DIGESTIVE DISEASES AND SCIENCES
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2025
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IF 2.5
Gao Tao,Zhang Huaisheng,Xu Yuan,He Guosong,Ma Huicong,Zheng Chuanming,Li Lei,Cheng Feng,Dou Hehe,Zhang Fulong,Zhao Heng,Qiu Zhaolei
Background Severe Acute Pancreatitis (SAP) is associated with significant intestinal injury and inflammation. Hypoxia-Inducible Factor-1α (HIF-1α) and NLRP3 inflammasome have been implicated in this process, but their specific roles remain unclear. Objective This study aims to elucidate the roles of HIF-1α and NLRP3 in the pathogenesis of SAP and their effects on intestinal injury, barrier function, and inflammatory responses. Methods A SAP rat model was established, and histological changes were assessed via HE staining. Western blot was used to analyze HIF-1α and NLRP3 expression in intestinal mucosa. The effects of HIF-1α modulation were examined using the activator DMOG and inhibitor BAY87-2243. Immunohistochemistry, ELISA, and TUNEL staining were used to evaluate intestinal barrier function, permeability markers, and apoptosis. Results HIF-1α and NLRP3 expression significantly increased in SAP rats, peaking at 72 h. HIF-1α activation aggravated intestinal injury and barrier dysfunction, decreasing tight junction protein levels and increasing epithelial apoptosis. Enhanced intestinal permeability and elevated pro-inflammatory cytokines were also observed. Furthermore, HIF-1α activation promoted NLRP3 inflammasome assembly, resulting in increased caspase-1 and IL-1β expression. Conclusion HIF-1α exacerbates intestinal injury and inflammation in SAP, likely through NLRP3 inflammasome activation. Targeting HIF-1α may offer a potential therapeutic approach for SAP-induced damage and inflammation.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Ma Qing,Gao Yongjun,Sun Bo,Du Jianlong,Zhang Hong,Ma Ding
Both plastics and CO 2 are waste carbon resources, and their accumulation in nature has led to severe environmental pollution. However, simultaneously converting plastic waste and CO 2 into value-added chemicals remains a challenge. Here we demonstrate a catalytic reforming process that converts plastics and CO 2 into syngas over an electrified FeCrAl heating wire. The temperature of the electrified heating wire can quickly exceed 800 °C, facilitating the decomposition of polyethylene into gaseous hydrocarbons. The high-temperature heating wire promote the CO 2 deoxygenation, resulting in the generation of CO, as well as the dehydrogenation of gaseous hydrocarbons. Significantly, the additional O species from CO 2 and the carbon species from hydrocarbons can react to form CO, maintaining the high catalytic activity of the electrified heating wire. This novel approach is of paramount to achieving a circular economy in addressing the ongoing environmental crisis caused by the accumulation of plastic waste and excessive CO 2 emissions.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Li Xinhui,Liu Bo,Wang Jian,Li Shuxuan,Zhen Xin,Zhi Jiapeng,Zou Junjie,Li Bei,Shen Zhonghui,Zhang Xin,Zhang Shujun,Nan Ce-Wen
Polymeric-based dielectric materials hold great potential as energy storage media in electrostatic capacitors. However, the inferior thermal resistance of polymers leads to severely degraded dielectric energy storage capabilities at elevated temperatures, limiting their applications in harsh environments. Here we present a flexible laminated polymer nanocomposite where the polymer component is confined at the nanoscale, achieving improved thermal-mechanical-electrical stability within the resulting nanocomposite. The nanolaminate, consisting of nanoconfined polyetherimide (PEI) polymer sandwiched between solid Al 2 O 3 layers, exhibits a high energy density of 18.9 J/cm 3 with a high energy efficiency of ~ 91% at elevated temperature of 200°C. Our work demonstrates that nanoconfinement of PEI polymer results in reduced diffusion coefficient and constrained thermal dynamics, leading to a remarkable increase of 37°C in glass-transition temperature compared to bulk PEI polymer. The combined effects of nanoconfinement and interfacial trapping within the nanolaminates synergistically contribute to improved electrical breakdown strength and enhanced energy storage performance across temperature range up to 250°C. By utilizing the flexible ultrathin nanolaminate on curved surfaces such as thin metal wires, we introduce an innovative concept that enables the creation of a highly efficient and compact metal-wired capacitor, achieving substantial capacitance despite the minimal device volume.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Cui Zhanding,Liu Jinlong,Xie Chong,Wang Tao,Sun Pu,Wang Jinlong,Li Jiaoyang,Li Guoxiu,Qiu Jicheng,Zhang Ying,Li Dengliang,Sun Ying,Yin Juanbin,Li Kun,Zhao Zhixun,Yuan Hong,Bai Xingwen,Ma Xueqing,Li Pinghua,Fu Yuanfang,Bao Huifang,Li Dong,Zhang Qiang,Liu Zaixin,Cao Yimei,Zhang Jing,Lu Zengjun
