CELLULOSE
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2024
·
IF 4.9
Yang Yang,Bi Yujie,Zhao Yang,Cai Changyu,Liang Xinmiao,Ke Yanxiong
In this work, a modified suspension polymerization method was developed to synthesize cellulose derivative hybrid polydivinylbenzene (PDVB) microspheres with particle sizes of 7–12 μm. Cellulose tris(4-methylbenzoate) (CTMB) and cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) hybrid PDVB were incorporated and well distributed in the microspheres. The chiral recognition ability of the chiral stationary phases (CSP) was evaluated by chiral high-performance liquid chromatography (HPLC) separation of 38 enantiomers with widely varied chemical structures. The influence of pore size and the loading of chiral selectors were investigated. The chiral recognition ability of the columns is comparable to that of the CHIRALCEL ® OD column and CHIRALCEL ® OJ column. For some enantiomers, the chiral selectivity of the prepared columns is even better than CHIRALPAK ® IB column and CHIRALPAK ® IJ column. In addition, the columns showed excellent stability in the basic mobile phase and organic solvents such as tetrahydrofuran (THF) and ethyl acetate (EA). This work enabled the synthesized polysaccharide-based CSPs with good chiral recognition ability and high stability.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2025
·
IF 2.6
Sun Yiwei,Luo Yuting,He Yuyang,Wang Haoxiang,Wang Ruoyu,Lu Mengqi,Li Ke,Wu Siqi,Wei Sucan,Song Huiqiao,Xu Dongpo
A highly efficient electrochemical molecularly imprinted sensor for the detection of chloramphenicol (CAP) was prepared using carbon nanofibers (CNFs). The conductivity and large surface area of CNFs improved the electrochemical detection performance while providing more binding sites for chloramphenicol molecularly imprinted polymers. CNF@MIP was prepared using polypyrene as the functional monomer and chloramphenicol as the template molecule. The electrochemical performance of CNF@MIP was evaluated with cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, CNF@MIP exhibited a wide detection range (0.1–100 nM), low detection limit (1.15 pM), and good selectivity, stability, and reproducibility. In addition, CNF@MIP can be used to detect chloramphenicol in milk samples.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2025
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IF 3.8
Li Wenya,Gao Bingling,Yang Tao,Tang Liping,Song Dan,Li Hongmei,Sun Keqi,Xiao Peng
3,3′,5-Triiodothyronine (T3) plays a crucial role in the diagnosis and evaluation of thyroid diseases. The current reference measurement procedure (RMP) has been in place for 20 years and is widely adopted by reference laboratories around the world. To enhance the performance of the RMP, we developed and validated a simplified, SI-traceable candidate RMP specifically targeting serum total T3 (TT3) using isotope dilution-liquid chromatography with tandem mass spectrometry (ID-LC–MS/MS). Specifically, T3 reference material was employed as the standard. Compared to the RMP, our method incorporates a simplified serum cleanup process involving protein precipitation and nitrogen drying. The method validation followed ISO guidelines for measurement uncertainty assessment. Our results indicated that there was no significant conversion of T4 into metabolites during the serum pretreatment. The lower limit of the measuring interval was determined to be 0.077 nmol/L, and the regression model was linear across a range of 0.016 to 13.086 nmol/L. The imprecision of intra-assays ranged from 0.1 to 1.9%, while inter-assay imprecision ranged from 0.5 to 1.2%. The bias observed when analyzing SRM971 was between − 0.34 and − 1.65%. This candidate RMP demonstrated excellent agreement with the RMPs developed by RELA activity, showing a mean bias falling within the educational mean ratio (6%). The measurement uncertainties were 0.022 nmol/L for RELA2023A and 0.120 nmol/L for RELA2023B. In conclusion, the developed candidate RMP is traceable, reliable, and easy to operate, showing promising potential for the development of serum reference materials and the standardization of routine assays. Graphical
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 6
·1-14
·
IF 23.2
Zhao Xiaotong,Du Peng,Qiu Fei,Hou Yuanlang,Lu Hanxiao,Zhang Jiemin,Geng Xiangshun,Dun Guanhua,Chen Sisi,Lei Ming,Ren Tian-Ling
