RSC Advances
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2026
·Vol. 16
·期 27
·25131-25143
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IF 6.1
Yaling Wu,Peipei Xu,Jing Lin,WanJing Li,Qing Lin,Hanhao Lu,Jingbo Chen,Zhenhua Liu,Yudong Lu
Colorectal cancer chemotherapy often faces challenges such as rapid drug clearance, non-specific biodistribution, and burst release, leading to systemic toxicity and reduced therapeutic efficacy. To overcome these limitations, this study developed a colon-targeted sustained-release hydrogel bead system based on β-cyclodextrin (β-CD) and biocompatible polymers (CMCS/CMCNa/SA). The results demonstrated that the incorporation of β-CD significantly enhanced the drug loading capacity through host–guest interactions. Under the optimal mass ratio of drug complex to wall material (15 : 35), the encapsulation efficiency reached as high as 81.23%. Drug release kinetics showed high correlation coefficients (R2 > 0.9) in zero-order, first-order, Higuchi, and Korsmeyer–Peppas models, indicating a diffusion-controlled release mechanism. The β-CD-modified hydrogel matrix effectively sustained the release of 5-fluorouracil (5-Fu) within the therapeutic window while minimizing the initial burst release. In conclusion, this intelligent delivery system takes advantage of the host–guest inclusion of β-CD and the pH-responsive properties of the polymers, showing promise for localized treatment of colorectal cancer.
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PHYTOMEDICINE
·
2026
·
IF 11.3
Xu Gao,Xiaofeng Zhu,Yibin Lin,Chengkuan Liu,Qingwen Wang,Xian Lin
Background Developing novel therapeutic targets and innovative drugs for rheumatoid arthritis (RA) remains highly challenging. Despite the involvement of 5-methylcytosine (m5C) RNA methylation in various biological processes, its specific roles in RA and potential applications in drug development remain unclear. Additionally, the role of CX26 in RA progression and its inflammatory effects on fibroblast-like synoviocytes (FLSs) have not been elucidated. Salvianolic acid B (SAB), a bioactive component derived from Salvia miltiorrhiza , possesses anti-inflammatory properties, but its potential in RA treatment has not been completely explored. Purpose This study aimed to clarify the role of m5C-methylated gene CX26 in RA-FLSs and evaluate the therapeutic potential of SAB for RA therapy. Methods Multi-omics analysis was used to determine the contribution of m5C RNA methylation to RA pathogenesis and characterize m5C-methylated genes during RA progression. Methylated RNA immunoprecipitation sequencing and RNA sequencing were employed to analyze the effect of SAB on m5C methylation of CX26 in RA-FLSs. Immunohistochemistry, quantitative real-time PCR, Western blot, Cell Counting Kit-8, 5-Ethynyl-2′-deoxyuridine, and Transwell assays were applied to assess the effects of CX26 and SAB on RA-FLSs. The anti-arthritic activity of SAB was validated in a collagen-induced arthritis (CIA) mouse model. Results This study demonstrated a vital role of m5C RNA methylation in RA progression. CX26 was identified as an m5C-methylated gene that was selectively overexpressed in RA-FLSs. The CX26 levels in the synovium of patients with RA demonstrated significant associations with an activated immuno-inflammatory phenotype, clinical features, and treatment outcomes. Moreover, the CX26 mRNA m5C methylation, stability and expression were elevated by TNF. CX26 augmented inflammation-induced proliferation, migration, and invasion of RA-FLSs via activating the IκBα/NF-κB signaling. SAB reduced m5C methylation of CX26 mRNA and impair CX26 expression, thus abrogating CX26/IκBα/NF-κB signaling–induced pathological phenotypes of RA-FLSs. Furthermore, computational modeling and the CIA model confirmed that SAB alleviated RA progression. Conclusions This cross-validated study, based on multi-omics analysis, outlines the potential of CX26 as a highly selective target and SAB as a novel therapeutic candidate for RA treatment.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2023
·
IF 5.2
Yixuan Zheng,Weiwei Ning,Quanhua Wang,Xueling Wei,Xingyang Li,Meng Pan
Hierarchical ZSM-5 was successfully prepared using l -carnitine and l -lysine as mesoporous templates, and the influence of the dosage of “secondary template” represented by l -carnitine on the formation of hierarchical zeolite was investigated in detail. Powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption-desorption, nuclear magnetic resonance (NMR), thermogravimetric-derivative thermogravimetry (TG-DTG), pyridine infrared and temperature programmed desorption of ammonia (NH 3 -TPD) were used to characterize the structural and textural properties of the as-prepared samples. The results showed that the hydrophilic property of the amino acid template overcame the phase separation and constructed a mesoporous system with an ultra-small size of 2–10 nm in the as-synthesized zeolite crystals. Not only the morphology and grain size, but also the Si/Al ratio and then the acidity of zeolite were affected by the “secondary template”. Catalytic cracking of triisopropylbenzene was chosen as a probe reaction so as to investigate the effect of the fabricated hierarchical porous system on the catalytic performances of the catalysts. The results showed that the introduction of hierarchical pores elevated the external surfaces of the catalyst and therefore significantly improved the catalytic cracking performance of the catalyst for the heavy molecules triisopropylbenzene. At the same time, the introduced mesopore structure also gave the macromolecule reactant a hierarchically cracking process because of the acid active sites located in the different spaces.