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) poses a major threat to the global swine industry, yet effective prevention and control measures remain elusive. This study unveils Nitazoxanide (NTZ) as a potent inhibitor of PRRSV both in vitro and in vivo. Through High-Throughput Screening techniques, 16 potential anti-PRRSV compounds are identified from a library comprising FDA-approved and pharmacopeial drugs. We show that NTZ displays strong efficacy in reducing PRRSV proliferation and transmission in a swine model, alleviating viremia and lung damage. Additionally, Tizoxanide (TIZ), the primary metabolite of NTZ, has been identified as a facilitator of NMRAL1 dimerization. This finding potentially sheds light on the underlying mechanism contributing to TIZ’s role in augmenting the sensitivity of the IFN-β pathway. These results indicate the promising potential of NTZ as a repurposed therapeutic agent for Porcine Reproductive and Respiratory Syndrome (PRRS). Additionally, they provide valuable insights into the antiviral mechanisms underlying NTZ’s effectiveness.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 36
·期 1
·1-8
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IF 2.8
Shan Zhang,Xin Song,Xing Gao,Chunxiao Lu,Pei Han,Yunying Liu,Xiaowei Li,Junyan Zhang,Yong Li
The ferroelectric photovoltaic (PE-PV) effect has been extensively explored and plays a crucial role in constructing self-powered photodetectors. Ferroelectric materials have been attracting great interest in self-powered ultraviolet (UV) photodetectors due to their polarization-induced photovoltaic effect. In this paper, the ultraviolet self-powered photodetection properties of polycrystalline rare-earth Yb 1-x Ho x MnO 3 (0 ≤ x ≤ 0.08, Δx = 0.02) ferroelectric materials have been investigated. The substitution of Ho atoms for Mn atoms has a great influence on the ferroelectric polarization, and Ho doping increases the photocurrent density. The photodetectors show excellent reproducibility responsivity (R) and detectivity (D*) under illumination at 365 nm. In addition, at the light density of 1 mW/cm 2 , the responsivity and detectivity of the photodetectors are as high as 0.09 W/A and 3.359 × 10 11 Jones, respectively. These outstanding photodetection performances are due to the relatively high short-circuit current density ( J sc ). High J sc implies that more photogenerated carriers can be produced under illumination, which makes the device more sensitive to optical signals. This study presents a feasible method for improving the light-detection performance of the ultraviolet self-powered detector.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 16
·1-12
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IF 2.8
Wang Huiya,Zhang Kaina,Zhu Yaofeng
Anion-doped induced vacancy engineering is an effective approach to modulate polarization behavior and enhance the microwave absorption property. Herein, bamboo leaf-like polyaniline-mediated nitrogen and sulfur co-doped carbon (N/S–B–C) nanoflakes were demonstrated and successfully prepared by in-situ polymerization method and carbonization process with oxygen limitation. The hollow N/S–B–C nanoflakes are decorated by orderly aligned nanorods on the surface, which effectively balances the intrinsic high conductivity and strong polarization behavior of carbon material. The substitution of heterogeneous atoms disrupts the symmetry of local microstructures, leading to the dipolar resonances and/or vibration for enhancing dielectric loss. The N/S–B–C nanoflakes possess the minimum reflection loss ( RL min ) of − 53.5 dB at 10.2 GHz and corresponding effective absorption band (EAB) of 4.5 GHz at 2.9 mm. When the thickness is only 2.22 mm, the widest EAB is up to 5.15 GHz ranging from 12.30 to 17.40 GHz. This outstanding conductivity loss and interfacial polarization relaxation as well as the improved impedance matching from hollow structure synergistically determine excellent microwave absorption performance. This study provides an effective strategy for exploring the underlying relations between conduction loss and polarization behaviors in graphitized carbon.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-8
·
IF 14.7
Xing Xing,Wu Luyan,Zhang Yuchen,Pan Jiahao,Ishigaki Yusuke,Xie Huaqing,Suzuki Takanori,Ye Deju,Zhang Jianhua,Zhang Weihua,Lu Zhenda
Early disease diagnosis hinges on the sensitive detection of signaling molecules. Among these, hydrogen sulfide (H 2 S) has emerged as a critical player in cardiovascular and nervous system signaling. On-chip immunoassays, particularly nanoarray-based interfacial detection, offer promising avenues for ultra-sensitive analysis due to their confined reaction volumes and precise signal localization. Beyond the DNA or protein biomolecules array, this work presents a promising hybrid small molecule nano-array for H 2 S detection, using the power of dual molecules: a dye for fluorescence emission and a quencher with specific H 2 S reactivity. Upon H 2 S interaction, the quenched fluorescence reignites, creating an easily detectable array of bright spots. The molecule nano-array sensor shows exceptional responses to H 2 S over 8 magnitudes of dynamic range from 1 fM to 0.1 μM, with a remarkable detection limit of 1 fM, just using a 10 μL solution. This H 2 S detection method has the potential to significantly improve bioassay platforms, and the hybrid small-molecule nano-arrays we developed could be a valuable tool for advancing signaling molecule detection.
