EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2020
·Vol. 246
·期 5
·1017-1029
·
IF 2.366
Tian Ruochen,Suo Hao,Zhang Shuting,Sun Baoshan
A series of thiol-nucleophiles, captopril, l -cysteine, and tiopronin, were introduced to the degradation reaction of grape seed extracts and the eight new bioactive flavan-3-ol derivatives were observed. Then, these derivatives were successfully separated and prepared in large quantity by high-speed counter-current chromatography (HSCCC) and semi-preparative HPLC under the optimized separation conditions. The appropriate two solvent systems consisted of n- hexane – ethyl acetate – methanol – water (0.05:1.5:0.5:1.2, v/v/v/v) and n- hexane – ethyl acetate – water (1:10:10, v/v/v) with head – tail mode were used for HSCCC two-step separation of captopril degradation products. N- butanol – ethyl acetate – methanol – water (2:4:0.5:6, v/v/v/v) with a combination of tail – head and head – tail elution modes in HSCCC run of l- cysteine degradation products, and n- hexane – ethyl acetate – methanol – water (0.15:1.6:0.4:1, v/v/v/v) was applied with head – tail and tail – head elution modes in HSCCC separation of tiopronin degradation products. The structures of these derivatives were confirmed by MS and 1 H NMR analysis. Moreover, a systematic comparison of antioxidant activity of all the eleven degradation products was first implemented and found that most of the derivatives had stronger antioxidant activity than free catechins.
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BULLETIN OF MATERIALS SCIENCE
·
2020
·Vol. 43
·期 1
·1-6
·
IF 1.392
Li Lili,Yang Lin,Fu Bowen,Li Zhiqiang
Herein, we demonstrate a hot-injection method towards the fabrication of \(\hbox {Sb}_{2}\hbox {S}_{3}\) . The evolution from amorphous \(\hbox {Sb}_{2}\hbox {S}_{3}\) nanoparticles to a sheaf of \(\hbox {Sb}_{2}\hbox {S}_{3}\) nanorods cross-linked together occurring with the increase of reaction temperature and time is studied. The structural, compositional and morphological features of \(\hbox {Sb}_{2}\hbox {S}_{3}\) products indicate the formation of crystalline \(\hbox {Sb}_{2}\hbox {S}_{3}\) with orthorhombic phase and high purity. As the reaction proceeds, it can be observed that the individual nanorod grows along the elongated direction ( c -axis), and it is noteworthy that its round cross-section could develop into the rectangular cross-section subsequently. In this study we also propose a possible formation mechanism for the growth process of \(\hbox {Sb}_{2}\hbox {S}_{3}\) , and it reveals that the present hot-injection could provide an ideal growth environment for synthesizing the nanostructured materials by optimizing the experimental parameters.
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ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Guohua Qi,Dan Sun,Yu Tian,Chen Xu,Ying Zhang,Dandan Wang,Kongshuo Ma,Shuping Xu,Yongdong Jin
Caspase-3 is considered as one of the key proteases that can spontaneously regulate the life activities of cells, and its activation (usually is a slow process) will execute the apoptosis process of cells. Rapid activation of caspase-3 on demand in living-cells is therefore highly desired toward precise cancer therapy but it is still a key challenge. Herein, we applied electrostimulus (ES) to achieve fast activation of caspase-3 and trigger cell apoptosis, and developed a smart magnetic-plasmonic assembly nanoprobes (A-nanoprobes) to real-time trace cellular caspase-3 activation at the single cell level. The designer core–satellite A-nanoprobe, working specific to the activated caspase-3 via a disassembly tactic, provides strong “hot spots” to improve the sensitivity and therefore enables SERS sensing of cellular caspase-3 upon activated by ES. Single-cell analysis revealed that the ES can rapidly activate the apoptosis pathway of caspase-3 on demand to make the DNA fragmentation and ultimately induce the cell apoptosis. Such method and nanoplatform were further used to monitor ES-triggered caspase-3 activation in cell apoptosis process of different cell types, revealing that more caspase-3 will be activated for cancerous cells than normal cells during the ES to induce cells apoptosis. This strategy and platform are promising for detecting cellular caspase-3 and other enzymes in the process of cancer diagnosis and treatments.
