JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Yidi Liu,Qiunan Xie,Ming Huang,Xin Qu,Jingcheng Liu,Xiaojie Li,Wei Wei
Although epoxy resins (EP) have been widely used in many fields, performing halogen-free flame-retardant modification on them while improving their mechanical properties still holds significant research value. Herein, a halogen-free P/N/B-containing modifier (DVB) was synthesized via mild nucleophilic substitution, esterification, and Schiff base reactions using diphenylphosphinyl chloride, vanilline, phenylboronic acid, and 3-amino-1,2-propanediol as precursors. Its efficacy on bisphenol A epoxy resin/4,4′-diaminodiphenylmethane thermosets was systematically evaluated, with comparisons to a phosphorus-only intermediate (DV). At 3 wt% DVB loading (0.18 wt% P content), the modified EP exhibited a limiting oxygen index of 28.5% and achieved UL-94 V-0 classification. Relative to pristine EP, EP/5% DVB demonstrated a reduction of 41.8% in peak heat release rate, 27.7% in total heat release, and 30.0% in total smoke production, outperforming EP/5% DV (17.8%, 15.8%, and 12.2% reductions, respectively). Furthermore, EP/DVB thermosets displayed maximal improvements of 37.0% in flexural strength and 59.4% in impact strength, coupled with a glass transition temperature retention rate of 98%. Collectively, DVB presents considerable application potential for synergistically enhancing the flame retardancy and mechanical performance of epoxy resins.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
Yaozu Guo,Junhua You,Wenli Pei,Yingdong Qu,Dong Zhao,Zhengwen Yang
This paper reports a novel chemical method to synthesize Nd-Fe-B magnetic nanoparticles . The fabrication mechanism of the particles have been studied through understanding formation of the corresponding intermediate phases as well as their microstructures after annealing and reduction-diffusion processes as function of the (C 2 H 5 ) 3 NBH 3 content. Nd-Fe-B intermediate phases were composed of small Fe 3 O 4 particles and Nd and Fe microcrystals encapsulated with nitriles . Fe 3 O 4 was reduced by BH 3 − into α-Fe as the (C 2 H 5 ) 3 NBH 3 content increased. After annealing, Nd-Fe-B oxide particles gradually agglomerated as the (C 2 H 5 ) 3 NBH 3 content increased, which affected the particle sizes after the reduction-diffusion step. Mixture of Nd 2 Fe 14 B and H 5 Nd 2 was obtained from precursors synthesized with 1.5 and 2.5 mmol of (C 2 H 5 ) 3 NBH 3 . Magnetic properties of these mixtures demonstrated soft magnetic phase characteristics. Relatively pure Nd 2 Fe 14 B nanoparticles with a coercivity of 5.09 kOe and magnetic energy product (BH max ) of 2.862 MGOe were obtained when (C 2 H 5 ) 3 NBH 3 initial content was 3.5 mmol. Exchange coupling nanoparticles of Nd 2 Fe 14 B, Fe 3 B and Fe 2 B were obtained with the coercivity of 3.787 kOe and (BH) max equal to 4.871 MGOe at (C 2 H 5 ) 3 NBH 3 content of 4.5 mmol.
✓ 已验证
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2020
·
IF 9.567
Dongjie Liu,Xiaohan Yun,Peipei Dang,Hongzhou Lian,Mengmeng Shang,Guogang Li,Jun Lin
Recently, there has been growing interest in developing Bi3+-activated luminescence materials for optoelectronic applications. Herein, new yellow/orange-emitting ABZn2Ga2O7:Bi3+ (ABZGO, A = Ca, Sr; B = Ba, Sr) phosphors with tunable optical properties are synthesized by an alkaline earth cation substitution. When Sr2+ substitutes Ca2+ and Ba2+, the excitation wavelength has a red shift from 325 to 363 nm, matching well with the n-UV chip based white light-emitting diodes (WLEDs). CaBaZn2Ga2O7:0.01Bi3+ (CBZGO:0.01Bi3+) exhibits two evident emission peaks at 570 and 393 nm originating from the respective occupation of Ca and Ba sites by Bi3+ ions. The optical tuning of the CBZGO:Bi3+ phosphor is achieved by changing the Bi3+ doping content and excitation wavelength based on the selected site occupation. Differently, both SrBaZn2Ga2O7:0.01Bi3+ (SBZGO:0.01Bi3+) and Sr2Zn2Ga2O7:0.01Bi3+ (SZGO:0.01Bi3+) phosphors exhibit a single broad emission band, peaking at 600 and 577 nm, respectively. Two different Bi3+ sites are also verified respectively in SBZGO and SZGO hosts by the Gaussian fitting of the asymmetric PL spectra and lifetime analysis. The different luminescence behaviors of ABZGO:0.01Bi3+ phosphors should be ascribed to the synergistic effect of the centroid shift, crystal-field splitting, and Stokes shift. Moreover, the temperature-dependent PL spectra reveal that cation substitutions of Sr2+ for Ca2+ and Ba2+ can efficiently improve the thermal stability of ABZGO:0.01Bi3+ phosphors. In view of different thermal responses to various temperatures for two emission peaks of the CBZGO:0.01Bi3+ phosphor, an optical thermometer is designed and has a good relative sensitivity (Sr = 1.453% K–1) at 298 K. Finally, a WLED with CRI = 97.9 and CCT = 3932 K is obtained by combining SZGO:0.01Bi3+ and BAM:Eu2+ phosphors with a 370 nm n-UV chip, demonstrating that SZGO:0.01Bi3+ is an excellent yellow-orange-emitting phosphor for n-UV WLED devices. This work stimulates the exploration of optical tuning by cation substitution to obtain remarkable luminescence materials for optical temperature sensing and WLED applications.
