MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Xue-Bo Hu,Yi-Peng Zhang,Zi-He Jin,Yi-Xiao Zhang,Yu-Ling Wang,Xiao-Long Fu,Jun-Tao Cao,Yan-Ming Liu
Three-dimensional cell culture has been considered as a powerful tool to achieve the in-vitro investigation that can mimics the cell behaviors and functions in body. With the advancement on this field, the requirements on applying effective identification and quantification strategy for real-time monitoring of cells are becoming more urgently. Therefore, we developed a PEDOT@Pt-based antifouling electrochemical sensor and collagen hydrogel integrated 3D platform. Among the 3D platform, the PEDOT@Pt-based electrochemical sensor presented high performance toward reactive oxygen species (hydrogen peroxide), with a high sensitivity of 176.0 nA/μM in the linear range of 100 nM to 100 μM, and a low detection limit of 43.1 nM. Besides, under the simulated cell culture environment, the electrochemical performance retained up to 70.8 % of the original performance, demonstrating good antifouling property. As a proof of concept, the A549 and HeLa cells were cultured into the 3D platform and the real-time monitoring of cell-released reactive oxygen species were further conducted. More importantly, the reactive oxygen species release behavior of cells under different stimulation were also explored within the 3D integrated platform, which is expected to enable precise biochemical analysis of cells under the in vivo -like microenvironment.
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Min Li,Chenlong Zhang,Jie Dou,Chi Jiang,Yingli Wang,Qiyao Guo,Xinyu Zhang,Bin Dong,Qunwei Tang
Constructing ultra-high activity, highly efficient and robust oxygen evolution reaction (OER) electrocatalysts, especially at large current density, plays a key role in the development of the electrolytic water industry but remains challenging. Highly dispersed alloy compound with large electrolyte contact area and excellent internal conductivity is considered as a kind of ideal candidate. Here, we have rationally designed and synthesized a nickel-platinum alloy with octahedral structure loaded on the surface of the carbon layer (NiPt/C). Under the in-situ modulation of the iron-containing electrolyte, the Fe modified NiPt/C catalyst displays an amazing OER activity in 1 M KOH, and only requires low overpotentials of 183 and 242 mV to reach 100 and 1000 mA cm −2 , respectively. The comprehensive characterization analysis and property measurements reveal that the pre-oxidation of Pt at OER potential contribute to the rapid production of nickel hydroxide, thus promoting the deposition of more iron active sites on its surface. Moreover, the Pt/C/CP (−) //NiPt/C/CP (+) couple embedded in anion-exchange membrane water electrolyser also displays a low cell voltage of 2.03 V at 1000 mA cm −2 with significant electrochemical stability, which endows it a great potential in the field of hydrogen production and electrochemical energy storage.
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高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Qu Zhengquan,Zhang Baozhong,Liu Xihong,Cui Xiaoying,Zhao Ke,Li Ying,Xie Lingling,Zhu Huina,Chen Hanyu,He Baoshan
Fumonisin B1 (FB1) is a secondary metabolite generated by Fusarium verticillioides , which can widely contaminate crops. Herein, an electrochemical aptamer sensor with high sensitivity and selectivity was constructed for FB1 detection, leveraging the specific recognition capability of aptamers. Polyethylenimine-functionalized cerium dioxide-supported platinum nanoparticles (PEI-CeO 2 @PtNPs) were used for the modification of electrodes. The nanocomposite enhanced electrical conductivity on the electrode, and provided more attachment sites to increase the loading capacity of aptamer chains. Additionally, polyethylenimine-functionalized melamine-cyanuric acid condensation polymers (PEI-MCA) were used as carrier for the signal probe. Because of the unique porous structure and abundant functional groups on the surface of MCA, the loading efficiency of methylene blue (MB) was significantly enhanced, and the complementary DNA (cDNA) strand of aptamers was effectively loaded on PEI-MCA by strong electrostatic interaction to construct signal probes. The cDNA was captured by aptamers through complementary base pairing, and PEI-CeO 2 @PtNPs amplified electrical responses cooperatively with PEI-MCA. In the presence of FB1, the aptamers preferentially bound to FB1, and the signal probes were detached from the electrode surface, resulting in a decrease in the electrochemical response. Under optimal conditions, the dynamic range of the constructed aptasensor was 1 × 10 −1 to 1 × 10 4 pg/mL, with a detection limit of 89 fg/mL. Additionally, the sensor had high selectivity, reproducibility, and stability, and could detect FB1 in milk and corn flour samples.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Man Yang,Keying Wu,Shaodong Sun,Yujing Ren
