INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Zhiwan Chen,Mengfei Yuan,Haojing Li,Lihua Li,Binghong Luo,Lu Lu,Qi Xiang,Shan Ding
The inflammation of chronic wounds plays a key hindering role in the wound healing process. Slowing down the inflammatory response is significant for the repair of chronic wounds. Studies have revealed that succinate can inactivate gastrin D (GSDMD) and prevent cell pyroptosis. Chitosan has anti-inflammatory properties and is commonly used as wound healing material. Therefore, we used succinic anhydride to modify chitosan and found that N-succinylated chitosan (NSC) was more effective in inhibiting inflammation. The results showed that the stimulation of TNF-α and high glucose induces overexpression of capase-1 and TNF-α in human umbilical vein endothelial cells (HUVEC), and down-expression of CD31. However, the expression of capase-1 and TNF-α decreased, while the expression of CD31, VEGF and IL-10 was up-regulated significantly in dysfunctional HUVEC cells after treated by NSC. Moreover, NSC can speed wound healing, histological examination results showed that wounds treated with NSC exhibited faster epithelial tissue regeneration and thicker collagen deposition. Overall, this study results suggested that NSC has the function of restoring the physiological functions of dysfunctional HUVEC cells induced by high glucose and TNF-α, and can accelerate wound healing, indicating that NSC has good potential to be applied in inflammatory chronic wounds such as diabetic foot.
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高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Yanbo Luo,Yuwei Liu,Xiangyu Li,Xingyi Jiang,Yongqiang Pang,Di Chen
α-Dicarbonyl compounds (α-DCs), formed during food heating and storage, are crucial for assessing food safety and quality. However, the low concentration, high reactivity, and absence of chromophores of α-DCs make their detection challenging, often requiring complex derivatization and extraction. This study developed a one-pot method for α-DCs that combines derivatization and magnetic solid-phase extraction. By mixing the sample, 2,3-diaminonaphthalene, and Fe 3 O 4 /MWCNTs-OH in a vial, simultaneous derivatization and extraction are achieved. Derivatization converts α-DCs into hydrophobic products, facilitating their adsorption and enabling sensitive liquid chromatography-fluorescence detection. The introduction of the magnetic adsorbent allows phase separation to be easily achieved using an external magnet, simplifying and speeding up the process. The detection limits for six α-DCs (glyoxal, methylglyoxal, diacetyl, 2,3-pentanedione, D-glucosone, and 3-deoxyglucosone) were determined to be in the range of 0.4–3.5 nM. This rapid and convenient analytical approach was successfully applied to analyze α-DCs in juices, coffees, and tea beverages.
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GREEN CHEMISTRY
·
2024
·
IF 9.3
Qi Zhu,Bo Gong,Shuquan Huang,Yangxin Jin,Shengqin Liu,Shan Shao,Yuwei Yang,Taren Cataldo,Nicholas M. Bedford,Jason Chun-Ho Lam
The electrochemical selective oxidative transformation of lignin feedstocks into valuable oxygenated aromatics is essential to establish a sustainable biorefinery. In this study, we used a rhombohedral ZnIn2S4 (R-ZIS) electrocatalyst to realise the efficient anodic cleavage of C–O bonds in benzyl phenyl ether (BPE), an α-O-4 lignin model compound, to a series of industrially relevant oxygenated mono-aromatics. The reaction occurred at +2 VAg/AgCl, 65 °C, and atmospheric pressure. In optimised conditions, the reaction achieved over 99% conversion rate with a Faraday efficiency of 51.6% at 91.3% conversion of BPE, that is greater than most known electrocatalytic oxidative cleavage examples. The ZnIn2S4 electrocatalyst was deposited on a carbon cloth support, and its structural properties and surface morphology were extensively investigated. Systematic potential controlled electrolysis coupled with 18O isotopic labelling confirmed that C–O scission occurred exclusively between the benzylic carbon and phenolic oxygen. Furthermore, substrate competition studies were conducted to compare the electrocatalytic performance of the R-ZIS catalyst with that of its structural analogue, hexagonal ZnIn2S4, in terms of BPE and mono-aromatics conversion. The experimental results were supported by density functional theory calculations. The substrate scoping study revealed the suitability of the R-ZIS induced electrocatalytic system for a variety of substituted α-O-4/β-O-4 model dimers. Overall, this work demonstrates an efficient anodic process that can enable the atom-efficient valorisation of lignin to produce oxygenated aromatics. The proposed approach can complement the numerous existing reductive lignin cleavage methods.
