POLYMER DEGRADATION AND STABILITY
·
2026
·
IF 8.1
Zhicheng Wu,Qingzhe Zhu,Ying Zhang,Jiayi Zhao,Qiyue Zhou,Zehao Zhang,Chao Gao,Guoli Wang,Qiaogen Zhang
Closing the material loop for end-of-life thermoset composites demands efficient solvolysis recycling, yet the coupled action of solvent diffusion into the crosslinked network, plasticization that unlocks chain-segment mobility, and catalytic bond cleavage remains poorly understood at the mechanistic level. In this work, in-situ dielectric spectroscopy combined with distribution of relaxation times (DRT) analysis is established as a real-time strategy for resolving the coupled mobility, diffusion, and reaction contributions during the chemical recycling of anhydride-cured epoxy resin. An interdigital electrode sensor embedded beneath the epoxy layer enables continuous dielectric acquisition throughout the solvolysis process, which is further considered to be different modes resolved by DRT. An orthogonal perturbation design assigns these modes to segmental mobility and catalytic bond cleavage. Dedicated swelling and thin-film degradation schemes provide the intrinsic diffusion and reaction parameters of a quantitative coupled kinetic framework. Assembling these parameters into a coupled kinetic framework with three local state variables produces a quantitative description of the simultaneous evolution of mobility, solvent penetration, and bond cleavage. The framework identifies a dual-gated positive-feedback mechanism in which both a mobility threshold and a concentration threshold must be exceeded before bond cleavage proceeds, after which two positive feedback loops accelerate degradation from the surface inward. The coupled model reproduces the in-situ response across conditions withheld from calibration, providing a general experimental and theoretical framework for resolving coupled transport-reaction processes in thermoset chemical recycling and for guiding the design of greener, energy-efficient solvolysis processes for thermoset waste valorization.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Meigui Huang,Ruifeng Ying,Mehraj Ahmad,Qiuhong Liao,Yonghong Li
The ultrasonic treatment was more likely to form V-shaped complexes. • UT enhanced the thermal stability of the complex. • UT significantly enhanced the anti-digestive property of the complex. This study aimed to investigate the effects of complexes formed by ultrasonicated highland barley starch (UHS) and ferulic acid (FA) at concentrations of 1% to 5% on the functional properties and digestive characteristics of starch. The XRD results showed that UHS formed more V-shaped crystal structures with FA, and the maximum amount of FA increased from 3% to 5%. Fourier transform infrared spectroscopy demonstrated that it enhanced the crystallization and hydrogen bond interaction of UHS with FA. The 1 H NMR spectrum of the complex revealed a more pronounced low-field shift, confirming that ultrasonic treatment significantly enhanced the interaction between starch and FA. This results in higher crystallinity, more complex structural density, and superior viscoelastic and thermal properties, enhancing anti-digestibility and increasing anti-starch content from 20.69% to 28.22%. UT effectively modulates the complex's physicochemical and digestive properties, suggesting potential applications in functional highland food development. Schematic diagram of the experimental procedure. Download: Download high-res image (263KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2026
·Vol. 15
·期 14
·2550
·
IF 6
Yuhan Jiang,Sha Ao,Xianwen Hu,Shilin Liu
Water-in-water (W/W) Pickering emulsions based on aqueous two-phase systems (ATPS) are promising for food applications, but their stabilization is challenged by the ultra-low interfacial tension inherent to ATPSs. This study developed food-grade W/W Pickering emulsions stabilized by bacterial cellulose nanocrystals (BCNCs) and evaluated their ability to regulate starch digestibility. The effects of dextran (Dex) concentration, maltodextrin (MD) concentration, and BCNC content on the microstructure, rheological properties, and stability of the emulsions were systematically investigated. The partitioning behavior of amylopectin (AMP) between the two phases and the in vitro digestion behavior of AMP-loaded W/W Pickering emulsions in the presence of α-amylase were further examined. Fourier-transform infrared spectroscopy confirmed the successful preparation of BCNCs. The optimal formulation (24 wt% Dex, 14 wt% MD, and 0.24 wt% BCNCs) exhibited a uniform droplet distribution