Carbon Letters
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2025
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IF 5.8
Xiao Xinyu,Li Mingyue,Chen Guangmeng,Zhou Weihua,Zhao Weiwei,Liu Xiaoqing
Improving the oxygen evolution reaction (OER) performance or replacing OER with the value-added conversion of biomass is of great significance for the green hydrogen energy production. In this work, bimetallic species-decorated laser-induced graphene (LIG) was fabricated and demonstrated as the self-supported electrodes towards efficient OER and 5-hydroxymethylfurfural oxidation reaction (HMFOR). Three-dimensional LIG was obtained via one-step irradiation process under ambient conditions, and active metal species were then introduced through electrodeposition, with Ni-based catalyst as the primary catalytic material and Fe and Co as modified metals. Among, LIG-NiFe electrode achieved an extremely low overpotential of 241.7 mV at a current density of 20 mA/cm 2 for OER and demonstrated long-term stability. This could be attributed to the promoted formation of Ni 3+ active centers by Fe modified and the intrinsic porous structure of LIG providing an enhanced surface area. As for LIG-NiCo, due to the low onset potential of Co for HMF, it could achieve 99.6% HMF conversion and yielded value-added 2, 5-furandicarboxylic acid (FDCA) with a selectivity of 87.1%. Coupled with the merit of facile fabrication of LIG framework, this study demonstrates that LIG-based electrodes assume great practical application value in electrocatalytic reactions. Graphical abstract
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npj Precision Oncology
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2025
·Vol. 9
·期 1
·1-21
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IF 8
Li Xiaoli,Wang Jiashuo,Guo Jiaxing,Zhang Ming
Cisplatin resistance is a major challenge in laryngeal cancer treatment. Tumor necrosis factor-alpha-induced protein 2 (TNFAIP2) has been implicated in chemoresistance, though its role in laryngeal cancer remains unclear. We identified TNFAIP2 as a key gene associated with cisplatin resistance and developed a second near-infrared (NIR-II) light-responsive CRISPR-Cas9 nanosystem (APC@RBCs) to target it. In cisplatin-resistant Tu177/CDDP cells, light-activated knockout of TNFAIP2 significantly increased cisplatin sensitivity (IC50 reduced from 12.55 to 4.37 µg/mL). Mechanistic studies revealed that TNFAIP2 modulates cisplatin resistance via the NRF2 pathway, affecting oxidative stress response and epithelial-mesenchymal transition. TNFAIP2 deletion also suppressed cancer cell migration and invasion. Our results establish TNFAIP2 as a critical mediator of chemoresistance and demonstrate the potential of APC@RBCs as a precise, non-invasive gene therapy platform. This strategy offers a promising approach to overcoming cisplatin resistance and improving treatment outcomes in laryngeal cancer patients.
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npj Materials Degradation
·
2025
·Vol. 9
·期 1
·1-14
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IF 7.6
Yang Jie,Shen Ting,Wei Jiahong,Chen Chong,Cao Wenkai,Li Weihua
Inspired by pH variation in corrosion microenvironment and the emerging solid-liquid composite strategies, this study presents an innovative self-healing coating based on pH-responsive confined solid-liquid transition behavior, with anti-corrosion functionality as a proof of concept. The coating integrates poly (vinyl alcohol) (PVA) crosslinked with boronic acid (BA) through an in-situ solvent exchange process, forming borate ester-based, pH-responsive PVA-BA (AB) hydrogel microdomains within a poly (3-(trimethoxysilyl) propyl methacrylate) (PTPM) network. The AB/PTPM coating achieves healing within 30 min, based on gel-sol transitions of the AB hydrogel microdomains triggered by different pH conditions (pH = 7 and 11). The hydrophobic PTPM network prevents AB hydrogel microdomains from water intrusion. This design balances the fluidity and stability, providing a solution to enhance the durability of protective coatings. The AB/PTPM coating was applied as a topcoat over an epoxy (EP) primer, and the formed bilayer AB/PTPM@EP coating exhibits excellent anti-corrosion restoration properties after self-healing.
