RSC Advances
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2016
·Vol. 6
·期 49
·42854-42862
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IF 3.289
He Liu,Aiting Wang,Xu Xu,Mengmeng Wang,Shibin Shang,Shiwei Liu,Jie Song
Cellulose aerogels based on crosslinking of cellulose with 1,4-butanediol diglycidyl ether (BDE) were homogeneously synthesized in NaOH/urea aqueous solution followed by freeze-drying. In the NaOH/urea aqueous solution, cellulose existed in a sodium alkoxide form that could react with the epoxide groups of BDE. The rheological behavior of the cellulose/NaOH/urea aqueous solution showed that the crosslinking reaction occurred immediately once the BDE was added to the cellulose/NaOH/urea aqueous solution at room temperature. The X-ray diffraction (XRD) characterization identified a transition from the crystalline structure of cellulose to an amorphous state of cellulose aerogels with increasing amount of BDE. Elemental analysis revealed the variation in carbon and oxygen elemental percentages in cellulose aerogels caused by the reaction between cellulose and BDE. The porous network of aerogels was observed by scanning electron microscopy (SEM) and the pore size of the aerogels increased as a function of BDE. The water adsorbent ability of aerogels was up to 41 g g−1—even after 30 squeezing–adsorption cycles, the water adsorbent ability was still 37 g g−1.
研究领域:
高分子材料科学
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纳米材料学
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绿色化学
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生物基功能材料
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环境功能材料
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高影响因子
FOOD CHEMISTRY
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2026
·
IF 10.4
Maratab Ali,Huizhi Chen,Weijie Wu,Ben Niu,Xiangjun Fang,Chaoyi Shen,Guannan Wang,Hangjun Chen,Ting Huang,Ming Yin,Ruiling Liu,Haiyan Gao
1-MCP upregulated the sugar and organic acid metabolism in goji berry. • Malic and fructose were main organic acid and sugar in goji berry. • 1-MCP interlinked sugar-acid homeostasis with extended shelf life of goji berry. • Molecular docking showed possible 1-MCP led modulations in enzyme function. • 1-MCP maintained postharvest quality and storage potential of goji berries. This study investigated postharvest quality and shelf life of “Ningnongqi 17” goji berries under 1-MCP-mediated sugar-acid metabolism. The results showed that 1-MCP-treated goji berries exhibited delayed firmness loss, TA loss, and color, along with a slower increase in TSS/TA ratio, weight loss, decay rate, and EL than control (CK). 1-MCP enhanced citric, succinic, fumaric, and malic acids accumulation by upregulating PEPC, CS, and NAD-MDH and suppressing ACL, ACO, and SDH enzymes and their transcription. Meanwhile, sucrose levels increased, and glucose and fructose remained lower via downregulated AI, NI, SS-c, and upregulated SPS and SPP enzymes and their transcription. Notably, malic acid and fructose were identified as the main organic acid and sugar in berries. Correlation analysis linked elevated malic, succinic, and sucrose levels with improved firmness, color, TSS, and lower weight loss, decay rate, and EL in treated berries. In conclusion, 1-MCP delayed ripening and senescence by maintaining optimal sugar-acid homeostasis, resulted in improved quality and extended shelf life of fresh goji berries. Download: Download high-res image (250KB) Download: Download full-size image
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ACS Applied Nano Materials
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2026
·
IF 5.8
Saifei Du,Lei Ding,Shuqi Li,Kun Wang,Baojiang Liu,Wei Wang,Dan Yu,Chunyan Hu
MXene-based aerogels are promising for electromagnetic interference (EMI) shielding due to their lightweight nature and high conductivity. However, their practical application is often hindered by severe impedance mismatch and excessive secondary reflection. To overcome this limitation, we developed a multifunctional ternary composite aerogel (MTCA) via a synergistic self-assembly strategy. In this architecture, TpPa-1 covalent organic framework (COF) was grown in situ and integrated with MXene nanosheets within a chitosan matrix. The resulting hierarchical porous structure significantly optimizes impedance matching. Consequently, the optimized MTCA achieves an EMI shielding efficiency of 39.93 dB in the X-band, operating via an absorption-dominated mechanism. This performance stems from enhanced interfacial polarization at the MXene/COF heterojunctions and prolonged microwave propagation paths facilitated by multiple scattering within the porous network. Furthermore, the aerogel exhibits multispectral stealth capabilities: it demonstrates low infrared emissivity (ε = 0.50), superior thermal insulation (surface temperature of 28.7 °C under an 80 °C heat source), and effective visual camouflage adaptable to environmental backgrounds. This work presents a robust strategy for designing advanced stealth materials that integrate efficient absorption-dominant EMI shielding with multispectral compatibility.
