NEW JOURNAL OF CHEMISTRY
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2018
·Vol. 42
·期 6
·4653-4660
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IF 3.201
Peipei Chen,Ting Wang,Xiangli Zheng,Dong Tian,Fangquan Xia,Changli Zhou
A convenient, highly efficient and ultrasensitive electrochemical immunosensor was developed using in situ deposited silver nanoparticles (Ag NPs) as tracing tags for fetoprotein (AFP) detection. The function of the immunosensor was achieved by a co-catalytic effect on the surface of nanocomposites containing polyamidoamine (PAMAM) dendrimers coated with C60 (PAMAM-C60 NPs) and gold nanoparticles (Au NPs). On the surface of Au@PAMAM-C60 NPs labeled with an antibody (Ab2), via a sandwich-type immunoreaction, silver ions in solution were reduced to metallic Ag NPs. The electrochemical signal of the in situ deposited Ag NPs could be utilized to monitor the immunoreaction. Under optimum conditions, the peak current of the Ag NPs increased with increasing AFP concentration in the range from 0.1 pg mL−1 to 10 ng mL−1, with a detection limit of 0.03 pg mL−1. Importantly, the designed electrochemical immunoassay strategy exhibited excellent sensitivity, stability, selectivity, and reproducibility.
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Materials
·
2018
·Vol. 11
·期 2
·239
·
IF 2.467
Dandan Men,Yingyi Wu,Chu Wang,Junhuai Xiang,Ganlan Yang,Changjun Wan,Honghua Zhang
Two-dimensional (2D) periodic micro/nanostructured arrays as SERS substrates have attracted intense attention due to their excellent uniformity and good stability. In this work, periodic hierarchical SiO2nanopillar arrays decorated with Ag nanoparticles (NPs) with clean surface were prepared on a wafer-scale using monolayer Au NP arrays as masks, followed by reactive ion etching (RIE), depositing Ag layer and annealing. For the prepared SiO2nanopillar arrays decorated with Ag NPs, the size of Ag NPs was tuned from ca. 24 to 126 nanometers by controlling the deposition thickness of Ag film. Importantly, the SiO2nanopillar arrays decorated with Ag NPs could be used as highly sensitive SERS substrate for the detection of 4-aminothiophenol (4-ATP) and rhodamine 6G (R6G) due to the high loading of Ag NPs and a very uniform morphology. With a deposition thickness of Ag layer of 30 nm, the SiO2nanopillar arrays decorated with Ag NPs exhibited the best sensitive SERS activity. The excellent SERS performance of this substrate is mainly attributed to high-density “hotspots” derived from nanogaps between Ag NPs. Furthermore, this strategy might be extended to synthesize other nanostructured arrays with a large area, which are difficult to be prepared only via conventional wet-chemical or physical methods.Keywords:wafer-scale;hierarchical arrays;RIE;Ag NPs;SERS substrate
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Molecular Medicine Reports
·
2017
·Vol. 17
·期 3
·3763-3768
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IF 1.692
Xiao‑Yu Li,Li Xu,Hong‑Li Li,Jing Du,Xue‑Song Liu,Feng‑Hua Li
The present study aimed to prepare and characterize an Au-poly(lactic-co-glycolic) acid (PLGA) complex, surfaced with gold nanoparticles (GNPs), and to assess its use as an ultrasound contrast agent for in vitro imaging. PLGA nanoparticles (NPs) were prepared by a modified double‑emulsion solvent evaporation method. GNPs were prepared via reduction with sodium citrate. Au‑PLGA complexes were created through the binding of polyethylene glycosylated GNPs to the surface of PLGA NPs. Various physical characteristics of PLGA NPs, GNPs and Au‑PLGA complexes, including morphology, size, dispersion, ζ potential and stability were observed and measured. The study of the in vitro imaging capability of the Au‑PLGA complex was conducted by setting multi‑parameter imaging conditions. The average sizes of PLGA NPs, GNPs and the Au‑PLGA complex were 144.5±30.28, 21.42±1.56 and 359.4±67.94 nm, respectively. Transmission electron microscopy (TEM) revealed that PLGA NPs and GNPs were spherically shaped, but GNPs had smooth surface while PLGA NPs had a capsular morphology with a wrinkled surface and large voids. The maximum absorption peak of 20 nm GNPs was 508 nm while that of the Au‑PLGA complex was 515 nm on an ultraviolet‑visible absorption spectrum curve. The results of TEM and the redshift spectrum demonstrated that GNPs successfully bound to the surface of the PLGA NPs. The complex demonstrated good stability and its size changed little over time. In vitro imaging experiments revealed that the Au‑PLGA complex had a good imaging ability. The present study demonstrated that the Au‑PLGA complex is a promising novel ultrasound contrast agent.