Tungsten-based catalyst has been widely investigated in the field of selective hydrogenolysis of secondary C O bond, such an important yet challenging strategy, in glycerol conversion, in which the product 1,3-propanediol (1,3-PDO) is of great value in polyester industry. Unfortunately, though it has been proved to be highly active, the identification of the intrinsic tungsten oxide active sites still remains unrevealed to date due to its complex microstructure. Herein, we incorporate atomically dispersed alumina as promoter in the context of the selective hydrogenation of glycerol and report a Pt/Al-WO x catalyst. This catalyst decidedly outperforms the unpromoted Pt/WO x , which elevates the 1,3-PDO yield to 2 times. Spectroscopy characterizations and chemisorption experiments have revealed that the high activity and selectivity of Pt/Al-WO x catalyst results from the more oxygen vacancies on WO x in-situ generation by the acceleration of atomically dispersed alumina in hydrogen atmosphere, which increases the selective adsorption of glycerol and the in-situ Brønsted acid sites for the selective activation of secondary C O bonds, thus largely augmenting the hydrogenolysis performance. This discovery not only provides the new strategy of defect engineering to enhance hydrogenolysis performance of secondary C O bond in biomass compounds, but reveals the unique role of the unsaturated coordination structure of WO x in chemoselective hydrogenolysis reactions.
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高影响因子
Science Bulletin
·
2025
·
IF 21.1
Han-Yue Yang,Bin Sun,Xue Xiao,Xuan Ai,Rui-Bin Jiang,Pei Chen,Yu Chen
Glycerol, a byproduct of biodiesel production, can be efficiently converted into valuable chemicals through electrocatalytic reaction. In this study, platinum (Pt) nanocrystals decorated on bismuth oxide (Bi 2 O 3 ) nanosheets (PtBi DONS) with an optimal Pt:Bi ratio of 1:1 were successfully synthesized using a galvanic replacement method. Pt 1 Bi 1 DONS exhibit remarkable electrocatalytic performance for glycerol electrooxidation, achieving an excellent catalytic activity (current of 0.82 A mg Pt –1 at 0.67 V vs. reversible hydrogen electrode (RHE)) and an exceptional selectivity of 96.6% for C 3 products, particularly glyceric acid. The superior performance stems from two key factors: (1) electron transfer from Bi 2 O 3 to Pt creates electron-rich Pt sites that suppress C–C bond cleavage and (2) Bi 2 O 3 facilitates favorable glycerol adsorption configurations through multiple hydroxyl group interactions. Mechanistic studies using operando spectroscopy and electrochemical impedance spectroscopy revealed that the synergistic effect between Pt and Bi 2 O 3 promotes rapid charge transfer and stable intermediate formation. Moreover, PtBi DONS showed excellent versatility in oxidizing other polyols compared with monoalcohols.
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PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Chunxue Wang,Zhao Li,Junjun Qiu,Xin Sun,Yixing Ma,Chi Wang,Kunlin Li,Ping Ning,Kai Li,Fei Wang
In various industrial processes, particularly iron ore sintering operations, the concurrent use of fossil fuels and selective catalytic reduction by ammonia (NH 3 -SCR) denitrification technology inevitably results in the coexistence of carbon monoxide (CO) and escaped NH 3 in the exhaust gases. While simultaneous catalytic oxidation of CO and NH 3 represents an ideal strategy, it encounters significant challenges due to competition for active centers. Moreover, NH 3 -selective catalytic oxidation (NH 3 -SCO) is potentially inhibited by high CO concentrations. In this investigation, we synthesized a series of Pt/Al-X catalysts (X indicating calcination temperature) that demonstrated inverse activity patterns in independent NH 3 -SCO and CO oxidation reactions. Comprehensive analysis incorporating oxygen activation capacity, reactant adsorption characteristics, reaction kinetics, and in situ diffuse reflection infrared Fourier transform spectrum (DRIFTS) measurements indicated that O 2 activation capacity functioned as the rate-determining factor for NH 3 -SCO, whereas CO adsorption capacity and OH group density predominantly governed CO oxidation. Building on these findings, we engineered a composite catalyst by integrating Pt/Al-600 and Pt/Al-900 catalysts. This novel composite effectively reduced active center competition through strategic combination of functional sites, thereby achieving superior performance in simultaneous CO and NH 3 removal, while maintaining excellent water resistance and operational stability.