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Lipids in Health and Disease
·
2025
·Vol. 24
·期 1
·1-16
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IF 4.2
Li Lishuang,Ren Xing,Gao Xinyu,Zhao Yujia,Ma Yuman,Gong Junxiao,Yang Shuo,Sun Yanan,Wang Yi
Objective This study aimed to investigate the regulatory role and mechanisms of chenodeoxycholic acid (CDCA) on lipid metabolism, and to evaluate its therapeutic potential in lipid metabolism-related diseases such as acne, seborrheic alopecia, and prostate cancer, with the aim of identifying safer and more sustainable treatment alternatives. Methods Lipid-overproduction models were established using RM-1 (murine prostate cancer cells) and primary sebaceous gland cells, stimulated by linoleic acid (LA) and dihydrotestosterone (DHT), respectively. CDCA’s mechanisms were explored using transcriptomics, proteomics, and fatty acid-targeted metabolomics. In vivo validation was conducted via intradermal injection of CDCA into the sebaceous gland area of golden hamsters to assess its effect on sebaceous lipid metabolism. Results CDCA significantly reduced intracellular lipid accumulation in both murine prostate cancer cells (RM-1) and primary sebaceous gland cells, and suppressed the expression of the androgen receptor (AR), along with the downregulation of key lipogenic enzymes (SREBF1, FASN, FADS2). Mitochondrial membrane potential was restored in CDCA-treated cells. Multi-omics analyses revealed that CDCA modulated fatty acid biosynthesis and degradation, energy metabolism, mitochondrial function, and Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) signaling. Lipidomic profiling demonstrated a shift from saturated to unsaturated fatty acid dominance after CDCA treatment. In vivo, CDCA decreased sebaceous lipid accumulation and downregulated PPAR-γ expression in golden hamsters. Conclusion CDCA exerted multifaceted regulatory effects on lipid metabolism, hormone signaling, and mitochondrial dynamics. These effects contributed to the maintenance of sebaceous gland homeostasis and supported the development of innovative and potentially more biocompatible therapies for lipid-related disorders.
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METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
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2025
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IF 3.1
Zhang Ningyu,Zhang Yang,Xiang Junyi,Xue Yuxiao,Yu Wenhao,Lv Xuewei
The conventional vanadium extraction and dephosphorization processes in the converter are carried out separately, which results in high energy consumption and operational complexity. Calcium ferrates possess the dual function of oxidizing agents and alkaline sources, which provides a novel approach for integrating vanadium extraction and dephosphorization processes. Accordingly, the simultaneous extraction of vanadium and dephosphorization from V-bearing hot metal by the addition of calcium ferrates was proposed in this study for the first time. The experiments were conducted in a low-frequency induction furnace at 1523 K to 1673 K in an inert atmosphere. Thermodynamic calculations and experimental studies demonstrate the potential of calcium ferrates to facilitate vanadium extraction and dephosphorization simultaneously. Especially CaFe 4 O 7 and CaFe 2 O 4 , due to their low melting point and high Oxidizing ability, can reduce the vanadium and phosphorus contents in hot metal to below 0.024 and 0.010 wt pct at 1623 K for 6 minutes of reaction. Correspondingly, the lg L V are 2.42 and 2.37, whereas the lg L P are 2.13 and 2.14, respectively. In the slag, vanadium is oxidized from V 3+ to V 5+ by Fe 2 O 3 with the CaO content increases. A shift from spinel to calcium vanadium silicate is observed. Phosphorus is always present in calcium silicate. The simultaneous vanadium extraction and dephosphorization are achieved only by adding calcium ferrate, effectively recovering vanadium resources and improving semi-steel purity.
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Journal of Material Cycles and Waste Management
·
2025
·
IF 3
Lou Wen-bo,Liu Dong-yan,Zhao Da,Wang Yun,Sun Zi-cheng,Zou Yi,Niu Xiao-wei,Cheng Quan-guo,Li Jian-zhong,Liu Hong-hui
The recovery of NCM (LiNi x Co y Mn 1-x-y O 2 , abbreviated as NCM) cathode materials from retired lithium-ion batteries is a research hotspot in resource recycling field. Nevertheless, due to aluminum impurities mixed in raw materials, Li(I) and Al(III) ions are easy to combine to form water-insoluble LiAlO 2 during reduction, affecting Li(I) ions’ water-leaching efficiency. In this study, the LiAlO 2 formation environment is analyzed. Thermodynamic analysis reveals that there is generally less spontaneity in the reaction of Li (I) ions with aluminum monomers compared to Al 2 O 3 , and the introduction of CO 2 can inhibit Li-Al-O substance production. Li-Al binding experiments show that there is almost no direct reaction between Li 2 CO 3 and aluminum monomers, but under Ar atmosphere, Li 2 CO 3 and Al 2 O 3 can easily lead to Li-Al binding, a kinetic analysis considers that binding is controlled by chemical reaction, with an activation energy of 57.78 kJ/mol, and the activation energy increases to 88.028 kJ/mol with CO 2 atmosphere. Under reduced optimization conditions (reduction temperature: 500 °C, time: 6 h, and m NCM : m Al = 1: 0.25), the carbonation water-leaching efficiency can reach 95.1% for Li(I) ions and less than 1% for Ni(II), Co(II), Mn(II), and Al(III) ions. Thus, this work offers a theoretical basis for the industrial Li(I) ions’ recovery from aluminum-containing NCM materials.
