Signal Transduction and Targeted Therapy
·
2022
·Vol. 7
·期 1
·1-13
·
IF 38.104
Ma Xiao-Hui,Liu Jiang-Han-Zi,Liu Chun-Yu,Sun Wan-Yang,Duan Wen-Jun,Wang Guan,Kurihara Hiroshi,He Rong-Rong,Li Yi-Fang,Chen Yang,Shang Hongcai
Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed that irreversible myocardial damage resulted from I/R occurs due to oxidative stress evoked during the reperfusion phase. Here we demonstrate that ischemia triggers a specific redox reaction of polyunsaturated fatty acids (PUFA)-phospholipids in myocardial cells, which acts as a priming signaling that initiates the outbreak of robust oxidative damage in the reperfusion phase. Using animal and in vitro models, the crucial lipid species in I/R injury were identified to be oxidized PUFAs enriched phosphatidylethanolamines. Using multi-omics, arachidonic acid 15-lipoxygenase-1 (ALOX15) was identified as the primary mediator of ischemia-provoked phospholipid peroxidation, which was further confirmed using chemogenetic approaches. Collectively, our results reveal that ALOX15 induction in the ischemia phase acts as a “burning point” to ignite phospholipid oxidization into ferroptotic signals. This finding characterizes a novel molecular mechanism for myocardial ischemia injury and offers a potential therapeutic target for early intervention of I/R injury.
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高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-16
·
IF 17.694
Zhang Shaofang,Li Yonghui,Sun Si,Liu Ling,Mu Xiaoyu,Liu Shuhu,Jiao Menglu,Chen Xinzhu,Chen Ke,Ma Huizhen,Li Tuo,Liu Xiaoyu,Wang Hao,Zhang Jianning,Yang Jiang,Zhang Xiao-Dong
Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN 4 , VN 4 , and Fe-Cu-N 6 with catalytic activities surpassing natural enzymes. Notably, Rh/VN 4 preferably forms an Rh/V-O-N 4 active center to decrease reaction energy barriers and mediates a “two-sided oxygen-linked” reaction path, showing 4 and 5-fold higher affinities in peroxidase-like activity than the FeN 4 and natural horseradish peroxidase. Furthermore, RhN 4 presents a 20-fold improved affinity in the catalase-like activity compared to the natural catalase; Fe-Cu-N 6 displays selectivity towards the superoxide dismutase-like activity; VN 4 favors a 7-fold higher glutathione peroxidase-like activity than the natural glutathione peroxidase. Bioactive sutures with Rh/VN 4 show recyclable catalytic features without apparent decay in 1 month and accelerate the scalp healing from brain trauma by promoting the vascular endothelial growth factor, regulating the immune cells like macrophages, and diminishing inflammation.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 32
·15267-15275
·
IF 4.682
Huang Yong,Chen Feng,Meng Lingyao,Hu Yongming,Chen Wanping
Room temperature gas-sensitive metal oxides have received growing concern over their long-term stability in recent years. Presently, Pt-SnO 2 composite nanoceramics of 1 wt% Pt have been prepared, and the time dependence of their room temperature hydrogen sensing capability has been carefully studied. A strong variation with time was observed, with the room temperature response to 1% H 2− 20% O 2 –N2 decreased by a factor of several dozen after only one week. Heat treatments were found highly effective to activate those aged samples. Their room temperature hydrogen sensing capability was almost completely restored through 10 min heat treatments at temperatures as low as 130 °C. It is proposed that impurity gases in air slowly deposit on Pt in Pt–SnO 2 composite nanoceramics, and the catalytic role of Pt is deactivated by the deposition and then activated after their desorption through heat treatments. These results suggest that periodic mild heat treatments can be a simple and feasible way for some room temperature gas-sensitive metal oxides to maintain a high long-term stability.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 24
·19331-19343
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IF 2.779
Li Weiyin,Zhao Tongtong,Ding Lingling
Au@BSA was prepared at pH 8, pH 9, pH 10, pH 11, pH 11.4, and pH 12 as the working electrode of the non-enzymatic glucose sensor by biological template method. The six kinds of gold-cluster film working electrodes sintered by Au@BSA show golden color, especially the golden films corresponding to pH 8 and pH 12 are obvious. The gold-cluster films at pH 8, pH 9, pH 10, and pH 11 showed mono-layer gold nanoparticles, while the gold-cluster film at pH 11.4 showed porous structure. The gold-cluster film prepared at pH 12 presents a multi-layer 3D structure composed of a large number of gold nanoparticles. The linear detection range of the non-enzymatic glucose sensor prepared at pH 8 is the widest among the six sensors, and its sensitivity is also better than the other four sensors except the sensor prepared at pH 12. The sensor with the gold-cluster film-modified working electrode prepared at pH 12 show the highest sensitivity (330.002 μA mM −1 cm −2 ), because multi-layer 3D structure can bring more electric catalytic active site for this sensor. The electrochemical impedance spectroscopy showed that the specific surface area of the sensor prepared at pH 12 was much larger than that of the other five sensors. We provide a pH cycling method for once shaping preparation that can be extended to other metal films or metal-oxide films electrochemical interfaces. The Au@BSA non-enzymatic glucose sensor prepared in this paper is stable and can resist the toxicity of excessive chloride ions without losing activity.
