LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
·
IF 6.6
Lin-Kun Sun,Tian Du,Pei-Ru Zhou,Yu-Cang Zhang,Yan-Zhen Zheng
Developing appropriate packaging technologies is crucial for maintaining shrimp quality and reducing potential food safety risks. Meanwhile, concerns over the environmental impact of petroleum-based plastics have accelerated the development of biodegradable packaging from renewable resources. In this study, bioactive chitosan (CS) composite films were developed by incorporating tea stem extract obtained using a choline chloride–glycerol-based natural deep eutectic solvent (NADES). The DES tea stem extract (DTSE) served a dual function as a plasticizer and a bioactive agent. Results showed that DTSE incorporation improved film flexibility (maximum EAB of 173%), enhanced antioxidant capacity (maximum DPPH scavenging rate of 94.8%), and provided moderate UV barrier properties without compromising hydrophobicity. Application of the CS/DTSE composite films in shrimp meat preservation demonstrated significant efficacy: the films effectively maintained shrimp meat appearance, slowed pH increase, reduced weight loss, suppressed lipid oxidation and protein degradation, inhibited microbial growth, and minimized off-odor development, thereby significantly extending shrimp shelf life by 2–3 days. These findings indicate that NADES-extracted tea polyphenols can serve as a sustainable and multifunctional additive, providing an effective strategy for the development of active packaging materials that extend the shelf life of perishable seafood products while valorizing tea stem waste.
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高影响因子
RSC Advances
·
2025
·Vol. 15
·期 14
·10816-10824
·
IF 4.6
Qifei Ma,Huaizhou Jin,Weihong Wang,Shangzhong Jin
Emulsions stabilized by protein/polysaccharide complexes have attracted great interest. However, the emulsion properties and interactions between droplets at the microscale require further investigation. In this work, the interaction forces between two rice bran oil droplets stabilized by casein–chitosan complexes, with a diameter of 3 ± 0.1 μm (pH 5.54 and no-salt), were measured under different aqueous conditions (pH and ionic strength) using optical tweezers. The measured force curves exhibited consistency with the interfacial layer conformation and interfacial charge, as determined through fluorescence spectroscopy and zeta-potential analysis. Furthermore, atomic force microscopy (AFM) and optical microscopy were employed to characterize the morphology and structural evolution of the emulsions under varying environmental conditions. Our results provide a useful method for studying the interaction forces between Pickering emulsion droplets with pN force resolution and reveal the correlation between interfacial layer properties and physical stability, offering deep insights into the stabilization mechanism of Pickering emulsions.
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PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Lifang Gao,Yuheng Wang,Jixuan Zhang,Haoran Wang,Yue Zhang
Herein, a zwitterionic hybridization approach is engineered to develop a functional hybrid framework (MPC) for the efficient separation of immunoglobulin G (IgG). The in-situ polymerization of octa-carboxyl polyhedral oligomeric silsesquioxane (OCPOSS)-chitosan polymer on Ti 3 C 2 T x MXene effectually enables the formation of local zwitterionic hydrophilic microregions in MPC, and meanwhile actuates its affinity ability and recognition selectivity toward IgG. When 1 mg of MPC serves as adsorbent to treat IgG solution (100 mg L −1 , 1 mL), an adsorption efficiency of approximately 99.0 % is facilely reached. Superior adsorption performance of MPC is well demonstrated by satisfactory enrichment factor (119.3) and high binding capacity (866.4 mg g −1 ). MPC is further employed for the separation of IgG from complex biological samples, achieving a protein purity of 97.9 %. Experimental characterization and molecular docking simulation successfully affirm the prominent role of multiple components in MPC in the collaborative contribution to the selective affinity separation of IgG. This study not only affords a highly efficient pretreatment platform for specific biomarker detection and antibody purification, but also illuminates the huge prospects of zwitterionic MXene-based frameworks in the field of proteomics research.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Wentao Qu,Zhikun Wang,Jiaqi Feng,Xupeng Li,Liqiang Yang,Li Wang,Jie Guo,Huiling Su,Miantuo Li,Yu Fu,Songqing Hu