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CANCER LETTERS
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2026
·
IF 11.8
Jie Wang,Huihao Ma,Baozhi Feng,Yan Fu,Chunlin Lu,Mingyang Fei,Yuxin Zhang,Bin Dong,Ying Li,Jing Liu
Aldo-keto reductase family 1 member C3 (AKR1C3) is a pivotal metabolic enzyme involved in arachidonic acid (AA) metabolism and cancer metabolic reprogramming, which plays a critical role in the initiation and progression of glioblastoma (GBM). We integrated single-cell and transcriptome data to characterize AA metabolism features in GBM and identify the key gene AKR1C3. Using CCK8 assays, wound-healing assays, transwell assays, and mouse tumor formation experiments, we elucidated the effects of AKR1C3. Dual-luciferase reporter assays and ChIP-PCR experiments were performed to investigate the regulation of transcription factor JUN on AKR1C3 expression. RNA-seq analysis, combined with rescue experiments, demonstrated that AKR1C3 significantly regulates the RhoA/ROCK pathway. Arachidonic acid metabolism is closely associated with clinical outcomes in glioma, with AKR1C3 identified as a key gene within this pathway. AKR1C3 knockdown enhanced tumor cell proliferation, migration, and invasion, whereas AKR1C3 overexpression suppressed these malignant behaviors. In vivo experiments further confirmed the inhibitory effect of AKR1C3 on glioma progression. Dual-luciferase reporter and ChIP-PCR assays demonstrated that JUN acts as an upstream regulator of AKR1C3. ELISA results indicated that AKR1C3 overexpression reduced cellular PGD2 levels. RNA-seq analysis suggested that the RhoA/ROCK pathway was a downstream effector of AKR1C3, and exogenous PGD2 supplementation could reverse AKR1C3-mediated regulation of this pathway. We identified curcumin, a natural product with anti-cancer metabolic regulatory activity, as an upstream modulator that suppresses JUN expression, thereby activating the JUN/AKR1C3 axis and inhibiting malignant phenotypes in GBM cells. JUN/AKR1C3 axis influences glioma progression via modulating PGD2-mediated RhoA/ROCK Signaling.
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Signal Transduction and Targeted Therapy
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2026
·Vol. 11
·期 1
·341
·
IF 81.2
Liu Shuai,Ma Yunfeng,Zeng Yujie,Lv Dekang,Hou Zhijie,Huang Junxiu,Gong Yaqi,Feng Ruijun,Wang Zihan,Sui Ran,Huang Dan,Wu Yameng,Chen Nuo,Yao Mingzhi,Shan Ying,Huang Yuan,Wang Yuesheng,Yan Jinsong,Peng Fei,Liu Quentin,Xu Jie
Activation of quiescent or extremely slow-cycling breast cancer stem-like cells (qsBCSCs) contributes to tumor progression, yet the regulatory mechanisms involved in triple-negative breast cancer (TNBC) remain elusive. We developed a dual-reporter system combining NANOG-EGFP and H2B-mCherry pulse-chase labeling to separately identify qsBCSCs and active BCSCs (aBCSCs) in vitro and in vivo. aBCSCs display significant enrichment of glycolysis and lactylation signatures, a finding corroborated by single-cell RNA sequencing (scRNA-seq) of TNBC patient samples. Glycolytic enzyme Enolase 1 (ENO1) expression is positively correlated with elevated histone H4 lysine 12 lactylation (H4K12la) in aBCSCs. Functional studies revealed a positive feedback circuit in which ENO1-increased lactate promotes H4K12la, which in turn activates ENO1 transcription. The ENO1-lactate-H4K12la axis enhances proliferating cell nuclear antigen ( PCNA ) transcription to activate qsBCSCs. Suppression of ENO1 or H4K12la prevents PCNA upregulation and qsBCSC activation. Importantly, PCNA knockdown alone blocks the activation of qsBCSCs induced by exogenous sodium L-lactate (NALA). In orthotopic breast cancer mouse models, both genetic depletion of ENO1 and pharmacological inhibition of lactate production attenuated tumor growth by blocking qsBCSC activation. Clinically, ENO1 expression was strongly correlated with PCNA expression, with high expression predicting poor OS, RFS, and DMFS. Our results establish the ENO1-H4K12la-PCNA axis as a key metabolic‒epigenetic driver of qsBCSC activation and a therapeutic target in TNBC.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Yongyue Bai,Lei Ye,Yunxing Bai,Peng Zhou,Yongrui Wang,Ying Ouyang,Weixin Huang,Jichang Liu,Xingtian Shu,Wenjie Yang,Youhao Xu