and enhanced storage stability. Contact angle analysis indicated preferential wettability of BCNCs toward the continuous Dex-rich phase, promoting interfacial adsorption and droplet stabilization. The emulsions remained stable at pH 3.0–7.0 but were sensitive to ionic strength above 7 mM sodium chloride. Importantly, in vitro digestion showed that BCNC-stabilized emulsions significantly inhibited α-amylase-mediated hydrolysis of AMP, with the hydrolysis extent reducing from ~54% to 14%. These results indicate that BCNCs act as effective natural stabilizers for W/W Pickering emulsions, forming a physical barrier that retards starch digestion. This work provides a sustainable strategy for designing slow-digestible, low-glycemic-index food systems with potential applications in functional foods and pharmaceuticals.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 14
·6340
·
IF 5.6
Jiacong Hong,Xiaoyan Zhang,Ganggang Kong,Bailing Chen,Shengli Zhao
Osteosarcopenia, which is the coexistence of sarcopenia and osteoporosis, is being increasingly recognized as a systemic musculoskeletal aging syndrome. However, shared molecular regulators of bone–muscle deterioration remain unclear. In this study, we integrated bulk transcriptomic datasets from sarcopenic skeletal muscle and osteoporosis peripheral blood mononuclear cells to identify shared differentially expressed genes, followed by two-sample Mendelian randomization using osteoporosis genome-wide association study summary statistics to prioritize genes with potential causal relevance. Furthermore, diagnostic performance, functional enrichment, immune infiltration, single-cell RNA sequencing, regulatory network reconstruction, compound prediction, and siRNA-mediated validation were conducted in C2C12 and MC3T3-E1 cells. Overall, 122 shared differentially expressed genes were preliminarily screened, andKAZNandSUPT3Hwere tentatively proposed as candidate genes genetically associated with osteoporosis risk. Both genes were upregulated in the disease groups and exhibited weak to modest diagnostic performance. Furthermore,KaznorSupt3hknockdown promoted myogenic differentiation in C2C12 cells as well as osteogenic differentiation and mineralization in MC3T3-E1 cells, supporting their roles as negative regulators of lineage differentiation. Moreover, functional analyses linkedKAZNmainly to mitochondrial-related programs andSUPT3Hto immune signaling, whereas single-cell analyses localized these genes to stromal, progenitor, and immune-related compartments. These hypothesis-generating findings suggest thatKAZNandSUPT3Hparticipate in shared bone–muscle dysfunction and generate candidate genes and mechanistic hypotheses for subsequent functional validation and translational research.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Zeyuan Li,Yuze Jiao,Huang Lin,Qianhong Shen,Xinglei Zhao,Peng Wang,Qilong Zhang
Traditional zirconia (ZrO 2 ) fibers suffer from severe limitations in mechanical performance under extreme conditions due to high-temperature phase transformation-induced cracking, abnormal grain growth, and inherent brittleness, making it difficult to meet the stringent requirements of fields such as aerospace and energy systems. This work proposes an innovative fabrication strategy that successfully achieves in-situ growth of an amorphous carbon coating layer on the surface of Al/Y co-doped ZrO 2 nanofibers through electrospinning and hot-stretching processes. In this work, zirconium acetate acts as both zirconium source and solvent, simplifying precursor preparation. The hot-stretching process utilizes the micropores on the fiber surface to form an in-situ amorphous carbon layer, which significantly enhances the mechanical properties of the fibers: tensile strength reaches 8.08 MPa, and the fiber membrane maintains structural integrity after 500 bending cycles at 80% strain, demonstrating excellent fatigue resistance and elastic recovery capability; it also exhibits outstanding thermal shock resistance at extremely low (-196°C) and ultra-high (1350°C) temperatures. Through the key innovation of introducing an amorphous carbon layer via hot-stretching, this work successfully integrates high strength, superior flexibility, and outstanding fatigue resistance into ZrO 2 fibers. Furthermore, owing to its high porosity (92%), the fiber membrane exhibits ultra-low thermal conductivity and effective sound absorption. Ultimately, this provides a reliable solution for multifunctional ceramic fiber materials applied in high-temperature environments (up to 800°C).