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ACS Biomaterials Science & Engineering
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2018
·
IF 4.432
Juqun Xi,Wenjuan Wang,Lanyue Da,Jingjing Zhang,Lei Fan,Lizeng Gao
Imaging-guided diagnosis and therapy has been highlighted in the area of nanomedicines. However, integrating multiple functions with high performance in one theranostic (“all-in-one”) still presents considerable challenges. Here, “all-in-one” nanoparticles with drug-loading capacity, catalase-mimetic activity, photoacoustic (PA) imaging ability and photothermal properties were prepared by decorating Au nanoparticles on doxorubicin (DOX) encapsulated poly(lactic-co-glycolic acid) (PLGA) vehicle. The results revealed that the as-prepared Au-PLGA hybrid nanoparticles possessed high photothermal conversion efficiency of up to approximately 69.0%, meanwhile their strong acoustic generation endowed them with efficient PA signal sensing for cancer diagnosis. On an 808 nm laser irradiation, the O2 generation, DOX release profile and reactive oxygen species (ROS) level were all improved, which were beneficial to relieving tumor hypoxia and enhanced the cancer chemo/PTT combined therapy. Overall, the multifunctional Au-PLGA hybrid nanoparticles with these integrated advantages shows promise in PA imaging-guided diagnosis and synergistic tumor ablation.
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RSC Advances
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2018
·Vol. 8
·期 8
·3964-3973
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IF 2.936
Li Sun,Yuechao Yin,Pengcheng Lv,Wenxian Su,Lixin Zhang
The controllable synthesis of Au–Ag alloy nanoparticles (NPs) without any hazardous or expensive chemical agent has been a challenge. This paper reports on the Chinese wolfberry fruit extract-assisted synthesis of Au–Ag alloy NPs with homogeneous composition, uniform alloy microstructure and a small average size less than 15 nm. The composition and the surface plasmon resonance (SPR) wavelength of Au–Ag alloy NPs could be linearly adjusted by the synthesis time in one-pot. Au–Ag alloy NPs were characterized by means of various techniques, and then their synthesis mechanism was discussed. The obtained Au–Ag alloy NPs were used as photocatalysts for the reduction reactions of 2-, 3-, and 4-nitrophenol and exhibited superior photocatalytic activity and stability. The rate constants of the above photocatalytic reactions could be linearly tuned by the composition of the Au–Ag alloy NPs and also by their addition amount, displaying a new method to control the rate constant. Furthermore, based on the controllable synthesis, the rate constant could even be predetermined just through setting the synthesis parameters of the Au–Ag alloy NPs.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Meng Cheng,Xingtai Yan,Wenjing Liu,Ruihua Li,Gangfu Song
Designing and synthesizing sustainable adsorbents for the separation and recovery of gold from waste resources has significant importance to alleviate the problems of the scarcity of resource and environmental pollution. Herein, a cyanide-functionalized ionic liquid-modified polymer (CPR-CN) was prepared by a simple one-step process for gold (Au(III)) recovery. The introduction of cyan group and cationic imidazolium ring gives CPR-CN significant adsorption ability with 1450.41 mg/g. Kinetics study suggested that the uptake of Au(III) onto CPR-CN could be commendably matched by the pseudo-second order kinetic model and it took only 10 min to reach adsorption equilibrium. The CPR-CN had a remarkable selectivity towards Au(III) for it presented much overwhelming affinity for Au(III) than that for other base metal ions such as K(I), Co(II), Cu(II), Ca(II), Mg(II), Al(III) and Fe(III), thus it was successfully applied to recover Au(III) from e-waste leaching solution. Besides, the CPR-CN displayed preferable reusability, and the possible mechanism of CPR-CN for Au(III) was investigated with the aid of several characterization techniques. These performance of CPR-CN indicates it can serve as an attractive adsorbent to efficiently and selectively separate and recover Au(III) from waste.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Jun Li,Jianwei Zhang,Yingzhe Du,Xiaoxia Liu,Ronghao Liu,Yanzhao Yang
