JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 6.054
Xia Yao,Xiuyun Sun,Shuyu Jin,Ling Yang,Hongjiang Xu,Yu Rao
A structure-hopping strategy was applied to discover a series of novel 4-aminoquinoline-3-carboxamide derivatives as potent, reversible BTK inhibitors. Compared to the previously described cinnoline scaffold compounds, the 4-aminoquinoline analogues showed significantly improved drug-like properties, especially in their aqueous solubility. The most potent compound, 25, displayed a stronger inhibitory effect on both BTKWT (IC50 = 5.3 nM) and BTKC481S (IC50 = 39 nM). In a rodent collagen-induced arthritis model, compound 25 efficiently reduced paw swelling without a loss in body weight. On the basis of potency, drug-like properties, stability, and noncovalent mode of inhibition, our representative inhibitors could have a promising profile to be treatments for a wide range of autoimmune diseases.
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Xin Xin,Huimin Liu,Nianbing Zhong,Mingfu Zhao,Dengjie Zhong,Haixing Chang,Bin Tang,Yuanyuan He,Cunling Peng,Xuefeng He
To realize the selective detection of 4-chlorophenol (4-CP) in water, a highly sensitive plastic optical fiber (POF) evanescent wave sensor was prepared using a D -shaped POF coated selective adsorption film of 4-CP. The film was composed of molecularly imprinted polymer (MIP) particles and PEBA2533 matrix. The MIP particles were employed to realize the selective adsorption and enrichment of 4-CP molecules, which lead to the changes in the refractive index of the MIP-PEBA2533 coating. These, in turn, resulted in changes in the light transmission in the D -shaped region and caused the attenuation of the evanescent field intensity on the surface of the sensing region. To illustrate the measurement principle, a theoretical model of the sensor was established. Furthermore, the performance parameters of the sensors, such as sensitivity, repeatability, selectivity and low limit of detection (LOD), were experimentally studied. The results highlighted that the proposed sensor exhibited a good sensitivity of -0.56 × 10 -6 (μg/L) -1 and LOD of 100 μg/L for the detection of 4-CP in water. Moreover, this optic-fiber sensor has high specific recognition ability for 4-CP. The results of this study could inform the development of methods for on-line and accurate detection of 4-CP.
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DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·
IF 5.7
Weiguang Ran,Jiayi Geng,Ziyou Zhou,Chunyuan Zhou,Fukai Wang,Ming Zhao,Tingjiang Yan
The development of efficient and thermally stable narrow-band-emitting phosphors is crucial for wide color gamut display applications. Herein, we have developed a novel narrow-band green-emitting RbK2Na(Li3SiO4)4:Eu2+ phosphor with remarkable luminescence properties. The phosphor exhibits a main green emission band at 535 nm, with a narrow full width at half maximum of 51 nm, attributed to its unique rigid structure and highly symmetric cationic sites. Furthermore, it demonstrates excellent thermal stability, retaining 90.95% of the integrated emission intensity at 500 K compared to that at 100 K, and exhibits a high internal quantum efficiency of 82.51%. By combining RbK2Na(Li3SiO4)4:5%Eu2+ with commercial red K2SiF6:Mn4+ phosphors and blue GaN chips, a white light-emitting diode device with a wide color gamut (103% NTSC) was prepared, demonstrating the potential of the RbK2Na(Li3SiO4)4:Eu2+ phosphor for liquid-crystal backlight applications.