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Advanced Composites and Hybrid Materials
·
2022
·Vol. 5
·期 3
·2138-2153
·
IF 11.806
Ding Zhaodong,Tian Zhongjian,Ji Xingxiang,Dai Hongqi,Si Chuanling
Inspired by the hydrophobic waxy layer structure on the back of the desert beetle, a super-hydrophobic material was prepared via the sol–gel silanisation of porous cellulose membrane (CM) using triethoxysilanes with different carbon chain lengths (R-siloxane) and (CH 3 CH 2 O) 4 Ti as a catalyst in 3 min. The R-siloxane CM was both super-hydrophobic and oleophilic (water contact angle (CA) > 150°, dodecane CA ≈ 0°) and resisted liquids with surface tensions as low as 15 mN·m −1 , correlated with the length of the R-siloxane and roughness of the CM. Instructed by the water collection behavior of the desert beetle, a pristine filter CM was added on the R-siloxane filter CM to accelerate separation of Span 80–stabilised water-in-oil emulsions by generating a surface energy gradient (SEG). The composite membrane with SEG separated the emulsions with higher surfactant concentrations and provided a higher efficiency up to 99.98% compared with single-layer R-siloxane membrane. This bio-inspired catalytic one-step approach for preparing R-siloxane cellulose composite membranes can potentially replace petroleum-based products for oil purification. Graphical Abstract Bio-inspired preparation of R-siloxane composite cellulose membrane with surface energy gradient for highly efficient water-in-oil emulsion separation.
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高影响因子
Advanced Composites and Hybrid Materials
·
2022
·Vol. 5
·期 3
·1939-1950
·
IF 11.806
He Yuxin,Zhou Mengyang,Mahmoud M. H. H.,Lu Xushen,He Guanyu,Zhang Li,Huang Mina,Elnaggar Ashraf Y.,Lei Qiang,Liu Hu,Liu Chuntai,Azab Islam H. El
With the rapid development of flexible wearable strain sensor systems, electronic textiles with comfort and controllable strain/pressure-sensing capabilities have attracted great interest. However, it is still a great challenge to prepare multifunctional wearable strain/pressure sensor with an ultra-low detection limit through a facile and cost-effective method. Here, conductive carbon nanotubes modified silk nonwoven fabric (CNTs/SNWF) composite was successfully prepared by the surface micro-dissolution and adhesion technology (SD&AT). Micromorphology analysis showed that CNTs were adhered firmly on the surface of silk fiber to form an effective conductive network. The conductive CNTs/SNWF-based strain/pressure sensor can detect a strain as low as 0.05% and an ultralow pressure of 10 Pa, showing an ultrahigh discernibility. Besides, it also exhibited excellent sensing stability and reproductivity under different conditions, making it applicable in the field of real-time human movement monitoring. Moreover, electronic skin was also established based on the conductive CNTs/SNWF to recognize different tactile stimulus. Interestingly, the prepared conductive CNTs/SNWF also displayed great applicability for optical and thermal sensing, endowing it with more functionality for next-generation wearable electronics.