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IRANIAN POLYMER JOURNAL
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2024
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IF 2.4
Shi Liang,Shen Xue,Qi Hongyun,Zhang Xiaomei,Shu Ruiwen
A novel lignin-based magnetic composite was synthesized using a facile method, with epichlorohydrin (ECH) serving as a cross-linker to bond amino-functionalized magnetic nanoparticles (AMNP), polyethyleneimine (PEI), and sodium lignosulfonate (LS). The synthesized composite (AMNP/LS-PEI) was subjected to characterization through multiple analytical techniques, namely FTIR, XRD, BET, TG, VSM, XPS, FE-SEM, EDS, HRTEM, and TEM. Following the synthesis, a thorough investigation was conducted into the composite’s adsorption capabilities for methylene blue (MB) and methyl orange (MO) dyes through batch adsorption, taking into account pivotal factors, including pH, contact time, solution concentration, and temperature. The experimental data suggested that the adsorption of MO and MB onto AMNP/LS-PEI was in good accordance with the Langmuir isotherm model. The AMNP/LS-PEI demonstrated maximum adsorption capacities ( Q max ) of 482.7 mg g −1 for MO and 375.6 mg g −1 for MB, respectively. The MB and MO-adsorption kinetics onto AMNP/LS-PEI closely fit the pseudo-second-order model. Furthermore, the thermodynamic analysis revealed that the adsorption process of dyes onto AMNP/LS-PEI was an endothermic one. Upon six adsorption–desorption cycles, AMNP/LS-PEI demonstrated sustained adsorption capacity, achieving removal rates of 81.3% for MB and 77.1% for MO, respectively. The potential advantage for practical applications lied in its highly selective adsorption capability for mixed solutions of MB and MO. Specifically, at a pH of 4, MO was preferentially adsorbed, whereas at a pH of 8, MB was favored for adsorption. In addition, the adsorption mechanism of AMNP/LS-PEI toward dyes was explored using FTIR and XPS, and was found to be mainly ascribed to the electrostatic interaction, hydrogen bonding interaction, and cation exchange. Graphical abstract
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Journal of Inorganic and Organometallic Polymers and Materials
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2024
·
IF 3.9
Zheng Lu,Zhu Jide,Chen Jipeng,Xu Yanlian,Jiang Lilong
The performance of silver nanoparticles (AgNPs) as highly efficient antimicrobial agents is limited by their agglomeration and instability. Environmentally friendly silver-based nanomaterials have attracted considerable attention, owing to the superior dispersion and antibacterial activity of AgNPs. In this work, polyurushiol (PUL) was used to modify an AgNPs-based material and prepare PUL-decorated AgNPs (PUL-AgNPs). The stability and dispersion of the composites varied with the reaction conditions. The PUL-AgNPs material showed higher antibacterial activity than the AgNPs, with minimum inhibitory concentration (MIC) values against E. coli and S. aureus of 3.13 mg/L ( p < 0.01) and 6.25 mg/L ( p < 0.01), respectively. PUL-AgNPs also showed inhibitory potential against three microalgae, P. tricornutum , I. zhanjiangensis , and N. closterium . The 72-h LC50 values of PUL-AgNPs for the three algae were 1.95, 1.89, and 4.07 mg/L, respectively. This study shows the promising potential of PUL-AgNPs for antibacterial and anti-microalgae applications, especially for marine antifouling. Graphical Abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
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IF 3.8
Ma Fen,Wang Weibiao,Wang Mei,Zhang Weiman,Zhang Shuxian,Wilson Gidion,Sa Yuping,Zhang Yue,Chen Guoning,Ma Xueqin