Coconversion of hydrocarbons offers a sustainable and efficient route to high-value products while lowering the cost and energy demand for pure feedstock preparation. Here, we propose a cocracking process for alkanes and alkenes, and systematically investigate their interactions under mixed feed conditions through experiments and simulations. Introducing 0–40% alkanes into the alkene feed enhances conversion and maintains high selectivity for light olefins while suppressing methane and aromatics. At 20% alkane, the combined selectivity of ethylene and propylene reaches 69.8%, with an ethylene/methane ratio of 11.94. Validation experiments using cocracking of pentadiene and n-pentane with in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) show that dienes improve the product profile of alkane cracking and strengthen n-pentane adsorption on acidic zeolites, which favors alkene formation and suppresses methane and aromatics. Density functional theory (DFT) calculations further support that interactions between pentadiene and n-pentane facilitate a shift in the cracking pathway from a pentacoordinate to a tricoordinate carbocation mechanism, lowering the energy barrier. This work demonstrates a feasible strategy for the production of light olefins via hydrocarbon coconversion and advances mechanistic understanding of alkane–alkene cocracking.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
·
IF 6.7
Di Zhang,Kunpeng Yang,Yuting Fan,Ding Jia,Dejun Ma,Yu-Cheng Gu,Han Xu,Zhen Xi
The development of 1-deoxy-d-xylulose-5-phosphate synthase (DXPS) inhibitors still needs an innovative extension with novel chemotypes to avoid herbicide resistance. Herein, a series of 2,4-diphenylquinoline derivatives were designed, synthesized, and structurally optimized from lead compound 24 via stepwise A/B/C-ring modification. Greenhouse assays identified a-3 (3-CF3 A-ring) as the most potent analogue, exhibiting the higher herbicidal activity (71.4% inhibition on DESSO at 375 g a.i./ha) and dosage tolerance than 24. The mechanism of compound a-3 targeting DXPS proteins has been also identified using surface plasmon resonance binding assay, physiological biomarker measurement, substrate accumulation, and molecular docking. The key active motifs between a-3 and DXPS have been further defined based on the structure–activity relationships. This work will further expand the structural diversity of DXPS inhibitors with higher bioactivity.
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PubMed
高影响因子
CURRENT MICROBIOLOGY
·
2026
·Vol. 83
·期 8
·424
·
IF 2.8
Xu Jialin,Yan Bohu,Fu Qifu,Li Haoyu,Jiang Zonghan,Zhou Rushun,Chen Xiaojun,Sun Zhiliang,Wang Yanan,Li Jiyun
In response to the critical challenge of colistin resistance in animal production, we examined the occurrence and genetic features of mcr-1 -positive E. coli isolates collected from livestock in Hunan province, China, between 2016 and 2021. A total of 1,358 animal samples from chickens and pigs were collected and screened. Monitoring data indicates that nineteen mcr-1 -positive E. coli isolates (1.40%) were identified, and all were resistant to colistin and tetracycline. The prevalence rate of mcr-1 positive E. coli has significantly declined since 2017 and has remained consistently low. Most isolates (89.47%) exhibited multidrug resistance and carried multiple antibiotic resistance genes, including tet (A) , sul3, bla TEM-1B, while a subset of strains (21.05%) harbored quinolone resistance-associated point mutations in gyrA , parC , and parE . Multi-locus sequence typing identified 14 sequence types, with ST48 being the most frequent (21.05%), and five clonal complexes, with CC10 as the predominant lineage (52.63%). Plasmid analysis revealed that 68.42% of the isolates carried plasmids, predominantly IncX4 (36.84%), and 57.89% of isolates harbored conjugative plasmids with complete relaxase and MPF system components. The mcr-1 gene was found within three main genetic arrangements: (i) mcr-1-pap2, (ii)IS Apl1-mcr-1-pap2, and (iii) IS Apl1-mcr-1-pap2- IS Apl1 . These findings highlight the potential for dissemination of mcr-1 in animal-derived E. coli and underscore the importance of monitoring and controlling antimicrobial resistance in livestock.
