ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2023
·Vol. 415
·期 27
·6785-6798
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IF 4.3
Lu Zongyan,Guo Hao,Wang Mingyue,Yang Zeyun,Wei Xiaoqin,Liu Yinsheng,Hui Yingfei,Yu Zhiguo,Yang Wu
The development of a simple and sensitive electrochemical sensing platform for levofloxacin (LVF) analysis is of great significance to human health. In this work, a covalent organic framework (TP-COF) was in situ grown on the surface of Sn-MoC nanospheres with nanoflower-like morphology through a one-pot method to obtain the TP-COF@Sn-MoC composite. The prepared composite was used to modify a glassy carbon electrode (GCE) to realize the sensitive detection of levofloxacin. TP-COF was formed by polycondensation of 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and pyromellitic dianhydride (PMDA), in which C = O and C = N groups served as double active centers for the recognition and electrocatalytic oxidation of the target molecule. Meanwhile, the introduction of Sn-MoC improved the conductivity of the electrode. The TP-COF@Sn-MoC composite produced a strong synergistic effect and showed a high electrocatalytic ability toward levofloxacin oxidation. The linear range of LVF was 0.6–1000 μM and the limit of detection (LOD) was 0.029 μM ( S / N = 3). In addition, the sensor has been successfully applied for the analysis of LVF in human urine and blood serum samples with acceptable recovery rates, demonstrating that the sensor was promising in practical applications. Graphical Abstract
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Nano Research
·
2023
·
IF 9.9
Yu Fan,Luo Chunjia,Niu Xiaohan,Chao Min,Zhang Pengfei,Yan Luke
Graphitic carbon nitride (g-C 3 N 4 ) nanosheets have attracted widespread interest in the construction of advanced separation membranes. However, dense stacking and a single functionality have limited the membrane development. Here, an advanced two-/three-dimensional (2D/3D) g-C 3 N 4 /TiO 2 @MnO 2 membrane is constructed by intercalating 3D TiO 2 @MnO 2 nanostructures into g-C 3 N 4 nanosheets. The 3D flower-like nanostructures broaden the transport channels of the composite membrane. The membrane can effectively separate five oil-in-water (O/W) emulsions, with a maximum flux of 3265.67 ± 15.01 L·m −2 ·h −1 ·bar −1 and a maximum efficiency of 99.69% ± 0.45% for toluene-in-water emulsion (T/W). Meanwhile, the TiO 2 @MnO 2 acts as an excellent electron acceptor and provides positive spatial separation of electrons–holes (e − –h + ). The formation of 2D/3D heterojunctions allows the material with wider light absorption and smaller bandgap (2.10 eV). These photoelectric properties give the membrane good degradation of three different pollutants, with about 100% degradation for methylene blue (MB) and malachite green (MG). The photocatalytic antibacterial efficiency of the membrane is also about 100%. After cyclic experiment, the membrane maintains its original separation and photocatalytic capabilities. The remarkable multifunctional and self-cleaning properties of the g-C 3 N 4 based membrane represent its potential value for complex wastewater treatment.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-8
·
IF 16.6
Zhang Xun,Guo Wenqi,Zhang Chengjian,Zhang Xinghong
Our society is pursuing chemically recyclable polymers to accelerate the green revolution in plastics. Here, we develop a recyclable polyester library from the alternating copolymerization of aldehyde and cyclic anhydride. Although these two monomer sets have little or no thermodynamic driving force for homopolymerization, their copolymerization demonstrates the unexpected alternating characteristics. In addition to readily available monomers, the method is performed under mild conditions, uses common Lewis/Brønsted acids as catalysts, achieves the facile tuning of polyester structure using two distinct monomer sets, and yields 60 polyesters. Interestingly, the copolymerization exhibits the chemical reversibility attributed to its relatively low enthalpy, which makes the resulting polyesters perform closed-loop recycling to monomers at high temperatures. This study provides a modular, efficient, and facile synthesis of recyclable polyesters using sustainable monomers.
