PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2021
·Vol. 38
·期 4
·2000333
·
IF 3.31
Qiaoqiao Zhou,Shaochen Wang,Peng Hu,Shuling Yu,Jiahua Shi,Jintao Yuan
A targeting and specific fluorescent gold nanoparticle is prepared for tracing of drug and effective treatment of cancers. First, 4-carboxybenzeneboronic acid (CBPA) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) are used to modify cyclodextrins (CDs), then modified cyclodextrins and polyethylene glycol (PEG) are used to stabilize gold nanoclusters to prepare fluorescent gold nanoparticles (AuNCs@CD-TPGS-CBPA/PEG). CBPA has targeting and TPGS can induce apoptosis, therefore, AuNCs@CD-TPGS-CBPA/PEG has targeting and certain anti-tumor activity. The structure and morphology of the nanomaterial are characterized by using nuclear magnetic resonance (NMR) spectroscopy and transmission electron microscope (TEM). Paclitaxel (PTX) is loaded into the hydrophobic cavity of CDs to form targeting specific drug-loaded fluorescent gold nanoparticles (AuNCs@CD-TPGS-CBPA/PEG/PTX). Biological performances of AuNCs@CD-TPGS-CBPA/PEG are studied by in vitro and in vivo experiments. In vitro test results confirm that AuNCs@CD-TPGS-CBPA/PEG could be internalized by tumor cells, and effectively against tumor cells, but it is biocompatible to normal cells. In vivo experiments prove that AuNCs@CD-TPGS-CBPA/PEG has excellent targeting, biocompatibility, and enhanced antitumor capability, could enrich and stay for a long time in the tumor regions, effectively prolong the lifetime of tumor-bearing mice. Therefore, this work provides an insight into the development of fluorescent gold nanomaterials for practical biomedical application.
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高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 5
·353
·
IF 3.504
Yue Chen,Yuanyuan Zhang,Qiangwei Kou,Yang Liu,Donglai Han,Dandan Wang,Yantao Sun,Yongjun Zhang,Yaxin Wang,Ziyang Lu,Lei Chen,Jinghai Yang,Scott Guozhong Xing
In this work, we report the enhanced catalytic reduction of 4-nitrophenol driven by Fe3O4-Au magnetic nanocomposite interface engineering. A facile solvothermal method is employed for Fe3O4hollow microspheres and Fe3O4-Au magnetic nanocomposite synthesis via a seed deposition process. Complementary structural, chemical composition and valence state studies validate that the as-obtained samples are formed in a pure magnetite phase. A series of characterizations including conventional scanning/transmission electron microscopy (SEM/TEM), Mössbauer spectroscopy, magnetic testing and elemental mapping is conducted to unveil the structural and physical characteristics of the developed Fe3O4-Au magnetic nanocomposites. By adjusting the quantity of Au seeds coating on the polyethyleneimine-dithiocarbamates (PEI-DTC)-modified surfaces of Fe3O4hollow microspheres, the correlation between the amount of Au seeds and the catalytic ability of Fe3O4-Au magnetic nanocomposites for 4-nitrophenol (4-NP) is investigated systematically. Importantly, bearing remarkable recyclable features, our developed Fe3O4-Au magnetic nanocomposites can be readily separated with a magnet. Such Fe3O4-Au magnetic nanocomposites shine the light on highly efficient catalysts for 4-NP reduction at the mass production level.Keywords:Fe3O4hollow microspheres;Fe3O4-Au magnetic nanocomposites;catalytic reduction;4-nitrophenol
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PubMed
高影响因子
ANALYST
·
2012
·Vol. 138
·期 4
·1141-1148
·
IF 4.23
Pingping Wang,Yongnian Ni,Serge Kokot
A novel biosensor consisting of a glassy carbon electrode (GCE) modified by a polydiphenylamine-4-sulfonic acid (PDPASA, conjugated polymer) film and double-stranded DNA (dsDNA), i.e. dsDNA/PDPASA/GCE, was researched and developed for the analysis of catechol – a potentially toxic substance for humans and the environment. The surface properties of the PDPASA film, particularly after dsDNA was immobilized on it, were characterized with the use of atomic force microscopy (AFM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The surfaces of the novel DNA/PDPASA/GCE biosensor changed during the fabrication process and displayed high sensitivity for catechol. The oxidation potential of catechol decreased significantly and the corresponding current increased substantially as compared with the values obtained at the GCE alone and at the dsDNA/GCE. Also, with the addition of hydroquinone, two well discriminated CV peaks were obtained, and it was demonstrated that hydroquinone did not interfere with catechol. DPV analysis produced a linear catechol calibration (range: 0.750 to 8.25 × 10−6 mol L−1; detection limit: 6.48 × 10−7 mol L−1), and thus, various water samples were analysed successfully by this novel method. In addition, the DNA/PDPASA/GCE was used to study DNA damage in the presence of catechol with the use of the Co(phen)33+ electroactive probe. Results indicated that the potentially toxic catechol and its metabolites were all responsible for DNA damage.