This work presents a dual-adsorbent strategy for enhanced phosphate removal via chitosan-based materials with molecular-level mechanistic elucidation. Two complementary adsorbents are designed: spherical bimetallic beads (CSQ@Zr/Fe) and a porous hydrogel (CSQ@Zr). The CSQ@Zr/Fe beads demonstrate outstanding cyclic stability, retaining 84.2 % adsorption capacity after 5 regeneration cycles, while achieving a maximum adsorption capacity of 122.51 mg/g under optimized conditions. The CSQ@Zr hydrogel exhibits superior single-cycle performance with a capacity of 126.50 mg/g and rapid uptake kinetics, reaching adsorption equilibrium within 240 min. Both materials maintain high removal efficiency over a broad pH range (3–9) and show remarkable selectivity in complex ionic environments, with phosphate removal exceeding 90 % even in the presence of competing anions (Cl − , NO 3 − , SO 4 2− ). Comprehensive characterization and simulation studies reveal a synergistic adsorption mechanism dominated by electrostatic interactions (85–92 % contribution to binding energy), complemented by outer-sphere coordination (P–O–Zr: 2.25 Å; P–O–Fe: 1.85 Å) and hydrogen bonding networks. The hydrogel exhibits stronger phosphate confinement (diffusion coefficient: 0.544 × 10 −12 m 2 /s) compared to the beads (0.685 × 10 −12 m 2 /s), which correlates with its enhanced adsorption performance. This work provides not only high-performance adsorbents but also fundamental insights into the design of chitosan-based materials for sustainable phosphate removal and recovery applications.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiawei Zhao,Gaoshuai Zhang,Shuwen Zhang,Rui Liu,Meijing Zhang,Biao Wang,Ye Zhang,Jianhui Liu,Hao Wang
Hydrogel dressings have emerged as promising tools for wound healing applications. However, the complex chemical synthesis and high cost of components, such as cytokines and stem cells, in most existing designs challenge their practical application. In this study, we adopted a modular design approach and natural materials to overcome these limitations, dividing the hydrogels into three distinct functional modules. The base module consisted of an interpenetrating polymer network of gelatin and chitosan. The drug release module incorporated liposomes loaded with quercetin, while the auxiliary module utilized a complex of protocatechuic aldehyde and trivalent iron. The presence of Schiff base crosslinking and hydrogen bond formation between the three modules enhanced the self-healing properties and mechanical strength of the hydrogel. Notably, the modular hydrogel exhibited excellent antioxidant, antibacterial, macrophage differentiation, and collagen promotion capabilities. This multifunctional hydrogel demonstrated the potential to provide safe and effective treatment, accelerate wound repair processes, and serve as a promising dressing for diabetic wound management. By utilizing natural components and a modular design strategy, this hydrogel offers a practical and cost-effective solution for improving wound healing outcomes, particularly in drug-resistant and diabetic wounds.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Xue Zhang,Chunyi Luo,Na Liu,Siyu Liu,Zhouquan Jiang,Jinjun Zhou,Lishu Shao,Weihua Luo
To enhance the clinical value of carboxymethyl chitosan (CMCS) as an osteogenic material, improving its bioactivity and mechanical strength is crucial. Meanwhile, ellagic acid (EA) has strong bioactivities but low bioavailability due to its hydrophobicity. In this study, by introducing EA units into CMCS molecules, a near-infrared (NIR) light-mediated nanofiber membrane based on polycaprolactone (PCL)/EA-CMCS blended nanofibers coated with an EA-CMCS/graphene oxide (GO) layer (PCL/EA-CMCS@EA-CMCS/GO) was designed. The bioactivity of CMCS and bioavailability of EA could be significantly improved by covalent coupling of EA with CMCS. Blending EA-CMCS with PCL significantly enhanced the mechanical properties of nanofiber membranes. The coated nanofibrous membrane featured a multi-level structure of coating and blending. By leveraging the photothermal conversion effect of GO, it enabled the programmed and sustained release of EA-CMCS from both the coating and the nanofibers. Moreover, the membrane exhibited excellent biomineralization and antioxidant capabilities. It effectively regulated macrophage polarization and promoted the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 osteoblasts. These properties enabled the membrane to regulate the harsh osteogenic immune microenvironment and promote bone regeneration. This biomimetic periosteum holds great potential as a substitute for periosteal grafts and offers a novel strategy for developing artificial periosteum.