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OPTICAL AND QUANTUM ELECTRONICS
·
2023
·Vol. 55
·期 11
·1-15
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IF 3
Li Xin,He Yu,Guo Yangyang,Mao Huibing,Chen Ye,Wang Jiqing
The Er 3+ , Yb 3+ and Mn 2+ co-doped perovskite NaMgF 3 submicron particles have been successfully fabricated and the related upconversion (UC) emission was investigated in this paper. The UC emission spectra confirm that the emission color of the Er 3+ ions can be modulated by the doping of the Mn 2+ ions, the incident laser power and the laser pulse-width. The UC emission results demonstrate that the key factor to modulate the UC emission color of the Er 3+ ions is the Mn 2+ ions in the submicron particles, in which the NaMgF 3 submicron particles have the largest relative green emission bands with the 3% Mn 2+ concentration. The experimental results also confirm that the UC intensities ratio of the green to the red emission will increase with the increase of the incident laser power and the decrease of the laser pulse-width. All the UC emission results imply that there are two energy transfer paths from the Mn 2+ state 4 T 1 to the Er 3+ ions, in which the transfer rate to the state 4 S 3/2 is far larger than the transfer rate to the state 2 H 11/2 and the energy transfer mechanism may related with the special structure of the Mn 2+ ions and the phonon-assisted processes.
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PHARMACEUTICAL RESEARCH
·
2023
·Vol. 40
·期 9
·2215-2228
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IF 3.7
Ullah Aftab,Khan Marina,Yibang Zhang,Raza Faisal,Hasnat Muhammad,Cao Jin,Qi Xueyong,Hussain Abid,Liu Daojun
Purpose This study aims at chemotherapy and starvation therapy of HCC via starvation and apoptosis. Methods Hollow mesoporous organosilica nanoparticles (HMONs) with the thioether-hybrid structure were developed using an organic/inorganic co-templating assembly approach. Hydrofluoric acid was used to remove the internal MSN core for yielding large radial mesopores for loading drug cargos. The morphology and structure of NPs were determined using TEM and SEM. HMONs were stepwise surface modified with glucose oxidase (GOx), oxygen (O 2 ) and Doxorubicin (DOX), and cancer cell membrane (CCM) for yielding CCM-coated HMONs (targeted stealth biorobots; TSBRs) for starvation, apoptotic, and enhanced cell uptake properties, respectively. The surface area and pore size distribution were determined via BET and BJH assays. The catalytic ability of GOx-modified NPs was measured using in vitro glucose conversion approach authenticated by H 2 O 2 and pH determination assays. MTT assay was used to determine the cytotoxicities of NPs. Cell uptake and apoptotic assay were used for the NPs internalization and apoptosis mechanisms. The subcutaneous HepG2 tumor model was established in mice. The long-term in vivo toxicity was determined using blood assays. Results The prepared NPs were spherical, hollow and mesoporous with excellent surface area and pore size distribution. The GOx-modified NPs exhibited excellent catalytic activity. The TSBRs showed better cytotoxicity and reduce the tumor size and weight. The NPs showed long-term safety in vivo . Conclusion TSBRs destroyed cancer cells by starvation and chemotherapy in both in-vitro and in-vivo settings which demonstrates its anti-cancer potential.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2023
·Vol. 129
·期 10
·1-14
·
IF 2.7
Shi Lin,Bi Qinling,Zhu Jiamei,Yan Shili,Chen Dongxiang
A magnetic molybdenum disulfide (Fe–Fe 2 O 3 @PDA@MoS 2 ) was prepared and evaluated as a dispersive viscosity reducing catalyst for the heavy oil. The catalysts were analyzed using a variety of characterization methods, and the effects of preparation method and oleic acid treatment on performance were also compared. The particle size of Fe–Fe 2 O 3 magnetic nanochains was about 80 nm, the saturation magnetization strength was 110 emu/g, and the components in the nanochains were mainly iron elements. The catalyst further prepared by liquid phase precipitation had unique flower-like structure and good viscosity reduction ability. The loading amount of MoS 2 was 16.7 wt% and the saturation magnetization was 36.3 emu/g, while the saturation magnetization of the oleic acid treated sample was 28.9 emu/g. The as-prepared Fe–Fe 2 O 3 @PDA@MoS 2 can reach more than viscosity reduction 99% under 10 MPa hydrogen pressure and 400 ~ 415 °C. In addition, the component analyses of four groups (saturate, aromatic, resin, and asphaltenes) for the liquid products in the heavy oil were conducted to analysis the mechanism of viscosity reduction of catalyst.
