Advanced Fiber Materials
·
2024
·Vol. 6
·期 3
·911-924
·
IF 17.2
Feng Mingxin,Feng Shuangjiang,Yu Tianrui,Zhu Shengyin,Cai Haoran,He Xu,Liu Yanmei,He Man,Bu Xiaohai,Huang Jun,Zhou Yuming
Existing personal thermal regulating fabrics fall short of meeting the demands for sustainable and protective outdoor temperature management. Here, a versatile and comfortable Janus fabric has been developed by embedding boron nitride nanosheets within a porous polyurethane matrix (BNNS@TPU) and introducing Ti 3 C 2 T x MXene into another layer of TPU pores (MXene/TPU). The well-distributed BNNS in porous TPU matrix enhances refractive index difference, increases porosity and optimizes pore size distribution, resulting in an excellent solar reflectivity ( R = 94.22%), while the distinct distribution of MXene in porous TPU effectively improves solar absorptivity ( α = 93.57%) and enhances the conduction loss of electromagnetic waves due to multiple scattering and reflection effects. With a simple flip, Janus fabric can switch between sub-ambient cooling of ~ 7.2 °C and super-ambient heating of ~ 46.0 °C to adapt to changing weather and seasonal conditions. The fabric achieves an electromagnetic interference shielding efficiency of 36 dB, protecting the human body from electromagnetic radiation, attributed to the hierarchical distribution of highly conductive MXene. Furthermore, Janus fabric offers excellent comfort, abrasion resistance, washability, and flame retardancy for practical wear. This study presents an effective strategy for developing personal thermal regulating fabrics with adaptability to environmental changes and resistance to electromagnetic radiation. Graphical abstract
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 46
·21537-21555
·
IF 3.5
Ma Jianfeng,Ma Shaoshuai,Shang Mengtian,Guo Luyao,Liu Cong,Xu Xinhua
In nature, various living organisms such as elephants can perceive and manipulate objects using their trunks. Inspired by biological structures, numerous hydrogel soft robots have been investigated; however, the weak mechanical properties and low conductivity of hydrogels limit their potential applications. Herein, the high-intensity, fast NIR-responsive hydrogel actuator based on bacterial cellulose (BC) as the passive layer and the high conductive hydrogel sensor with BC treated by thermionic source of butyl-3-methylimidazolium chloride (B-BC) as the passive layer are reported. The active layer consists of poly(N-isopropylacrylamide) (PNIPAm), functionalized silica nanoparticles (VSNPs), and 2-isocyanatoethyl methacrylate-modified MXene (M-MXene). Polymer is capable of grafting onto the VSNP surface to generate fast-transport channels for water expulsion, thereby significantly enhancing photoresponsive speed. Leveraging the pre-polymerization solution’s penetration into BC and the strong hydrogen bonding present, the interfacial toughness of the bilayer hydrogel (BC-GEL) reaches 33 N m −1 with a tensile strength of 2.1 MPa. As a proof of concept, BC-GEL is programmed as multidimensional grippers and perceptual actuators for intelligent traffic monitoring. Additionally, B-BC, obtained through in situ molecularization with a thermionic source, exhibits a conductivity of up to 6.74 S m −1 . Owing to the excellent sensing properties, B-BC-GEL can be prepared as somatosensory actuators and multi-appliance sensors. This research offers innovative insights into hydrogel self-sensing actuators for intelligent traffic safety monitoring systems and demonstrates significant potential for applications in human health detection and medical wearable electronic devices.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Tong Li,Wang Jie,Ma Yunjin,Wang Chunying,Fu Yue,Li Qi,Gao Chengjiang,Song Hui,Qin Ying,Zhao Chunyuan,Zhao Wei
Viruses rely on intracellular materials, including iron, to complete their life cycles and iron withholding may limit viral infections. However, the mechanisms through which viruses disrupt host iron homeostasis and the impact of intracellular iron on the host’s antiviral defense aren’t well studied. Here we show that viral infections facilitate the polyubiquitination and degradation of ferroportin (FPN1, the only cellular iron exporter) by upregulating the host E3 ubiquitin ligase DTX3L, leading to an elevation in cellular iron levels. Excessive ferrous iron suppresses type I IFN responses and autophagy by promoting TBK1 hydroxylation and STING carbonylation in macrophages. FPN1 deficiency suppresses host antiviral defense and facilitates viral replication in vitro and in vivo, while DTX3L deficiency has the opposite effect. These results reveal that viruses hijack host FPN1 to disrupt iron withholding and achieve immune escape, and suggest that iron homeostasis maintained by FPN1 is required for the optimal activation of TBK1- and STING-dependent antiviral responses.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Lu Yao,Tian Yu,Hong Bo,Xu Jingcai,Peng Xiaoling,Li Jing,Chen Hongwei,Qiu Shi,Zhang Nan,Wang Xinqing