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PubMed
高影响因子
Medicinal Chemistry
·
2017
·Vol. 13
·期 8
·753-760
·
IF 2.331
Guo Ping,Xie Zixin,Zhang Huan,Zhang Zaikui,Han Chao,Cheng Donghua,Lin Dan,Zhang Yuan,Wang Xuebao,Guo Xin,Ye Faqing
Background: Thienopyrimidinone is a newly designed, selective fibroblast growth factor receptor 1 (FGFR1) inhibitor with an excellent anticancer effect. Objective: The goal of the present study was to design and synthesize better FGFR1 inhibitors through modifications of the lead
compound thienopyrimidinone. Methods: In the present study, a series of C-2 substituted derivatives of thienopyrimidinone, namely L1-L16, were synthesized, and their inhibitory effects on FGFR1 were evaluated. The anti-proliferative activities of these compounds were assessed by MTT assay.
Results: Among the novel derivatives, L11 was found to exert remarkable FGFR1 inhibitory activity (79.93% at 10 μM) and anti-proliferative activity, with IC50 values of 2.1, 2.5, and 3.5 µM in the FGFR1-overexpressing cell lines, H460, HT-1197, and B16F10, respectively.
Conclusion: Our newly synthesized thienopyrimidinone derivatives may be candidate FGFR1 inhibitors for future development as novel anticancer agents.
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 14
·6475-6488
·
IF 3.269
Shaojun Yuan,Jing Zhang,Zhenyi Yang,Shengwei Tang,Bin Liang,Simo O. Pehkonen
Chelating 1,2,3-triazole-4-carboxylic acids were successfully introduced onto the cross-linked PGMA microsphere surfaces by the combination of ring-opening reactions and the click chemistry process between the alkynyl groups of propiolic acid (PA) and the epoxy groups on the surfaces of the PGMA microspheres. The resultant PA-conjugated PGMA microspheres were found to be an effective adsorbent for Pb(II) removal from aqueous solutions. Success in each functionalization step was ascertained by ATR-FTIR, XPS and SEM characterization. Batch and column adsorption experiments were performed to determine the adsorption kinetics, adsorption isotherms and thermodynamics of Pb(II) ions on the as-synthesized microspheres. The Langmuir-fitted maximum adsorption capacity for Pb(II) ions was found to be 69.41 mg g−1 at a solution pH of 5.0, together with the adsorption equilibrium being achieved within 60 min. The thermodynamic studies demonstrated an endothermic and spontaneous adsorption process of Pb(II) ions on the PA-conjugated PGMA microspheres. Column adsorption studies revealed the decrease in the adsorption capacities of the breakthrough and exhaustion points with increasing flow rate. The postulated adsorption mechanism was attributed to the electrostatic interactions from carboxylic groups and chelation or coordination of Pb(II) ions from the triazole moieties, which was facilitated to form a pluralistic potential trap for Pb(II) ions, as confirmed by XPS characterization.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Hongqiang Xu,Hailong Wang,Yixia Lu,Yanbo Zeng,Yiwen Yang,Zulei Zhang,Hongmei Wang,Xiao Wang,Lei Li
A rapid and simple fluorescence probe based on CeO 2 quantum dots (QDs) was developed for highly selective and ultrasensitive direct determination of 4-nitrophenol (4-NP). CeO 2 QDs were prepared using the sol-gel method with the precursor of Ce(NO 3 ) 3 ·6H 2 O as a cerium source. The products were characterized through high-resolution electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and Raman spectroscopy. The fluorescent probe based on CeO 2 QDs exhibited a broad linear response to the concentration of 4-NP in the range of 0.005–75.00 μM and provided a low detection limit of 1.50 nM. The fluorescence of CeO 2 QDs was quenched by 4-NP through the fluorescence resonance energy transfer mechanism owing to the well overlaps between the fluorescence emission spectrum of CeO 2 QDs with the ultraviolet absorption spectrum of 4-NP. This result was confirmed by the time-resolved fluorescence spectra and the evaluation of the interaction distance between CeO 2 QDs and 4-NP. The prepared CeO 2 QDs are successfully applied to the determination of 4-NP in real water samples, where the spiked recoveries range from 98.2% to 102.4%.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Zhiming Guo,Alberta Osei Barimah,Chuang Guo,Akwasi A. Agyekum,Viswadevarayalu Annavaram,Hesham R. El-Seedi,Xiaobo Zou,Quansheng Chen