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高影响因子
TALANTA
·
2024
·
IF 5.6
Yueying Yu,Hongli Zhao,Kaicha Chen,Shida Cao,Minbo Lan
When an acute myocardial infarction (AMI) occurs, myoglobin (Mb) is the biomarker whose concentration firstly increases, and the high sensitive detection of Mb is critical for early diagnosis of AMI. Herein, a sandwich-type electrochemical aptasensor for the sensitive detection of Mb was constructed by using Pt@Cu 1.33 OCo 0.83 O as the signal marker. On one hand, nano-flower-like Cu 1.33 OCo 0.83 O was synthesized by hydrothermal method and Pt nanoparticles (Pt NPs) were loaded on its surface. Pt@Cu 1.33 OCo 0.83 O could immobilize aptamer 2 (Apt2) successfully by the Pt–S bond. And because of the synergistic effect between Pt and bimetallic oxide, Pt@Cu 1.33 OCo 0.83 O had an excellent catalytic effect on the signal source of hydrogen peroxide (H 2 O 2 ) to amplify the current signal, which enhance the sensitivity of the aptasensor. On the other hand, the screen-printed gold electrode (SPGE) was used as the sensing base, which had good conductivity and ensured the immobilization of aptamer 1 (Apt1). The quantitative detection of Mb was achieved by specific recognition between Mb and Apt1, Apt2. As a result, the constructed electrochemical aptasensor had a good linear range (1–1500 ng/mL) with a low detection limit (LOD) of 0.128 ng/mL (S/N = 3), and a high sensitivity of 29.47 μA dec −1 . The aptasensor also realized the detection of Mb in human serum samples with good accuracy, and the results were consistent with the hospital's biochemical indicators, which demonstrated the potential application of the prepared sensor in the clinical detection of Mb.
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PubMed
高影响因子
Research
·
2024
·
IF 8.5
Hong Wei,Hongjun Huang,Haoqiang He,Yuanming Xiao,Lu Chun,Zhiqiang Jin,Hanyang Li,Li Zheng,Jinmin Zhao,Zainen Qin
The activation of pro-inflammatory M1-type macrophages by overexpression of reactive oxygen species (ROS) and reactive nitrogen species (RONS) in synovial membranes contributes to osteoarthritis (OA) progression and cartilage matrix degradation. Here, combing Pt and Se with potent catalytic activities, we developed a hybrid Pt–Se nanozymes as ROS and RONS scavengers to exert synergistic effects for OA therapy. As a result, Pt–Se nanozymes exhibited efficient scavenging effect on ROS and RONS levels, leading to repolarization of M1-type macrophages. Furthermore, the polarization of synovial macrophages to the M2 phenotype inhibited the expression of pro-inflammatory factors and salvaged mitochondrial function in arthritic chondrocytes. In vivo results also suggest that Pt–Se nanozymes effectively suppress the early progression of OA with an Osteoarthritis Research International Association score reduction of 68.21% and 82.66% for 4 and 8 weeks, respectively. In conclusion, this study provides a promising strategy to regulate inflammatory responses by macrophage repolarization processes for OA therapeutic.
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PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Jiejing Kong,Miaoqiu Tang,Yujia Luo,Shengnan Song,Ziwei Xiang,Yunlong Guo,Weiping Zhang,Guiying Li,Taicheng An
The trade-off between high visible-light response quantum yields and strong redox activity to achieve effective overall photocatalytic performance is still challengeable in the field of photocatalytic application. Herein, S-scheme heterojunction catalyst with high redox potential was developed by introducing small amount of Pt and excessive Bi into Bi 2 WO 6 /CeO 2 (denoted as BWO/CeO 2 ) through simple hydrothermal method, and applied to efficiently photocatalytic degradation of typical VOCs containing soot under visible light. It is experimentally proven that photogenerated charge transfer follows an S-scheme mechanism with interfacial Bi as a charge-transfer bridge and surface-deposited Pt as a photoexcited-electron trapper, which not only promotes charge separation but also enhances redox activity. Besides, both surface plasmon resonance of Bi nanoparticles and photothermal effect of soot trigger pyroelectric polarization of BWO to boost charge generation and separation, meanwhile induce photothermal synergistic effect of Pt/Bi-BWO/CeO 2 . All these beneficial factors lead to remarkably higher photocatalytic activity of Pt/Bi-BWO/CeO 2 catalyst in comparison with single component of photocatalysts, with higher reaction rate constant of 2.3 times than BWO/CeO 2 and 20.2 times than commercial CeO 2 . This work provides a visible photocatalytic strategy to efficiently purify VOCs containing soot, while perfectly transform soot pollutant into a valuable cocatalyst during catalytic processes.