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Desalination and Water Treatment
·
2024
·
IF 1
Wenqian Cao,Dedong Wu,Pengfei Xiao
The chitosan-glutaraldehyde/activated carbon composite (CS-G/AC) was successfully prepared as an adsorbent for methylene blue (MB)-containing wastewater. Various techniques such as Brunauer–Emmett–Teller, X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscopy characterized CS-G/AC. The response surface methodology-Box–Behnken design, a method for experiments design and optimization, was employed to find the optimal MB removal conditions. The predicted maximum removal rate of MB was found to be 99.19% at an initial pH of 6.58, CS-G/AC dose of 3.2 g L –1 for 35 min at 42.65°C. Compared to activated carbon (AC), the removal rate of MB by CS-G/AC increased by 44.74% at 35 min. The adsorption performance and mechanisms of CS-G/AC for MB were also investigated. Adsorption of MB onto CS-G/AC followed a pseudo-first-order kinetic model, as well as Temkin and Langmuir isothermal models with a maximum MB adsorption (Q m ) of 300.75 mg g –1 . Various interactions such as electrostatic interaction, π–π bonding, and hydrogen bonding were proposed as mechanisms for MB adsorption by CS-G/AC. Furthermore, CS-G/AC has been proven to be an excellent reusable adsorbent with high adsorption capacity even after six adsorption–desorption cycles. Overall, theoretical references for the preparation of CS-G/AC, treatment of MB-containing wastewater, and mechanistic analysis were provided.
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Desalination and Water Treatment
·
2024
·
IF 1
Jin-ni Wu,Wenkui Mu,Wen-bin Li,Hong-yan Deng,Tianjiang Jin,Touqeer Abbas,Yu-ting Song,Jia-peng Pan,Bixia Wang
The antibiotic adsorbability and economic performance of modified semi-carbonized fiber (SF) were investigated by using 100% chitosan (CS) to modify SF (prepared by cotton) for preparing CS-modified SF (CS-SF). Then, different ratios (0%, 10%, 20%, 50%, 100%, and 200%) of sodium alginate (SA) were used to modify 100CS-SF for preparing SA and CS-modified SF (SA/CS-SF). Batch method was used to investigate the adsorption characteristic of chlortetracycline (CTC), tetracycline (TC), and oxytetracycline (OTC) on different SA/CS-SFs. The effects of temperature, pH, and ionic strength on antibiotic adsorption were compared, and the economic performance of different SA/CS-SFs was analyzed. Results showed that (1) the Langmuir model is suitable for describing the adsorption process of antibiotics by different SA/CS-SFs. The maximum adsorption amount ( q m ) of different SA/CS-SFs for CTC, TC, and OTC were 11.17–36.36, 6.14–26.11, and 9.90–32.87 mmol/kg, respectively, ranking in the order of CTC > OTC > TC. (2) The adsorption antibiotics by different SA/CS-SFs conformed to the pseudo-first-order kinetics equation. Antibiotic adsorption on different SA/CS-SFs increased with the increase in temperature, and the adsorption was a spontaneous, endothermic, and entropy-increasing process. (3) In the pH range of 3–9 and ionic strength range of 0.01–0.2 mol/L, the adsorption amount of antibiotics on different SA/CS-SFs all increased first and then decreased with increasing pH and ionic strength, reaching the maximum value at pH = 5 and ionic strength of 0.1 mol/L, respectively. (4) The economy ( q m /price) of different SA/CS-SFs for antibiotic adsorption ranged from 7.18 to 22.91 mg/¥, and 100SA/CS-SF showed the highest economy. Compared with biochar and modified biochar, 100SA/CS-SF had higher economy in antibiotic adsorption.
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Polymer Chemistry
·
2014
·Vol. 5
·期 16
·4734-4746
·
IF 5.368
Haiyan Chen,Yuqi Chen,Haibo Yang,Weixia Xu,Min Zhang,Yuxiang Ma,Samuel Achilefu,Yueqing Gu
Conventional chemotherapy suffers from non-specificity, lack of aqueous solubility and multidrug resistance. Tumor-targeting nanotherapeutics exhibit unique advantages in the delivery of drugs specifically into tumors. Here, folic acid (FA), methionine (Met) and a near infrared (NIR) fluorescence probe (cypate, ICG derivative) were all bio-conjugated to succinyl-chitosan (SC) micelles. An anti-cancer drug (paclitaxel, PTX) was loaded into the hydrophobic cores of the formed FA–Met–SC–ICG derivative (FMSCI) micelles, which were under 200 nm in size. In comparison with micelles containing a single targeting moiety (FA or Met), FA and Met co-mediated micelles presented excellent biocompatibility, much higher affinity for cancer cells and excellent tumor-specific distribution in tumor-bearing mice. In vivo anti-tumor activity demonstrated that PTX-loaded FMSCI provided favourable therapeutic efficacy for tumors. In this research, novel nanotherapeutics based on FMSCI loaded with an anti-cancer drug provide a promising nanocomposite for combined tumor-targeting imaging and therapy.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Qianqian Zhang,Lei Zhao,Hezhen Yang,Lingbin Kong,Fen Ran