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高影响因子
Foods
·
2021
·Vol. 10
·期 2
·315
·
IF 4.35
Zhenxing Wang,Zongcai Tu,Xing Xie,Hao Cui,Kin Weng Kong,Lu Zhang
This study aims to evaluate the bioactive components, in vitro bioactivities, and in vivo hypoglycemic effect ofP. frutescensleaf, which is a traditional medicine-food homology plant.P. frutescensmethanol crude extract and its fractions (petroleum ether, chloroform, ethyl acetate, n-butanol fractions, and aqueous phase residue) were prepared by ultrasound-enzyme assisted extraction and liquid–liquid extraction. Among the samples, the ethyl acetate fraction possessed the high total phenolic (440.48 μg GAE/mg DE) and flavonoid content (455.22 μg RE/mg DE), the best antioxidant activity (the DPPH radical, ABTS radical, and superoxide anion scavenging activity, and ferric reducing antioxidant power were 1.71, 1.14, 2.40, 1.29, and 2.4 times higher than that of control Vc, respectively), the most powerful α-glucosidase inhibitory ability with the IC50value of 190.03 μg/mL which was 2.2-folds higher than control acarbose, the strongest proliferative inhibitory ability against MCF-7 and HepG2 cell with the IC50values of 37.92 and 13.43 μg/mL, which were considerable with control cisplatin, as well as certain inhibition abilities on acetylcholinesterase and tyrosinase. HPLC analysis showed that the luteolin, rosmarinic acid, rutin, and catechin were the dominant components of the ethyl acetate fraction. Animal experiments further demonstrated that the ethyl acetate fraction could significantly decrease the serum glucose level, food, and water intake of streptozotocin-induced diabetic SD rats, increase the body weight, modulate their serum levels of TC, TG, HDL-C, and LDL-C, improve the histopathology and glycogen accumulation in liver and intestinal tissue. Taken together,P. frutescensleaf exhibits excellent hypoglycemic activity in vitro and in vivo, and could be exploited as a source of natural antidiabetic agent.Keywords:P. frutescensleaf;phytochemical composition;antioxidant activity;enzyme inhibitory;anticancer ability;antidiabetic activity
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ORGANIC & BIOMOLECULAR CHEMISTRY
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2017
·Vol. 15
·期 16
·3427-3434
·
IF 3.564
Dan Wang,Kuan Zhang,Luhan Jia,Danting Zhang,Yue Zhang,Yujia Cheng,Chang Lin,Bo Wang
Presented here is the first example of synthesizing an array of primary-, secondary-, and tertiary-α-ketoamides with a non-metal catalyst nBu4NI from methyl ketones and inexpensive readily available amine/ammonium salts; the reactions proceeded smoothly under mild conditions, TBHP was used as an oxidant and the corresponding α-ketoamides were afforded in moderate to excellent yields.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2017
·
IF 6.216
Zheng Fang,Wei He,Tao Tu,Niuniu Lv,Chuanhong Qiu,Xin Li,Ning Zhu,Li Wan,Kai Guo
α-Fe 2 O 3 nanoparticles were prepared by using a continuous precipitation method with a valve assisted micromixer in the presence of iron (III) sulfate and ammonia water. The resulting nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM). Meanwhile, CaCO 3 nanoparticles were synthesized in a tube-in-tube flow reactor AF-2400. The acylation process catalyzed by modified lipophilic α-Fe 2 O 3 and CaCO 3 nanoparticles in the flow reactor were systematically investigated. Under the optimal conditions, a yield of 97.8% was obtained. Addition of CaCO 3 nanoparticles resulted in higher catalytic efficiency compared with pure modified α-Fe 2 O 3 nanoparticles. Moreover, this novel acylation also worked well for other substrates.