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高影响因子
Journal of Coatings Technology and Research
·
2020
·Vol. 17
·期 2
·563-572
·
IF 1.815
Li Dan,Xu Feigao
Silicon dioxide coatings modified by (3-aminopropyl)triethoxysilane (ATS) were studied to test their potential use as materials for stone protection. The synthetic route is simple and environmentally friendly due to the lack of volatile organic components. These materials are simply obtained by mixing tetraethylorthosilicate (TEOS), ATS, and OH-terminal polydimethylsiloxane (PDMS-OH). The ATS acts as a curing catalyst and coupling agent. The formulations can be directly applied onto stone substrates, particularly the external stone of buildings. Thus, the goal of an application of silicon dioxide modified by ATS is to restore and to protect building substrates. In the hybrid materials, PDMS acts to form bridges linking the silica particles. Finally, the effectiveness of these products as a stone consolidant and coating was assessed by multiple indicators, including the mechanical resistance, peeling performance, water uptake by capillarity, and contact angle.
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ACS Catalysis
·
2021
·
IF 13.084
Yiwen Yang,Haifeng Qi,Huixiang Li,Zhanwei Xu,Xiumei Liu,Shuyin Yu,Zongchao Conrad Zhang
Efficient hydrolysis of β-1,4-glycosidic bonds of cellulose is a pivotal step in biorefineries of cellulosic biomass. In this work, we discovered that paired PdCl2–CuCl exhibited excellent synergetic catalytic activity over the single PdCl2 or CuCl in the hydrolysis of β-1,4-glycosidic bonds in 1-butyl-3-methylimidazolium chloride ([BMim]Cl) and further investigated the catalytic species in this system. The catalytic activity increased and reached a plateau at a CuCl/PdCl2 ratio of 1 with increasing molar ratio of CuCl/PdCl2 while keeping the Pd concentration constant. A combination of experimental evidence based on in situ far-infrared absorption, X-ray absorption, X-ray photoelectron, and electron paramagnetic resonance spectroscopies and DFT calculations demonstrate the coupling reaction between [PdIICl4]2– and [CuICl3]2– via the Cl bridge to form the heterometallic complex anion [Cl2PdII–Cl–CuICl2]2–. The heterometallic species is stable during the reaction and maintains its catalytic performance in the presence of various oxygenate additives. Using paired PdCl2–CuCl as a catalyst, the activation energy of hydrolytic cleavage of β-1,4-glycosidic bonds of cellobiose is determined as low as 95.8 kJ/mol. PdCl2–CuCl/[BMim]Cl combined with CrCl3 can be reused five times in cellobiose conversion to 5-hydroxymethylfurfural (5-HMF) without an apparent decrease of catalytic activity. The performance of this catalytic system is further verified for efficient cellulose conversion. More than 60% product yield is obtained at 100 °C from the cellulose, affording monosaccharides for efficient production of high value-added chemicals, such as 5-HMF, when CrCl3 is present to catalyze the conversion of glucose to 5-HMF.
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DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 42
·15057-15061
·
IF 4.39
Ming-Yang Cao,Chun-Li Hu,Fang Kong,Zhe-Yao Xiong,Jiang-Gao Mao
Exploration of new types of borates is important because of their promising applications in diverse fields. Two new boroselenites, namely, M(B(SeO3)3)H2O (M = Al, Ga), which represent the first IIIA metal boroselenite, were synthesized by hydrothermal reactions. M(B(SeO3)3)H2O (M = Al, Ga) possesses a unique sandwich like double-layer structure formed by two 2D [MSe2O8]5− layers interconnected by 1D [BSeO5]3− chains. More interestingly, both compounds display large band gaps (4.86/4.79 eV) and moderate birefringences (Δn = 0.063/0.064 at 1064 nm) based on density functional theory (DFT) calculations.
