplishment of energy conversion and bias-free production of 2,5-furandicarboxylic acid (FDCA). After optimization, the PFC achieves a maximum power density of 859.0 ± 3.0 μW cm–2 at 0.52 V. TEMPO-mediated 5-hydroxymethylfurfural (HMF) oxidation occurs spontaneously within the PFC upon illumination due to the potential difference between the photoanode and biocathode, effectively and selectively converting HMF to FDCA with a yield (%) and Faradaic efficiency of approximately 100%, and possesses good durability after six cycles (30 h) of FDCA production (retaining 90.8% of its initial value). Therefore, the proposed PFC offers a promising solution to the challenges associated with the conversion of renewable biomass.
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INORGANIC CHEMISTRY
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2025
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IF 4.7
Yidan Ouyang,Yongxuan Wang,Jingjing Kou,Junhui Cai,Ruijie Jin,Zehong Chen,Ruilan Xu,Zhengbao Wang,Yong Peng
Efficient adsorptive removal of dyes from aqueous solutions by solid porous materials depends on the number of adsorption sites and rapid mass transfer in the pore channel networks. In this work, alkaline coetching on conventional bulky ZSM-5 zeolite by tetrapropylammonium hydroxide and sodium metaaluminate was developed to produce hierarchical ZSM-5 zeolites with a hollow structure. The synergistic etching effect was systematically investigated by adjusting the etchant amount and etching conditions. The dissolution-protection reconciled etching mechanism was demonstrated, and a map illustrating the synergistic relationship was proposed. The etched zeolite exhibited a hierarchical pore structure with a high mesopore volume of 0.68 cm3 g–1 and a large pore size centered around 30 nm, which are beneficial for the mass transfer of large dye molecules. Besides, it had more silanol groups and a lower Si/Al ratio (11–15) with evenly distributed Al element, thus significantly increasing the active adsorption sites. The hierarchical hollow ZSM-5 zeolites presented a great adsorption capacity of 120.95 mg g–1 for methylene blue at a pH of 12 and a high rhodamine B uptake (23.84 mg g–1 under specified conditions). The synergistic etching method is expected to finely manipulate the microstructure of zeolite materials, which would expand their applications in many fields, such as adsorption and catalysis.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Li Cui,Rongling Zhong,Wanqiu Peng,Zhenhai Zhang,Zhentao An,Hui Li
Current clinical management of diarrhea-predominant irritable bowel syndrome (IBS-D) faces substantial challenges due to the limited efficacy of existing therapeutic strategies. This study aimed to synthesize and characterize the hyaluronic acid-ethylenediamine-cinnamic acid conjugate (HA-EDA-CA), investigate its oral bioavailability and colonic tissue distribution, and validate its therapeutic potential along with underlying mechanisms of action in IBS-D models. Following oral administration of free CA or HA-EDA-CA, the colon concentration of CA released from the derivative was significantly higher than that of free CA alone. Both free and conjugated forms of CA likely contributed to the therapeutic effects against IBS-D. The IBS-D model was established by a combination of senna decoction administration and physical restraint stress. After HA-EDA-CA intervention, IBS-D model mice showed marked improvements in stool consistency, fecal water content, stool output, body weight, visceral hypersensitivity, and colon length. ELISA results indicated significant reduction in enteric neurotransmitter levels, including 5-hydroxytryptamine, substance P, and vasoactive intestinal peptide, after oral gavage administration of HA-EDA-CA. Additionally, intestinal permeability assessment and immunofluorescence analyse revealed that HA-EDA-CA improved intestinal barrier function. Western blot analysis indicated HA-EDA-CA inhibited 5-hydroxytryptamine signaling pathway. Furthermore, HA-EDA-CA modulated gut microbiota composition. These findings suggested the potential of HA-EDA-CA as a promising therapeutic candidate for IBS-D treatment. Key novelties: (i) First colon-targeted CA-HA conjugate: We developed and characterized the first hyaluronic acid-based conjugate specifically designed for colon-targeted delivery of cinnamic acid. (ii) Multi-mechanism rescue: The conjugate simultaneously restores gut homeostasis by modulating the 5-hydroxytryptamine signaling pathway, enhancing intestinal barrier function, and rebalancing gut microbiota. (iii) Enhanced therapeutic efficacy: HA-EDA-CA demonstrates superior colonic drug accumulation and integrated therapeutic outcomes compared to free cinnamic acid or simple drug mixtures. (iv) Open-source data availability: All relevant data and analysis scripts supporting the findings are publicly accessible to ensure reproducibility and further research.