Interface polarization and conduction loss constitutes a crucial loss mechanism in electromagnetic wave absorption (EWA) materials, the dissipation capacity could be enhanced by regulating the electrical conductivity and heterogeneous interfaces of EWA composites. In this work, the hollow CoFe 2 O 4 microspheres are fabricated using the hydrothermal method and are subsequently compounded with polyaniline (PANI) through mechanical mixing to synthesize hollow CoFe 2 O 4 @PANI (H-CFP) composites. By adjusting the PANI content and thereby altering the interfaces of CoFe 2 O 4 and PANI, the impact on the microstructures and EWA performance is systematically analyzed for the H-CFP composites. All results indicate that the CoFe 2 O 4 microspheres are well-dispersed on PANI and greatly affect the EWA performance of the H-CFP composites. The optimized H-CFP-4 displays the outstanding EWA capacity with a minimum reflection loss (RL min ) of − 43.60 dB and an effective absorption bandwidth (EAB) of 1.71 GHz at 5.5 mm. Additionally, the superior performance of the H-CFP composites in the domain of radar stealth is further verified through CST simulation. The excellent EWA behavior is attributed to the interface polarization, conduction loss and impedance matching due to the synergistic effect of conductive PANI and magnetic CoFe 2 O 4 microspheres. This study offers a novel concept for designing high-performance EWA materials suitable for complex electromagnetic environments and possesses broad application prospects.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-11
·
IF 5.3
Luo Shiyi,Zhang Jiexiang,Chen Lifen,Yao Yuanyuan,Wang Yueliang,Lin Bingyong,Huang Hong,Li Zuguang,Guo Longhua
The development of strategies for ultralow-content organic pollutants such as microcystin-LR (MC-LR) is critical for environmental monitoring and pollution prevention. Herein, a novel surface-enhanced electrogenerated chemiluminescence (SEECL) strategy integrated with resonance energy transfer (RET) was developed for ultrasensitive MC-LR detection. By co-modifying graphitic carbon nitride (g-C 3 N 4 ) as the donor and a core–shell nanocomposite (Au@SiO₂-Ir) as the acceptor on the electrode, the electron-transfer path was significantly shortened. Furthermore, gold nanoparticles (Au NPs) enhanced the ECL signal of the iridium complex through localized surface plasmon resonance (LSPR). After the successive introduction of ferrocene-labeled aptamer on the modified electrode, the ECL signal remarkably decreased. Upon specific recognition of the target by the aptamer, the ECL signal was restored, enabling ultrasensitive detection of microcystin-LR. The developed sensor exhibited good selectivity, ultrasensitivity, excellent stability for the determination of MC-LR, with a dynamic linear range of 1 to 10 ng/mL, and a limit of detection of about 0.86 pg/mL. The present work provides a novel way for the exploration of iridium complex in ECL realm with integrated surface enhance strategy. Graphical
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-12
·
IF 5.3
Ji Jingjing,Li Jiahao,Wu Minghui,Wang Bin,Lu Yu-nan,Zhang Chuhan,Shan Yanke,Liu Fei
A multiplex colloidal gold immunochromatographic assay (mCGIA) was developed for the simultaneous detection of feline calicivirus (FCV), feline panleukopenia virus (FPV), and feline herpesvirus (FHV) antibodies in feline serum. The expressed and purified recombinant FCV-VP1, FPV-VP2, and FHV-gD proteins exhibited strong antigenic reactivity. The mCGIA test strip achieved rapid (< 15 min) and specific detection, showing no cross-reactivity with other feline viral antibodies. The assay achieved a low visual limit of detection (vLOD) of 1:1 × 10 5 for FCV and 1:1 × 10 4 for FPV and FHV antibodies. Stability testing revealed 90% retention of detection capability after 4 weeks of storage at 37 °C. Reproducibility was robust, with intra- and inter-assay coefficients of variation (CVs) of less than 7% and 13%, respectively. The smartphone-based portable reader enabled quantitative detection with wide linear ranges (from 1:1000 to 1:100000 for FCV, 1:250 to 1:10000 for FPV and FHV) and excellent linearity (FCV: R 2 = 0.992, FPV and FHV: R 2 = 0.991). Compared with indirect ELISA using 164 clinical serum samples, the assay showed 98.17% (FCV), 98.78% (FPV), and 97.56% (FHV) concordance rates, respectively. This novel mCGIA platform provides a rapid, cost-effective tool for sero-surveillance, vaccine evaluation, and assisting clinical diagnosis, enhancing feline health management. Graphical
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Biochar
·
2025
·Vol. 7
·期 1
·1-11
·
IF 13.5
Li Fangfang,Duan Xizhao,Zhou Jiahao,Feng Siyue,Du Wei,He Xinhua,Peng Hongbo,Li Hao,Ahmad Shakeel,Pan Bo