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TETRAHEDRON
·
2018
·
IF 2.377
Jie Zhu,Wenhui Zhu,Ping Xie,Charles U. Pittman,Aihua Zhou
A novel and efficient Ni-catalyzed aryl- and alkyl-selenation of imidazo[1,2-α]pyridines employing selenium powder has been developed for the first time. The significant advantages of this protocol are that it is an inexpensive nickel catalyst and exhibits broad functional-group compatibility and good reaction yields.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2019
·
IF 14.229
Quan Huo,Xiaoran Qi,Jianshu Li,Gongquan Liu,Yao Ning,Xubiao Zhang,Boyu Zhang,Yanfei Fu,Suyan Liu
A series of direct Z-scheme α-Fe 2 O 3 /MIL-101(Cr) hybrids were successfully prepared through a facile hydrothermal method in this work. And, the materials were characterized by some technologies including X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), N 2 adsorption-desorption, photoluminescence (PL) spectroscopy, Ultraviolet-visible (UV–vis) diffuse reflectance spectroscopy (DRS) and electron spin resonance (ESR). The photocatalytic activities of the hybrids were evaluated by degradation of carbamazepine (CBZ) under visible light irradiation. It is found that 100% of CBZ was able to be removed after 180 min irradiation over the optimum α-Fe 2 O 3 (0.3)/MIL-101(Cr) hybrid. The superior activity was engendered from good textural properties and the formation of a direct Z-scheme heterojunction in the hybrid. The decomposition process of CBZ and the formation of intermediate products were analyzed through liquid chromatography-tandem mass spectrometry (LC–MS) and a possible photodegradation pathway of the CBZ was proposed. Also, the possible mechanism for the photodegradation process was provided to illustrate the excellent performance. The work has paved a new way for the application of MOF materials in the design of efficient Z-scheme system for organic pollution degradation in wastewater.
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高影响因子
Frontiers in Energy Research
·
2022
·
IF 3.858
Baimoldina Adel,Papadikis Konstantinos,Konysheva Elena Yu.
The incorporation of mono-sized particle catalysts in real industrial systems for biomass conversion is a significant challenge, hence the impact of individual α-Fe2O3 catalysts with varying non-ideal spherical sizes of 54 nm (FS054), 221 nm (FS221), and ∼2 µm (FSm002) as well as dual-sized mixtures (FS054-FS221 and FS221-FSm002) were considered in the catalytic upgrading of pinewood pyrolysis vapors. The size variation of the α-Fe2O3 catalyst revealed a substantial effect on the product distribution. Although the yield of phenols shows a decrease by almost a factor of two irrespective of the catalyst particle size, the FS221 catalyst demonstrates the most potent effect on reducing phenols through decarboxylation reactions. Considering the role of the catalyst on the individual phenolics, the FS221 catalyst reveals higher selectivity towards the reduction of 2-methoxyphenol, isoeugenol, and eugenol, whereas the application of FS054 catalysts displays a stronger impact on the decrease of creosol and other phenols. Both FS054 and FS221 catalysts showed the highest effectiveness in reducing the relative yield of 2-methoxy-4-vinylphenol. Applying a dual-size mixture (FS054-FS221) shows a synergetic effect, simultaneously decreasing the content of phenols, acids, and aldehydes followed by a strong CO2 release attributed to competitive decarbonylation reactions of aldehydes. The appearance of γ-Fe2O3 small fraction was revealed in the powders with mono-(FS221) and dual particle size (FS054-FS221 and FS221-FSm002), whereas the FS054 and FSm002 catalysts demonstrate good chemical and phase stability.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Ang Li,Siru Ren,Chuanjiang Teng,Hongmei Liu,Qi Zhang