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MOLECULES
·
2024
·Vol. 29
·期 4
·850
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IF 4.2
Meng Guo,Dou Wu,Hongyu Yang,Xiao Zhang,Dong-Xu Xue,Weiqiang Zhang
The use of gaseous CO in Pd-catalyzed carbonylative quinolone synthesis presents challenges related to safety and precise pressure control. In response, a streamlined non-gaseous synthesis of 4-quinolone compounds has been developed. This study introduces a tunable CO-releasing system utilizing Fe(CO)5activated by a dual-base system of piperazine and triethylamine. This alternative liquid CO resource facilitates the palladium-catalyzed carbonylative C-C coupling and subsequent intramolecular cyclization. By tuning the tandem kinetics of carbonylation and cyclization, this non-gaseous method achieves the successful synthesis of 22 distinct 4-quinolones with excellent yields. This is achieved through the three-component condensation of sub-stoichiometric amounts of Fe(CO)5with 2-iodoaniline and terminal alkynes. Operando mechanistic studies have revealed a novel CO transfer mechanism that facilitates homogeneous carbonylative cyclization, distinguishing this method from traditional techniques. In addition to addressing safety concerns, this approach also provides precise control over selectivity, with significant implications for pharmaceutical research and the efficient synthesis of pharmaceutical and bioactive compounds.
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FUEL PROCESSING TECHNOLOGY
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2012
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IF 2.945
Chao Duan,Xin Zhang,Rui Zhou,Yuan Hua,Li Zhang,Jie Chen
HZSM-5/SAPO-34 catalysts were prepared by physical mixture (named as ZS(m)-MM-n) and hydrothermal synthesis (named as ZS(m)-HS-n), respectively. Ethanol to propylene over these as-prepared catalysts was investigated under different reaction conditions. In addition, the physicochemical properties of these catalysts were characterized by AAS , XRD , N2 isothermal adsorption–desorption, SEM , NH3-TPD and TPO . The catalytic reactivity of HZSM-5/SAPO-34 catalyst was strongly dependent on its preparation method and composition as well as the reaction conditions. ZS(25)-MM-4 (HZSM-5/SAPO-34 = 4, weight ratio; HZSM-5 with Si/Al2 = 25 molar ratio) in isothermal fixed-bed reactor showed the highest propylene yield of ca. 34.5% among these catalysts and the poor catalytic stability. The use of nonisothermal fixed-bed reactor with the temperature configuration (2) significantly improved the catalytic stability of ZS(25)-MM-4. Synergetic effect of HZSM-5 with SAPO-34 occurred in HZSM-5/SAPO-34 catalyst, which modified its properties and catalytic reactivity. The concentration and the strength distribution of acid sites were closely relative to the catalytic reactivity of HZSM-5/SAPO-34 catalyst. For achieving the high yield of propylene, it was necessary that HZSM-5/SAPO-34 catalyst had the moderate concentration and strength distribution of acid sites.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2019
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IF 3.375
Zhiyong Xu,Wenbo Zhao,Xuhao Xie,Yanhong Li,Yuan Chen
Phase-change absorption has shown a promising application prospect for acid gas capture because only the gas-rich phase needs to be transported to the stripper for recovery, which could drastically reduce the energy consumption of the regeneration process. In this study, the liquid–liquid phase-change behavior of a new recyclable ternary system, composed of 1,5-diazabicyclo[4.3.0]non-5-ene (DBN)/hexadecane/hexanol, was evaluated for capturing H2S. The absorption adduct was the [DBNH]+[SH]− salt, and the cause of the phase change was attributed to the polarity difference between the upper and lower phases. Furthermore, considering that only the lower phase needed to be heated for regeneration, the gravimetric absorption capacity was calculated to be 0.205 g H2S/g lower phase at 1 bar and 293.15 K. To the best of our knowledge, this is the largest gravimetric absorption capacity for H2S capture obtained to date. Additionally, when the absorption reached equilibrium, DBN, hexanol, and H2S were concentrated in the lower phase, while hexadecane mostly remained in the upper phase. The DBN/hexadecane/hexanol system showed that the benign desulfurization efficiency was nearly 100% under the condition that the molar ratio of H2S gas to DBN is not more than 0.6 mol/mol. The cyclic absorption experiments showed that the H2S gas could be easily released by bubbling N2 at 80 °C, which indicated the low energy requirement for the regeneration of the absorbent.