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ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
·
2025
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IF 2.9
Yang Chunming,Yu Mengjie,Wang Yuan,Liu Yang,Zhou Chunyuan,Shi Jieyi,Bao Dan,Zhong Cheng,Li Benhui,Li Yifan,Fan Yuzhu,Zhou Chengyu
Wellbore instability is a key challenge in drilling engineering, significantly affecting the efficiency and safety of oil and gas extraction. This study addresses the wellbore instability problem in the Shaximiao Formation and proposes a polyamine drilling fluid system based on micro-nanofillers sealing technology. The system’s efficiency and stability are verified through multi-scale characterization and performance optimization. Techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and contact angle measurement are employed to systematically analyze the mineral composition, microstructure, and surface properties of the Shaximiao Formation. It is revealed that the main cause of instability stems from the hydration expansion of clay minerals and the development of micro-cracks. Based on this, the synergistic effect of the micro-nanofiller sealing agent and the polyamine inhibitor is optimized to construct a high-performance drilling fluid system. Experimental results show that this system exhibits excellent rheological properties (API fluid loss < 5 mL, HTHP fluid loss < 10 mL), significant inhibition (rock sample recovery rate 96.79%, expansion rate < 4%), and long-term temperature stability (48 h). The micro-nanocomposite sealing structure effectively fills the micro-cracks in the formation and reduces pore pressure and permeability, thereby significantly enhancing wellbore strength. Compared to traditional drilling fluids, this system has significant advantages in sealing performance, inhibition, and high-temperature stability. This study provides crucial theoretical foundations and technical support for addressing wellbore instability and inadequate plugging performance of drilling fluids in unconventional reservoir drilling operations.
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Carbon Letters
·
2025
·
IF 5.8
Deng Pengfei,Wang Shuangquan,Zhang Qiuxue,Li Songsong,Deng Yunjiao,Fu Zhongyu,Zhou Chao,Zhang Huixuan
Poor bonding occurs with resin due to surface inertness of carbon fiber (CF), so CF surfaces were often treated. In some common surface treatments, sizing was a simple and effective modification method. Polyurethane (PU) was used as the main component of sizing agents due to its similar structure to polyamide 6 (PA6). The CF/PA6 composites’ interfacial properties were improved using PU as a sizing agent. Meanwhile, in this paper, glycidol (GLD) was introduced into the PU emulsion so that the epoxy group reacted with the carboxyl group on the acidified CF. After testing, when the content of glycidyl in the sizing agent is 2%, the CF/PA6 composites showed an important improvement in tensile, impact, and flexural strengths, which increased by 49.4%, 94.6%, and 53.2%, respectively. In addition, the effect of modified WPU sizing agents with different GLD contents on the properties of CF/PA6 composites was investigated.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 9
·1-10
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IF 5.3
Fang Qiaoling,Zhang Guiyun,Ju Huan,Ni Jiancong,Yang Weiqiang
An innovative amine-enriched vertically-ordered mesoporous silica film (VMSF) on indium tin oxide (ITO) electrodes (A-VMSF/ITO) utilizing an anionic template strategy was successfully developed, resulting in the inner walls of the nanochannel being adorned with well-ordered and abundant tertiary amine groups. In the context of A-VMSF/ITO, the elevated solution conductivity not only facilitates the permeation of Ru(bpy) 3 2+ within nanochannels by compressing the inner electric double layer (EDL), but also greatly improves the electron-transfer efficiency that is critical for enhanced electrochemiluminescence (ECL) generation. Therefore, the A-VMSF/ITO platform exhibited a consistent increase in ECL intensity with rising ionic strength. This property was subsequently employed for monitoring Escherichia coli ( E. coli ) metabolism, as the metabolic byproducts result in alterations in solution conductivity. Experimental results demonstrated that the ECL signal had closed relationships with the process of E. coli growth, which can be used to evaluate the inhibitory effects of antibiotics. Given its amine-enriched characteristics, A-VMSF/ITO is anticipated to serve as an ideal architecture for nanoconfined ECL research, thereby establishing a robust foundation for homogeneous ECL biosensing. Graphical