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Catalysts
·
2021
·Vol. 11
·期 9
·1126
·
IF 4.146
Qingman Li,Qihua Jiang,Pengcheng Gu,Lianju Ma,Yiwu Wang
Ni2+-NTA-boosted magnetic porous silica nanoparticles (Ni@MSN) to serve as ideal support for bi-functional enzyme were fabricated for the first time. The versatility of this support was validated by one-step purification and immobilization of bi-functional enzyme MLG consisting of 3-Quinuclidinone reductase and glucose dehydrogenase, which can simultaneously catalyze both carbonyl reduction and cofactor regeneration, to fabricate an artificial bi-functional nanobiocatalyst (namely, MLG-Ni@MSN). The enzyme loading of 71.7 mg/g support and 92.7% immobilization efficiency were obtained. Moreover, the immobilized MLG showed wider pH and temperature tolerance and greater storage stability than free MLG under the same conditions. The nanosystem was employed as biocatalyst to accomplish the 3-quinuclidinone (70 g/L) to (R)-3-quinuclidinol biotransformation in 100% conversion yield with >99% selectivity within 6 h and simultaneous cofactor regeneration. Furthermore, the immobilized MLG retained up to 80.3% (carbonyl reduction) and 78.0% (cofactor regeneration) of the initial activity after being recycled eight times. In addition, the MLG-Ni@MSN system exhibited almost no enzyme leaching during biotransformation and recycling. Therefore, we have reason to believe that the Ni@MSN support gave great promise for constructing a new biocatalytic nanosystem with multifunctional enzymes to achieve some other complex bioconversions.Keywords:porous silica nanoparticles;immobilized enzyme;nanosystem;cofactor regeneration;(R)-3-quinuclidinol;biocatalysts’ recycling
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OPTICAL MATERIALS
·
2019
·
IF 2.687
Jidong Deng,Jiao Xun,Rongxing He
All-inorganic cesium lead halide perovskite nanocrystals (NCs) are promising photoelectric materials for their high photoluminescence quantum yield (PLQY), narrow emission width and tunable optical band gap. Traditionally, the hot injection (HI) method has been utilized to prepare perovskite NCs. However, the HI method requires high temperature, protection under inert gas and other harsh synthetic conditions, which severely hinders large-scale production of these NCs. Herein, we directly synthesized CsPbBr 3 perovskite NCs by a modified LARP (ligand-assisted re-precipitation) approach, and then conducted a specific anion exchange reaction with inexpensive, readily available, non-toxic, and non-polluting KX (X = Cl, I) salts aqueous solution to obtain various compositions of CsPbX 3 perovskite NCs at room temperature (RT). The obtained RT-NCs have high PLQY and outstanding stability, and their photoluminescence can be precisely regulated across the whole visible region (419–670 nm). The use of inorganic salts for the ion exchange provides an efficient method for the design of various halogenated perovskite NCs and their large-scale synthesis at RT.
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SYNTHETIC COMMUNICATIONS
·
2019
·
IF 1.439
Shuang Chen,Jing Yue,Xiong-Li Liu,Jun-Xin Wang,Xiong Zuo,Yu Cao
A new method was developed for the facile one-pot multicomponent construction of heterocycle-fused spiro compounds containing chromanone and pyrrolidinyl spirooxindoles, two potential pharmacophores, in one molecule through a decarboxylative 1,3-dipolar [3 + 2] cycloaddition reaction of carboxylic acid group-activated chromones 1 with isatin-derivated azomethine ylides based on molecular hybridization strategy. A wide variety of products with three contiguous stereocenters including a spiro quaternary stereocenter were smoothly prepared with high efficiency (up to 87% yield and 20:1 diastereomeric ratio). This method could offer libraries of architecturally diverse and multiple pharmacore collections, potentially useful in medicinal chemistry.
