Small Structures
·
2026
·Vol. 7
·期 3
·e202500861
·
IF 8.9
Hui Dong,Tongyang Li,Zhen Tang,Dongmei Yu,Cheng Ju,Yiran Zhang,Jia Sha,Yongping Liang,Xinghui Wei,Yichao Liu,Lei Shi,Liang Yan,Hao Wu,Baolin Guo,Zheng Guo
3D-printed titanium implants are extensively utilized in bone reconstruction. However, their bioinertness and lack of antibacterial activity increase risks of aseptic loosening and implant-associated infection—the primary causes of implant failure. To address these limitations, we developed a dual-functional 3D-printed porous titanium–hydrogel composite scaffold to enhance the osteogenic and antibacterial capacities of titanium. This composite scaffold was fabricated by integrating quaternized chitosan (QCS)/aldehyde-terminated Pluronic F127 (PF127-CHO) hydrogel loaded with magnesium ions (Mg 2+ ) and zeolitic imidazolate framework-8 (ZIF-8) into polydopamine-coated 3D-printed porous titanium scaffold. The composite scaffold exhibited sustained and controlled release of Mg 2+ and ZIF-8 with enhanced binding strength at titanium–hydrogel interface. In vitro experiments demonstrated that the composite scaffold possessed favorable biocompatibility, promoted the adhesion and proliferation of MC3T3-E1 cells, and facilitated their osteogenic differentiation through synergistic effect of Mg 2+ and ZIF-8. Furthermore, it also inhibited bacterial growth via synergistic action of QCS/PF127-CHO hydrogel and ZIF-8. In vivo experiments confirmed enhanced bone ingrowth into the composite scaffold and its effective antibacterial activity. In summary, this composite scaffold provides a promising strategy to simultaneously improve the osteogenic and antibacterial capacities of titanium implants.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Qian Xu,Zilong Liu,Jiawei Du,Yueqi Zhu,Min Ruan,Huaqiang Chu
A robust photothermal superhydrophobic coating was prepared via in-situ growth of ZIF-8. • Exceptional anti-icing shows 3.95 times freezing delay and 68.05% lower ice adhesion. • High photothermal efficiency of 76.56% enables rapid active ice melting and shedding. • Chemical bonding ensures durable performance after severe abrasion. In low-temperature and high-humidity environments, the accumulation of surface ice layers poses a serious safety threat to fields such as aerospace, power transmission, and transportation. However, traditional superhydrophobic coatings commonly suffer from poor mechanical robustness and functional failure under complex mechanical service conditions. In this work, Metal–organic frameworks (ZIF-8) were successfully grown in-situ on carboxylated multi-walled carbon nanotubes (MWCNTs-COOH), constructing a novel photothermal superhydrophobic composite coating with a multilevel micro-nanostructure. With the synergistic effect of an E51/PDMS resin matrix and subsequent modification by a low-surface-energy fluorosilane (PFTS), the coating achieves excellent superhydrophobicity and outstanding mechanical robustness. Anti-/de-icing tests demonstrate that at −20 ℃, the icing time is delayed by 3.95 times and the ice adhesion strength is reduced to 123.66 kPa. Benefiting from a high light absorption of 97.81% and a photothermal conversion efficiency of 76.56%, the coating enables rapid active melting of accumulated ice under simulated illumination. This integrated strategy—combining tough interfacial design, long-term passive anti-icing, and efficient active de-icing—provides an effective and stable solution for long-lasting ice protection of infrastructure. Download: Download high-res image (180KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Siyu Liu,Nan Pang,Xiaoqing Yin,Yanyan Wang,Zhiqiang Yao,Dongzhi Wang,Meijie Yu
To meet the diversity of usage scenarios, it is often difficult to simultaneously achieve superior mechanical properties, antistatic properties, wave-transparent properties, and thermal stability in blended systems. In this study, on a “soft-rigid” interfacial concept, a multi-interface was constructed between low-temperature carbonized carbon fiber (CF) and silicone resin (SR) by grafting a “soft” polydopamine/polyethyleneimine layer and growing “rigid” ZIF-8 particles on the CF surface. The improved mechanical meshing and interfacial polarization of the “soft-rigid” interface enhanced the mechanical properties and thermal stability of CF/SR composites. Notably, the tensile strength and elongation at break of ZCF-3/SR were 36.54% and 40.43% higher, respectively, than those of UCF/SR with unmodified CFs. After being held at 350 °C for a duration of 3 h, the weight loss of ZCF-3/SR was 17.47% lower than the corresponding value of UCF/SR. Subsequently, the electrical analysis showed that the surface resistance of ZCF-3/SR was more stable than that of UCF/SR after heating and maintained the wave-transparent properties (ε<3.3, tan δ <0.2). The electromagnetic wave analysis of ZCF-3 alone at a higher filler content of 60 wt% showed that ZCF-3 achieved an effective absorption bandwidth of 5.9 GHz and a maximum reflection loss of −53.6 dB, which demonstrates the tunability of electromagnetic properties by varying fiber content and offers a broad design window of the composites. It has promising applications in lightweight and flexible aerospace electronics. Download: Download high-res image (265KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Qinye Liu,Zhaoxiang Li,Tong Ye,Guifeng Kang,Hui Gan,Yueyue Chen