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 9
·1-15
·
IF 5.3
Wu Yuqi,Shan Xueling,Zhao Ziyu,Jiang Ding,Yan Guoping,Wang Wenchang,Shiigi Hiroshi,Hu Zhibang,Chen Zhidong
A dual-ligand strategy was employed to construct an electrochemiluminescence (ECL) sensing platform based on dual-ligand Tb-MOF and Ag 3 PO 4 @TCPP for sensitive detection of chloramphenicol (CAP), demonstrating its potential applications in environmental monitoring and food safety. The dual-ligand Tb-MOF can be used as a co-reactant promoter, facilitating the rapid electroreduction of S 2 O 8 2− to generate more oxidative mediator SO 4 •− , thereby enhancing the luminescence efficiency of the luminescent material Ag 3 PO 4 @TCPP. Furthermore, the integration of Ag 3 PO 4 @TCPP emitter could effectively overcome the aggregation-caused quenching (ACQ) effect of TCPP and then increase the luminescence intensity by seven-fold, which was attributed to the efficient electron transfer and energy transfer between Ag 3 PO 4 and TCPP. Additionally, ECL spectra and electron spin resonance (ESR) spectra were utilized to investigate the possible ECL mechanism of the dual-ligand Tb-MOF/Ag 3 PO 4 @TCPP system. As a proof of concept, we successfully established an ECL biosensor for detecting CAP, which displayed a wide linear range (10 −6 ~ 10 −15 M) and low detection limit (8.29 × 10 −16 M), demonstrating practical feasibility. This study introduces a dual-ligand strategy to enhance ECL signals, expands the application scope of dual-ligand lanthanide MOFs, and provides new insights into designing high-performance sensing platforms. Graphical
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2025
·
IF 2.6
Xiao Feng,Wang Lei,He Qihang,Xu Fan,Wu Donghua,Chen Chao,He Ping,Tang Bin
Designing promising electrode material for supercapacitor application with rich redox activities, high capacity and great cycling stability has become a research priority. Herein, a nanohybrid (CoS 1.097 -NiS-MoS 2 ) with nanosheets combining nanorods morphology is prepared by high-temperature pyrolysis sulfuration of ZIF-67/NiMoO 4 . Co-existence of multiple crystalline phases is favorable for enriching electrochemical active sites and facilitating electron transfer. Consequently, CoS 1.097 -NiS-MoS 2 displays better supercapacitor performance with a specific capacity of 373.6 C g −1 at current density of 1 A g −1 and excellent cycling stability of 70.01% after 3000 cycles, surpassing CoS 1.097 (49.1 C g −1 ; 59.26%) and NiS-MoS 2 (105.8 C g −1 ; 62.00%). Moreover, a hybrid supercapacitor is assembled with CoS 1.097 -NiS-MoS 2 and activated carbon, exhibiting high energy density of 21.0 Wh kg −1 at 800 W kg −1 . This work opens a path for preparation of promising ternary metal sulfide-based materials for the field of energy storage.
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 9
·1-17
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IF 2.8
Zhang Rui,Ma Haihong,Zhou Zhengfa,Xu Weibing,Ren Fengmei
A modified silicone oil containing nitrogen, phosphorus, and sulfur was synthesized by the reaction of n-butyl thiophosphoric triamine (NBPT) and epoxidized silicone oil (ETSO), and named NBSO. The successful synthesis of NBSO was confirmed by Fourier infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). The flame retardant and smoke suppression properties of NBSO were investigated by open flame ignition method and cone calorimetry test (CCT). The results showed when the molar ratio of NBPT to ETSO was 1:1, the flame height of the modified silicone oil was significantly reduced, and compared with ETSO, the total smoke release (TSR) and the total heat release (THR) of NBSO was reduced by 67.6% and 68%, respectively. Thermogravimetric analysis (TGA), infrared thermogravimetric coupling (TG-IR), thermal field emission scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) techniques were used to analyze the mechanism of flame retardant and smoke inhibition. The results indicate that compared with ETSO. NBSO has a slower thermal decomposition rate and releases less flammable gas.In the condense phase, nitrogen, phosphorus, silicon, and sulfur could improve the carbon forming ability through synergistic effect. At the same time, a silicon oxide layer was formed on the outer surface of the carbon layer, which could increase the flame retardation and smoke suppressing effect.
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