The drive to deliver ever-more powerful and feature-rich organic integrated circuits has made the interface contact quality improvement—that is, the process of alleviating the hysteresis phenomenon and contact resistance of the electrical properties in organic field-effect transistors (OFETs)—a critical challenge for the organic semiconductor (OSC) microelectronics industry. The use of blends of OSCs and insulating binding polymers has offered a breakthrough to circumvent these limitations. Here, we introduced a novel method for preparing high-performance OFETs based on a direct-writing inkjet printing (DWIP) blend composed of 6,13-bis(triisopropylsilylethinyl) pentacene (TIPS-pentacene) and poly(methyl methacrylate) (PMMA). The small molecular weight of PMMA imparted significantly superior crystallization of small-molecule OSCs, and the OFETs exhibited better electrical performance than other comparative conditions. The crystallization and characteristics improved because of two mechanisms: First, the PMMA delivered superior mechanical strength, stability, and improved film uniformity and created a more uniform interface that decreased the charge accumulation, thereby alleviating the hysteresis and contact resistance. Second, combined with DWIP technology and thanks to the advantages of horizontal solution shearing and spatially restricted domains, the blends contributed to solute draw and thus handled mass transport more efficiently and controllably. The proposed method provides attractive properties for industrial applications.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-19
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IF 10.6
Zhang Xiaojie,Liang Qiangwei,Cao Yongjin,Yang Ting,An Min,Liu Zihan,Yang Jiayu,Liu Yanhua
Myeloid-derived suppressor cells (MDSCs) have played a significant role in facilitating tumor immune escape and inducing an immunosuppressive tumor microenvironment. Eliminating MDSCs and tumor cells remains a major challenge in cancer immunotherapy. A novel approach has been developed using gemcitabine-celecoxib twin drug-based nano-assembled carrier-free nanoparticles (GEM-CXB NPs) for dual depletion of MDSCs and tumor cells in breast cancer chemoimmunotherapy. The GEM-CXB NPs exhibit prolonged blood circulation, leading to the preferential accumulation and co-release of GEM and CXB in tumors. This promotes synergistic chemotherapeutic activity by the proliferation inhibition and apoptosis induction against 4T1 tumor cells. In addition, it enhances tumor immunogenicity by immunogenic cell death induction and MDSC-induced immunosuppression alleviation through the depletion of MDSCs. These mechanisms synergistically activate the antitumor immune function of cytotoxic T cells and natural killer cells, inhibit the proliferation of regulatory T cells, and promote the M2 to M1 phenotype repolarization of tumor-associated macrophages, considerably enhancing the overall antitumor and anti-metastasis efficacy in BALB/c mice bearing 4T1 tumors. The simplified engineering of GEM-CXB NPs, with their dual depletion strategy targeting immunosuppressive cells and tumor cells, represents an advanced concept in cancer chemoimmunotherapy. Graphical Abstract
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2025
·Vol. 131
·期 3
·1-10
·
IF 2.8
Yang Chunrong,Wu Huazhong,Gao Xiaojie,Zhang Congfa
Manganese is an essential micronutrient for all living organisms and plays a crucial role in bone metabolism. The purpose of this study was to investigate the effects of manganese on the structure and chemical dissolution behavior of bioactive glasses, as well as its effects on in vitro biological activity and oxidative stress levels. Manganese doped bioglass was synthesized by sol-gel method. Its structure was studied using FTIR combined with Raman spectroscopy. The in vitro mineralization performance in simulated body fluids was analyzed using X-ray diffraction, FTIR and ultraviolet spectroscopy. The antioxidant capacity of manganese doped bioglass was studied using MC3T3-E1 cells against H 2 O 2 induced damage. The doping of manganese caused slight changes in the bioglass structure, and enabled it to obtain crystalline phases of calcium manganese silicate and calcium silicate through calcination. All bioglass exhibited good ability to form hydroxyapatite. Compared to the parent bioglass, manganese doping significantly enhanced the dissolution and biomineralization behavior. The protective potential of manganese doped bioglass exhibited dose-dependent effects within a limited concentration range, with excellent anti-oxidant ability observed at low doses of doping. Manganese doped bioglass has potential applications in bone regeneration and healing.
