JOURNAL OF FOOD SCIENCE
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2019
·Vol. 84
·期 8
·2042-2049
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IF 2.081
Lipeng Han,Qingna Lin,Guoqin Liu,Dongxue Han,Li Niu,Dongxiao Su
It is important to inhibit the food-derived, potentially hazardous chemical glycated lipids by natural products. A model system was established and the products are identified to study the inhibitory mechanism of four types of catechin, resveratrol (RES), and the synthetic antioxidants butylated hydroxylanisole (BHA) and tert-butylhydroquinone (TBHQ) on the formation of carboxymethyl 1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine (CM-DPPE) by determining hydroxyl radical (OH·), Amadori-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine (Amadori-DPPE) and glyoxal (GO). The results show that the inhibitory rates of catechin and RES on the content of CM-DPPE in the model system are higher than those of BHA and TBHQ. There are at least two inhibitory mechanisms of antioxidants on CM-DPPE. (1) Antioxidants scavenge OH·, which blocks the process of Amadori-DPPE oxidation to form CM-DPPE. (2) Antioxidants trap GO, which blocks the reaction between GO and DPPE to form CM-DPPE. This research will reveal the inhibitory mechanisms of natural antioxidants on glycated lipids from the aspect of scavenging OH· and trapping GO. Practical Application Food manufacturers should pay attention on the production of glycated lipids in food processing. This study will provide the theoretical basis for the use of natural products to inhibit the formation of food-derived glycated lipids. Natural products, such as catechin and resveratrol, can substitute chemical synthesis antioxidants, such as butylated hydroxylanisole and tert-butylhydroquinone, in food processing, which inhibit the formation of glycated lipids.
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FOOD RESEARCH INTERNATIONAL
·
2019
·
IF 3.579
Wei Xu,Nan Zhang,Zhentao Zhang,Pu Jing
Anthocyanins exist likely as complexes with flavones/metal ions in some plants. However, few studies indicate the complexation effects on bioactivities, i.e. antioxidant activities. The aim of this study was to evaluate effects of complexes of cyanidin-3-diglucoside-5-glucoside (CY3D5G) with rutin/Mg(II) on intrinsic antioxidant enzymes and mRNA expressions. All complexes exhibited cellular antioxidant activity in RAW264.7 cells, whereas half maximal effective concentration (EC 50 ) values of CY3D5G complexes were significantly lower than its alone. Combination indexes of CY3D5G-rutin, CY3D5G-Mg(II), and CY3D5G-rutin-Mg(II) complexes were < 1 ( p < .05), indicating of synergistic effects. Additionally, CY3D5G-Mg(II) rather than others significantly enhanced total antioxidant capacity, superoxide dismutase activity, and glutathione peroxidase activity while reducing malonic dialdehyde contents in H 2 O 2 -induced RAW264.7 cell model ( p < 0.05), which were further confirmed with the up-regulated mRNA expression of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), and the down-regulated p21 ( p < 0.05). Our results demonstrated that CY3D5G and its complexes might enhance cellular antioxidant activities via the Nrf2/HO-1 signaling pathway. Additionally, a synergistic antioxidant effect of CY3D5G in the present of rutin/ Mg(II) as regular food components was evident, suggesting anthocyanin might interact with dietary components such as Mg(II) or rutin in food matrix or biological systems and exhibit a stronger antioxidant activity than it alone. The Mg (II) that exhibited no antioxidant activities alone shows potential as a co-adjuvant for the anthocyanin antioxidant activity.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2019
·
IF 4.084
Xiaorong Zhang,Muhammad Shakeel,Baoshan Li,Muhammad Arif,Xianglong Kong,Jianjun Liu,Shengli Zuo
The present study is about the fabrication of an efficient photo-/electrocatalyst, prepared via in-situ hydrothermal coupling of ZnO with g-C 3 N 4 . The results prove this electrocatalyst as suitable band structure semiconductor. The crystalline nature and related morphological parameters are controlled by optimized hydrothermal and calcination temperatures conditions. A series of physicochemical characterization are applied to inquire the crystalline structure, surface morphology , optical capabilities and charge transportation properties. Results revealed that the sample acts as excellent electrocatalyst with OER current density at 10 mAcm −2 @ 335 mV and the HER at 100 mAcm −2 @ −225 mV. While upon illuminations its catalytic properties further enhance at OER 10 mAcm −2 @ 326 mV and for HER current density of 100 mAcm −2 @ −167 mV. It can be seen from the present study that g-C 3 N 4 play gigantic role in enhancing the catalytic property of ZnO and hence it leads to a relationship between hierarchical features and photo-/electrochemical activity for water splitting.