Biochar has great potential in the application areas of carbon sequestration and environmental remediation. A significant amount of dissolved organic matter (DOM) may be released from biochar, which is highly reactive and mobile. However, it is unknown how this highly reactive DOM migrates in soil column, especially in rainfall events. In this study, pristine and aged corn biochars were applied to simulated soil columns filled with hematite/quartz or montmorillonite/quartz (3:7, w:w), and the DOM vertical migration was investigated under high- and low-intensity rainfalls. Results showed that montmorillonite could significantly inhibit the migration of the DOM by over 80% compared to the pure quartz system and 50% compared to hematite/quartz system. Minerals, especially montmorillonite, mainly preferentially adsorbed humic-like substance of DOM compared to polycyclic aromatic-like substance. Notably, under the same cumulative rainfall amount, DOM concentration gradually increased with the number of rainfall events in low-intensity rainfalls, but decreased sharply in high-intensity rainfalls. The relatively higher DOM concentration is beneficial to DOM sorption on minerals. These findings demonstrated that low-intensity rainfall facilitated the DOM retention on minerals especially in montmorillonite-rich soils. Graphical
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Experimental Hematology & Oncology
·
2025
·Vol. 14
·期 1
·1-17
·
IF 13.5
Ren Xueting,Wu Jinpeng,Li Jing,Zhai Zhen,Li Xiang,Guan Feng,Wang Meng,Ma Xiaobin,Tan Zengqi,Kang Huafeng,Lin Shuai
Background The abundance of PD-L1 on the surface of tumor cells is a critical factor in sensitizing these cells to T cell-mediated immune killing. While abnormal glycosylation of PD-L1 is known to influence its expression and function, the precise regulatory mechanisms remain unclear.Methods This study utilized bioinformatics analysis to explore the role of MGAT3, a key gene involved in the formation of the bisecting GlcNAc structure, in breast cancer (BC). Experimental approaches were employed to increase bisecting GlcNAc levels in BC cells, followed by assessments of PD-L1 expression, CD8+ T cell-mediated cytotoxicity, extracellular vesicle (EV)-associated PD-L1, and PD-L1/PD-1 interaction. Additionally, forskolin, a bisecting GlcNAc agonist, was combined with anti-PD-L1 antibody to evaluate its antitumor effects in vivo.Results MGAT3 was found to be expressed at low levels in BC tissues but positively correlated with CD8+ T cell infiltration. Elevating bisecting GlcNAc levels in BC cells significantly enhanced the cytotoxic efficacy of CD8+ T cells. High bisecting GlcNAc modification promoted PD-L1 degradation via the lysosomal pathway, reducing PD-L1 expression and its binding to PD-1. Furthermore, increased bisecting GlcNAc levels reduced PD-L1 in tumor cell-derived EVs, impairing the EVs’ ability to block CD8+ T cells and indirectly enhancing T cell cytotoxicity. The combined use of forskolin and anti-PD-L1 antibody significantly increased CD8+ T cell abundance and activity, achieving a more effective antitumor response in vivo.Conclusion sThese findings demonstrate that enhancing bisecting GlcNAc modification in BC cells promotes PD-L1 degradation and inhibits its binding to PD-1, thereby boosting CD8+ T cell-mediated cytotoxicity, providing a promising strategy for immune modulation in BC therapy.
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Lipids in Health and Disease
·
2025
·Vol. 24
·期 1
·1-16
·
IF 4.2
Li Lishuang,Ren Xing,Gao Xinyu,Zhao Yujia,Ma Yuman,Gong Junxiao,Yang Shuo,Sun Yanan,Wang Yi
Objective This study aimed to investigate the regulatory role and mechanisms of chenodeoxycholic acid (CDCA) on lipid metabolism, and to evaluate its therapeutic potential in lipid metabolism-related diseases such as acne, seborrheic alopecia, and prostate cancer, with the aim of identifying safer and more sustainable treatment alternatives. Methods Lipid-overproduction models were established using RM-1 (murine prostate cancer cells) and primary sebaceous gland cells, stimulated by linoleic acid (LA) and dihydrotestosterone (DHT), respectively. CDCA’s mechanisms were explored using transcriptomics, proteomics, and fatty acid-targeted metabolomics. In vivo validation was conducted via intradermal injection of CDCA into the sebaceous gland area of golden hamsters to assess its effect on sebaceous lipid metabolism. Results CDCA significantly reduced intracellular lipid accumulation in both murine prostate cancer cells (RM-1) and primary sebaceous gland cells, and suppressed the expression of the androgen receptor (AR), along with the downregulation of key lipogenic enzymes (SREBF1, FASN, FADS2). Mitochondrial membrane potential was restored in CDCA-treated cells. Multi-omics analyses revealed that CDCA modulated fatty acid biosynthesis and degradation, energy metabolism, mitochondrial function, and Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) signaling. Lipidomic profiling demonstrated a shift from saturated to unsaturated fatty acid dominance after CDCA treatment. In vivo, CDCA decreased sebaceous lipid accumulation and downregulated PPAR-γ expression in golden hamsters. Conclusion CDCA exerted multifaceted regulatory effects on lipid metabolism, hormone signaling, and mitochondrial dynamics. These effects contributed to the maintenance of sebaceous gland homeostasis and supported the development of innovative and potentially more biocompatible therapies for lipid-related disorders.