Chemotherapy with spatiotemporal precision and noninvasiveness offers a new treatment strategy for colorectal cancer. However, this therapy still has shortcomings in how chemotherapeutic drugs are visualized and their antitumor effects. To improve the therapeutic efficacy, we have fabricated a facile host–guest complex (OTC) that resorts to noncovalent interactions among oxaliplatin (OxPt), photosensitizer (TTVP), and cucurbit[8]uril (CB[8]). OTC significantly enhanced the aggregation-induced emission (AIE) effect of TTVP. We further confirmed that OTC targeted aggregation in tumors by xenograft nude mouse models. This enabled the functions of tracing the chemotherapeutic drug, localizing the tumor, and targeting tumor accumulation. The tumor growth inhibition value (TGI) was 68.01% in the OTC group. Importantly, OTC-regulated drug release was observed through spermidine exchange in vitro and in vivo. The toxicity of OTC to normal cells under light-avoidance conditions was significantly less than that of conventional chemotherapeutic agents (OxPt), implying that OTC exhibited high efficacy and low toxicity. Upon light irradiation, OTC generated reactive oxygen species (ROS), leading to oxidative damage, while MDA levels were elevated, but SOD and CAT activities were reduced. We found that HMGB1, CRT, and ATP in the OTC-treated group increased by 87.20, 43.30, and 34.60% in vitro, respectively, compared with the control group. Transcriptomic analysis revealed upregulation of pathways related to immune activation, suggesting that OTC treatment primed the tumor for immunotherapy. The possible biological mechanism behind this was that OTC activated oxidative damage to induce immunogenic cell death (ICD). Overall, OTC offers a simple, visual, and highly efficient method for transporting platinum to improve chemotherapy. It also provides a novel strategy for combining chemotherapy and immunotherapy in solid tumors.
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zhentao Chen,Lijing Lei,Xiangze Fan,Jinhua Zhu,Haodong Zhou,Yun Zhang,Fanyi Ma,Xiuhua Liu,Md. Zaved H. Khan
ZIF-8 as multi-dentate crosslinking hub converts weak CS/γ-PGA complexes into robust dual-network hydrogel. • Ultra-large pores eliminate diffusion limitation (Da ≈ 0.001) with K m increase of only 2.2-fold. • HSP regression (R 2 = 0.76, p ≈ 0.0002) validates synergistic thermodynamic exclusion and size-sieving mechanism. • Immobilized α-Glu@PC/ZIF-8 enables ligand fishing of two α-glucosidase inhibitors via capture-wash-elute workflow. Herein, a composite hydrogel based on two natural macromolecules—chitosan (CS) and γ-poly(glutamic acid) (γ-PGA)—was developed, crosslinked by zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, which serve as reactive crosslinking hubs to covalently connect the biopolymer chains for efficient immobilization of α-glucosidase (α-Glu). A carboxyl-terminated poly(ethylene glycol)–poly(glutamic acid) copolymer was first synthesized and its activated carboxyl groups underwent amidation with amino groups of CS to rapidly form a three-dimensional PC/ZIF-8 hydrogel. The effects of ZIF-8 content and CS concentration on micro-morphology, swelling behavior, and rheological properties were systematically investigated. ZIF-8-mediated crosslinking was essential for gel formation, enabling effective modulation of network density and pore architecture. The optimized hydrogel showed no inhibitory effect on α-Glu. Immobilized α-Glu@PC/ZIF-8 exhibited enhanced pH stability (retaining 53% and 70% activity at pH 4.0 and 9.0), outstanding storage stability (>90% after 4 weeks), excellent organic solvent tolerance (>90% in most solvents), and good reusability (near 100% activity over 6 cycles). Mass transfer studies confirmed that the designed crosslinking density provided efficient substrate/product diffusion channels, minimizing product inhibition. Hansen solubility parameter analysis revealed a synergistic “thermodynamic exclusion + size-sieving” mechanism for solvent tolerance. Coupled with HPLC, the immobilized enzyme successfully identified two α-glucosidase inhibitors—batatasin I and 2,4-dimethoxy-6,7-dihydroxyphenanthrene—from Dioscorea opposita Thunb. peel. This work demonstrates that rational chemical modification of natural macromolecular networks via MOF crosslinkers provides an effective strategy for constructing high-performance enzyme immobilization platforms. Download: Download high-res image (72KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xinyu Cui,Yichao Lin,Shuchen Wang,Ruiqi Li,Jian Liu,Jun Sun,Ye-Tang Pan,Sheng Zhang