Black tea like other food crops is prone to mercury ion (Hg 2+ ) contamination right from cultivation to industrial processing. Due to the dangerous health effects posed even in trace contents, sensitive detection and quantification sensors are required. This study employed the surface-enhanced Raman scattering (SERS) enhancement property of 4-aminothiophenol (4-ATP) as a signal turn off approach functionalized on Ag-Au alloyed nanoparticle to firstly detect Hg 2+ in standard solutions and spiked tea samples. Different chemometric algorithms were applied on the acquired SERS and inductively coupled plasma-mass spectrometry (ICP-MS) chemical reference data to select effective wavelengths and spectral variables in order to develop models to predict the Hg 2+ . Results indicated that Ag-Au/4-ATP SERS sensor combined with ant colony optimization partial least squares (ACO-PLS) exhibited the best correlation efficient and minimum errors for Hg 2+ standard solutions (R c = 0.984, R p = 0.974, RMSEC = 0.157 μg/mL, RMSEP = 0.211 μg/mL) and spiked tea samples (R c = 0.979, R p = 0.963, RMSEC = 0.181 μg/g and RMSEP = 0.210 μg/g). The limit of detection of the proposed sensor was 4.12 × 10 −7 μg/mL for Hg 2+ standard solutions and 2.83 × 10 −5 μg/g for Hg 2+ spiked tea samples. High stability and reproducibility with relative standard deviation of 1.14% and 0.84% were detected. The potent strong relationship between the SERS sensor and the chemical reference method encourages the application of the developed chemometrics coupled SERS system for future monitoring and evaluation of Hg 2+ in tea.
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高影响因子
MATERIALS RESEARCH BULLETIN
·
2019
·
IF 3.355
Sefiu Abolaji Rasaki,Chunlei Zhao,Rui Wang,Jiacheng Wang,Heng Jiang,Minghui Yang
In this work, Ag/ZnO nanorods are prepared via simple and cost-saving liquid precipitation citrate reduction process (LPCR). The system shows appreciable catalytic activity for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) wherein NaBH 4 is used as electron sacrificer at ambience. It is found out that ZnO nanorods can effectively prevent Ag NPs agglomeration; a problem normally reduces active sites density. The coupling effect between the Ag NPs and ZnO greatly enhances electron transfer rate. This gives rise to high reduction rate constant ( k app ) of ˜3.97 × 10 −3 s −1 for the catalytic reduction of 4-NP. The result is about 1.9times better than that of Ag NPs (2.07 × 10 −3 s −1 ). The k app is well fitted into pseudo-first order kinetics with high correlation coefficient (R 2 ) of about 0.994, indicating chemisorptive reduction process. The remarkable performance obtained here is attributed to strong coupling effect between Ag NPs and ZnO nanorods derived from LPCR synthesis method.
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高影响因子
RSC Advances
·
2021
·Vol. 11
·期 28
·16955-16961
·
IF 3.361
Zeng-Feng Wei,Li-Jie Ni,Heng Quan,Jiang Duan
4-Substituted catechols with different CC bonds as urushiol analogues were synthesized through the a three-step route including reductive amination reaction of 3,4-dihydroxybenzaldehyde with N-Boc-piperazine, Boc deprotection, and amidation with various fatty acids. Electrochemical polymerization of these analogues on a copper surface afforded robust coatings with desirable adhesive force, hydrophobicity and thermal stability. Cyclic voltammetry and infrared spectroscopic characterizations revealed that the coating formation of urushiol analogues resulted from the electrooxidation-induced radical coupling of phenoxyl radicals with a phenyl ring and the side chain CC bond. The coating of the urushiol analogue bearing only one side chain CC bond exhibited the best performance in copper corrosion inhibition, with an inhibition efficiency of 99.99% and long-term effect (99.9% after 4 weeks of immersion in 3.5 wt% NaCl). The desired performance of these urushiol analogues suggests that they could be of practical applications as an alternative to the resource-limited natural urushiol.
