INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2023
·
IF 7.2
Peng Cui,Tongheng Wang,Xuhai Zhang,Chongyang Ba,Yangkun Wu,Kai Peng,Yuqiao Zeng,Jianqing Jiang
Though various active electrocatalysts for hydrogen evolution reaction (HER) have been reported, it remains a challenge to develop efficient non-noble HER catalysts with pH-independent catalytic activity and high stability. In this work, novel porous NiCoCuP was prepared by combining the dynamic hydrogen bubble templated deposition with a low-temperature phosphorization process. The three-dimensional hierarchical porous structure provided the NiCoCuP with both self-supporting ability and ideal channels for fast mass transportation. As a consequence, the NiCoCuP foam exhibited excellent HER catalytic activity and outstanding durability over the entire pH range.
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CHEMICAL ENGINEERING JOURNAL
·
2023
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IF 15.1
Qingxiang Guo,Chengbo Yin,Yuzhe Chen,Zhuoyao Fang,Hong Xiao,Jinsong He,Liping Huang,Ganxue Wu,Zhenxing Zeng,Fei Shen,Shihuai Deng,Fangying Ji,Dexin Fang
Layered double hydroxides (LDH) are potentially industry-producible adsorption materials for phosphate removal from wastewater. However, the sustainable desorption strategy to support its application in practical scenarios is still lacking. In this study, we proposed to control the phosphate uptake and release behavior of LDH through periodic pH regulation. After twelve stages of regulation, the restoration rates of phosphate and pH were maintained at 86.5 % and 96.2 %, respectively, indicating that LDH was robust to resist multiple rounds of pH shock. But extremely acidic or alkaline conditions can accelerate metal ion loss from LDH laminates, so the regulation needs to be in a mild pH range (4.0–11.0). Under this condition, an alternating pattern appeared in the surface interaction of LDH and phosphate. Spectroscopic data showed that the formation of metal-phosphate coordination complexes (M O P) was the dominant mode of phosphate adsorption at high pH, while the formation of electrostatic attraction complexes dominated at low pH. For the interlayer interaction, it is interesting to find the exchanged Cl − ions would not re-enter the interlayer of LDH, suggesting that the charge-balancing anions were almost entirely composed of phosphate. Quantitative analysis revealed that the ion-exchanged phosphate amount kept increasing/decreasing in parallel with the total adsorbed amount, implying the driving effect of ion exchange on the periodic uptake/release of phosphate. Overall, the switching mechanism and reversibility of the binding state of phosphate-LDH were revealed during pH regulation. These findings may provide new insights for the development of sustainable desorption options for LDH.
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Biosensors-Basel
·
2023
·Vol. 13
·期 2
·157
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IF 5.4
Dong Liu,Zhenyu Liu,Shilun Feng,Zehang Gao,Ran Chen,Gaozhe Cai,Shengtai Bian
Traditional exercise training monitoring is based on invasive blood testing methods. As sweat can reveal abundant blood-related physiological information about health, wearable sweat sensors have received significant research attention and become increasingly popular in the field of exercise training monitoring. However, most of these sensors are used to measure physical indicators such as heart rate, blood pressure, respiration, etc., demanding a versatile sensor that can detect relevant biochemical indicators in body fluids. In this work, we proposed a wearable microfluidic sweat chip combined with smartphone image processing to realize non-invasive in situ analysis of epidermal sweat for sports practitioners. The polydimethylsiloxane (PDMS) based chip was modified with nonionic surfactants to ensure good hydrophilicity for the automatic collection of sweat. Besides, a simple, reliable, and low-cost paper-based sensor was prepared for high-performance sensing of glucose concentration and pH in sweat. Under optimized conditions, this proposed chip can detect glucose with low concentrations from 0.05 mM to 0.40 mM, with a pH range of 4.0 to 6.5 for human sweat. The ability of this microfluidic chip for human sweat analysis was demonstrated by dynamically tracking the changes in glucose concentration and pH in long-distance running subjects.Keywords:exercise monitoring;microfluidics;sweat analysis;glucose;pH
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LANGMUIR
·
2023
·
IF 3.9
Pei Liu,Xiaomei Pei,Zhenggang Cui,Binglei Song,Jianzhong Jiang,Bernard P. Binks
A novel nonionic–anionic Bola surfactant (abbreviated as CH3O(EO)7-R11-COOH) was designed and synthesized by condensation of methyl polyoxyethylene (7) ether with 12-bromododecanoic acid. In neutral aqueous solution, the surfactant behaves as a nonionic one and can stabilize oil-in-water (O/W) conventional emulsions alone and costabilize O/W Pickering emulsions with positively charged alumina nanoparticles with n-decane as the oil. In alkaline solution, the carboxylic acid group is deprotonated, becoming anionic and the surfactant is converted to Bola form, which is an inferior emulsifier and does not adsorb on particle surfaces, resulting in demulsification of both kinds of emulsions. With strong hydrophilicity, both the Bola surfactant and the bare particles return to the aqueous phase after demulsification, which is therefore recyclable and reusable in accordance with sustainable chemistry and engineering. In acidic media between pH 3 and 6, the ethyleneoxy groups tend to desorb from particle surfaces, slightly reducing the hydrophobicity of the particles. However, Pickering emulsions are still stable but their droplet size increases on lowering the pH. The Pickering emulsions are therefore pH-responsive and size-controllable. This newly designed Bola surfactant is effective in preparing smart emulsions, which are extensively applied in heterogeneous catalysis, oil product transportation, emulsion polymerization, and new material preparation.