Graphical abstract
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高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2022
·Vol. 30
·期 10
·4287-4303
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IF 4.705
Shi Liang,Liu Wenwu,Zhang Xiaomei,Hu Jingsong
In this study, an environmentally friendly lignin-based hybrid hydrogel (LS/OMMT) was prepared by grafting of acrylamide (AM) and acrylic acid (AA) onto calcium lignosulfonate (LS) and homogeneously distributing organic montmorillonite (OMMT) using an ultrasonic technique. FT-IR, XRD, TGA, SEM, EDS, BET, and XPS were used to characterize the physicochemical and structural properties of LS/OMMT. Then, LS/OMMT was applied to remove methylene blue (MB) from an aqueous solution and a systematic study of pH, contact time and initial MB concentration was carried out. The MB adsorption capacity on LS/OMMT was up to 492.7 mg g −1 at 313.15 K and pH 7.0. The Langmuir model well described the MB adsorption on LS/OMMT and the calculated thermodynamic parameters, such as ΔG°, ΔH°, and ΔS°, suggested that MB adsorption on LS/OMMT was spontaneous and endothermic. LS/OMMT adsorption of MB followed a pseudo-second-order kinetic model. Electrostatic attraction and hydrogen-bonding interaction were the mechanisms of adsorption. As a result, this study illustrates that LS/OMMT is an environmentally friendly and efficient adsorbent for wastewater treatment applications.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 26
·12672-12684
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IF 4.682
Wu Leqi,Yu Qijian,Wang Sui,Mao Jie,Guo Zhiyong,Hu Yufang
Intelligent hydrogels are widely studied for their unique responsiveness, but single responsiveness limited the application of hydrogels. Compared with traditional electronic conducting hydrogels, ionic conducting hydrogels have good transparency, mechanical properties, and wear resistance, but the preparation of conductive hydrogels with stability, and multi-functional response is still a difficult challenge. This work reports a preparation strategy for the development of dual cross-linked poly(N-isopropylacrylamide-co-acrylic acid) P(NIPAM-co-AA) hydrogel through rapid photopolymerization. N,N′-methylenebis-acrylamide (BIS) is used as a cross-linking agent to form chemical cross-linking. At the same time, by introducing AA and Al 3+ to form electrostatic and coordination interactions, the hydrogel has enhanced conductivity and exhibits adjustable low critical solution temperature behavior. The hydrogel achieved visual temperature response, enhanced mechanical properties, and stable electrical conductivity. The hydrogel can be applied to visual qualitative detection of the intelligent windows by using the high sensitivity temperature response characteristics. Stable high conductivity also motivates the design of thermo-sensitive sensor windows and visual detection materials. This study will promote the synthesis of hydrogels with multiple response capabilities and realize their applications in smart devices.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 39
·期 2
·246-252
·
IF 2.726
Wang Renquan,Li Tiantian,Gao Rui,Qin Jiaqi,Li Mengyao,Guo Yizheng,Song Yujiang
With the excessive consumption of fossil fuels and the massive emission of CO 2 , it has led to a series of environmental crises posing a serious threat to sustainable development. Electrochemical CO 2 reduction reaction (CO 2 RR) to ethylene helps solve these serious environmental crises. Herein, we report the synthesis of a copper-based electrocatalyst by pyrolysis of yolk-shell structured HKUST-1 with partial substitution of trimesic acid by benzimidazole(nitrogen source). The electrocatalyst exhibits an ethylene Faradic efficiency(FE) of 25.8% and a partial ethylene current density of 23.7 mA/cm 2 , in addition, the electrocatalyst can maintain stable performance during 10 h of electrolysis, which are all better than those of the electrocatalyst without nitrogen dopant. According to electrochemical measurements and X-ray photoelectron spectroscopy(XPS), we propose that the nitrogen dopant plays an effective role in stabilizing Cu(I) species and promoting CO 2 molecules activation, as well as suppressing the reduction of Cu(I) species during electrolysis. Eventually, the performance of the electrocatalyst toward CO 2 RR is studied in a flow cell. This work provides a new route for the design of Cu-based electrocatalyst toward electrochemical CO 2 conversion into ethylene.