Polylactic acid (PLA) is a promising renewable polymer material known for its excellent biodegradability and good mechanical properties. However, its easy flammability and slow natural degradation limit its further applications. In this work, we designed a multi-layer core-shell flame retardant (ZIF-8@CH@APP) with interfacial characteristics through organic-inorganic hybrid technology. The interfacial functionalization of inorganic flame retardant ammonium polyphosphate (APP) was carried out with bio-based chitosan (CH), and the three-dimensional network was constructed by in-situ growth of metal-organic framework (ZIF-8). With 7 wt% addition of ZIF-8@CH@APP, the PLA composite exhibited excellent flame retarded properties. It showed V -0 vertical burning (UL-94) grade, and reduced total smoke produce (TSP) (0.2 m 2 ). Additionally, the PLA/7 % ZIF-8@CH@APP composite exhibited higher degradation rate at mild condition. Additionally, the final degradation product of ZIF-8@CH@APP was confirmed to be DL-lactic acid. The design not only improves the interface compatibility between inorganic phase and polymer matrix, but also realizes the double breakthrough of flame retardant and catalytic degradation function through physical-chemical synergism, providing an innovative solution for the recycle of PLA material.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2025
·
IF 4.3
Xiaohui Wang,Lin Zhou,Yingying Shi,Wang Wang,Peng Li,Rui Cui,Yajuan Wu,Feng Wang,Qiuzheng Du
The mortality rate of primary liver malignant tumors is very high. Curcumin (Cur) is one of the most commonly used drugs for the treatment of liver cancer. However, due to its low bioavailability, nano-drug delivery systems are rapidly developing. Zeolitic imidazolate framework-8 (ZIF-8), is pH-sensitive and biodegradable in acidic environments, providing a very suitable platform for drug delivery. Here, the anti-tumor properties of Cur and the anti-inflammatory properties of gold nanoparticles (Au NPs) were integrated and encapsulated in ZIF-8 material to prepare a composite drug delivery system (Cur/Au@ZIF-8). The prepared materials were characterized by scanning electron microscopy and elemental analysis, transmission electron microscopy, and powder X-ray diffraction. The drug loading efficiency of Cur in this delivery system reached 47.16 %. The drug release curve showed that the release rate of Cur/Au@ZIF-8 was faster at pH 5.5, with a release rate of 72.34 %. Ultrasound-guided in situ liver cancer models were constructed in SD rats to investigate the in vivo anti-tumor effects of Cur/Au@ZIF-8 and its impact on the metabolomics of tumor-bearing rats before and after treatment. In vivo results indicated that Cur/Au@ZIF-8 showed better anti-tumor effects, with a tumor inhibition rate of 46.81 %. After treatment, 26 key differential metabolites (p < 0.05) were identified from expression patterns and metabolic pathways, which were mainly related to fatty acid metabolism. This treatment strategy provides a reference for future cancer treatment and mechanism exploration.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysis Science & Technology
·
2026
·
IF 4.2
Kaifa Liu,Yingzi Huang,Xin Wang,Zhi Ling,Di Chen,Fengying Yan,Beili Pang,Qian Zhang,Jianhua Yu,Liyan Yu,Lifeng Dong
The performance of zinc–air batteries (ZABs) is often hindered by the limited activity and sluggish kinetics of bifunctional electrocatalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). In this work, a high-performance bifunctional catalyst (FeCo-NC@rGO) was synthesized by anchoring ZIF-derived Co5.47N and CoFe nanoparticles (NPs) onto a reduced graphene oxide (rGO) aerogel, accompanied by in situ growth of carbon nanotubes (CNTs). The M–N–C sites within the carbon matrix provide abundant ORR active centers, while Co5.47N and CoFe NPs impart excellent OER activity. As a result, FeCo-NC@rGO exhibits a high ORR half-wave potential of 0.85 V (vs. RHE) and a low OER overpotential of 400 mV at 10 mA cm−2, outperforming Pt/C (0.82 V) and RuO2 (508 mV), respectively. A liquid ZAB using this catalyst achieves an open-circuit voltage of 1.51 V, a power density of 114.6 mW cm−2, a specific capacity of 838.2 mAh g−1, and stable cycling for 250 h. The solid-state ZAB also demonstrates strong performance with excellent durability. This study provides an effective and scalable strategy for developing advanced bifunctional electrocatalysts for high-performance ZABs.