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MICROCHIMICA ACTA
·
2022
·Vol. 190
·期 1
·1-9
·
IF 6.408
Ma Yao,Zhao Liping,Li Linsen,Zhu Chao,Qu Feng
A new type of aptamer-functionalized pH-responsive polymer-modified magnetic nanoparticles (ApMNPs) is introduced for specific enrichment and sensitive determination of lactoferrin (Lf) in complex matrixes. In the construction, Fe 3 O 4 @3-(Triethoxysilyl)propylmethacrylate@poly(4-Vinyl-1, 3-dioxolan-2-one-acrylic acid) (Fe 3 O 4 @MPS@p(VEC-AA)) were synthesized as pH-responsive polymer-modified magnetic nanoparticles (pMNPs) through free radical polymerization to increase the tunable interaction. Lf-binding aptamers were conjugated onto pMNPs through the reaction of amino-group in aptamer and epoxide-group in VEC, innovatively applied to prepare Lf-ApMNPs. On the basis of the synergistic effect of specific affinity of aptamer on Lf and tunable hydrophobic/hydrophilic property of pH-responsive polymer, Lf-ApMNPs presented good selectivity toward Lf, excellent adsorption capacity (as high as 233.9 mg g −1 ), as well as good recoveries in the range 93.6–99.6% in Lf-related nutrition samples. Significantly, the introduction of pH-responsive monomer (AA) effectively regulated the adsorption–desorption process of Lf, with the function similar to a switch. Moreover, the good performances of Ct-ApMNPs toward α-Chymotrypsin showed that ApMNPs exhibited universality to other proteins through easily changing the binding aptamer, thereby offering a facile and efficient approach for specific enrichment and sensitive determination of targets in real biological samples. Graphical Abstract
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NANOTECHNOLOGY
·
2023
·Vol. 34
·期 12
·125501
·
IF 3.5
Shenna Chen,Yunping Hao,Ronghui Li,Yanxu Liu,Jinxia Li,Lina Geng
Recently, carbon dots (CDs) have exhibited promising applications in the fluorescence detection of various ions and biomolecules. In this work, one kind of nitrogen-doped CDs (N-CDs) with high fluorescence intensity was synthesized, characterized by transmission electron microscopy, x-ray diffraction, x-ray photoelectron spectroscopy, Fourier-transform infrared, UV–vis absorption spectra, and fluorescence spectra. The results show that the spherical and uniform N-CDs (quantum yield: 60.2%) have remarkable fluorescence properties and photostability, which makes N-CDs can be utilized as an 'on-off-on' sensor for Hg2+ and glutathione (GSH). In addition, the pH-sensitive behavior of N-CDs makes it also applicable to H+ detection under acid conditions (pKa = 3.53). The linear range of the 'turn-off' sensor detecting Hg2+ was 0.014–50 μM, with a 0.014 μM limit of detection (LOD). GSH was detected by the fluorescence 'turn-on' method with a linear range of 0.125–60 μM and a LOD of 0.125 μM. The outstanding performance of N-CDs makes it potential applications in ecological pollution and biomolecule visualization monitoring.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Qian Liu,Zhenrong Tan,Dafeng Zheng,Xueqing Qiu
In order to improve the effect of anti-tumor drugs, a magnetic delivery system for targeted drug was reported. Firstly, aminated lignosulfonate (ALS) and carboxymethyl chitosan (CMCS) were used to fabricate nano Fe 3 O 4 to obtain pH-responsive magnetic Fe 3 O 4 /CMCS/ALS nanoparticles. Then the nanoparticles were loaded with doxorubicin hydrochloride (DOX), realizing the targeted delivery and controlled release of anti-tumor drugs. It was found that the amount of crosslinking agent and emulsifier were the key factors affecting the morphology and size of the magnetic nanoparticles. Under optimized conditions, the particle size was about 79.9–169.9 nm, exhibiting excellent pH responsiveness. When the drug-to-material ratio was 11:10, the DOX loading rate and the encapsulation rate of the nanoparticles was 48.68 % and 86.23 %. While the Fe 3 O 4 /CMCS/ALS-DOX particles could release 63.14 %, 56.71 %, and 14.28 % of DOX at pH 4.0, 5.3, and 7.4, respectively. The results showed that the Fe 3 O 4 /CMCS/ALS particles exhibited excellent drug loading and release behavior based on the pH responsiveness, which could be described by Langmuir adsorption model and Fick's law of diffusion respectively. MTT assay and Live/dead staining experiments also showed that the drug-loaded particles had obvious growth inhibition on cancer cells.