Tremendous efforts have recently been made in optimizing the electrolyte of flexible devices. Unfortunately, the bottleneck factors in electrolytes that largely limit the stability and applicability of devices have long been relatively neglected. Alkali-tolerant devices need alkali-tolerant hydrogel electrolyte as an essential component, while most hydrogels will lose their stability after being immersed with strong alkaline solution. This is why alkali-tolerant quasi-solid supercapacitors have less been reported so far. In this work, an alkali-tolerant hydrogel electrolyte membrane based on carboxylated chitosan hydrogel electrolyte membrane is fabricated through graft co-polymerization and crosslinking among acrylic acid, N, N′ -methylene bisacrylamide, and potassium persulfate, followed by intense uptake of KOH electrolyte. In addition, we make an extension of the above work and prepare another hydrogel electrolyte membrane by selecting FeCl 3 as crosslinking agent using the same method. The prepared alkali-tolerant hydrogel electrolyte membranes present obviously improved properties compared to PAAS electrolyte in terms of ionic conductivity (at room temperature) and electrolyte uptake. The quasi-solid supercapacitor in alkaline electrolyte exhibits admirabl eenergy density and power density (4.39 Wh kg −1 and 224.99 W kg −1 , respectively), while has relatively low energy density and power density (3.77 Wh kg −1 and 225.00 W kg −1 , respectively). Gratifyingly, the polymeric gel electrolyte can also be applied in acidic and neutral electrolytes. Our results highlight the potential of the alkali-tolerant hydrogel electrolyte to be widely used in next-generation alkaline energy devices.
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BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Xiu-Xiu Dong,Jin-Yi Yang,Lin Luo,Yi-Feng Zhang,Chuanbin Mao,Yuan-Ming Sun,Hong-Tao Lei,Yu-Dong Shen,Ross C. Beier,Zhen-Lin Xu
Histamine (HA) is a biogenic amine that can accumulate to high concentration levels in food as a result of microbial activity and can cause toxic effects in consumers. In this work, a portable electrochemical immunosensor capable of detecting HA with high sensitivity and selectivity was developed. Prussian blue-chitosan-gold nanoparticle (PB-CS-AuNP) nanocomposite films with excellent biocompatibility were synthesized and characterized by scanning electron microscopy and energy dispersive X-ray analysis. The PB-CS-AuNP were coated onto a screen-printed electrode by one-step electrodeposition and used to conjugate the HA ovalbumin conjugate (HA-Ag). HA was determined by a competition between the coating HA-Ag and the HRP labeled HA antibody (HRP-HA-Ab). After careful optimization of assay conditions and Box-Behnken analysis, the developed immunosensor showed a linear range from 0.01 to 100 μg/mL for HA in fish samples. The average recoveries from spiked samples ranged from 97.25% to 105%. The biosensor also showed good specificity, reproducibility, and stability, indicating its potential application in monitoring HA in a simple and low cost manner.
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Desalination and Water Treatment
·
2024
·
IF 1
Yongjun Sun,Aowen Chen,Wenquan Sun,Kinjal J. Shah,Huaili Zheng,Chengyu Zhu
In this work, carboxylated chitosan and acrylamide are used to synthesize a graft-modified natural polymer flocculant carboxylated chitosan-graft-acrylamide (CCSPAM) by UV-induced polymerization for copper and chromium removal. The effects of total monomer concentration, monomer mass ratio, pH value, photoinitiator concentration, and illumination time on the synthesis performance of CCSPAM were investigated regarding intrinsic viscosity (IV), grafting rate (GR), and grafting efficiency (GE). Various analytical techniques characterize the physicochemical characteristics of CCSPAM. Single factor experiments are used to investigate the effect of dosage, pH value, and reaction time on the chelation and capture of heavy metal ions by CCSPAM. The results show that the optimal IV, GR, and GE of CCSPAM achieved at total monomer concentration 30%, monomer mass ratio 1:4, pH 7.0, photoinitiator concentration 0.03%, and irradiation time 2 h are 1412.2 mL/g, 394.1%, and 84.1%, respectively. The experimental data of flocculation show that CCSPAM has a good total Cu and total Cr removal efficiency of 74.8% and 70.6% at dosage 2.0 mg/L, pH 6.0, and reaction time 2h, respectively. Fom the investigation, it is concluded that the grafted chitosan (CCSPAM) could be a be an effective and eco-friendly flocculant for removal of total Cu and total Cr ions from aqueous system.
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