Journal of Environmental Chemical Engineering
·
2025
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IF 7.2
Yibing Feng,Kun Qiao,Xiaohan Jiang,Huiling Ji,Jiang Meng,Jigang Wang
A photocatalysis–self-Fenton system (PSFs) offers a viable solution to the continuous hydrogen peroxide (H 2 O 2 ) dosing and insufficient Fe 2 + regeneration challenges in conventional Fenton chemistry. An oxygen-doped g-C 3 N 4 microrod (OCNT)-based PSFs was synthesized via a facile oxalic acid-mediated supramolecular self-assembly route, enabling efficient pollutant degradation. In situ H 2 O 2 production was achieved through a two-electron oxygen reduction reaction (2e − -ORR), with photogenerated electrons accelerating Fe 2+ /Fe 3+ cycling and enhancing H 2 O 2 utilization. The system exhibited an apparent rate constant of 0.071 min −1 for tetracycline (TC) removal, 12.2- and 4.2-fold higher than pristine g-C 3 N 4 and a photo-Fenton system, respectively. Density functional theory (DFT) calculations and experimental results indicated that oxygen heteroatom doping increased the molecular dipole moment and optimized the band structure, while the one-dimensional microrod morphology exposed abundant active sites. These synergistic effects facilitated charge-carrier separation, improved interfacial mass transfer, and promoted the two-electron oxygen-reduction pathway, thereby accelerating Fe 2+ /Fe 3+ cycling and hole oxidation. The platform demonstrated broad pH adaptability, strong anti-interference capability, and long-term operational stability. This work provides an effective strategy for on-site H 2 O 2 generation and utilization in photocatalytic–Fenton systems for the degradation of organic contaminants.
研究领域:
环境化学
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材料科学
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催化
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水处理技术
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物理化学
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纳米技术
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产品关联
DOI
高影响因子
CNS Neuroscience & Therapeutics
·
2024
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IF 4.8
Lu Wang,Yingjuan Wei,Zhenzhou Sun,Wenya Tai,Hui Li,Yaling Yin,Lin‐Hua Jiang,Jian‐Zhi Wang
Background Oxidative stress is a well‐known pathological factor driving neuronal loss and age‐related neurodegenerative diseases. Melatonin, coenzyme Q10 and lecithin are three common nutrients with an antioxidative capacity. Here, we examined the effectiveness of them administrated individually and in combination in protecting against oxidative stress‐induced neuronal death in vitro, and neurodegenerative conditions such as Alzheimer's disease and associated deficits in vivo. Methods Mouse neuroblastoma Neuro‐2a (N2a) cells were exposed with H 2 O 2 for 6 h, and subsequently treated with melatonin, coenzyme Q10, and lecithin alone or in combination for further 24 h. Cell viability was assessed using the CCK ‐8 assay. Eight‐week‐old male mice were intraperitoneally injected with D‐(+)‐galactose for 10 weeks and administrated with melatonin, coenzyme Q10 , lecithin, or in combination for 5 weeks starting from the sixth week, followed by behavioral tests to assess the effectiveness in mitigating neurological deficits, and biochemical assays to explore the underlying mechanisms. Results Exposure to H 2 O 2 significantly reduced the viability of N2a cells and increased oxidative stress and tau phosphorylation, all of which were alleviated by treatment with melatonin, coenzyme Q10, lecithin alone, and, most noticeably, by combined treatment. Administration of mice with D‐(+)‐galactose‐induced oxidative stress and tau phosphorylation, brain aging, impairments in learning and memory, anxiety‐ and depression‐like behaviors, and such detrimental effects were mitigated by melatonin, coenzyme Q10, lecithin alone, and, most consistently, by combined treatment. Conclusions These results suggest that targeting oxidative stress via supplementation of antioxidant nutrients, particularly in combination, is a better strategy to alleviate oxidative stress‐mediated neuronal loss and brain dysfunction due to age‐related neurodegenerative conditions.
研究领域:
神经科学
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药理学
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细胞生物学
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衰老研究
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
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IF 8.1
Yanjun Guo,Chuan Cao,Lixia Zheng,Yuxiang Zhong,Pingzhou Duan,Xiang Hu
A MOF-derived carbon/metal oxide composite (Fe/Ce@NPC-600) by doping Ce into NH 2 -MOF-101(Fe) precursor and simple one-step carbonization was fabricated. Fe/Ce@NPC-600 as a floating cathode was innovatively applied to the solar photoelectro-Fenton (SPEF) process to increase the yield of H 2 O 2 and activate it for degradation tetracycline (TC). The characterizations showed that the presence of Ce greatly increased the content of Fe 2+ and photoresponse ability in the material. Thanks to the synergistic effect of Fe and Ce, Fe/Ce@NPC-600 cathode could efficiently degrade TC by 98.2 % within 30 min, and the removal rate of total organic carbon (TOC) was 68.2 %, and the photoelectric synergistic enhancement factor ( f PEF ) was 1.4. Besides, based on machine learning, a XGB model was established to predict electrode performance. The degradation mechanism and pathway of TC were also proposed. Our results inspired the application of floating cathodes, MOF-derived materials and artificial intelligence for advanced oxidation processes for efficient removal of emerging contaminants.