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CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Armin Rezayan,Renfeng Nie,Jianshe Wang,Tianliang Lu,Chunbao Charles Xu,Yongsheng Zhang
Selective cellulose transformation into the 5-hydroxymethylfurfural (HMF), a versatile platform chemical, has been researched using various catalysts, while desirable efficiency remains a challenge. This study revealed an alternative conversion approach to strong acidic/basic catalysis, an efficient one-pot synthesis of HMF without external catalyst from microcrystalline cellulose (MCC), functionalized via milling and subsequent oxidation pretreatment. The outstanding HMF yield (∼55%) was obtained under moderate reaction conditions (3 h, 190 °C), demonstrating the significant impact of functionalized MCC’s characteristics (e.g., reduced crystallinity index (CI), degree of polymerization (DP), and the formed –COOH) and the reaction conditions (e.g., the role of NaCl and H 2 O/THF ratio) for HMF synthesis. The formed –COOH group demonstrated a dual-function i ) in-situ destruction of MCC’s β -1,4-glycosidic linkages during pretreatment ii ) catalyzing hydrolysis/dehydration reactions of carbohydrates to form HMF. Furthermore, chloride ions could selectively promote consecutive reactions. The promising findings in this study provide a greener route to produce HMF from cellulose without using acid/base catalysts through cellulose structure functionalization by green/simple methods.
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RENEWABLE ENERGY
·
2023
·
IF 8.7
Yuewen Shao,Mingzhu Guo,Mengjiao Fan,Kai Sun,Guoming Gao,Chao Li,Félix Mérimé Bkangmo Kontchouo,Lijun Zhang,Shu Zhang,Xun Hu
2,5-Dimethylfuran (DMF) is a promising fuel additive. Its selective production from 5-hydroxymethylfurfural (HMF) requires effective hydrodeoxygenation and simultaneous retainment of C C in furan ring, which is challenging over nickel-based catalysts. In this work, an alloying method was explored for selective conversion of HMF to DMF by introducing Fe species into Ni–Al catalysts to form oxyphilic FeNi alloy. The results showed that the formation of alloy in Ni–Fe–Al lowered the capability for adsorption and activation of hydrogen, reducing the activity for hydrogenation of the furan ring in HMF, forming mainly 2,5-dihydroxymethyl furan (DHMF) and 5-methylfurfuryl alcohol (5-MFA). In addition, the oxyphilic FeNi alloy had the high affinity for the adsorption/activation of C–OH in DHMF and 5-MFA, enhancing their hydrogenolysis to DMF. The kinetic study indicated that the hydrogenolysis of 2,5-dihydroxymethyl furan was the rate-determining step, showing a higher Ea (89.2 kJ mol −1 ) than that in hydrogenation of C O in HMF (59.7 kJ mol −1 ). Under optimized condition, DMF with yield of 93.4% from HMF was achieved over 1.5Ni-1.5Fe-1.0Al catalyst. In comparison with Ni–Al, 1.5Ni-1.5Fe-1.0Al also showed much higher resistivity towards sintering of metallic species, rendering the catalyst with superior catalytic stability.