研究领域:
材料科学
·
光电子学
·
发光与荧光粉
·
固态照明
·
温度传感
✓ 已验证
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Nan Wang,Ge Chen,Zhenyun Li,Qizhao Xia,Jie Xin,Chi Zhang
D. officinale cellulose was extracted and oxidized into nanofibrils. • CNFs and zein formed nanostructured W/O/W Pickering delivery systems. • Higher oil fractions enhanced emulsion viscoelasticity and gel networks. • The delivery nanosystems protected Sal B for targeted oral delivery. This study developed novel W/O/W Pickering double emulsions (PDEs) stabilized by Dendrobium officinale Kimura et Migo-derived cellulose nanofibrils (CNFs) and zein nanoparticles (ZNPs) for the delivery of salvianolic acid B (Sal B). CNFs were obtained via TEMPO oxidation, forming a highly extended, interwoven nanoscale network. Driven by electrostatic, hydrogen-bonding, and hydrophobic interactions, CNFs and ZNPs (1:2) co-assembled at pH 4.0. This assembly enabled the one-step fabrication of W/O/W PDEs, as confirmed by optical and confocal laser scanning microscopy. The emulsion droplets remained uniformly distributed and highly stable over a 30-day storage period. Rheological analyses showed that increasing the oil fraction from 50% to 70% induced pronounced elastic gel behavior and enhanced system viscoelasticity. These higher lipid fractions effectively reduced free fatty acid release during simulated in vitro gastrointestinal digestion. More importantly, the construct successfully protected Sal B from premature degradation, enabling its release in the gut. These results highlight the potential of D. officinale cellulose as a sustainable plant stabilizer and establish a nanocellulose-based formulation platform for plant bioactive compounds in pharmaceutical and industrial applications. Download: Download high-res image (236KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
EMBO Molecular Medicine
·
2026
·Vol. 18
·期 5
·1679
·
IF 7.9
Yufei Wu,Xiaomei Yang,Yu Bai,Chenze Li,Peng Wang,Qing Xu,Hui Li,Xiaoli Rao,Yangkai Xu,Jie Chen,Huanhuan Cao,Qi Zhang,Mingming Zhao,Rui Zhan,Xue Fan,Yuedong Hou,Jie Liu,Hong S Lu,Tianyun Wang,Wei Dong Gao,Linzhang Huang,Han Xiao,Lingyun Zu,Alan Daugherty,Mingguo Xu,Lemin Zheng
Cardiac microvascular endothelial cells (CMECs) dysfunction is a well-recognized mediator of heart failure with preserved ejection fraction (HFpEF), but the underlying mechanism remains unclear. Here we find that scavenger receptor class B type I (SR-B1) is predominantly expressed in CMECs and decreased significantly in HFpEF. Endothelial-specific SR-B1 deficiency exacerbates cardiac pathological remodeling and diastolic dysfunction in HFpEF, which can be prevented by endothelial SR-B1 reconstitution through adeno-associated virus serotype 1 (AAV1)-mediated delivery in endothelial-specific SR-B1-deficient mice. Single-cardiac-endothelial-cell transcriptomics and lineage-tracing system reveal that inflammatory CMECs subcluster activation is responsible for the deteriorating HFpEF progression induced by endothelial SR-B1 loss, rather than endothelial-to-mesenchymal transition. Mechanistically, SR-B1 loss drives increased CXCL10 secretion, which orchestrates CMECs activation and CXCR3-positive T-cell cardiotropism to promote diastolic dysfunction—a process associated with endothelial IRF1 activation. Most importantly, the SR-B1-CXCL10-CXCR3 axis is activated in human HFpEF cardiac tissue, and the elevated CXCL10 level in plasma is independently associated with a higher HFpEF prevalence. This study uncovers that activation of the SR-B1–CXCL10-CXCR3 axis in CMECs aggravates HFpEF pathogenesis through the accumulation of CXCR3-positive T-cells in hearts. This study demonstrates that SR-B1 deficiency in cardiac microvascular endothelial cells (CMECs) exacerbates heart failure with preserved ejection fraction (HFpEF) by driving the CXCL10-CXCR3 signaling, thereby linking inflammatory CMEC activation to CXCR3 + T-cell recruitment. This study demonstrates that SR-B1 deficiency in cardiac microvascular endothelial cells (CMECs) exacerbates heart failure with preserved ejection fraction (HFpEF) by driving the CXCL10-CXCR3 signaling, thereby linking inflammatory CMEC activation to CXCR3 + T-cell recruitment.