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Nanoscale Advances
·
2019
·Vol. 1
·期 9
·3607-3613
·
IF 0
Zhaohong Su,Yongbing Cheng,Chaorong Li,Yuanfu Xiong,Langtao Xiao,Shu Chen,Xiaoli Qin
An amperometric immunosensor based on new thiolated bionanocomposite with a high dispersion of gold nanoparticles (AuNPs) for the sensitive detection of indole-3-acetic acid (IAA) is being reported herein. Briefly, a thiolated nanocomposite was prepared via the microwave-assisted thiol–ene reaction of 2,5-dimercapto-1,3,4-thiadiazole (DMcT) with oxidized polyaniline (PANI), which was synthesized in the presence of multiwalled carbon nanotubes (MWCNTs), yielding thiolated polyaniline (TPANI)-MWCNTs. Further, AuNPs were deposited on the TPANI-MWCNTs by microwave-assisted method to obtain a AuNPs/TPANI-MWCNTs nanocomposite. Finally, the thiolated bionanocomposite film was constructed via the specific chemical reaction between boronic acid functionalized AuNPs and the vicinal diol functionalized AuNP labeled immunoglobulin G (IgG–AuNPs). The change in the reduction peak current of Fe(CN)63− was used to monitor the immunoreaction between IAA and antibody. The TPANI-MWCNT nanocomposites uniformly disperse AuNPs, IgG–AuNPs and anti-IAA-AuNPs, leading to the amplification of the signal of the immunosensor. Fourier transform infrared spectra (FTIR), cyclic voltammetry (CV), transmission electron microscopy (TEM), ultraviolet visible spectroscopy (UV-vis) and differential pulse voltammetry (DPV) were used to characterize the nanocomposite film and the stepwise modification of the immunosensor. The prepared thiolated bionanocomposite material has good biocompatibility, a highly uniform dispersion of the AuNPs with a narrow size distribution as verified by TEM, and high load/activity of the immobilized antibody proved via DPV. The fabricated IAA amperometric immunosensor not only exhibits a good linear arrange from 1.0 pg mL−1 to 10 ng mL−1 with the limit of detection of 0.97 pg mL−1 (S/N = 3), but also possesses good selectivity, reproducibility and stability for the detection of IAA.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Yancun Yu,Yi Li,Changyu Han,Liguang Xiao
The aim of this study is to use natural orotic acid (OA) as a sustainable, environmentally friendly additive to improve the crystallization, rheological, thermal, mechanical, and biodegradation properties of bacterially synthesized poly(3-hydroxybutyrate- co -4-hydroxybutyrate) (P34HB). OA was found to be an efficient nucleating agent for P34HB, and dramatically enhanced both non-isothermal and isothermal crystallization rates. The incorporation of OA increased nucleation density and decreased spherulite size, but had little effect on the crystalline structure. The rheological properties of the P34HB were greatly improved by the solid filler OA, particularly when a percolation network structure was formed in the blends. The thermal stability of P34HB was strongly enhanced, as exemplified by the ~23 °C increase in the onset thermal decomposition temperature ( T o ) for the blend loaded with 5 wt% OA compared to that of pure P34HB. Moreover, the yield strength and elongation at break of P34HB containing 0.5 wt% OA increased by 25% and 119%, respectively. The most intriguing result was the clear enhancement in the enzymatic hydrolysis rates of the P34HB/OA blends compared to that of neat P34HB. The synergetic improvement in these properties may be of significant importance for the wider practical application of biosourced P34HB.
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Nanomaterials
·
2019
·Vol. 9
·期 3
·364
·
IF 4.034
Yanfeng Chen,Cuiyin Liu,Yue Situ,Jian Liu,Hong Huang
In this work, the CMK-3 is successfully prepared with SBA-15 as the template and first annealed to 2000 °C to improve thermal conductivity. The annealed CMK-3 has a thermal conductivity of 6.981 W m−1K−1higher than un-annealed CMK-3. The annealed CMK-3 is used to encapsulate the RT44HC, and RT44HC/annealed CMK-3 has 10-fold of thermal conductivity and enhanced thermal stability than RT44HC. The RT44HC/annealed CMK-3 has a large melting enthalpy of 177.8 J g−1and good thermal stability. The RT44HC/annealed CMK-3 has optical absorptive coefficient of visible range of solar spectrum, which identify seven-fold higher than RT44HC. The RT44HC/annealed CMK-3 has great photo-thermal performance, and the photo-driven energy charging and discharging rate of RT44HC/annealed CMK-3 is almost 30-fold larger than the RT44HC. The results show that the annealed CMK-3 is a great mesoporous carbon nanomaterial for phase change materials and the annealed CMK-3 based phase change material has great potential in solar thermal utilizations such as solar water heating system and solar heating building systems.Keywords:solar thermal systems;phase change material;annealed CMK-3;thermal conductivity;photo-driven charging and discharging rate
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