Efficient gold extraction is of paramount importance, but how to improve the extraction efficiency and enhance the driving force of the extraction process is still to be explored. This study introduces an innovative approach using versatility ionic liquids (ILs) to overcome existing challenges. A tailored IL was synthesized and employed computational tools, including the Interaction Region Indicator, to predict its effectiveness in gold extraction. Quantum chemical calculations elucidated the interplay between hydrogen bonding capability and ion exchange properties of the ILs. Subsequent optimization of experimental conditions (0.1 mol/L HCl, 10.6 mg IL) yielded a remarkable 98.4 % extraction efficiency at 45 °C. Molecular dynamics simulations affirmed the IL's exceptional selectivity for Au(III) extraction, with analysis revealing that the extraction mechanism primarily hinged on electrostatic attraction and van der Waals interactions between ionic liquid cations and [AuCl 4 ] − . This mechanism aligns with the established anion exchange mechanism, validated through Ultraviolet–visible spectrometer (UV–Vis), Nuclear Magnetic Resonance spectrometer (NMR), and Liquid Chromatograph Mass Spectrometer (LC-MS) analyzes. To complete the extraction cycle, 1.0 mol/L K 2 C 2 O 4 was employed as a stripping agent for efficient Au(III) recovery from the loaded IL phase, facilitating repeated extraction cycles. This study underscores the sustainability of the IL-based Au(III) extraction process, maintaining consistently high extraction rates even after five cycles. In summary, this method does not use solvent, enabling environmentally friendly Au(III) extraction.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Zengliang Ren,Zhicheng Shi,Qingyang Tang,Shuimiao Xia,Liang Sun,Runhua Fan,Hongzhi Cui,Hong Wang
Polymer dielectrics have been widely employed in pulsed power systems, but their applications are severely restricted by the low energy density. Incorporating core-shell nanofillers is one promising strategy to enhance the energy density of polymer dielectrics. Nowadays, core-shell nanofillers are mainly prepared via chemical coating strategies, which always involve complex chemical synthesis procedures. Herein, a unique physical coating strategy is developed to prepare core-shell TiO 2 @Au nanofibers consisting of monodispersed Au nanoparticles homogeneously anchored on the TiO 2 nanofibers. Interestingly, the TiO 2 @Au nanofibers show outstanding dielectric energy storage boosting capability. Specifically, with merely introducing 0.1 wt.% TiO 2 @Au nanofillers, the TiO 2 @Au/PVDF composite exhibits a substantially enhanced breakdown strength of 749 MV m −1 , which reaches 152.8% of PVDF. Meanwhile, a high dielectric constant of 10.2 (114.1% of PVDF) is obtained. Consequently, an ultrahigh energy density of 18.6 J cm −3 , which is 250.1% of PVDF, is achieved. It is further revealed that the significant energy storage boosting effect is originated from the Coulomb blockade and micro-capacitor effects of the TiO 2 @Au nanofibers. This work establishes a unique paradigm for the facile preparation of core-shell nanomaterials, which have huge potential for both dielectric energy storage and other functional nanocomposites.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
·
IF 8.1
Ruiting Li,Tengyang Gao,Yao Wang,Yan Chen,Wen Luo,Yang Wu,Yu Xie,Yong Wang,Yifan Zhang
The application of metal catalysis has gained prominence as a study area in recent years. In this work, we use adsorptive reduction and calcination to create Au–Pd alloy catalysts on COCN-2 with varying metal loadings. The plasma resonance effect of the alloys increases the photoresponse of the catalysts, and the engineering of nitrogen defects strengthens the strong bonds between Au–Pd alloy particles and carbon nitride graphite, optimizing the electronic structure, encouraging electron-directed migration, and increasing the efficiency of the reduction reaction. As a result, the efficiency of hydrogen generation by the Au–Pd 0.6 /COCN-2 catalyst is 5.089 mmol g −1 h −1 , which is 2367 times higher than that of the g-C 3 N 4 catalyst. Our findings highlight the crucial part that flaws play in strengthening the strong bonds that exist between the metal and the support, which enhances photocatalytic hydrogen generation. This work offers insightful information about creating effective photocatalysts.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xuan Zhang,Weiquan Zhan,Qizheng Weng,Sheng Wang,Shaoxian Song,José Luis Arauz-Lara,Feifei Jia