✓ 已验证
DOI
PubMed
高影响因子
Scientific Reports
·
2026
·
IF 4.9
Han Ying,Yang Xinyao,Jia Yuhao,Liu Mingying,Sun Xinglin,Yu Dan,Zhang Dayi
Salmonella is a Gram-negative bacterium causing intestinal infections. Polymyxin B (PMB) is an effective antibiotic against Salmonella , but the emergence of antibiotic resistance poses a growing concern. To address this challenge, this study synthesized a new nanocarrier by functionalizing nano-montmorillonite (NMMT) with PMB by adsorption, namely NMMT@PMB. PMB adsorption on NMMT followed the Langmuir isotherm and pseudo‑first‑order kinetics, and its release kinetics followed a diffusion-controlled mechanism. Although the minimum inhibitory concentration (MIC) of NMMT@PMB (2.78 and 44.54 µg/mL) was slightly higher than that of free PMB (2 and 32 µg/mL) for PMB-sensitive (S AT ) and resistant (S AT−P ) Salmonella typhimurium , the nanocarrier demonstrated sustained long‑term antibacterial activity over time. The antibacterial mechanism was the disruption of bacterial membrane integrity. Additionally, ex vivo results demonstrated that NMMT@PMB regulated the microbial community composition, increasing the relative abundance of probiotic bacteria (from 72.34% to 75.20%) and inhibiting pathogenic bacteria (from 8.54% to 2.36%), thereby facilitating its return toward the original state. These findings suggest that NMMT@PMB is a promising nano-delivery system that may support sustained antibacterial action and microbiota homeostasis, offering a potential strategy for improved management of Salmonella infections.
✓ 已验证
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2026
·
IF 7.9
Han Yu,Ying Wang,Zhen Shi,Chenxi Fang,Hang Zeng,Junting Sun,Vilko Mandić,Xuefeng Zhang
Although superhydrophobic coatings have been widely employed for corrosion protection due to their low surface energy, their low surface energy characteristic also results in weak interfacial adhesion and the influence of interfacial adhesion on the overall anti-corrosion performance remains poorly understood. Herein, we explored the corrosion resistance of superhydrophobic coatings on sintered Nd-Fe-B magnets from the perspective of work of adhesion (Wₐ), which represented the interfacial stability and bonding strength. By precisely controlling the PDA shell thickness and the degree of hydrophobization, the work of adhesion can be regulated correspondingly. The results revealed that the overall anti-corrosion performance of superhydrophobic coatings was directly proportional to the work of adhesion. At an optimized Wₐ of 49.44 mN·m -1 , the coated magnet exhibited a low corrosion current density of 1.09 × 10 −8 A/cm 2 , which was three orders of magnitude lower than that of 3.27 × 10 −5 A/cm 2 for bare Nd-Fe-B magnet. Moreover, outstanding protection durability was also demonstrated in both acidic and alkaline environments with robust interfacial contact. In contrast, weak adhesion induced the formation of interfacial gaps, which served as preferred penetration pathways for the corrosive medium. This study evidenced the importance of interfacial structural integrity, revealing the critical role of adhesion layer design in enabling robust and durable anti-corrosion performance of superhydrophobic coatings.