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Ting Liu,Yinghui Sun,Bo Jiang,Wei Guo,Wei Qin,Yiming Xie,Bo Zhao,Liang Zhao,Zhiqiang Liang,Lin Jiang
The large amount of 4-nitrophenol (4-NP) wastewater produced by the chemical industry has received increased concern over the growing risk of environmental pollution. The ability to catalyze the reduction of highly concentrated 4-NP wastewater is highly desirable for the practical treatment of industrial wastewater, yet it remains a significant challenge. Herein, we report Pd nanoparticle-decorated 3D-printed hierarchically porous TiO2 scaffolds (Pd/TiO2 scaffolds) for the efficient reduction of highly concentrated 4-NP wastewater (2 g·L–1, ∼14.38 mM). The millimeter-sized interconnected channels in the scaffolds are conducive to rapid mass and ion transportation; meanwhile, the abundant micrometer- and nanometer-sized pores on the surface of the scaffolds offer adequate anchoring sites for Pd nanoparticles. The turnover frequency of the hierarchically porous Pd/TiO2 scaffold (16 layers) is up to 2.69 min–1, which is 1063 times higher than that of the Pd/TiO2-bulk material with the same size (0.00253 min–1). Importantly, no obvious deactivation of the catalytic activity is observed even after 20 cycles of catalytic reduction of 4-NP, showing excellent catalytic stability and reusability. Our strategy of loading the nanostructured catalyst on 3D-printable hierarchically porous structures put forward a flexible and versatile approach for boosting the catalytic performance of the catalysts, including catalytic activity, stability, and reusability, which can help promote their practical application in industry.
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 6
·066512
·
IF 3.721
Nannan Dou,Jianying Qu
A novel highly sensitive nanoelectrochemical sensor was prepared using graphene oxide/titanium dioxide/gold nanoparticles composites (GT@AuNPs) modified glassy carbon electrode (GCE) to measure paracetamol (PA) and 4-aminophenol (4-AP) simultaneously. It can be found that PA and 4-AP could be completely separated on the GT@AuNPs/GCE using cyclic voltammetry and differential pulse voltammetry technique. Under the best conditions, the linear responses for PA from 0.10 to 300.00 μM with the detection limits of 0.78 nM. And the linear responses for 4-AP from 0.10 to 150.00 μM with the detection limits of 2.36 nM. This sensor can be used to detect acetaminophen in pharmaceutical formulations with satisfactory results, indicating that the electrochemical sensor has potential application value.
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DOI
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 33
·期 3
·035601
·
IF 3.874
Jian-Hang Yin,Mengxuan Liu,Lei Meng,Nai-Di Tan,Na Xu
In this work, we reported a facile reduction approach for fabrication of water-soluble and ultrabright Cu nanoclusters with core–shell structure. A certain amount of reducing agent as NaBH4 was introduced into the polyethyleneimine-stabilized Cu nanoclusters (CuNCs@PEI) system, which exhibited 4-fold fluorescence enhancement along with a blue shift of the emission peak. The variations of morphology, valence states and functional groups demonstrated that a Cu shell was formed surround CuNCs (defined as CuNCs-Cu@PEI), attributable to metal complex (PEI-Cu+ and PEI-Cu2+) reduction. The effect of core–shell morphology on luminous and electron relaxation mechanism of CuNCs-Cu@PEI was investigated via temperature-dependent steady and time-resolved fluorescence measurements. The CuNCs-Cu@PEI with a high fluorescence quantum yields of 22.59% were able to homogeneously disperse in aqueous phase, indicating their potential applications in biological labeling, sensing and in vivo imaging. Finally, the CuNCs-Cu@PEI was employed as a fluorescence probe to determine 4-nitrophenol, of which the detection limit was much lower than initial CuNCs@PEI.
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2014
·
IF 4.086
Shuaiyuan Han,Baohua Yue,Liuming Yan
The poly(vinylphosphonic acid) (PVPA), poly(4-(α-methyl)vinyl-1 H -1,2,3-triazole) (PMVTri), and poly(VPA- co -MVTri) were synthesized, and proton exchange membranes were prepared based on the acid-base polymeric composite of PVPA and PMVTri, and acid-base amphoteric copolymer of poly(VPA- co -MVTri). The overall performances of PVPA, proton conductivity, thermal and oxidative stability, and water resistance, are greatly improved by compositing of PMVTri or copolymerization with 4-(α-methyl)vinyl-1 H -1,2,3-triazole (MVTri). About four or eight folds improvement in maximum proton conductivity was observed in the polymeric composite of PVPA/PMVTri or acid-base amphoteric copolymer poly(VPA- co -MVTri) because of the redistribution of ions in the heterostructures of PVPA and PMVTri, respectively, compared with the pristine PVPA. At the same time, the oxidative stability and the water resistance of PVPA were also greatly improved attributing to the absent of α-H in the main chain of PMVTri and the acid-base interaction between the phosphonic acid groups and the triazolyl groups, respectively.