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PubMed
高影响因子
Journal of Cannabis Research
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2026
·Vol. 8
·期 1
·90
·
IF 3.8
Nichols Niara A.,Dane A. John,Musah Rabi A.
Background Cannabidiol (CBD) is one of over 100 naturally occurring phytocannabinoids in Cannabis . While extensive research has evaluated the effects that CBD and other phytocannabinoids have on consumers, less attention has been directed towards studying the health impacts of the compounds formed when cannabinoids are burned. Such an investigation is highly desirable, as smoking remains the most common form of Cannabis consumption. Previous research has investigated the structures of CBD pyrolysis products that are of a molecular mass similar to or greater than CBD. However, studies of the lower molecular weight products formed when CBD is pyrolyzed at the temperatures of a burning cigarette are limited. This work investigated the identities of the small-molecule cracking products formed from the pyrolysis of CBD. Methods CBD standards were pyrolyzed within the temperature range of 400 °C – 800 °C and analyzed using two-dimensional gas chromatography – high-resolution mass spectrometry. A combination of mass spectral fragmentation patterns, retention index data, GC retention times, and comparison of the profiles of detected compounds with those of authentic standards were used to identify cracking products that eluted during the first 19 min of a 90-min analysis. Results This investigation revealed a mixture of pyrolysis products whose complexity increased with increasing temperature. A total of 86 compounds were detected, 81 of which were identified. They spanned the alkane (both cyclic and acyclic), alkene (both cyclic and acyclic), alkyne, substituted benzene, aromatic heterocycle, phenol, and ketone compound classes. Seventy-eight of the identified molecules are reported here for the first time as CBD pyrolysis products. Several are known to have adverse health effects, including genotoxicity and neurotoxicity. Others have been reported to possess health benefits such as anti-inflammatory and antioxidant properties. Conclusions The pyrolysis of CBD revealed a complex mixture of 86 C 3 - C 10 cracking products across all five temperatures analyzed. The largest number of compounds were formed at 800 °C, while the smallest number of products was observed at 400 °C. The vast majority of these compounds have not been reported in previous studies of CBD pyrolysis. Many of the identified products are known to have impacts on human health.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
·
IF 5.4
Chunyu Zhao,Di Gao,Yuxuan Weng,Liquan Xiong,DongSheng Chen,Ying Wang
Size-controlled cubic–octahedral HKUST-1 is synthesized for modifying both inner and outer walls of hollow microtubes. • The Mn 3 O 4 -derived MnO 2 @HKUST-1 hollow composite micromotor integrates pollutant adsorption-enrichment with redox-mediated catalytic degradation within a unified platform. • Controlled HKUST-1 crystal size and deposition enabled uniform coating on hollow MnO₂ microtubes, enhancing pollutant enrichment while preserving catalytic sites and self-propulsion. In this study, cotton was employed as a biological template, and a size-controlled octahedral HKUST-1 structure was constructed via a combined calcination and hydrothermal process. Subsequently, a hollow tubular MnO 2 @HKUST-1 composite micromotor, derived from Mn 3 O 4 , was successfully fabricated. Under H 2 O 2 -driven conditions, the as-prepared micromotor exhibits stable autonomous motion and enables efficient removal of methylene blue (MB). Under optimized reaction conditions, a 90.4% removal efficiency was achieved within 10 min, and complete degradation was reached within 40 min. Kinetic and mechanistic analyses indicate that HKUST-1 primarily contributes to pollutant enrichment via its porous structure, whereas MnO 2 is responsible for H 2 O 2 activation and reactive oxygen species (ROS) generation. This work, for the first time, proposes a structural design principle for MOF-based micromotors that differs fundamentally from conventional MOF-coating strategies. Rather than improving performance by increasing MOF coverage or forming dense, continuous MOF coatings, the crystal size and deposition behavior of HKUST-1 were deliberately regulated to achieve a uniform yet non-continuous distribution over the inner and outer surfaces of hollow MnO 2 microtubes. This architecture simultaneously enhances pollutant enrichment, preserves the accessibility of MnO 2 catalytic sites, and maintains autonomous micromotor propulsion, thereby establishing a rational design principle for integrating adsorption, catalytic activity, and self-propulsion in multifunctional MOF-based environmental micromotors. Download: Download high-res image (318KB) Download: Download full-size image