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Biomaterials Science
·
2023
·
IF 6.6
Siyi Li,Qinglin Wang,Yingying Ren,Pengfei Zhong,Pengtao Bao,Shanyue Guan,Xiaochen Qiu,Xiaozhong Qu
The development of cancer treatment is of great importance especially in the early stage. In this work, we synthesized pH-sensitive amphiphilic ruthenium complex containing two alkyl chains and two PEG chains which was utilized as oxygen sensitive fluorescent probe for co-assembly with lipids to harvest a liposomal delivery system (RuPC) for the encapsulation of a photothermal agent indocyanine green (ICG). The resultant ICG encapsulated liposome (RuPC@ICG) enabled to deliver ICG into cells via membrane fusion pathway by which the ruthenium complex was localized in the cell membrane for better detecting the extracellular oxygen concentration. Such characteristic endowed the ratiometric imaging feature to distinguish tumour location from normal tissues at just 3 days after cancer cells were implanted by monitoring the hypoxia condition and tracing the metabolism. Moreover, the pH sensitivity of the liposomes favoured the cell uptake, and improved the anti-tumour efficiency of the formulation in vivo under NIR irradiation. Should liposomal systems have less safety issue, our work not only provided a facile way for the construction of theragnostics by combining phototherapy with photoluminescent imaging, but hopefully paving the way for the clinical translation from bench to bedside.
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EUROPEAN POLYMER JOURNAL
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2023
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IF 6
Shulan Jiang,Li Xia,Hao Ma,Tingting Yang,Linmao Qian
Smart hydrogels have received attentions for the great potentials in biomedical and robots applications. However, the deformation performance of hydrogels still needs to be improved, especially for the pH and thermal dual responsive hydrogels. In this study, a pH and temperature dual-responsive poly(acrylamide-acrylic acid-3-acrylamidophenylboronic acid)/Poly(N-isopropylacrylamide) (P(AAm-AAc-3-AAPBA)/PNIPAM) bilayer structures have been prepared by UV polymerization. The PNIPAM layer shrinks/swells when the temperature is higher/lower than the low critical solution temperature , while P(AAm-AAc-3-AAPBA) layer will swell/shrink when pH is too high/low. The volume change trend of the two layer is different, resulting in the bending behaviors of P(AAm-AAc-3-AAPBA)/PNIPAM hydrogel actuator. The bidirectional bending performance can be reversibly, repeatedly, and precisely controlled by pH and temperature-induced cooperative swelling-shrinking properties from both layers. The bending angle of the bilayer structure achieves about 1420° at the environment of pH 2 and 55 ℃. It takes about 70 s to convert the bending angle of the bilayer structures from 355° (10 ℃, pH 2) to −360° (55 ℃, pH 12). In addition, three kinds of biomimetic hydrogel structures, such as mechanical gripper, bionic flower and bionic hand, have been prepared and demonstrated good performance. The obtained P(AAm-AAc-3-AAPBA)/PNIPAM hydrogels exhibit excellent pH and thermal responsive bending properties, which enable them as an ideal smart hydrogel system.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Fangqian Sui,Zengjun Fang,Lingjun Li,Xinhuan Wan,Yongqing Zhang,Xiaoqing Cai
Multifunctional nanoparticles have attracted significant attentions for oncology and cancer treatment. In fact, they could address critical point for tumour treatment by creating a stimuli-responsive targeted drug delivery system that can exist stably in the systemic circulation, efficiently penetrate the tumour tissue, and then accumulate in tumour cells in large quantities. A novel stepwise pH-responsive multifunctional nanoparticles (FPDPCNPs/DTX) for targeted delivery of the antitumour drug docetaxel (DTX) is prepared by coating a tumour acidity-sensitive “sheddable” FA modified β-carboxylic amide functionalized PEG layer (folic acid-polyethylene glycol-2,3-dimethylmaleic