研究领域:
环境科学
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材料科学
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化学工程
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人工智能
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DOI
高影响因子
Analytical Methods
·
2019
·Vol. 11
·期 16
·2197-2203
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IF 2.378
Xiaoqiang Wang,Haiyan Sun,Chengkun Liu,Chao Wang
Following an inspiration from the chemistry of protein nanocages in nature, we evaluated the performance of a hemin-functionalized GroEL nanocage as peroxidase mimics for chromogenic detection. The reactivity of this biohybrid formed by detergent dialysis was found to be highly dependent on the amount of hemin encapsulated inside the GroEL central cavity. In comparison with horseradish peroxidase (HRP), the hemin–GroEL complex exhibited a higher recognition ability and reactivity towards the chromogenic substrate tested, while, similar to HRP, the peroxidase mimic followed a ping-pong catalytic mechanism. Moreover, the efficacy of hemin–GroEL for the chromogenic detection of H2O2 or glucose was demonstrated, with the detection limits determined to be 7 μM for H2O2 and 11 μM for glucose. This assay was also shown to be useful for the oxidative removal of phenolic compounds. Thus, the GroEL cage is a valuable tool for the development of analytical nano-materials and practical applications such as clinical analysis and environmental monitoring.
研究领域:
生物化学
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纳米技术
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分析化学
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环境科学
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产品关联
DOI
高影响因子
Food & Function
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2021
·Vol. 12
·期 16
·7198-7213
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IF 5.396
Xinyao Liu,Fei Zheng,Sheng Li,Zhitong Wang,Xinyuan Wang,Liankui Wen,Yang He
Malvidin (MV) and its derivatives, such as malvidin-3-O-guaiacol (Mv3C) and malvidin-3-O-6-(acrylic acid-(2-hydroxy,4-carboxy-cyclohexanol)ester)-guaiacol (Mv3ACEC), are natural compounds with antioxidant properties. However, the basic mechanisms underlying their functional activities are unclear. In this study, we show that MV, Mv3C, and Mv3ACEC inhibit reactive oxygen species production and malondialdehyde content, promote glutathione peroxidase activity, and increase superoxide dismutase levels in ARPE-19 cells treated with H2O2. Western blotting and immunofluorescence analysis revealed that MV, Mv3C, and Mv3ACEC regulate mitogen-activated protein kinase signal transduction pathways related to endoplasmic reticulum stress. Interestingly, Mv3C and Mv3ACEC showed greater beneficial properties than MV. Our results show that MV and its derivatives have potential as therapeutic compounds for ocular diseases associated with oxidative stress, such as age-related macular degeneration.
研究领域:
药理学
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细胞生物学
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眼科
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
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2020
·
IF 6.785
Weiwei Cheng,Xu Teng,Chao Lu
Highly ordered structure of catalysts could spring up unique properties in catalytic activities. There is apparently no good reason to disregard the structurally ordered catalyst-amplified chemiluminescence (CL) signals. Herein, we have fabricated the structurally ordered ionic liquid-layered double hydroxide (LDH) assembly through the hydrogen bonding interactions between abundant hydroxyl groups on the surfaces of LDHs and the amino groups in 1-(3-aminopropyl)-3-methyl-imidazolium tetrafluoroborate ([apmim]BF4). Interestingly, we found that the CL signals of luminol–H2O2 system in the presence of structurally ordered [apmim]BF4 ionic liquid-LDH assembly were extraordinarily enhanced, in comparison with those in the presence of the disordered 1-aminoethyl-3-methyl imidazolium tetrafluoroborate ([aemim]BF4) ionic liquid-LDH assembly. The improved CL performances of the structurally ordered [apmim]BF4 ionic liquid-LDH assembly were attributed to the increasing amounts of superoxide anion radicals (O2•–) and hydroxide radicals (•OH) by accelerating of the mass transport from the solution to the surface of ionic liquid–LDH assembly. In addition, such a highly orderly arrangement could increase the emission of the luminol oxidation products by facilitating the electron transfer. Our findings open up new possibilities in the structurally ordered catalyst-enhanced CL emissions, which can be expected to provide a novel and sensitive platform for the CL amplified detection.