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高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.6
Yixing Shi,Yinghao Huang,Chentao Ding,Hao Lin,Jiachen Lin,Shaowei Wang,Ren-shan Ge,Wangning Shangguan
This study identifies environmental chemicals 4-nonylphenol, 4-dodecylphenol, pentabromophenol, and popular anesthetics drug propofol as moderate to potent inhibitors of human and rat 5α-reductase type 1 (5α-R1), revealing novel endocrine-disrupting mechanisms in human brain cell and rat brain microsomes. Pentabromophenol exhibited the highest potency (IC₅₀ = 1.71 µM for human 5α-R1) with mixed/noncompetitive inhibition, supported by Surface Plasmon Resonance binding ( KD = 1.22 µM). A 3D-QSAR pharmacophore model (Hypo1) highlighted critical structural features, including a hydrogen-bond acceptor and hydrophobic interactions, explaining pentabromophenol efficacy. Species differences emerged, with human 5α-R1 showing high pentabromophenol binding affinity (-6.80 kcal/mol via halogen bonds with Arg176). Inhibition may reduce neurosteroids (e.g., allopregnanolone) and androgens (e.g., dihydrotestosterone). These findings underscore industrial phenolic compound capacity to dysregulate neurosteroid homeostasis in a structure- and species-dependent manner, highlighting their endocrine-disrupting risks.
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PubMed
高影响因子
Frontiers in Pharmacology
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2026
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IF 5.4
Zhao-Lei Ding,Yi-Chen Ma,Chuan-Mei Liu,Xiu Lu,Rong-Rong Wang,Min-Min Tang,Dong-Xu Hua,Ling Zheng,Hui Zhao,Lin Fu
Background 1-Nitropyrene (1-NP) is harmful to the respiratory system and can evoke acute lung injury (ALI). Pyroptosis and apoptosis, two important types of programmed cell death, are involved in the pathological process of ALI. However, the roles and mechanisms of pyroptosis and apoptosis on 1-NP-incurred ALI remain unclear. Methods All the mice were exposed to a single dose of 1-NP (20 μg/mouse, dissolved in saline) or normal saline via intratracheal instillation. At different times after 1-NP exposure, the mice were sacrificed. Mouse lung epithelial (MLE-12) cells were incubated with 1-NP (5 μM), the indicators of pyroptosis and apoptosis were detected. Results Pulmonary pathological injury and inflammatory cell infiltration was observed in 1-NP-exposed mice. Additionally, the indicators of apoptosis, Bcl-2 was downregulated, Bad and Caspase-3, and apoptotic cells were increased in 1-NP-exposed mouse lungs and mouse lung epithelial (MLE-12) cells. Meanwhile, the proteins of GSDMD and Pro- and Cleaved Caspase-11 and the mRNAs of Il-1β and Il-18 , which are markers of pyroptosis, were increased after 1-NP treatment. Moreover, pretreatment with wedelolactone (WED), an antagonist of Caspase-11, alleviated 1-NP-induced ALI. As expected, pharmacological inhibition or genetic deletion of Caspase-11 abolished 1-NP-induced apoptosis and pyroptosis. Interestingly, 1-NP attenuated Caspase-11 proteasome degradation. Mechanistically, 1-NP downregulated the expression of SYVN1, an E3 ubiquitin ligase of Caspase-11. 1-NP promoted the interaction between SYVN1 and Caspase-11 and inhibited Caspase-11 ubiquitination and subsequent proteasome degradation. Transfection with SYVN1 overexpression plasmids abolished 1-NP-mediated the reduction of Caspase-11 ubiquitination-dependent degradation, apoptosis, and pyroptosis. Conclusions These results revealed that acute 1-NP may induce ALI via Caspase-11-mediated apoptosis and pyroptosis by downregulating SYVN1.
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高影响因子
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