✓ 已验证
DOI
高影响因子
Immunity & Ageing
·
2026
·Vol. 23
·期 1
·12
·
IF 8.3
Sun Ruiqing,Luo Lan,Chen Yang,Sun Liangjie,Huo Yuhao,Ding Chong,Wang Yixiang
Background Senile osteoporosis (SOP) is becoming a critical public health burden particularly in aging societies due to escalating fracture susceptibility among elderly populations. Despite advances in SOP research, the mechanistic role of immune cell alterations in senile osteoporosis remains unclear. Methods As a validated SOP model, senescence-accelerated mouse prone 6 (SAMP6) mice were used for mechanistic studies, comparing with age- and gender-matched controls-senescence-accelerated mouse resistant 1 (SAMR1) mice. We combined micro-CT, molecular biology and histological techniques to assess the bone mineral density in femurs. To investigate dynamic interactions and differential pathways of immune cells within the bone marrow microenvironment, we employed a multi-omics integration strategy including single-cell RNA sequencing, transcriptome sequencing and flow cytometry. Furthermore, we conducted multicolor immunofluorescence and multiplex cytokine analysis to verify the above results. Moreover, we utilized BaF3 and RAW 264.7 cell lines to study the cell interactions during osteoclastogenesis and BX471(a CCR1 antagonist) was used to block this process. Results SAMP6 mice showed a marked decline in bone mass accompanied by elevated reactive oxygen species (ROS) level in 3-month-old. The single-cell RNA sequencing of bone marrow revealed that a prominent depletion of B lymphocytes, with pro-B cells exhibiting the most pronounced reduction. Multi-omics integration analysis of pro-B cells suggested a significant activation of the Fos/Jun (AP-1) transcription complex accompanied by upregulation of chemokine CCL3 in the SAMP6 group. In vitro assays showed that H 2 O 2 -induced oxidative stress in BaF3 cells triggers Fos/Ccl3 axis activation and promoted osteoclastogenesis in RAW 264.7 cells. Moreover, blocking CCR1 with BX471 could suppress this effect. Conclusions Our findings suggest that the elevation of ROS levels within bone marrow microenvironment accelerates immune-senescence of B lymphocytes, characterized by a significant reduction in progenitor B-cell populations, which subsequently activates the Fos/Jun-mediated stress signaling pathway. The cascade ultimately results in the overexpression of CCL3, further promoting osteoclastogenesis of macrophage through CCL3-CCR1 axis. CCR1 antagonist could alleviate pro-inflammatory osteoclast formation, revealing a potential therapeutic target for senile osteoporosis.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Huanhuan Gao,Jianzhong Liu,Tingting Suo,Haiou Wang,Jianren Fan
Directionally modulated Al-Mg-B/Al-Ti-V alloys enable dual-mode synergy. • Lower ignition thresholds, boost heat release, and enhance motor safety. • Agglomerate size reduced by 45.8% (AMB) and 54.8% (ATV), boosting energy release efficiency. • “On-demand” alloy design delivers predictable optimization for tailored fuels. Low energy release efficiency due to aluminum agglomeration remains a critical bottleneck limiting the performance of composite propellants. This study employs two directionally modulated ternary alloys, Al-Mg-B and Al-Ti-V, to optimize the full-cycle performance of HTPB composite propellants via multi-element synergy. Optimal alloy ratios are identified via combustion experiments. The selected alloys are subjected to thermal oxidation analysis, and the corresponding composite propellants are prepared. Systematic tests evaluate ignition, combustion, agglomeration, and products under high pressure. Results indicate that ternary alloy modification promotes efficient ignition, significantly increases combustion heat release, and markedly reduces pressure sensitivity. Specifically, the modification suppresses agglomeration (mean particle size reductions of 45.8% and 54.8%, respectively), thereby improving energy-release efficiency. Further investigation clarifies the mechanisms governing the behavior of Al-Mg-B and Al-Ti-V in composite propellants. These findings suggest that directionally modulated ternary alloys offer a viable strategy for simultaneously enhancing energy release and potentially improving motor operational safety.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Kaixuan Wang,Fei Teng,Zixu Zhang,Xiaoxia Ou,Xiaofeng Chen,Junfeng Niu