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TOXICOLOGY IN VITRO
·
2019
·
IF 3.067
Yonghong Miao,Xiaoxue Sun,Guojun Gao,Xianglei Jia,Hao Wu,Ying Chen,Liyong Huang
(-)-epigallocatechin-3-gallate (EGCG), the main component of green tea, has long been explored in the treatment and/or prevention of central nervous system (CNS) disorders. However, EGCG has been recently shown to exhibit acute and subacute toxicity. Although a lot of work has been done, the mechanisms of EGCG-induced mitochondrial dysfunction has not been delineated in primary astrocyte. Here, the mitotoxic effect of EGCG on primary astrocytes was investigated by measuring Ca 2+ overloading-induced mitochondrial dysfunction. As expected, EGCG dose-dependently inhibited astrocytes growth depending on Ca 2+ overloading, especially at 50 μM EGCG group. It is interesting to note that Ca 2+ influx from the extracellular space was responsible for an increase in the cytosolic Ca 2+ level ([Ca 2+ ] i ) by opening voltage-gated calcium channels (VGCCs) and, consequently, mitochondrial Ca 2+ ([Ca 2+ ] m ) overloaded via the mitochondrial Ca 2+ uniporter (MCU). As a result, mitochondrial dysfunction was induced, including the opening of the mitochondrial permeability transition pore (mPTP), mitochondrial membrane depolarization, an increasing in reactive oxygen species (ROS), and cytochrosome c (cyt c) releasing. Therefore, more apoptotic cells were observed in 50 μM EGCG group than that of in 1 μM EGCG group. These findings suggested that a high dose of EGCG was toxic to astrocytes partly by targeting mitochondria via calcium pathway, which would extend our understanding of the toxicity of EGCG and the underlying mechanisms.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Wenqi Zhao,Yitong Dai,Haiyun Sun,Yongsheng Guo,Wenjun Fang
Biofuel mixed with fossil jet fuels has a lot of potential in applications of jet fuel extenders. To understand the fundamental properties of this typical mixture, measurements on densities and viscosities for the ternary model system of exo-tetrahydrodicyclopentadiene (1) + isopropylcyclohexane (2) + methyl laurate (3) and three corresponding binary mixtures have been implemented over the entire composition range at eleven different temperatures from 293.15 to 343.15 K. The excess molar volumes (VmE) and viscosity deviations (Δη) of binary mixtures were calculated and correlated by the Redlich–Kister equation, while the corresponding data of ternary mixtures were fitted to Nagata–Tamura, Cibulka, Singh, and Redlich–Kister equations. Furthermore, the variations of VmE and Δη were represented and discussed based on molecular interactions and structural effects in detail.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2019
·Vol. 138
·期 2
·1251-1257
·
IF 2.471
Wang Yanfei,Liu Xiaoyu,Zhao Xiaoyu,Chen Zhao,Yang Libin,Zhu Liang
Solid–liquid-phase equilibrium is an important part of chemical thermodynamics, and its basic theoretical research plays a vital role in the advancement of the chemical industry. Solid–liquid equilibria for binary mixtures of 3-nitrotoluene and 4-nitrotoluene were measured using differential scanning calorimetry under atmospheric pressure (101.3 kPa). The results showed that the phase diagram of the 3-nitrotoluene + 4-nitrotoluene binary system presented a eutectic behavior, and the eutectic point was x 1 = 0.6487, T E = 272.15 K. Furthermore, the experimental results were correlated with Wilson and nonrandom two-liquid (NRTL) activity coefficient models well. The relative standard deviations were 0.496 and 0.236, respectively, and the absolute mean deviations were 0.005 and 0.001, respectively.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2018
·Vol. 165