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高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2022
·Vol. 37
·期 4
·765-772
·
IF 1.271
Du Yonggang,Shi Gonghui,Wang Jiaming,Wang Yiming,Wang Xuhua,Wang Liwei,Yang Jinhui,Ren Shitong
The bio-based epoxy nanocomposite (GAER/DOPO-POSS) was prepared from gallic epoxy resin (GAER) and polyhedral oligomeric silsesquioxane (which containing 9,10-dihydrogen-9-oxo-10-phosphorus-phenanthrene-10-oxide groups, called DOPO-POSS). The polyhedral oligomeric silsesquioxane containing epoxy groups (E-POSS) was grafted onto aminated graphene oxide (E-GO), then the novel POSS-E-GO was obtained. The POSS-E-GO was used as modifier for GAER/DOPO-POSS nanocomposite. The influences of POSS-E-GO content on mechanical properties, dynamic mechanical properties and thermal stability of GAER/DOPO-POSS nanocomposites were determined. The experimental results show that POSS-E-GO can significantly improve the toughness of the GAER/DOPO-POSS nanocomposite. When 0.5wt% POSS-E-GO was added in GAER/DOPO-POSS nanocomposite, the impact strength of the nanocomposite was 4.74 kJ/m 2 higher than that in the absence of POSS-E-GO, meantime the initial thermal degradation temperature was 277 °C.
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AAPS PHARMSCITECH
·
2022
·Vol. 23
·期 6
·1-11
·
IF 4.026
Zou Linghui,Zhang Zhongbin,Chen Jinqing,Yang Xu,Li Yuyang,Tang Jing,Du Xiaolu,Tang Ling,Liang Dan,Zhu Xiaoyong,Feng Jianfang,Ding Wenya
β-Cyclodextrin (CD) and chitosan (CS) have attracted great attention due to their unique properties and structures. β-Cyclodextrin-grafted chitosan (CD-CS) has been widely used as a drug carrier to prepare nano-formulations for drug delivery. However, few researches have been conducted to investigate the effect of CD-CS as an excipient on cellular uptake and intestinal absorption. Herein, Caco-2 cells were used to investigate the influence of CD-CS on cellular uptake. The MTT assay showed that CD-CS was non-toxic to Caco-2 cells in concentrations ranging from 15.62 to 125 μg/mL. Confocal laser microscopy and flow cytometry measurements indicated that the uptake ability of Caco-2 cells was significantly enhanced after being treated with CD-CS at a concentration of 31.25 μg/mL or incubation for 0.5 h, and the uptake enhancement gradually increased with increasing CD-CS concentration and incubation time. The Caco-2 monolayer cell model and the everted intestinal sac method were employed to preliminarily explore the mechanism of the improved intestinal absorption. The results demonstrated that CD-CS might open the tight junctions and enhance the clathrin-dependent endocytosis, macro-pinocytosis, and phagocytosis of the intestinal epithelial cells. Such findings can serve as references and inspiration for the design of absorption enhancers. Graphical abstract
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高影响因子
IONICS
·
2022
·Vol. 28
·期 10
·4685-4695
·
IF 2.961
Wang Jie,Xuan Haicheng,Meng Lingxin,Yang Jiangtao,Yang Jiale,Liang Xiaohong,Li Yuping,Han Peide
The development of low-cost and high-efficiency hydrogen evolution reaction (HER) electrocatalysts has become extremely essential to address global energy issues. Herein, we have fabricated arrays of nitrogen and sulfur co-doped CoMoO 4 ultrathin nanosheets grown on nickel foam (N, S-CoMoO 4 /NF 400 ). The experimental results demonstrate that modulating the electronic structure of CoMoO 4 by co-doping N and S atoms is one of the most powerful methods to boost the performance of HER. N, S-CoMoO 4 /NF 400 displays superior HER activity under alkaline environment, with overpotentials of 58 and 119 mV at 10 and 100 mA cm −2 . The excellent performance of the N, S-CoMoO 4 /NF 400 electrode proves that the N, S co-doping engineering can significantly improve the catalytic activity of transition metal-based oxide HER.
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