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高影响因子
Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 4
·1-19
·
IF 21.8
Lu Jiao Yang,Xie Zhi Xin,Zhou Jie,Wu Meng Yao,Tian Yu Qing,Fu Tian Tian,Wang Dong Hua,He Bin Sheng,Huang Wei Tao
Inspired by the emergent functions of molecular interactions and signal processing networks in living systems, exploring the multifunctional properties and perceptual capabilities of molecular or nanosystems and digitizing their signal responses and interaction networks remains a key challenge. Here, multifunctional antimonene-gold nanocomposites (AM-Au NCs) were synthesized efficiently and conveniently and applied in molecular sensing and digital applications, including multi-component detection and multi-coding information protection. After mixing surfactant, AM, Au 3 ⁺ and NaBH₄, AM-Au NCs with dispersed Au nanoparticles on AM nanosheets, exhibiting prominent Au plasmonic absorption. This endows NCs with unique broad-spectrum fluorescence quenching abilities, facilitating the development of fluorescence sensing platforms with dyes and fluorescence-labeled aptamers for selective and sensitive detection of metal ions and tumor biomarkers (CD63 and tumor-derived exosomes), even in real samples. Through binary or digital encoding of the selective responses and diverse DNA sequences of these sensing systems, a series of molecular encryption and hiding techniques are presented and applied to the molecular-level conservation of special text information. This work provides a new framework for the preparation and multifunctional use of two-dimensional nanocomposites, paving the way for greater integration of molecular sensing and information technology.
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Light-Science & Applications
·
2025
·Vol. 14
·期 1
·1-10
·
IF 23.4
Liu Ting,Zhu Zihao,Wang Shengjie,Shen Li,Abdurahman Alim,Liu Xiaomin,Lu Geyu
Diradicaloids have garnered significant attention due to their unique electronic, photophysical properties and potential applications in functional materials. Characterized by a narrow band gap and near-infrared (NIR) absorption, diradicaloids are promising candidates for NIR-guided photothermal therapy. However, they are often unstable and exhibit non-emissive properties due to high chemical reactivity and very efficient internal conversion. Herein, we report a remarkably stable Chichibabin diradicaloid, TT-CzPh, which exhibits NIR luminescence (λ em = 821 nm) with an efficient photoluminescence quantum yield (PLQY) of 6.4%. Surprisingly, TT-CzPh not only exhibits excellent NIR imaging but also has a very high photothermal conversion efficiency (PCE) of 87.5%. In vivo experiments with TT-CzPh nanoparticles demonstrated their effectiveness in tumor photoablation guided by NIR imaging. This work not only advances the development of stable, efficient luminescent Chichibabin’s hydrocarbons but also opens new avenues for bioimaging and cancer phototherapy applications.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 4
·1-12
·
IF 21.8
Wang Lijuan,Shi Yaqin,Wang Yuan,Jia Chunijang,Hou Jie,Su Yizhen,Xu Ben Bin,Liao Zhijian,Zhu Linhua
Synergistic effect between M-N X sites and M X O Y particles in hierarchical porous M–N-C catalysts holds great promises in boosting oxygen reduction reaction (ORR). In this work, 1,4-dicyanobenzene was utilized as a molecular template to prepare the hierarchical porous Fe–N-C catalysts with size-tunable Fe 3 O 4 particles for enhanced ORR in Zn-air battery. The as-prepared Fe 3 O 4 #Fe–N/C DB0.1 owned a half-potential of 0.90 V vs RHE, exceeding that of commercial 20%Pt/C (E 1/2 = 0.82 V vs RHE), showing a maximum power density of 321 mW cm −2 in a homemade Zn-air battery. Density functional theory (DFT) calculations indicate that the electronic interaction between Fe 3 O 4 and Fe-N 4 sites enhances the adsorption energy of *OOH, effectively optimizing the energy barrier for *O formation, significantly reducing the limiting energy barrier. Such superior ORR activity in Fe 3 O 4 #Fe–N/C originated from the optimized hierarchical pores and synergistic effect between Fe-N X sites and Fe 3 O 4 particles. This work provides a new and facile template strategy for engineering hierarchical porous carbon-based materials to achieve highly efficient catalytic reactions.
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