研究领域:
催化
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分析化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2020
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IF 4.3
Xuqian Wang,Yi Xie,Wenhua Tong,Wanrong Hu,Yabo Wang,Yongkui Zhang
Rational selection of affordable catalyst and effective degradation process are significant for antibiotic-containing wastewater treatment. Herein, a photochemical catalytic system comprising of bio-synthesized jarosite and oxalic acid (Ox) was investigated for degradation of antibiotic chloramphenicol (CAP) under light irradiation. Benefiting from abundant reactive species including H 2 O 2 , OH, O 2 − produced in photochemical process, a 97.5 % removal efficiency of CAP was obtained within 40 min. Consecutive testing cycles indicated jarosite had excellent stability and reusability in photocatalytic system. Radical chain reaction induced by photosensitive Fe(III)-Ox complexes under light irradiation was suggested to be the main mechanism for CAP degradation. A few degradation intermediates were identified to propose the possible degradation pathways of CAP. Further investigation showed that the antibacterial activities of CAP solution towards Escherichia. coli ATCC 8739 and Staphylococcus. aureus ATCC 6538 were largely reduced after treatment by photochemical process. Typical operation parameters of light/jarosite/Ox system were also investigated. CAP degradation performance in actual water demonstrated the feasibility of light/jarosite/Ox process. Overall, the developed light/jarosite/Ox system possesses great potential for antibiotic-containing wastewater treatment.
研究领域:
环境科学
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化学工程
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水处理
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2020
·
IF 7.1
Yingxia Zhou,Lai Wei,Lihua Chen
Herein, a small molecule, hemin/G-quadruplex (G4-hemin), was physically embedded into NH 2 -MIL-53 (Al) to construct a novel metal-organic framework (MOF)-based enzyme ( [email protected] ). Its catalytic activity and stability were investigated in detail by catalyzing a reaction of 3,3′,5,5′-Tetramethylbenzidine (TMB) in the presence of H 2 O 2 . The results show that the activity and stability of this new enzyme is better than that of traditional hemin or G4-hemin, and even stronger than that of [email protected] ( [email protected] > G4-hemin > [email protected] > hemin). No significant loss in catalytic activity was observed for at least one day. Even after eight days, only a 13.8 % decrease in activity was recorded. An electrochemical biosensor was successfully developed based on a signal amplification strategy utilizing the catalysis of [email protected] The sensor was able to sensitively detect TB in buffer, even in a diluted solution of many proteins. The proposed method offers high selectivity against mismatch sequences of TB, a good linear response range of 10 −18 moL L -1 to 10 -14 moL L -1 and a low minimum detection limit of 0.330 aM.
研究领域:
生物化学
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分析化学
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材料科学
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生物医学工程
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产品关联
DOI
高影响因子
ANALYTICAL BIOCHEMISTRY
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2017
·
IF 2.334
Aicheng Wang,Huimin Zhao,Xiaochi Chen,Bing Tan,Yaobin Zhang,Xie Quan
A sensitive, rapid and label-free colorimetric aptasensor for sulfadimethoxine (SDM) detection was developed based on the tunable peroxidase-like activity of graphene/ [email protected] nanoparticle (Gr/ [email protected] ) hybrids. The addition of the SDM aptamer could inhibit the peroxidase-like catalytic activity of the hybrids. However, the target SDM and aptamer could be triggered tightly and recover the catalytic activity of the Gr/ [email protected] hybrids. Due to the peroxidase-like catalytic activity, Gr/ [email protected] could catalyze the decomposition of H 2 O 2 with releasing hydroxyl radicals which further oxidized reagent 3, 3′, 5, 5′-Tetramethylbenzidine (TMB) to oxTMB accompanied with a colorless-to-blue color change. The original color change could be applied to obtain quantitative detection of SDM, due to the relationship between the concentration of the target and the color difference. As a result, this approach performed a linear response for SDM from 1 to 500 ng/mL with a limit detection of 0.7 ng/mL (S/N = 3) under the optimized conditions and realized the detection of SDM in spiked lake water samples. Therefore, this colorimetric aptasensor was an alternative assay for SDM detection in real water. Moreover, with its design principle, this work might be applied to detecting other small molecule by employing appropriate aptamer.