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DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2024
·
IF 3.2
Pengju Xia,Wanyuan Li,Kaiting Wu,Yifeng Lei,Wubin Dai
In the process of studying newfangled phosphor-converted white-light-emitting diodes (pc-wLEDs), some basic and important objectives of phosphor, i.e., high chemical/thermal stability, color rendering index (CRI), and low correlated color temperature (CCT), should pass muster simultaneously. Herein, for the first time, a series of photoluminescence (PL) color-tunable single-phase Ca3Y(GaO)3(BO3)4: Dy3+/Sm3+/La3+ (CYGB: Dy/Sm/La) phosphors with good dispersivity, crystallinity, and size uniformity have been designed and synthesized via a facile solid-state reaction method. Structurally, based on XRD and Rietveld refinements, the tendentious occupations of Dy/Sm/La on the Y3+ site with a 9-coordinated number (CN) over other cationic sites are in line with the facts that the ionic radius and charge difference of Dy/Sm/La are much closer to Y3+ in 9-CN than Y3+ in 7-CN and Ca2+ in both 9- and 7-CN. Spectrally, thanks to the “cool” white PL from 4f–4f transitions of Dy and red-emitting from Sm, polychromatic PL including “warm” white light with high efficiency could be realized in CYGB: Dy/Sm via the regulation of doping content and energy transfer (ET). Intriguingly, the “abnormal” phenomena of zero-thermal-quenching in the range from room temperature (RT) to 573 K were observed, probably owing to the synergistic effects of electron–phonon coupling, ET, and structural defects. Moreover, by tridoping La3+ to legitimately adjust the site environments, the PL of both Dy/Sm could be further tuned because they all include hypersensitive transitions that are closely related to the crystal field environment. Finally, as a proof-of-concept fabrication, the pc-wLED assembled by a combination of the composition-optimized CYGB: Dy/Sm/La and an n-UV LED chip via remote “capping” packaging shows attractive performances, indicating its potential as an efficient phosphor for n-UV wLEDs.
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 13
·136513
·
IF 3.721
Nannan Dou,Jianying Qu
Herein, a hybrid nanomaterial of copper-nickel bimetal and reduced graphene (rGO) was simply and quickly synthesized by hydrothermal method, which was characterized by transmission electron microscope, field emission scanning electron microscopy, fourier transform infrared spectroscopy, electrochemical impedance and X-ray diffractometry. A new type of electrochemical sensor was constructed by fixing this hybrid on the glassy carbon electrode (GCE). Square wave voltammetry and cyclic voltammetry indicate that this Cu-Ni/rGO/GCE sensor has highly sensitive electrocatalytic activities to 4-aminophenol (4-AP) and acetaminophen (AC). The linear detection ranges were 0.10∼50.00 μM for AC and 0.10∼30.00 μM for 4-AP, with the detection limits of 2.13 nM for AC and 2.19 nM for 4-AP, respectively. The Cu-Ni/rGO/GCE was successfully used for the determination of 4-AP and AC simultaneously of paracetamol tablets, and satisfactory results were obtained.