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Biomass Conversion and Biorefinery
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2023
·
IF 4
Zeng Xiang,Dai Huijia,Liu Bing,Wen Yao
In this study, the extraction process of Tieguanyin tea polyphenols was optimized and its hypoglycemic activity was tested. The response surface method was used to design the experiment to optimize the extraction process and explore the best extraction conditions. The extract was purified by AB-8 macroporous resin, and its hypoglycemic activity was studied by the inhibition rate of two enzymes (α-glucosidase and α-amylase). The optimum conditions of ultrasonic-assisted extraction of Tieguanyin tea polyphenols were as follows: material-to-liquid ratio of 40 mL/g, ultrasonic power of 240 W, and ultrasonic time of 30 min. The extraction rate of tea polyphenols was 13.82%, which was consistent with the predicted value of 13.78%. The purification experiment results showed that the purity of tea polyphenols was 50.62%. The IC 50 of Tieguanyin tea polyphenol extract on α-glucosidase and α-amylase was 1.93 × 10 −8 mg/mL and 7.65 × 10 −11 mg/mL, respectively, indicating that it could inhibit both of them. In this study, the optimum extraction process of Tieguanyin tea polyphenols was optimized and confirmed, and it was confirmed that Tieguanyin tea polyphenols had strong hypoglycemic activity.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2023
·Vol. 332
·期 11
·4463-4470
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IF 1.6
Fu Yingwen,Zou Shufen,Zhang Shuang,Na Bing,Lin Shan,Lv Ruihua
This study reports Zn 2+ -mediated supramolecular composite hydrogels from the mixtures of sodium alginate and polyethyleneimine in the aqueous solutions. The composite hydrogels, consisting of both carboxylate and amino groups, show enhanced uptake capacity of 718 mg-U/g in a 20 mg/L uranium-spiked water at pH = 6. Furthermore, uranium uptake by the composite hydrogels, an endothermic and spontaneous process, follows pseudo-second-order kinetic model and Langmuir model. Importantly, the composite hydrogels can reach a high uranium uptake capacity of 692 mg-U/g in a simulated uranium wastewater with other metal ions.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 2
·1-10
·
IF 5.479
Li Weixia,Chen Ning,Zhu Yan,Shou Dan,Zhi Minyu,Zeng Xiuqiong
A novel nanocomposite consisting of an amorphous seed and a molecularly imprinted covalent organic framework shell was prepared via a heterogeneous nucleation and growth method. By using ibuprofen as the dummy template, a molecularly imprinted covalent organic framework (MICOF) with a large surface area was prepared from 1,3,5-triformylbenzene and 4,4'-diaminobiphenyl. It was placed on the surface of monodisperse amorphous seeds. Owing to strong π-interaction, the MICOF@SiO 2 nanocomposite displays fast binding kinetics, large adsorption capacities and selectivity for nonsteroidal anti-inflammatory drugs (NSAIDs). Following desorption from the MICOF@SiO 2 with methanol containing 1% ammonium hydroxide, the NSAIDs ketoprofen, ibuprofen, diclofenac, indomethacin, flurbiprofen and naproxen were quantified by HPLC with UV detection. Under optimized conditions, the method exhibits good linearity within the range of 0.002–1.0 μg mL-1, low limits of detection (0.38–2.92 μg L-1), and acceptable repeatability. The recoveries of NSAIDs at three spiking levels range from 77 to 112%, and the RSDs are <9.4%. The method was successfully applied to the analysis of NSAIDs in spiked environmental water samples.
A molecular imprinted covalent organic framework nanocomposite (MICOF@SiO 2 ) was prepared by heterogeneous nucleation and growth method. It was explored as a sorbent for the solid phase extraction of nonsteroidal anti-inflammatory drugs before determination by HPLC with UV detection.