研究领域:
分析化学
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纳米技术
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环境科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2026
·
IF 12.8
Lumeng Jia,Wenchao Yu,Xiangting Hou,Mengxue Li,Qi Shi,Zhaoyong Bian,Hui Wang
Photoelectrocatalytic (PEC) in situ hydrogen peroxide (H 2 O 2 ) production offers a green strategy for activating singlet oxygen ( 1 O 2 ) and degrading refractory organic pollutants. However, it suffers from low cathode yield, sluggish anode kinetics, mass-transfer losses, and low selectivity for 1 O 2 . This study ingeniously designed an S-O double vacancy β-In 2 S 3 -Er/Yb@WO 3 -Ov S-type heterojunction full-spectrum photoanode, offered new perspectives on in situ oxygen reduction at the photoanode for H 2 O 2 generation, and presented a dual-electrode cooperative PEC system. In the experiment, double vacancies at the photoanode acted as electron traps, accumulating electrons. Meanwhile, an applied bias voltage, more electrons on the surface, and weakly acidic and oxygen-permeable conditions the electrons trapped by vacancies, together with conduction band electrons, were conducive to driving the in-situ two-electron oxygen reduction reaction to H 2 O 2 formation at the photoanode. O vacancies dominated interfacial adsorption and catalysis, while S vacancies served as electron traps for charge separation, forming a complementary synergy. Coupled with charge modulation at the S-scheme heterojunction interface, accelerating photogenerated carrier separation and preserved highly reactive holes, providing key conditions for 1 O 2 generation. β-In 2 S 3 -Er/Yb@WO 3 -Ov photoanode realized in-situ oxygen reduction reaction-induced H 2 O 2 production and cathodic H 2 O 2 activation simultaneously. Both routes yield ·OOH/·O 2 - intermediates, which were oxidized by holes to form 1 O 2 , thereby enabling efficient carbamazepine removal (98.4%, k app = 0.093 min -1 ), efficient 1 O 2 production (53.13 μmol L -1 min -1 ), and low energy consumption (0.155 kWh m -3 -log). This work presents an advanced PEC strategy for the synergistic synthesis of H 2 O 2 and 1 O 2 , offering a promising approach for high-efficiency environmental remediation.
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DOI
高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2025
·
IF 4.7
Dake Huang,Ke Shen,Li Gui,Qiongqiong Cao,Fangmei Yu,Yunxia Lu
Given resveratrol's (RES) potential as an anti-aging agent, this study explored its ability to inhibit the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome through the miR-217/SIRT1 axis in senescent endothelial cells. Male C57BL/6 mice were administered a customized regular diet supplemented with 0.04 % RES for 64 consecutive weeks. Subsequently, the effects of RES on senescent human umbilical vein endothelial cells (HUVECs) induced by H 2 O 2 were evaluated. Gene expression analyses were conducted following SIRT1 knockdown in HUVECs treated with H 2 O 2 and RES, or transfected with miR-217 mimics and inhibitors. The study found that RES reduced body weight, improved endothelial function, enhanced SIRT1 expression, and suppressed the expression of miR-217, NADPH oxidase 4 (NOX4), and NLRP3 in the senescent thoracic aorta. Additionally, RES significantly reduced the expression of NOX4, X-box binding protein 1 spliced (XBP1s), and reactive oxygen species (ROS) production in a dose-dependent manner in senescent HUVECs. SIRT1 knockdown resulted in the activation of the NLRP3 inflammasome by upregulating NOX4 and XBP1s expression, an effect that was partially attenuated by RES pretreatment. RES also suppressed the expression of miR-217 induced by H 2 O 2 . The miR-217 mimic facilitated cellular senescence; however, RES mitigated this effect, which was further amplified by the miR-217 inhibitor.
研究领域:
分子生物学
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老年医学
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心血管病学
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细胞衰老
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信号转导
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氧化应激
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RNA干扰
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药理学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Chengyu Duan,Yinglong Lu,Zheshun Ou,Mengdi Sun,Guanghui Luo,Huimin Liu,Ruilin Wang,Yijie Wang,Zhuofeng Hu
The spontaneous oxygen reduction is a potential technology for in-situ H 2 O 2 production, which gets rid of the dependence on electricity and solar energy. Previous some metal–carbon compounds reported are feasible to trigger oxygen reduction. These reports always claim the high H 2 O 2 generation ability of metal–carbon composites, while rarely discuss the contribution of carbon and the carbon–metal junction to the oxygen reduction process. Inspired by the dual active sites, we infer that the role of interfacial carbon in metal–carbon composites is underestimated. By a heat treatment of the co-precipitate of zinc and glucose, the Zn-C junction is constructed in Zn-gc to achieve a spontaneous selective reduction of O 2 to H 2 O 2 . The Zn-C interface edge is active site, where an asymmetric activation is achieved by bonding two O atoms from O 2 to C and Zn, respectively. The Zn traction to one of the O atoms is mainly in xy plane, while the C traction to the other O atom is parallel to z-axis. The yield of H 2 O 2 produced per gram of Zn increases from 27.89 mg to 122.21 mg, an improvement of 4.38 times. And the inertness of Zn and its oxygen-containing compounds towards H 2 O 2 enables Zn-gc/O 2 system to stabilize H 2 O 2 over a long period of time. This work reveals the crucial role of neglected junction interfaces in oxygen reduction reactions in metal–carbon composites.
研究领域:
材料科学
·
化学工程
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）