Given the inherent complexity of natural medicines, finding a straightforward and efficient method for identifying active ingredients remains a significant challenge, yet it is of paramount importance. Influenza virus neuraminidase (NA), a primary target for anti-influenza drug development, plays a crucial role in the infection process, making it essential to develop rapid and facile methods for screening NA inhibitors. Herein, we developed a novel and efficient analytical technique for the identification of NA inhibitors from complex herbal medicines by integrating dual sensing with affinity chromatography. This approach simplifies the experimental process and highlights the benefits of being quicker, more sensitive, and cost-effective. Regarding the biosensing section, the innovative concept of a 4-methylumbelliferyl-N-acetylneuraminic acid-NA-based fluorescence paper sensor strategy enables the rapid detection of NA inhibitors in complex herbal samples. In affinity chromatography, bioactive compounds were precisely captured, separated, and identified. The efficacy and reliability of the developed method were confirmed using both negative and positive controls. Then, the method was applied to screen for NA inhibitors in 20 different herbal medicines. The results revealed that Bupleurum chinense DC. exhibited the most pronounced inhibitory effect on NA. Subsequent analysis utilizing affinity chromatography identified three bioactive compounds, namely saikosaponin a, saikosaponin d, and baicalin, as the active agents responsible for this inhibitory effect, with IC 50 values of 177.3 μM, 262.9 μM, and 241.4 μM, respectively. Molecular docking studies further indicated that these three bioactive compounds exhibit a strong binding affinity with NA. This research provides novel insights into the screening of enzyme inhibitors within herbal medicines. Graphical abstract
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Carbon Letters
·
2024
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IF 5.5
Chen Jinghong,Xie Huan,Lin Yuyin,Tan Zhenxing,Zheng Mingchen,Yuan Yong,Zhou Lihua
Ibuprofen (IBU), a common pharmaceutical and personal care product (PPCP), is a pervasive water pollutant with adverse ecological and human health effects after transformation and accumulation. In this study, we synthesized Fe, N-doped carbon quantum dots (Fe, N-CQDs) using pig blood and FeCl 3 as a precursor via a one-step hydrothermal method. TEM, XRD, XPS, and UV–Vis were used to characterize the physical and chemical properties of Fe, N-CQDs. We investigated the feasibility of Fe, N-CQDs in activating peroxymonosulfate (PMS) for IBU degradation under visible light. The experimental results revealed that Fe in Fe, N-CQDs predominantly formed a stable complex through Fe–N and Fe-OH, with a high degree of graphitization and a sp 2 -hybridized graphitic phase conjugate structure. The Fe, N-CQDs/Light/PMS system exhibited strong activity, degrading over 87% of IBU, maintaining a wide pH range (3–10) adaptability. Notably, Fe, N-CQDs acted as visible-light catalysts, promoting Fe 3+ /Fe 2+ cycling and PMS activation, generating both free radicals (SO 4 •– , ·OH) and non-radicals ( 1 O 2 , h + ) to effectively degrade IBU. This study presents an innovative approach for the sustainable utilization of pig blood as a biomass precursor to synthesize Fe- and N-doped carbon materials. This study provides a new approach for the sustainable and value-added utilization of natural wastes and biomass precursors of Fe- and N-doped carbon materials, which can be used to treat pollutants in water while treating discarded pig blood. Graphical abstract
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International Journal of Minerals Metallurgy and Materials
·
2025
·Vol. 32
·期 3
·668-677
·
IF 7.2
Huo Yuying,Wang Zhengyan,Zhang Yanlan,Wang Yongzhen
High-entropy design is attracting growing interest as it offers unique structures and unprecedented application potential for materials. In this article, a novel high-entropy ferrite (CoNi) x /2 (CuZnAl) (1− x )/3 Fe 2 O 4 ( x = 0.25, 0.34, 0.40, 0.50) with a single spinel phase of space group \(Fd\bar{3}m\) was successfully developed by the solid-state reaction method. By tuning the Co–Ni content, the magnetic properties of the material, especially the coercivity, changed regularly, and the microwave absorption properties were improved. In particular, the effective absorption bandwidth of the material increased from 4.8 to 7.2 GHz, and the matched thickness decreased from 3.9 to 2.3 mm, while the minimum reflection loss remained below −20 dB. This study provides a practical method for modifying the properties of ferrites used to absorb electromagnetic waves.
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