Low-concentration gold recovery from thiosulfate solutions (Au(S 2 O 3 ) 2 3– ) was vital for the application of thiosulfate leaching instead of traditional cyanide leaching in gold industries. Herein, electro reduction-recovery of gold in thiosulfate solutions via multi-porous activated carbon (AC) was proposed. Recovery of Au(S 2 O 3 ) 2 3– within a low concentration range by multi-porous AC electrodes reached to almost 100 %. Even in the presence of high concentration interferential ions (molar ratio of S 2 O 3 2− to Au was 300:1), there was not any effect on the recovery. Interestingly, Au(S 2 O 3 ) 2 3– was recovered on the surface of multi-porous AC electrodes as the form of gold metal, realizing the recovery and reduction at the same time, which would be prone to shorten the traditional recovery procedure. Besides, the correlation of Au(S 2 O 3 ) 2 3– adsorption behaviors and multi-porous AC structure was well studied. Appropriate activation temperature was beneficial for the generation of multi pores together with oxygen functional groups, providing rich activate sites for Au(S 2 O 3 ) 2 3– adsorption and reduction. High electric double layer capacity (EDLC) and low charge transfer resistance jointly affected the Au(S 2 O 3 ) 2 3– recovery ability. The work provided an approach for gold recovery within a low concentration range in thiosulfate leaching solutions using multi-porous AC electrodes, thus to promote the green development of gold resources.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Tian Wang,Wei Wang,Yunqing Zhu,Baozhong Zhang
AuNPs/rGO composite cathode was prepared using in-situ reduction method and was applied for H 2 O 2 generation through molecular oxygen (O 2 ) undergoing a 2-electron reduction reaction in the electro-Fenton system. The results showed the AuNPs/rGO cathode exhibited good activity and stability. The size and loading amount of AuNPs, as well as applied voltages were considered for evaluating the catalytic activity of AuNPs/rGO cathode. AuNPs 2:1 /rGO with the smallest size (2.8 ± 0.6 nm) exhibited higher catalytic activity in the electro-Fenton system when the AuNPs 2:1 loading amount was 2.7 %, pH= 3, and applied voltage was −0.6 V (vs. SCE), resulting in an H 2 O 2 yield of 19.3 ± 0.1 mmol g −1 . The synergistic effect of AuNPs 2:1 and rGO enhanced the activation of H 2 O 2 , generating a large number of hydroxyl radicals (∙OH) for efficient degradation of rhodamine B (RhB), corresponding to a degradation efficiency of 100 % within 30 min. In addition, AuNPs 2:1 /rGO exhibited excellent stability and reusability in cyclic experiments. The quenching experiment and the radical spin trap test showed ∙OH and superoxide anion (∙O 2 ̄) as the active species during the reaction process. Furthermore, LC-MS and in-situ FTIR were used to analyze the intermediate products of the degradation process and determine the reaction mechanism.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jing Zhang,Yang Xue,Lan Zhang,Jun Chen,Dayan Ma,Yingang Zhang,Yong Han
Bacterial infections seriously retard skin wound healing. To enhance the antibacterial efficiency and subsequent skin regeneration, a core–shell structured therapeutic platform, named FZAM, was designed with multiple antimicrobial pathways. FZAM consists of nanosized Fe3O4 as the core and ZIF-8 loaded with Au nanoparticles (NPs) and maltodextrin as the shell. Fe3O4 and Au NPs form a heterojunction that generates hyperthermia and abundant reactive oxide species (ROS) under near-infrared (NIR) irradiation. This heterojunction also exhibits outstanding peroxidase-like activity. When bacteria invade, maltodextrin plays a targeting effect to increase the interaction between FZAM and bacteria, and with the synergistic action of NIR-induced hyperthermia and ROS as well as Zn2+ from ZIF-8, FZAM kills more than 99% of bacteria at 200 μg mL–1. Fortunately, FZAM is cytocompatible and even promotes the biofunctions of fibroblasts and endothelial cells. In infected skin wound models, FZAM sterilizes bacteria with NIR irradiation and subsequently reduces the inflammatory response and accelerates skin regeneration. This work provides a core–shell structured therapy platform for treating infection with the assistance of NIR irradiation and helping skin wound healing.
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