·期 9
·A1915
·
IF 3.662
Yazhen Chen,Zhengliang Gong,Yong Yang
A fluorinated electrolyte consisting of fluorinated ether 1,1,2,2-Tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane (F-EPE) and 1,2-Dimethoxyethane (DME) is evaluated as a new electrolyte for Li-S batteries. The coulombic efficiency and capacity retention of Li–S batteries are significantly improved with the use of F-EPE/DME based electrolyte combing with PEO as binder. The Li-S batteries exhibit a high coulombic efficiency of ∼96% and capacity retention of 78% after 100 cycles at 0.1C. Moreover, the F-EPE based electrolyte can work well without LiNO3 additive, thus make it possible to eliminate the safety concerns raised by the gassing reaction of LiNO3. The function mechanism of F-EPE as cosolvent was investigated by self-discharge test, polysulfide dissolution experiments, SEM and UV-Vis spectra. The enhanced electrochemical performances can be attributed to that F-EPE cannot only decrease the solubility of lithium polysulfides in electrolyte thus suppress the shuttle effect, but also take part in the formation of passivation film on lithium metal anode, indicating the positive effect of F-EPE on electrochemical properties of Li-S batteries.
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CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
C.F. Xing,H.T. Wu
A series of Li 4 Mg 3 [Ti 1-x (Mg 1/3 Ta 2/3 ) x ] 2 O 9 (LMT 1-x (MT) x ) (x = 0–0.4) ceramics were prepared via the traditional solid-state method. The effects of the substitution of (Mg 1/3 Ta 2/3 ) 4+ on the sintering characteristic, crystal structure, phase composition and dielectric properties of Li 4 Mg 3 Ti 2 O 9 ceramics were investigated for the first time. The analysis of the X-ray diffraction pattern indicated that the pure cubic Li 4 Mg 3 Ti 2 O 9 phase could be formed in the whole composition range of 0 ≤x ≤ 0.4. Dense and homogeneous microstructures of LMT 1-x (MT) x ceramics sintered at 1400–1550 °C could be revealed from the scanning electric microscope. The optimum microwave dielectric properties, with a permittivity 15.77, a quality factor 160,575 GHz (at 8.38 GHz) and a τ f value 0 ppm/°C, were achieved in the Li 4 Mg 3 [Ti 0.8 (Mg 1/3 Ta 2/3 ) 0.2 ] 2 O 9 ceramic sintered at 1550 °C.
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Canadian Journal of Chemistry
·
2018
·Vol. 96
·期 12
·
IF 1.084
Guanhong Liu,Peipei Ren,Fan Yang,Xuekai Dou,Jun Wang,Youtao Song
Two novel isomeric colorimetric probes are established for simultaneous determination of copper ions using 2-hydroxy-5-methoxybenzaldehyde fluorescein hydrazone (5-HMBA-FH) and 2-hydroxy-3-methoxybenzaldehyde fluorescein hydrazone (3-HMBA-FH). They are synthesized by reacting fluorescein hydrazide with 2-hydroxy-5-methoxybenzaldehyde and 2-hydroxy-3-methoxybenzaldehyde, respectively, and then characterized by 1H-NMR, 13C-NMR, and infrared spectrum. The addition of copper ions to the solutions of two novel colorimetric probes can generate the obviously peaks at 498 nm in UV–vis absorption spectra along with a rapid colour change from colourless to dark yellow. The detection limits of the method for Cu2+ ion were 3.442 × 10−6 mol/L and 3.682 × 10−6 mol/L separately for 5-HMBA-FH and 3-HMBA-FH, respectively. The additions of other metal ions hardly affect the determination of copper ions. The proposed method was successfully applied to the analysis of Cu2+ ions in various samples. This method possesses high sensitivity, high simplicity, and minimized interference and will provide a great advantage in detecting copper ions in the environment, food, and medical applications.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Xing Chen,David Julian McClements,Jian Wang,Liqiang Zou,Sumeng Deng,Wei Liu,Chi Yan,Yuqing Zhu,Ce Cheng,Chengmei Liu