anhydride, FA-PEG-DA) on the cationic drug-loaded core (poly(β-amino ester-cholesterol, PAE-Chol) through electrostatic interaction in this study. The charge shielding behaviour of the FPDPCNPs/DTX was confirmed by zeta potential assay. The surface charges of the nanoparticles can change from positive to negative after PEG coating. The IC 50 values of FPDPCNPs/DTX was 3.04 times higher than that of PEG “unsheddable” nanoparticles in cytotoxicity experiments. The results of in vivo experiment further showed that FPDPCNPs/DTX had enhanced tumour targeting effect, the tumour inhibition rate of FPDPCNPs/DTX was as high as 81.99%, which was 1.51 times that of free DTX. Under a micro acidic environment and folate receptor (FR)-mediated targeting, FPDPCNPs/DTX contributed to more uptake of DTX by MCF-7 cells. In summary, FPDPCNPs/DTX as a multifunctional nano-drug delivery system provides a promising strategy for efficiently delivering antitumour drugs.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Shuifang Mao,Yanming Ren,Shiguo Chen,Donghong Liu,Jinhu Tian,Xingqian Ye
Favorable hydrogels can be used as a material to deliver bioactive molecules and improve the stability of bioactive substances, while their safety needs to be improved. In this study, protocatechuic acid (PCA) and Fe 3+ were rapidly self-assembled to form a metal-phenolic network under different pH conditions, and then sodium alginate (SA) was added to prepare the SA/PCA/Fe hydrogel without adding other chemical reagents. The structural characteristic of SA/PCA/Fe hydrogel was characterized by infrared spectroscopy, X-ray diffraction analysis and scanning electron microscopy. The results showed that the structures of SA/PCA/Fe hydrogels prepared at different pH values were significantly different. The texture analysis, water-holding measurement and rheological analysis indicated that the SA/PCA/Fe hydrogel showed higher gel strength, water holding capacity and storage modulus. Thermogravimetric analysis illuminated that the SA/PCA/Fe hydrogel enhanced the thermal stability of free anthocyanins through encapsulating anthocyanins. Moreover, in vitro simulated digestion experiment revealed that SA/PCA/Fe hydrogel could control the release of anthocyanins in the simulated gastrointestinal tract. To sum up, this present study might provide a safer and feasible way for the delivery of bioactive substances.
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Materials Today Bio
·
2023
·
IF 8.2
Zhong-Hua Chen,De-Yan Du,Yi-Fei Fu,Jun-Jie Wu,Dan-Yang Guo,Yue-Yue Li,Meng-Nan Chen,Zheng-Dong Yuan,Kai-Wen Zhang,Zhen-Yu Zhang,Xia Li,Feng-Lai Yuan
Bone targeted delivery of estrogen offers great promise for the clinical application of estrogen in the treatment of postmenopausal osteoporosis (PMOP). However, the current bone-targeted drug delivery system still has several issues that need to be solved, such as the side effects of bone-targeted modifier molecules and the failure of the delivery system to release rapidly in the bone tissue. It is important to aggressively search for new bone-targeted modifier molecules and bone microenvironment-responsive delivery vehicles. Inspired by the distribution of citric acid (CA) mainly in bone tissue and the acidic bone resorption microenvironment, we constructed a CA-modified diblock copolymer poly(2-ethyl-2-oxazoline)–poly(ε-caprolactone) (CA-PEOz) drug delivery system. In our study, we found that the CA modification significantly increased the bone targeting of this drug delivery system, and the delivery system was able to achieve rapid drug release under bone acidic conditions. The delivery system significantly reduced bone loss in postmenopausal osteoporotic mice with a significant reduction in estrogenic side effects on the uterus. In summary, our study shows that CA can act as an effective bone targeting modifier molecule and provides a new option for bone targeting modifications. Our study also provides a new approach for bone-targeted delivery of estrogen for the treatment of PMOP.
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