Synthesized the metal-free B and N co-doped porous carbon (B X NPC) catalysts. • Promoting •OH generation via B doping on B 50 NPC revealed by theoretical calculations. • •OH and 1 O 2 oxidation synergistically enhanced refractory antibiotics removal. • Treating actual pharmaceutical factory wastewater with a low energy consumption. • Excellent detoxification and disinfection performance of B 50 NPC electro-Fenton. Heterogeneous electro-Fenton (EF) is an attractive process for refractory and hazardous pollutants degradation that usually relies on •OH produced via the in-situ decomposition of electro-generated H 2 O 2 on metal-based catalytic sites, which faces the problems of metal shedding and leaching under acidic or even neutral conditions. Designing and investigating a bifunctional metal-free catalyst is a sensible strategy for the development of heterogeneous EF process. Herein, the bifunctional metal-free boron and nitrogen co-doped porous carbon (B X NPC) catalysts were prepared. Total organic carbon removals of hazardous and refractory antibiotics (ciprofloxacin, levofloxacin, sulfamethoxazole, tetracycline, and norfloxacin) by B 50 NPC EF process were 67 ± 2% − 90 ± 2% in 3 h. This process could efficiently treat actual pharmaceutical factory wastewater that chemical oxygen demand (COD) removal was 86.8 ± 1.3% with specific energy consumption of 3.7 ± 0.2–6.7 ± 0.1 kWh (kg COD) −1 superior to previous reports (5.5–290 kWh (kg COD) −1 ). Theoretical calculations and experiments revealed that the B sites and carbon defects in B 50 NPC promoted •OH and 1 O 2 generation, respectively, synergistically enhancing antibiotics removal. The results of toxicity evaluation and E. coli deactivation demonstrated excellent detoxification and disinfection performance. The results gain deep insights into the O 2 reduction mechanism of bifunctional metal-free B X NPC and developing an energy-efficient electrochemical process for promoting the decomposition of hazardous and refractory antibiotics. Download: Download high-res image (218KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2026
·
IF 6.6
Kun Li,Fangdu Chen,Junbao Yu,Juan Yang
Fe₇₈Si₉B₁₃ maintained stable NOR degradation during ten reuse cycles. • Surface chemical evolution of Fe₇₈Si₉B₁₃ was revealed after catalytic cycling. • Thirty transformation products enabled the proposal of five pH-dependent NOR pathways. • QSAR predicted pathway-dependent ecological risks of NOR transformation products. Fe₇₈Si₉B₁₃ amorphous alloy was employed as a heterogeneous Fenton-like catalyst for norfloxacin (NOR) degradation, with emphasis on pH-dependent transformation behavior and ecological implications of generated intermediates beyond parent-compound removal. The Fe₇₈Si₉B₁₃/H₂O₂ system achieved rapid NOR degradation, with complete removal within minutes under acidic conditions, and maintained catalytic activity during ten consecutive cycles. Structural and surface analyses demonstrated that the amorphous framework remained stable during repeated reactions, accompanied by surface oxidation and chemical-state changes. The transformation of B species from B B to B O during cycling suggested a possible contribution of B evolution to maintaining catalytic performance. High-resolution mass spectrometry identified 30 transformation products and revealed five NOR transformation pathways under acidic and weakly acidic conditions. Density functional theory (DFT) calculations further demonstrated that pH-dependent protonation states altered the electronic distribution and radical-reactive regions of NOR, providing molecular-level insights into pathway variations. Under acidic conditions, transformation products were mainly associated with pathways I–III, whereas weakly acidic conditions were mainly associated with pathways IV and V, leading to distinct transformation profiles and QSAR-predicted ecotoxicity characteristics. These findings highlight that the environmental performance of Fenton-like oxidation processes should be evaluated by integrating degradation efficiency, transformation behavior, and ecological risks of generated intermediates. Download: Download high-res image (211KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2026
·
IF 5.3
Zhu Guo,Yujing Zhang,Ping Zou,Caiyun Sun,Liya Cui,Gang Wang,Chao Wang
A novel class of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyrazine derivatives was designed and synthesized as tubulin polymerization disruptors. Among them, compound 10t emerged as the most potent agent, exhibiting IC₅。 values of 0.13-0.18 µM against HeLa, SGC‑7901, and MCF‑7 cancer cell lines. Functional studies revealed that 10t effectively inhibits tubulin assembly in vitro, destabilizes cellular microtubule networks, induces G₂/M cell‑cycle arrest, and triggers apoptosis. Molecular docking indicated that 10t binds to the colchicine site on tubulin, forming a unique hydrogen bond with β‑Asn349 that is not observed with the reference compound CA‑4. Importantly, 10t showed significantly lower cytotoxicity toward normal HUVECs than CA‑4, suggesting an improved safety profile. Collectively, these findings establish the pyrazolo[3,4‑b]pyrazine scaffold as a promising platform for microtubule‑targeting anticancer agents and identify 10t as a compelling lead for further development.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）