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CHEMICAL PAPERS
·
2024
·
IF 2.1
Guo Jinxiu,Kong Tao,Zhang Huaijie,Ma Runtian,Ma Zijun,Hu Bing
The development of rapid and sensitive malachite green (MG) detection methods is particularly important for food safety supervision and ecological protection. Using fulvic acid (FA) as a stabilizer and NaBH 4 as a reducing agent, ellipsoidal gold nanoparticles (AuNPs) with the average particle size of 5–20 nm were successfully prepared. Based on the interaction between fulvic acid protected gold nanoparticles (FA-AuNPs) and MG, the color change of FA-AuNPs from ruby red to blue was observed, the corresponding absorbance ratio change of gold nanoparticles at 611 nm and 529 nm (A611/A529) was also studied. Through the optimization of experimental conditions, the linear relationship between A611/A529 with the concentration of MG was established. The detection limit and linear range of this method were 0.02 μM and 0.04–2 μM, respectively. This method was successfully applied to detect malachite green in three different water samples with the recovery of 97.4–110.8%. Graphical abstract
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FIBERS AND POLYMERS
·
2024
·
IF 2.2
He Xia,Liu Qingchun,Pan Lianjun,Zhou Ying,Xu Le,Zhou Shiyu,Ma Yixin
Wearable electronics based on natural biocompatible fibers have attracted considerable interests due to the promising use for healthcare monitoring, human–machine interactions, and smart clothing. However, crucial challenges to design robust, flexible, and highly sensitive fiber sensors remain, to meet various requirements for practical application. Herein, Fischer esterification and in situ polymerization technologies were employed to produce conductive nanocelluloses (CNC–PEDOT), which possessed excellent mechanical stiffness and high conductivity (238 μS/cm). Then, silk yarns as supporting materials were functionalized by as-prepared conductive units to construct all-in-one fiber sensor (SCP) for multiple signals monitoring. Surprisingly, the resulted SCP fiber showed impressive mechanical performances (422.86 MPa at 18.44%), due to the strong hydrogen-bond interaction between SY substrate and CNC–PEDOT conductive units. More importantly, SCP fiber was employed a dual-function sensor for real-time monitoring of strain and temperature, illustrating remarkable sensitivities, i.e., gauge factor = 4.28 in a large strain range of 0–16%, and sensitivity = 1.55%/℃ in a broad temperature range of 25–60 ℃. The SCP fiber sensor with impressive mechanical performances and high sensitivity, can be applied for real-time health monitoring in wearable biosensors, smart healthcare, and on-demand therapy.
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MONATSHEFTE FUR CHEMIE
·
2024
·
IF 1.7
Qiu Shengzhou,Wu Chenxi,Akter Sima,Hong Shaoli,Liu Huihong,Mahmud Sakil
Addressing the challenges of tuberculosis drug detection, this study investigates the application of copper(II) oxide modified screen-printed carbon electrodes (CuO/SPCEs) for the electrochemical detection of rifampicin, a critical drug in the treatment of tuberculosis and mycobacterial infections. The CuO/SPCE was fabricated via a constant potential electrodeposition technique and characterized using voltammetry. The bare SPCE surface exhibited a rough, porous structure, whereas the electrodeposition of CuO resulted in a smoother CuO/SPCE surface. The sensor exhibited high sensitivity with a detection limit of 2.89 μM for rifampicin and demonstrated excellent stability with a relative standard deviation of 3.5% over 10 measurements. The reproducibility was confirmed with an RSD of 4.2% across different electrodes. It also showed a linear response to rifampicin concentrations ranging from 10 to 200 μM. The real sample analysis showed a linear relationship between rifampicin concentration and peak current ( I = 0.739 + 0.008 c ), with a high correlation coefficient ( R 2 = 0.995). This electrochemical sensor’s simplicity, cost-effectiveness, and rapid response make it a promising tool for point-of-care applications in tuberculosis management. Graphical abstract
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Bio-Design and Manufacturing
·
2024
·
IF 8.1
Jing Luyi,Xu Zhaojie,Fan Penghui,Lu Botao,Mo Fan,Hu Ruilin,Xu Wei,Shan Jin,Jia Qianli,Zhu Yuxin,Duan Yiming,Wang Mixia,Wu Yirong,Cai Xinxia