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2014
·
IF 3.468
Kun Zhou,Chao Qin,Li-Kai Yan,Wen-E Li,Xin-Long Wang,Hai-Ning Wang,Kui-Zhan Shao,Zhong-Min Su
Three silver(Ι) alkynyl compounds, [Ag 5 (C C t Bu)(CF 3 COO) 7 ( n Bu 4 N) 3 ·H 2 O] ( 1 ), [Ag 8 (C C t Bu) 2 (CF 3 COO) 10 (Et 3 N) 4 ] ( 2 ), and [Ag 12 (C C t Bu) 6 (CF 3 COO) 8 ( n Bu 4 N) 2 (Et 3 N) 2 (CF 3 COO) 2 ] ( 3 ), have been obtained. Concomitantly, isolated [Ag 5 (C C t Bu)(CF 3 COO) 7 ] 3– , [Ag 8 (C C t Bu) 2 (CF 3 COO) 10 ] 4– and [Ag 12 (C C t Bu) 6 (CF 3 COO) 8 ] 2– clusters ( Ag 5 , Ag 8 and Ag 12 for short) appear in 1 – 3 , respectively. The synthesis of 1 – 3 demonstrates silver(I) alkynyls are better systems for the study of the template effect. ESI-MS analysis indicates compounds 1 – 3 can stably exist in methanol, and they have been proved to be potential wide gap semiconductor materials by the reflectance spectra. Notably, the second hyperpolarizabilities ( γ values) of Ag 5 , Ag 8 and Ag 12 have been studied by using time-dependent density functional theory (TDDFT) calculations and the finite filed (FF) approach combining CAM-B3LYP. The calculated results show that they can be applied as potential third-order nonlinear optical (NLO) materials owing to their second hyperpolarizabilities rising from 39.1 × 10 −36 , 60.3 × 10 −36 to 97.7 × 10 −36 esu with the growth of the number of Ag atoms and C C groups.
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.4
Jie Xia,Liping Zhu,Yongqiang Ye,Yue Chen,Yangting Zeng,Kaiyuan Li,Fei Xiao
A facile and eco-friendly strategy was developed to synthesize IL@MOF hybrid FR. • The optimized composite achieved a UL-94 V-0 rating with a LOI value of 27.1%. • The peak heat release rate and total smoke production were reduced by −76.1% and −83.1%. • The reaction to fire and its underlying mechanisms were systematically characterized. The deployment of thermoplastic polyurethane (TPU) in high-safety applications is critically hindered by its inherent flammability and the emission of toxic smoke during combustion. To address these limitations, this study proposes a new strategy driven by structural engineering and spatial confinement. Specifically, a zeolitic imidazolate framework-8 (ZIF-8) precursor was selectively etched using an eco-friendly tannic acid to engineer a mesoporous host architecture (TZIF-8). By encapsulating a bespoke phosphorus-containing ionic liquid (PMDP) within these tailored cavities, a highly efficient inorganic-organic hybrid (PM@TZ) was synthesized. It was subsequently compounded with piperazine pyrophosphate (PAPP) to construct a synergistic fire-protection network within the TPU matrix. The optimized composite (incorporating 6.5 wt% PAPP and 1.5 wt% PM@TZ) demonstrated excellent flame retardancy, achieving a UL-94 V -0 rating alongside a limiting oxygen index (LOI) of 27.1%. Forced-flaming evaluations confirmed dramatic reductions in the peak heat release rate (−76.1%), total heat release (−62.1%), and total smoke production (−83.1%) relative to the TPU. Mechanistic investigations across the volatile and condensed phases elucidated a robust synergic reaction to fire. The liberation of active phosphorus radicals facilitates profound gas-phase flame quenching, whereas the confined ionic liquid and MOF-derived catalytic zinc nodes cooperatively accelerate the formation of a highly graphitized, heteroatom-doped (P/Zn) char barrier. In summary, this study provides a versatile structural engineering route for resolving the interfacial incompatibilities of ionic liquids, paving the way for next-generation, high-performance, fire-safe elastomers. Download: Download high-res image (170KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Keyang Feng,Da Wang,Yufan Zhang,Dini Zou,Xinyue Zhang,Chu Chu,Yan Liu,Min Xu,Wanying Zhu