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POLYMER BULLETIN
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2023
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IF 3.2
Ma Puhao,Lu Wentong,Chen Jiacheng,Tian Hao,Wang Jincheng,Xiao Jianhua
The industry’s mechanical equipment often faces a significant demand for damping rubber. Simultaneously improving damping and toughness of rubber materials is a challenging task. It was achieved by incorporating crystal particles into the chlorinated butyl rubber (CIIR) network, inspired by the “sliding crystal mechanism”. To create the elastomers with high damping and toughness, polyurethane was used along with polyethylene glycol as a soft segment. The combination factors, including coordination and hydrogen bonds, played a crucial role in facilitating the formation of crystal particles within the material. These crystal particles acted as rigid fillers, enhancing the material’s toughness. Additionally, the sacrificial reversible bonds present in the crystal particles allowed for energy dissipation during stress. These bonds can be repeatedly broken and regenerated, enabling the material to dissipate energy efficiently. Comparing these elastomers to pure CIIR, they exhibited a tensile strength and elongation at break of 5.76 MPa and 1973%, a fracture energy of 28.73 MJ/m 3 , a damping factor of 1.52, and a damping temperature range of 80 °C. These results indicate significant improvements in both damping and toughness properties. This advancement could have valuable implications for the industry’s mechanical equipment, which often relies on effective damping rubber.
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NATURE
·
2021
·Vol. 590
·期 7846
·410-415
·
IF 49.962
Ou Xiangyu,Qin Xian,Huang Bolong,Zan Jie,Wu Qinxia,Hong Zhongzhu,Xie Lili,Bian Hongyu,Yi Zhigao,Chen Xiaofeng,Wu Yiming,Song Xiaorong,Li Juan,Chen Qiushui,Yang Huanghao,Liu Xiaogang
Current X-ray imaging technologies involving flat-panel detectors have difficulty in imaging three-dimensional objects because fabrication of large-area, flexible, silicon-based photodetectors on highly curved surfaces remains a challenge 1 , 2 , 3 . Here we demonstrate ultralong-lived X-ray trapping for flat-panel-free, high-resolution, three-dimensional imaging using a series of solution-processable, lanthanide-doped nanoscintillators. Corroborated by quantum mechanical simulations of defect formation and electronic structures, our experimental characterizations reveal that slow hopping of trapped electrons due to radiation-triggered anionic migration in host lattices can induce more than 30 days of persistent radioluminescence. We further demonstrate X-ray luminescence extension imaging with resolution greater than 20 line pairs per millimetre and optical memory longer than 15 days. These findings provide insight into mechanisms underlying X-ray energy conversion through enduring electron trapping and offer a paradigm to motivate future research in wearable X-ray detectors for patient-centred radiography and mammography, imaging-guided therapeutics, high-energy physics and deep learning in radiology.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 28
·期 23
·30101-30110
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IF 4.223
Bian Xiaoxue,Gao Yongfei
An unexplored attributing molecular mechanism of Cd toxicity is interference with the epigenetic machinery, such as DNA methylation, processes that are crucial for early fetal development. In order to investigate the effects of Cd on the expression of metallothionein (MT) and Dnmts transcripts, markers of DNA methylation, and signaling pathway gene expression, zebrafish embryos were exposed during 24 hours post-fertilization (starting at maximum 8-cell stage) to 0.0089, 0.089, and 0.89 μM Cd. The results showed that the Cd accumulation in zebrafish embryo reached a stable level after 12 hpf, and the Cd accumulation at individual time points was significantly different among different concentration groups. MT mRNA fold was significantly positive with the Cd content in embryos. We observed that the expression level of DNA methyltransferase ( Dnmts ) in the 0.089 μM Cd exposure group was significantly up-regulated. Dnmt1 expression was significantly up-regulated in the 0.89 μM Cd exposure group, and Dnmt3s expression and global methylation levels were significantly down-regulated. Cd up-regulated ErbB-3 gene expression, down-regulated ErbB-4 gene expression, and neutralized ErbB-1 gene expression. Cd activated Ca 2+ , MAPK-JUK , p38 MAP kinase, PI3K-AKT , and VEGF signaling pathway genes, indicating these pathway genes related to Cd exposure level. The results are helpful to clarify the molecular mechanism of DNA methylation in zebrafish embryo under metal pressure and further interference with the epigenetic machinery.
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