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DOI
高影响因子
POLYHEDRON
·
2018
·
IF 2.067
Fuxian Wan,Lipeng Wang,Wenxin Xu,Changcheng Li,Ying Li,Chunbao Zhang,Lin Jiang
A novel dimeric gadolinium(III) complex, bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ), was successfully synthesized using bis(4-aminophenyl)adamantane to link two Gd-DTPA units. All the intermediates and bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ) have been characterized by 1 H NMR, 13 C NMR, ES-API-MS, HR-ESI-MS, FT-IR and elemental analysis (EA). The longitudinal relaxivity of bis(4-Gd-DTPA-aminophenyl)adamantane is 8.43 mM −1 Gd −1 s −1 at 0.43 T (32 °C, pH 7.0), and 4.89 mM −1 Gd −1 s −1 at 3.0 T (32 °C, pH 7.4). The T 1 -weighted imaging in vitro showed that bis(4-Gd-DTPA-acetylaminophenyl)adamantane can enhance the contrast of images distinctly. But most of all, the kinetic inertness of bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ) was comparable to that of [Gd(DTPA)(H 2 O)] 2− (Magnetvist®). Moreover, cytotoxicity tests indicated that the bis(4-Gd-DTPA-acetylaminophenyl)adamantane exhibited low toxicity to healthy liver cells (L-02 cells). These results demonstrate that the Gd(III) complex 5 may be a promising MRI contrast agent candidate.
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DOI
高影响因子
Solar RRL
·
2021
·Vol. 5
·期 7
·2100181
·
IF 8.582
Yali Sun,Pengfei Qiu,Siyu Wang,Hongling Guo,Rutao Meng,Xiaowei Zhou,Li Wu,Wei Yu,Jianping Ao,Yi Zhang
Cu 2 ZnSn(S,Se) 4 are emerging as promising photovoltaic materials due to their outstanding photoelectrical performances, benign grain boundaries, and Earth-abundant constituent elements. However, there are largely distributed cation-disordering defects and defect clusters, which lead to an increase in recombination and a large open-circuit voltage deficit and thus deteriorate device performance. Herein, defect control for a high-efficiency Cu 2 ZnSn(S,Se) 4 solar cell by atomic layer deposition of aluminum oxide (ALD-Al 2 O 3 ) on the precursor film is reporter. Cu Zn defects and Sn-related deep defects are largely suppressed because of the decrease in Sn 2+ and the increase in Sn 4+ in the film by ALD-Al 2 O 3 on the precursor are found, and the crystallinity of absorber layer is improved from a double-layer structure to a completely single-layer structure. Furthermore, the carrier lifetime and recombination in the bulk and interface are significantly improved for devices with ultrathin Al 2 O 3 . Using this approach, the conversion efficiency increases from 8.8% to 11.0% and the open-circuit voltage deficit decreases from 0.621 to 0.577 V. Herein, a deep understanding of the relationship between Al 2 O 3 incorporation and high-efficiency Cu 2 ZnSn(S,Se) 4 devices and a new direction for controlling defects to further improve the performance of kesterite solar cells are provided.
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DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2013
·Vol. 20
·期 7
·1-9
·
IF 2.019
Xu Jingmei,Ren Chunli,Cheng Hailong,Ma Li,Wang Zhe
Double fluoride 2,5-bis(4-fluorophenyl)-1,3,4-oxadiazole (BFO) monomer was synthesized. Copolymerization of BFO, 2,2-bis(4-hydroxypheny)propane (bisphenol A) and 3′3-disulfonate-4′4-dichloro dipheny sulfone (SDCDPS) at different molar ratio resulted in a new poly (aryl ether sulfone) containing 1, 3, 4-oxadiazole polymers (SPAESO). The structures of monomer BFO and copolymer were confirmed by FT-IR and 1 H NMR. The TEM pictures showed that the ion clusters were formed and distributed evenly in SPAESO copolymer matrix. The sulfonated polyoxadiazole membranes exhibited excellent thermal, dimensional and oxidative stability and lower methanol diffusion coefficient. The proton conductivity of SPAESO-3 was 7.5 × 10 −2 Scm −1 at 120 °C while the methanol permeability coefficient of SPAESO-3 was only 2.23 × 10 −7 cm 2 S −1 at 25 °C. According to the comprehensive performance, the sulfonated polyoxadiazole membranes may be the alternative materials as proton exchange membrane for PEMFC at medium-high temperature operation.
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DOI
高影响因子
危险品化学品经营许可证（带存储）