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DRUG METABOLISM AND DISPOSITION
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2026
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IF 3.6
Qianqian Zhang,Jingyi Hu,Yangbo Liu,Dongzhao Xie,Linyue Bai,Zhuang Hu,Yanjun Tang,Siqi Feng
The therapeutic efficacy of 5-fluorouracil (5-FU), a cornerstone of gastric cancer chemotherapy, is predominantly limited by its catabolic inactivation in tumors. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme responsible for 5-FU inactivation, and its tumor-specific overexpression constitutes a primary mechanism of 5-FU resistance. Here, we report a novel strategy to increase the sensitivity of 5-FU by targeting the post-translational regulation of DPD. We demonstrate that the NEDD8-activating enzyme (NAE) inhibitor MLN4924 significantly enhancesthe antitumor activity of 5-FU in both cellular and animal models of gastric cancer without augmenting systemic toxicity. Mechanistically, MLN4924 treatment inhibits the neddylation of DPD, which is dependent on the NAE1/UBC12 axis. This inhibition triggers the ubiquitination and subsequent proteasomal degradation of DPD, thereby reducing intracellular 5-FU catabolism and augmenting its cytotoxic effects. Our findings identify neddylation as a previously unrecognized regulatory mechanism governing DPD protein stability and activity. This work identifies the neddylation-DPD axis as a novel therapeutic target and provides a strong rationale for combining NAE inhibition with 5-FU-based chemotherapy in gastric cancer.
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Journal of Energy Chemistry
·
2026
·
IF 15.6
Yanan Chang,Qiao Tan,Qingjun Jiang,Xuexuan Zhong,Xiaoxuan Li,Jianchun Bao,Jie Zhang,Dongdong Xu,Ying Liu
The reactant-adsorption mechanism and reactive oxygen species (ROS) oxidation mechanism represent two vital strategies for boosting the selectivity of the 5-hydroxymethylfurfural oxidation reaction (HMFOR). Still, their compatibility remains challenging and has rarely been reported. Herein, using Pd nanoparticles as the reactant adsorption center and ROS producer, and NiMoO 4 nanorod array as the electrocatalytically active component, a Pd/NiMoO 4 Mott-Schottky heterojunction on Ni-foam skeleton is constructed. The Mott-Schottky structure tailors the Fermi level and energy band structure of Pd/NiMoO 4 , thereby reinforcing its plasmon effect. The prominent plasmon effect increases the carrier density (from 0.6 × 10 27 to 2.4 × 10 27 cm −3 ), lowers the activation energy of HMFOR (from 11.7 to 5.8 kJ mol −1 ), and triggers the formation of ROS ( 1 O 2 and ·O 2 − ) that directly attack HMF, accelerating its conversion to FDCA. Meanwhile, in situ Fourier transform infrared and Raman spectroscopy tests reveal that the decorated Pd nanoparticles not only effectively accelerate the adsorption of HMF and OH − reactants, but also promote the formation of NiOOH active sites. Under the joint effect of these favorable factors, the Pd/NiMoO 4 /NF requires only 1.32 V to afford 50 mA cm −2 under 561 nm illumination, and importantly, achieves a high HMF conversion rate of 99.3%, FDCA selectivity of 98.2%, and Faradaic efficiency of 95.2%, which are superior to those without light irradiation (98.5% HMF conversion rate, 88.7% FDCA selectivity, and 85.0% Faradaic efficiency). When assembled as an HMF-assisted anion exchange membrane HER||HMFOR electrolyzer, a voltage of merely 1.63 V is needed to deliver 500 mA cm −2 , demonstrating its vast production capacity. This multiscale regulation merges the reactant adsorption mechanism with plasmon-induced ROS, enabling the synergistic use of renewable electricity and light energy, and delivering exceptional light-assisted electrocatalytic HMF-to-FDCA performance.