Glutamate, the main excitatory neurotransmitter, exhibits release imbalance associated with epilepsy, Down syndrome, and other disorders. However, limited human tissue, interspecies differences, and inadequate in situ detection hinder mechanistic studies and interventions for glutamatergic dysfunction. Here, we constructed an integrated glutamatergic neuron-MNP@ZIF-8/ENZ platform that combines hiPSC-based directional differentiation of glutamatergic neurons on the enzyme-modified sensing surface with in situ neurotransmitter detection. Owing to the high porosity and electrical conductivity of the MNP@ZIF-8 nanocomposite, the platform exhibited a linear range of 1–50 μM (R 2 = 0.999), a detection limit of 0.76 μM, and high selectivity against common interferents such as DA, 5-HT, and Glc. After seven days of cell culture, the sensor response current retention rate is approximately 90.1%. Notably, the integrated platform was applied to Down syndrome (DS) research, revealing that depolarization-evoked glutamate release from DS patient iPSC-derived glutamatergic neurons was only approximately 28% of that from normal controls, providing direct quantitative evidence of excitatory transmitter secretion deficit in DS. This integrated sensing disease modeling platform provides a personalized, reproducible, and scalable analytical tool for disease pathogenesis research and drug screening, representing a promising technological platform.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Weikun Sun,Jiahui Zou,Yufang Liao,Can Li,Jian Zhang,Mohammad Younas,Zumin Qiu
A Zn dosage-mediated thermal reconstruction strategy was proposed to fabricate LDH@ZIF derived catalyst. • Moderate Zn addition achieves uniformly dispersed ZnCo 2 O 4 spinel. • Optimized LZ-0.2 removes levofloxacin rapidly through multiple ROS pathways involving 1 O 2 . • The catalyst realizes stable 144 h continuous degradation in fixed-bed reactor. Peroxymonosulfate-based advanced oxidation processes (PMS-AOPs) are effective for refractory antibiotic removal, yet conventional layered double hydroxide (LDH) catalysts often suffer from lamellar collapse, active site aggregation and poor pore accessibility after calcination. Herein, a series of LDH(Co/Al)@ZIF-8 derived catalysts (LZ-x) were prepared through the growth of ZIF-8 on LDH(Co/Al), followed by pyrolysis, for PMS activation and levofloxacin (LFX) degradation. Regulating the Zn dosage controlled ZIF-8 growth and the subsequent thermal reconstruction of the hybrid precursor. Among them, LZ-0.2 exhibited an open hierarchical architecture and the highest catalytic activity, achieving 95.11% LFX removal within 5 min with a k obs of 0.576 min −1 . In addition, structural characterization indicated that an appropriate Zn dosage favored the formation and dispersion of ZnCo 2 O 4 -containing spinel domains within the porous nanosheet architecture. Meanwhile, mechanistic investigations supported a hybrid radical/non-radical oxidation pathway involving 1 O 2 , •OH, SO 4 •- and • O 2 − . Additionally, the LZ-0.2 + PMS system maintained effective performance in various real water matrices and stable fixed-bed operation for 144 h in hospital wastewater, with low Co and Zn leaching. Moreover, phytotoxicity, antibacterial activity, and zebrafish developmental toxicity were reduced after treatment. This work highlights Zn-dosage regulation as an effective strategy for directing the thermal reconstruction of LDH@MOF derived catalysts for efficient PMS activation and antibiotic abatement.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）