Deep eutectic solvents (DESs) are emerging as potential candidates as additives/modifiers in chiral electrokinetic chromatography (EKC). However, the true role of DESs in the chiral separation process is far from being fully elucidated. Since most previous studies have been restricted to using choline chloride as the hydrogen-bond acceptor (HBA) in DESs, here we first evaluated the effect of five types of DESs (containing different HBAs) on the enantioseparation performance of an α-CD-based EKC system. The results demonstrate that these DESs are capable of moderately improving the enantioresolutions of several model drugs. A series of comparative experiments indicate that the improvement is mainly due to the contribution of the HBAs, rather than the selected hydrogen-bond donors (HBDs). Considering that most of these DESs are achiral, we further prepared five chiral DESs, aiming to investigate whether there is a synergistic effect between α-cyclodextrin and chiral DESs. However, these chiral DESs did not show obvious superiority compared with achiral DESs. This conclusion is different from the use of achiral or chiral ionic liquids (ILs) as additives in chiral EKC, in which chiral ILs usually exhibit significantly better enantioseparation performance than achiral ILs. Another important conclusion of this work is that there seems to be no significant difference between using DESs and their individual components, which is also different from the performance of most previously reported ILs. This conclusion indicates that the DESs may be virtually completely dissociated into their initial components (HBAs + HBDs) in the separation medium due to the destruction of their hydrogen-bond network. Therefore, a question which deserves particular attention of researchers in this field is raised here: whether it is absolutely necessary to use DESs in chiral EKC since adding HBAs and HBDs separately seems to have the same function?
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高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2017
·
IF 2.084
Xiaowei Mu,Bihe Yuan,Ying Pan,Xiaming Feng,Lijin Duan,Ruowen Zong,Yuan Hu
A layer-by-layer (LBL) assembly coating composed of α-cobalt hydroxide (α-Co(OH) 2 ) and sodium alginate (SA) is deposited on flexible polyurethane (FPU) foam to reduce its flammability . Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) are employed to prove the LBL assembly process. It is obvious from SEM results that a uniform and rough coating is deposited on FPU foam compared with that of untreated one. The peak intensity of methylene of SA in FITR spectra and typical (003) diffraction peak of α-Co(OH) 2 nanosheets at 11.0° in XRD patterns increases gradually with increment of bilayer number. Combustion behavior and toxicity suppression property of samples are characterized by cone calorimeter (under an irradiance of 35 kW m −2 ) and Thermogravimetry/Fourier transform infrared spectroscopy. The one and two bilayers (BL) coating on FPU foam can achieve excellent flame retardancy. Compared with untreated sample, the peak heat release rate of the coated FPU foam containing only one BL coating is reduced by 58.7%. The content of gaseous toxic substances during pyrolysis of FPU foam deposited with a single bilayer coating, such as CO and NCO-containing compounds, are reduced by 20.0% and 9.2%, respectively. Besides, the flame retardant mechanism of the coated FPU foam is also revealed.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2024
·Vol. 59
·期 3
·1761-1769
·
IF 2.6
Jing Zhao,Wenwei Chen,Hua Liu,Xiaosan Zhang,Fei Tao,Zhenbao Jia
Summary Inhibition of α-glucosidases is recognised as an effective approach towards managing postprandial hyperglycaemia. This study aimed to identify a specific compound in Carya cathayensis Sarg. kernels (CCSKs) exhibiting strong inhibitory activities against α-glucosidase and elucidate the inhibitory kinetic mechanism. Employing a bioassay-guided approach, an α-glucosidase inhibitor was isolated from CCSKs through sequential chromatography protocol involving AB-8 macroporous adsorptive resin, Sephadex LH-20 and C 18 -reversed phase silica gel. The resulting inhibitor was a novel tannin compound, identified as rugosin C ethyl ester. Rugosin C ethyl ester displayed superior inhibitory activity (IC 50 of 2.60 μg/mL) compared to acarbose (IC 50 of 105.95 μg/mL). The kinetic analysis indicated that rugosin C ethyl ester had a mixed-type reversible inhibition against α-glucosidase. The inhibition constants ( K i and K is ) were determined to be 3.119 and 0.856 μg/mL, respectively. The findings indicated that rugosin C ethyl ester might serve as a promising functional ingredient in low-glycemic index foods.
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