Particle-stabilized W1/O/W2 emulsion gels were fabricated using a two-step procedure: (i) a W1/O emulsion was formed containing saccharose (for osmotic stress balance) and gelatin (as a gelling agent) in the aqueous phase and polyglycerol polyricinoleate (a lipophilic surfactant) in the oil phase; (ii) this W1/O emulsion was then homogenized with another water phase (W2) containing wheat gliadin nanoparticles (hydrophilic emulsifier). The gliadin nanoparticles in the external aqueous phase aggregated at pH 5.5, which led to the formation of particle-stabilized W1/O/W2 emulsion gels with good stability to phase separation. These emulsion gels were then used to coencapsulate a hydrophilic bioactive (epigallocatechin-3-gallate, EGCG) in the internal aqueous phase (encapsulation efficiency = 65.5%) and a hydrophobic bioactive (quercetin) in the oil phase (encapsulation efficiency = 97.2%). The emulsion gels improved EGCG chemical stability and quercetin solubility under simulated gastrointestinal conditions, which led to a 2- and 4-fold increase in their effective bioaccessibility, respectively.
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NEUROREPORT
·
2018
·Vol. 29
·期 5
·432
·
IF 1.266
Zhang Jinghui,Qiao Nana,Ding Xiufang,Wang Jiwen
Excitotoxicity and neuronal death following epilepsy involve α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). It forms a protein complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and co-internalizes upon activation of AMPA receptors after epilepsy. Disruption of the GluA2 /GAPDH complex with an interfering peptide , TAT- GluA2 NT1-3-2 , protects cells against AMPAR-mediated excitotoxicity, which have been identified in in-vitro and in-vivo models of brain ischemia. We postulated that disruption of the GluA2 /GAPDH interaction with the TAT- GluA2 NT1-3-2 peptide would also protect against AMPAR-induced neuronal injury in an in-vivo model of status epilepticus (SE). In the present study, we divided pilocarpine -induced SE Wistar rats into three main groups: the TAT- GluA2 NT1-3-2 peptide group, the TAT- GluA2 NT-scram peptide group, and the normal saline group, and injected different doses of peptides stereotaxically into the hippocampus of SE rats to investigate whether the GluA2 /GAPDH interaction could be disrupted by our TAT- GluA2 NT1-3-2 peptide and determine its most appropriate dose. Then, the dose was administered stereotaxically at different time points after SE to determine the best administration time of neuronal protection. We found that the TAT- GluA2 NT1-3-2 peptide can disrupt the GluA2 /GAPDH interaction and protects against epilepsy-induced neuronal damage. The GluA2 /GAPDH interaction may be a novel therapeutic target for epilepsy.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2014
·
IF 2.045
Kelei Zhuo,Hao Ren,Yujing Wei,Yujuan Chen,Jingjing Ma
Activity coefficients of the 1-alkyl-3-methylimidazolium bromide [Cnmim]Br (n = 3 to 8) ionic liquids (ILs) in fructose + water mixed solvents at 298.15 K were determined by cell potential measurements. The molalities of [Cnmim]Br ranged from (0.005 to 0.1) mol·kg–1 and those of fructose from (0.2 to 0.8) mol·kg–1. Gibbs free energy interaction parameters were also obtained together with salt constants. The interactions between [Cnmim]Br and fructose are mainly controlled by electrostatic interactions. Gibbs free energy interaction parameters (gES) and salting constants (kS) are negative for the ILs (n = 3 to 6), indicating fructose are salted-in by the ILs in water, whereas fructose are salted-out by the ILs (n = 7 and 8).
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