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高影响因子
LANGMUIR
·
2022
·
IF 4.331
Zhenyu Zhao,Xuting Wang,Shifu Wang,Zuoyi Xiao,Shangru Zhai,Jiliang Ma,Xiaoli Dong,Haodong Sun,Qingda An
The development of g-C3N4-based photocatalysts with abundant active sites is of great significance for photocatalytic reactions. Herein, a smart and robust strategy was presented to fabricate three-dimensional (3D) g-C3N4 nanosheet-coated alginate-based hierarchical porous carbon (g-C3N4@HPC), including coating melamine on calcium alginate (CA) hydrogel beads, freeze-drying hydrogel beads as well as pyrolysis at high temperatures. The resulting photocatalyst possessed a significantly high surface area and a large amount of interconnected macropores compared with porous carbon without the melamine coating. The unique structural features could effectively inhibit the curling and agglomeration of g-C3N4 nanosheets, provide abundant photocatalytic active sites, and promote mass diffusion. Therefore, the g-C3N4@HPC composite exhibited remarkable photocatalytic activity and outstanding stability toward the photoreduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) by NaBH4 under natural sunlight and simulated visible-light irradiation (λ > 420 nm) using a 300 W xenon lamp. Moreover, the mechanism toward the photocatalytic reaction was extensively studied by quenching experiments and electron spin resonance (ESR) experiments. The results showed that active hydrogen species were able to be achieved by following a dual-channel pathway in the NaBH4 system, which included photocatalytic reduction of H+ ions and photocatalytic oxidation of BH4– ions. This work not only opens up a new way to design efficient photocatalysts for various reactions but also provides a reference for an in-depth study of the photoreduction mechanism.
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高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2018
·
IF 1.703
Zi-Mei Ding,Wen-Li Cao,Xiao-Jing Hang,Xiao Ma,Hui Zheng,Kang-Zhen Xu,Jie Huang
The green nitrogen-rich coordination compound Cd(SCZ)2(AFT)2 (1) (AFT =4-amino-3-(5-tetrazolate)-furazan and SCZ = semicarbazide) was first synthesized and characterized by EA and Fourier Transform Infrared (FT-IR). The single crystal was cultivated and determined with X-ray diffraction. It revealed that 1 crystallizes in the monoclinic space group P21/c. A Cd2+ ion is coordinated by four N atoms and two O atoms to form a distorted octahedral structure. Among them, two nitrogen atoms are from the two AFT ions and the other four atoms are from two SCZ molecules. The thermal decomposition behavior of 1 was studied with DSC and TG-DTG methods. The apparent activation energy (E), thermal stability, and safety parameters (T
SADT, T
TIT, and T
b) were calculated for 1. Moreover, entropy of activation (ΔS
≠), enthalpy of activation (ΔH
≠), free energy of activation (ΔG
≠), specific heat capacity (C
p), and impact sensitivity were also discussed in detail.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yaowu Wei,Xiujuan Wang,Yuan Chen,Wenguo Zhang,Junfeng Chen
The effect of Ca(OH) 2 and Zr(OH) 4 on the sintering behavior and thermal shock resistance of Y 2 O 3 ceramics were investigated in this study. The results showed that Ca(OH) 2 enhanced the densification of Y 2 O 3 ceramics. CaO generated from the decomposition of Ca(OH) 2 reacted with Y 2 O 3 to form a solid solution. The substitution of Ca 2 + for Y 3+ created V O ∙ ∙ that facilitated substance migration and pore elimination. Conversely, the introduction of Zr(OH) 4 exerted an adverse effect on the sintering. ZrO 2 produced by the decomposition of Zr(OH) 4 formed a solid solution with Y 2 O 3 which inhibited the sintering of Y 2 O 3 ceramics, where Zr 4+ primarily enhanced lattice stability rather than promoting sintering. The O i ′ ′ created by the substitution of Zr 4+ for Y 3+ reduced cation diffusion and hindered grain boundary migration. The mechanisms by which two types of additives affect the thermal shock stability of Y 2 O 3 ceramics are different. The Zr(OH) 4 -doped ceramics demonstrated better thermal shock resistance owing to their higher porosity, which changed energy release pathway and increased the resistance to crack propagation. In comparison, the improvement in the Ca(OH) 2 -doped ceramics mainly originated from the enhanced mechanical properties, which would suppressed crack initiation and delayed failure under thermal stress.
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