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Journal of Environmental Chemical Engineering
·
2023
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IF 7.7
Yifan Wu,Guangbing Liang,Xinna Zhao,Hui Wang,Zhenping Qu
It is feasible and profitable to figure out multidiscipline environmental issues synergistically. Coal fly ash based adsorbent materials are widely used in the emission control of volatile organic compounds. A solvent-free method which was more environmental-friendly for ZSM-5 zeolites synthesis from coal fly ash was proposed to eliminate toluene. The results indicated that ZSM-5 zeolites were successfully synthesized from the precursor gel of coal fly ash with 30–60 wt% moisture contents. The SiO 2 /Al 2 O 3 mole ratio of gel was up to 99 after the pretreatment of alkali roasting and acid precipitation. During the synthesis process, the appropriate Na 2 CO 3 -to-SiO 2 ratio was 0.3, and the mesoporous formation would be facilitated along with the moisture content of gel. On the tendency of adsorption testing, the microporous structure was prone to the toluene adsorption, and the desorption was dependent on the mesoporous structure. The maximum adsorption capacity of 75.1 mg·g −1 was observed on S-40 sample, and the minimum desorption activation energy of 39.97 kJ·mol −1 was found on S-60 sample. The humid condition can reduce the toluene adsorption performance, and the maximum adsorption capacity was down to 63.7 mg·g −1 . Additionally, the synthetic ZSM-5 zeolites still have some superiority in economics and ecology when compared with commercial zeolites. The novel synthesis method, preparing controllable ZSM-5 zeolites from coal fly ash with the advantages of low cost and environmental friendliness, exhibited the tremendous application potential in environmental field.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2023
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IF 4.2
Xingyilong Zhang,Houfang Lu,Man Zhang,Hui Han,Rubo Tian,Kejing Wu,Yingying Liu,Yingming Zhu,Bin Liang
Low-temperature production of 5-hydroxymethylfurfural (HMF) from fructose in ternary deep eutectic solvents (TerDESs) of choline chloride (ChCl), ethylene glycol (EG), and maleic acid (MalA) is proposed. A fructose conversion of 99.9% and an HMF yield of 87.3% are achieved in TerDES with ChCl/EG/MalA = 3:1:1 at 70 °C in 30 min. The ChCl can effectively activate the hydroxy groups of fructose by lengthening the C–O bonds. The EG can both improve the formation of ChCl–MalA DES with wide ranges of component ratios and reduce the viscosity of the DES. A reaction mechanism considering the synergistic effect of the components in TerDES is suggested to explain the enhanced dehydration of fructose under mild conditions. The recycling results of the TerDES show stable yields of HMF within five recycle runs. This work offers an efficient solution to a green and sustainable process for a high yield of HMF production.
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Journal of Energy Chemistry
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2023
·
IF 13.1
Mengxia Li,Tianxi Zheng,Dongfei Lu,Shiwei Dai,Xin Chen,Xinchen Pan,Dibo Dong,Rengui Weng,Gang Xu,Fanan Wang
The electrochemical hydrogenation of HMF to BHMF is an elegant alternative to the conventional thermocatalytic route for the production of high-value-added chemicals from biomass resources. In virtue of the wide potential window with promising Faradic efficiency (FE) towards BHMF, Cu-based electrode has been in the center of investigation. However, its structure–activity relationship remains ambiguous and its intrinsic catalytic activity is still unsatisfactory. In this work, we develop a two-step oxidation–reduction strategy to reconstruct the surface atom arrangement of the Cu foam (CF). By combination of multiple quasi-situ/in-situ techniques and density functional theory (DFT) calculation, the critical factor that governs the reaction is demonstrated to be facet effect of the metallic Cu crystal: Cu(110) facet accounts for the most favorable surface with enhanced chemisorption with reactants and selective production of BHMF, while Cu(100) facet might trigger the accumulation of the by-product 5,5′-bis(hydroxymethy)hydrofurion (BHH). With the optimized composition of the facets on the reconstructed Cu(OH) 2 -ER/CF, the performance could be noticeably enhanced with a BHMF FE of 92.3% and HMF conversion of 98.5% at a potential of −0.15 V versus reversible hydrogen electrode (vs. RHE) in 0.1 M KOH solution. This work sheds light on the incomplete mechanistic puzzle for Cu-catalyzed electrochemical hydrogenation of HMF to BHMF, and provides a theoretical foundation for further precise design of highly efficient catalytic electrodes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xinyi Xing,Xian Shi,Mengya Ruan,Qichun Wei,Ying Guan,Hui Gao,Siquan Xu