The subthalamic nucleus (STN) is considered the best target for deep brain stimulation treatments of Parkinson’s disease (PD). It is difficult to localize the STN due to its small size and deep location. Multichannel microelectrode arrays (MEAs) can rapidly and precisely locate the STN, which is important for precise stimulation. In this paper, 16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (MWCNT/PEDOT:PSS) nanocomposites were designed and fabricated, and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths. These results showed that nuclei in 6-hydroxydopamine hydrobromide (6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains. In addition, the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN. Moreover, higher values of spike firing rate, spike amplitude, local field potential (LFP) power, and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain, and may therefore be biomarkers of STN localization. Compared with the STNs of unlesioned brains, the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains. This may be a cause of sleep and motor disorders associated with PD. Overall, this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei. Graphic abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-22
·
IF 10.6
Li Bin,Jiao Siwen,Guo Shiqi,Xiao Ting,Zeng Yao,Hu Yingwei,Li Xiaojuan,Xiong Sha,Xu Yuehong
Background Transdermal delivery of sparingly soluble drugs is challenging due to their low solubility and poor permeability. Deep eutectic solvent (DES)/or ionic liquid (IL)-mediated nanocarriers are attracting increasing attention. However, most of them require the addition of auxiliary materials (such as surfactants or organic solvents) to maintain the stability of formulations, which may cause skin irritation and potential toxicity. Results We fabricated an amphiphilic DES using natural oxymatrine and lauric acid and constructed a novel self-assembled reverse nanomicelle system (DES-RM) based on the features of this DES. Synthesized DESs showed the broad liquid window and significantly solubilized a series of sparingly soluble drugs, and quantitative structure-activity relationship (QSAR) models with good prediction ability were further built. The experimental and molecular dynamics simulation elucidated that the self-assembly of DES-RM was adjusted by noncovalent intermolecular forces. Choosing triamcinolone acetonide (TA) as a model drug, the skin penetration studies revealed that DES-RM significantly enhanced TA penetration and retention in comparison with their corresponding DES and oil. Furthermore, in vivo animal experiments demonstrated that TA@DES-RM exhibited good anti-psoriasis therapeutic efficacy as well as biocompatibility. Conclusions The present study offers innovative insights into the optimal design of micellar nanodelivery system based on DES combining experiments and computational simulations and provides a promising strategy for developing efficient transdermal delivery systems for sparingly soluble drugs.
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Light-Science & Applications
·
2024
·Vol. 13
·期 1
·1-15
·
IF 20.6
Lv Xulong,Liang Yanjie,Zhang Yi,Chen Dongxun,Shan Xihui,Wang Xiao-Jun
Extensive research has been conducted on visible-light and longer-wavelength infrared-light storage phosphors, which are utilized as promising rewritable memory media for optical information storage applications in dark environments. However, storage phosphors emitting in the deep ultraviolet spectral region (200–300 nm) are relatively lacking. Here, we report an appealing deep-trap ultraviolet storage phosphor, ScBO 3 :Bi 3+ , which exhibits an ultra-narrowband light emission centered at 299 nm with a full width at half maximum (FWHM) of 0.21 eV and excellent X-ray energy storage capabilities. When persistently stimulated by longer-wavelength white/NIR light or heated at elevated temperatures, ScBO 3 :Bi 3+ phosphor exhibits intense and long-lasting ultraviolet luminescence due to the interplay between defect levels and external stimulus, while the natural decay in the dark at room temperature is extremely weak after X-ray irradiation. The impact of the spectral distribution and illuminance of ambient light and ambient temperature on ultraviolet light emission has been studied by comprehensive experimental and theoretical investigations, which elucidate that both O vacancy and Sc interstitial serve as deep electron traps for enhanced and prolonged ultraviolet luminescence upon continuous optical or thermal stimulation. Based on the unique spectral features and trap distribution in ScBO 3 :Bi 3+ phosphor, controllable optical information read-out is demonstrated via external light or heat manipulation, highlighting the great potential of ScBO 3 :Bi 3+ phosphor for advanced optical storage application in bright environments.
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