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TOPICS IN CATALYSIS
·
2026
·
IF 3.7
Mu Yifang,Li Yanhong,Huang Aisheng
Direct synthesis of dimethyl ether (DME) from carbon dioxide (CO 2 ) hydrogenation by using bifunctional catalysts has attracted much attention in view of CO 2 conversion and utilization. However, direct CO 2 hydrogenation to DME is challenging due to kinetics and thermodynamic limitations, thus requiring the development of more effective bifunctional catalysts. In this work, metal-organic framework (MOF) Cu/Zn-BTC derived CuZnO catalyst is developed and combined with HZSM-5 for direct CO 2 hydrogenation to DME. The influence of Si/Al ratio of HZSM-5, mass ratio of CuZnO and HZSM-5, reaction temperature, reaction pressure and space velocity on the catalytic performances of the CuZnO/HZSM-5 bifunctional catalysts is systematically examined in a fixed-bed reactor. Attributing to a high activity of the Cu/Zn-BTC derived CuZnO catalyst for CO 2 hydrogenation to methanol, the CuZnO/HZSM-5 bifunctional catalysts display high CO 2 conversion and DME selectivity. Under a mild reaction condition (225 °C and 3.0 MPa), a high CO 2 conversion of 54.3% and DME selectivity of 79.5% are obtained for the bifunctional catalysts, which outperform the state-of-the-art catalysts for CO 2 hydrogenation to DME. Further, after 100 h of reaction, the bifunctional catalyst can still maintain a high CO 2 conversion rate (~ 52.6%) and DME selectivity (~ 77.3%), which suggests promising prospects for industrial applications.
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Journal of the Taiwan Institute of Chemical Engineers
·
2026
·
IF 6.9
Abrar Hussain,Ndumiso Vukile Mdlovu,Kuen-Song Lin,Chi-Jung Chang,Amin Hussain
Background The conversion of CO 2 into value-added fuels and chemicals remains one of the major challenges in catalysis and sustainable energy research. Developing efficient catalysts for CO₂ hydrogenation to methanol and dimethyl ether (DME) is essential for reducing greenhouse gas emissions and promoting carbon recycling. Methods In this work, a Zr-modified CuO–ZnO–Al₂O₃ (CZZA) catalyst was synthesized via a co-precipitation method for CO 2 hydrogenation. The catalyst systems “CZZA/HZSM-5-L” and “CZZA/com-HZSM-5” represent Zr-modified CZZA physically integrated with loofah-templated and commercial HZSM-5 (Si/Al = 25), respectively. A bio-HZSM-5 catalyst was also prepared using loofah sponge and rice husks as dual biotemplates to promote methanol dehydration into DME. The novelty lies in (i) the dual-biomass templating strategy (silica-rich rice husk vs. low-silica loofah) to achieve macro– meso –micro hierarchies while retaining MFI crystallinity, and (ii) Zr-promotion of the Cu–ZnO–Al₂O₃ matrix to enhance Cu⁺/Cu²⁺ and Cu–Zn interfacial sites, enabling efficient one-pass CO₂ → MeOH → DME conversion at 280 °C and 30 bar. Significant findings Zr incorporation significantly improved the structural and electronic properties of the CZZA catalyst, leading to enhanced surface area, active site dispersion, and CuO–ZnO interfacial synergy. Among all tested catalysts, the CZZA/HZSM-5-L bifunctional catalyst achieved the highest DME yield (13.2 %), DME selectivity (58.6 %), and CO₂ conversion (22.5 %) at 280 °C and 30 bar. An economic evaluation of 5- and 10-ton-per-day (TPD) DME production using refinery waste CO₂ showed payback periods of 2.98 and 2.44 years, respectively. Sensitivity analysis (±20 % variation in H 2 and DME prices) confirmed the payback remained below 4 years, demonstrating the technical and economic viability of the developed Power-to-DME process.
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