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高影响因子
Nature Catalysis
·
2022
·Vol. 5
·期 10
·900-911
·
IF 40.706
Li Peng,Jiang Yaling,Hu Youcheng,Men Yana,Liu Yuwen,Cai Wenbin,Chen Shengli
The origin of the large kinetic pH effect in hydrogen electrocatalysis, that is, the approximately two orders of magnitude decrease in reaction kinetics when moving from acid to alkaline, remains far from having a consensus. Here we show that it is the significantly different connectivity of hydrogen-bond networks in electric double layers that causes the large kinetic pH effect. This result has been obtained by meticulously comparing the electric double layers of acid and alkaline interfaces from ab initio molecular dynamics simulations, and the computed vibrational density of states of water molecules in the interfaces simulated with ab initio molecular dynamics, with the results of in situ surface-enhanced infrared absorption spectroscopy. Using a Pt–Ru alloy as a model catalyst, we further reveal an unanticipated role of OH adsorption in improving the kinetics of alkaline hydrogen electrocatalysis, namely, by increasing the connectivity of hydrogen-bond networks in electric double layers rather than by merely affecting the energetics of surface reaction steps. These findings highlight the key roles of electric double layer structures in electrocatalysis.
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高影响因子
Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 10
·6316-6324
·
IF 12.732
Kun Xiang,Zhongxin Song,Dan Wu,Xiaohui Deng,Xuewan Wang,Wen You,Zhikun Peng,Lei Wang,Jing-Li Luo,Xian-Zhu Fu
Electrocatalytic seawater splitting has been considered as a transformative technology for industrial-scale hydrogen generation. However, the competition between the oxygen evolution reaction (OER) and chlorine evolution reaction (CER) at the anode with sluggish kinetics is the main bottleneck. Herein, an organic-oxidation-assisted strategy has been demonstrated, in which the thermodynamically favorable methanol selective oxidation reaction (MSOR) is used to suppress the undesired OER/CER using carbon paper supported Pt–Co3O4 electrocatalysts (denoted as Pt–Co3O4/CP), leading to hydrogen and value-added formate generation simultaneously with significantly low energy consumption. In the integrated two-electrode electrolyzer using Pt–Co3O4/CP bifunctional electrocatalysts, the required cell voltage at 10 mA cm−2 is only 0.555 V when adding 2.0 M methanol, which is 1022 mV lower than that in alkaline seawater. The integrated cell also produces hydrogen and formate simultaneously with high faradaic efficiency and considerable durability. The findings in this work represent a new direction for energy-saving production of hydrogen from seawater.
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高影响因子
APPLIED CATALYSIS A-GENERAL
·
2018
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IF 4.521
Ting Yi,Yibo Zhang,Xiangguang Yang
Pt@CeO 2 /MCM-56 (PCM) and CeO 2 -CuO (9:1)/MCM-56 (CCM) were combined to purify the exhaust emissions from diesel vehicles in three configuration statuses, defined as configuration A—where CCM stays above PCM, configuration B—where PCM stays above CCM, and configuration C—where CCM mixes with PCM homogeneously in loose contact. Among these combined catalysts, the configuration A is most favorable for the selective catalytic reduction (SCR) reaction, with >80% NO x conversion obtained at the temperature range of 150–550 °C and gas hourly space velocity (GHSV) of 240,000 ml g −1 h −1 . NH 3 -TPD, H 2- TPR and NH 3 conversion measurements demonstrated that NH 3 can be selectively used to reduce NO x in the configuration A but is over-oxidized if the reaction is operated in configuration B or configuration C status, deteriorating the deNO x activity at temperature above 250 °C. Hence, configuration A not only takes advantage but also overcomes the shortcomings of PCM and CCM, leading to high NO x conversion and N 2 selectivity. A significant decrease in the onset temperature of soot combustion was also observed in this research.
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高影响因子
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