Introduction of the sulfonic acid group into H-β zeolite to prepare β-SO 3 H bifunctional catalysts for the efficient synthesis of 5-hydroxymethylfurfural (HMF) from cellulose . Catalysts characterization, such as XRD, ICP-OES, SEM (Mapping), FTIR, XPS , N 2 adsorption-desorption isotherm, NH 3 -TPD, Py-FTIR demonstrate the sulfonic acid group was successfully grafted onto the β zeolite. A superior HMF yield (59.4 %) and cellulose conversion (89.4 %) was obtained in the H 2 O(NaCl)/THF biphasic system under 200 °C for 3 h with β-SO 3 H(3) zeolite as catalyst. More valuable, β-SO 3 H(3) zeolite converts other sugars and obtains ideal HMF yield, including fructose (95.5 %), glucose (86.5 %), sucrose (76.8 %), maltose (71.5 %), cellobiose (67.0 %), starch (68.1 %), glucan (64.4 %) and also converts plant material (25.1 % for moso bamboo and 18.7 % for wheat straw) with great HMF yield. β-SO 3 H(3) zeolite catalyst keeps an appreciable recyclability after 5 cycles. Moreover, in the presence of β-SO 3 H(3) zeolite catalyst, the by-products during the production of HMF from cellulose were detected, and the possible conversion pathway of cellulose to HMF was proposed. The β-SO 3 H bifunctional catalyst has excellent potential for the biorefinery of high value platform compound from carbohydrates.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2023
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IF 4.3
Mu-Ying Guan,Chang-Ying Hu,Qi-Shan Peng,Ying Zeng,Wen-Wei A.,Ze-Chun Wu,Zhi-Wei Wang,Huai-Ning Zhong
Bamboo sticks intended for food contact can produce 5-Hydroxymethylfurfural (5-HMF) and Furfural (FF) when used in high-temperature scenarios (e.g., barbecue and Kanto boil). The influencing factors in terms of baking conditions, salinity, pH, and dipping time of water on the formation of 5-HMF and FF in bamboo sticks were investigated. Specific migration of 5-HMF and FF also have been studied in bamboo sticks in contact with food simulants (water, 10 % ethanol, and 4 % acetic acid). The results showed that the effects of baking temperature and time on the formation of both showed a similar pattern which firstly increased and decreased afterward. Both 5-HMF and FF levels in bamboo sticks increased with decreasing pH and the presence of salt. After dipping bamboo sticks in water for a while, the moisture content of higher than 10 % in bamboo sticks presented low levels of 5-HMF and FF. In the case of all food simulants, the highest migrated concentration of 5-HMF and FF were found in 4 % acetic acid. Since there are no specific migration limits for 5-HMF and FF, estimated daily intake is calculated to evaluate their safety. Based on the studied migration results, 5-HMF and FF in bamboo sticks are relatively safe for consumers.
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TALANTA
·
2022
·
IF 6.556
Hao Feng,Fan Wang,Junhua Li,Qian Wu,Ying Cui,Lingzhi He,Xing Liu,Zeng Liu,Dong Qian,Haixia Tong
Lack of highly efficient, inexpensive, and easily available catalysts severely limits the practical applicability of electrochemically sensing assay towards 5-hydroxytryptamine (5-HT). Herein, four kinds of Fe–Co bimetallic Prussian blue analogues (FeCo–PBAs) with different molar ratios of Fe to Co were prepared using a simple coprecipitation method. Interestingly, Fe(III) in K 3 [Fe(CN) 6 ] can be reduced to Fe(II) by adding trisodium citrate dehydrate, which could offer a new clue to synthesize PBAs with Fe(II) core ions. With the optimizational FeCo-PBA synthesized at a 0.5/1 M ratio of Fe to Co as an electrocatalyst , the constructed sensor shows excellent comprehensive performance for the 5-HT assay with a high sensitivity of 0.856 μA μM −1 and an ultralow detection limit of 8.4 nM. Under the optimum conditions, linearity was obtained in the ranges of 0.1–10.0 μM and 10.0–200.0 μM and preferable recoveries ranged from 97.8% to 103.0% with relative standard deviation (RSD) < 4.0%. The integrated properties of FeCo-PBA can be comparable to previously reported electrocatalysts for the 5-HT assay including noble metal-based and expensive carbon (graphene and carbon nanotubes)-based electrocatalysts. The proposed sensor also exhibits outstanding selectivity, reproducibility, and practicality for real sample analyses. This work is the first report on the PBA-based sensor for the 5-HT assay, verifying the practicability of this high-performance sensor for the 5-HT assay.
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PROGRESS IN ORGANIC COATINGS
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2022
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IF 6.206
Liying Song,Zhan Gao,Qiang Sun,Guiwen Chu,Hao Shi,Ningjing Xu,Zhenxing Li,Nini Hao,Xiaoying Zhang,Fubin Ma,Lifei Wang
Hollow mesoporous silica microspheres (HMSN) were selected as carriers for storing 2-aminino-5-mercato-1,3,4-thiadizole (ATM) in this experiment. The synthesised microspheres were uniformly dispersed, with a diameter of approximately 500 nm, as identified by scanning electron microscopy. HMSN, as excellent nanocarriers, were used to encapsulate ATM with a 19 wt% loading rate. Then, 18 wt% HMSN loaded with ATM was added to the coating. Electrochemical impedance spectroscopy and scanning Kelvin probes were used to investigate the self-healing ability of the coating with ATM encapsulated in hollow mesoporous silica microspheres. The copper corrosion caused by microdefects in the coating was delayed by controlling the slow release of ATM from the microspheres. The active corrosion resistance of the coatings was strengthened. By optimising the coating, the service life of the coating can be extended to achieve the long-term corrosion protection of copper.
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