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2026
·
IF 4.7
Zhaoyue Yang,Yujian Du,Yian Hu,Yanfeng Miao,Yuljae Cho
Self-powered photodetectors (SPPDs), operating without an external bias, hold significant potential for next-generation optoelectronic systems. Their performance, however, is intrinsically constrained by the heterojunction interface, since charge extraction depends solely on the built-in potential. Here, we report a strategy to enhance the built-in potential and device performance in quasi-2D perovskite (PVK)-based SPPDs through energy landscape engineering at the heterojunction interface. By incorporating self-assembled molecules (SAMs) onto a hole transport layer (HTL), we achieve suppression of low-n phase of quasi-2D PVK, reduced interfacial recombination, and an enhanced built-in electric field. Systematic characterization reveals that the SAM promotes favorable energy alignment, passivates interfacial defects, and promotes improved PVK film growth. The SPPDs exhibit a high responsivity of 0.373 A/W, a specific detectivity of 8.34 × 1012 Jones at 560 nm, and an external quantum efficiency exceeding 70% across wavelengths of 460–610 nm with a peak of 82% at 560 nm. Furthermore, the devices demonstrate rapid response times of 7.25/3.68 μs and improved operational stability, retaining 96.4% of their initial performance over 4200 h. This work demonstrates interfacial energy landscape engineering as an effective strategy for improving the potential of quasi-2D PVKs for self-powered optoelectronic devices.
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zichen Shangguan,Xingzhong Yuan,Longbo Jiang,Chencheng Qin,Xiangyan Chen,Jing Bai,Zhiyan Feng,Jingyi Wang,Hou Wang,Hui Wang
A Co Mn atomic switch reconstructs radical and non-radical PMC activation pathways. • Nominal waste O 2 is valorized into selective 1 O 2 via a unique cascade. • The non-radical route yields 13.3-fold rate hike and effluent detoxification. • High robustness is proven over 100-h continuous flow operation in real water matrices. Advanced oxidation processes (AOPs) hold great promise for pollutant abatement, yet selectively triggering non-radical pathways remains a formidable challenge, as radical and non-radical routes often compete kinetically. Here, by exploiting the confined framework of Silicalite-1 zeolites, we engineer bimetallic Co Mn sites where tailoring the Co/Mn ratio drives a structural evolution from isolated diatomic to nanoclusters, functioning as an atomic-scale switch to govern this competition in peroxymonocarbonate (PMC) activation. A Co-rich composition stabilizes atomically dispersed heteronuclear Co Mn sites featuring Mn-promoted Co(II) centers. This precise configuration kinetically inhibits direct peroxide cleavage and instead promotes interfacial single-electron transfer to oxygen (O 2 ), thereby valorizing this traditionally wasted byproduct into the non-radical singlet oxygen ( 1 O 2 ) generation. Conversely, a Mn-rich composition induces aggregated nanoclusters with abundant electron-deficient oxygen vacancies, which facilitate peroxy-bond dissociation and shift the reaction toward radical pathways. Corroborated by density functional theory and comprehensive experimental validations, this composition-dependent pathway regulation affords the optimized non-radical system a 13.3-fold kinetic enhancement and stable continuous-flow operation over 102 h. Download: Download high-res image (130KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Physiological Reports
·
2026
·Vol. 14
·期 11
·e70975
·
IF 2.1
Yunxian Wang,Fenglan Chu,Yanhua Gong,Ruihong Guo,Hui Dong
Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short-circuit current ( I sc ) in the murine ileum, which was significantly reduced by extracellular Cl − , Na + , and Ca 2+ removal. Mechanistically, MSG-induced I sc was significantly attenuated by pharmacological inhibition of key transporters (NCX, SGLT1, NKA) and secretory channels (CaCC, CFTR, IK Ca ). Furthermore, disrupting intracellular Ca 2+ homeostasis via endoplasmic reticulum (ER) chelation or blockade of IP 3 R, RyR, SOCE/CRAC, and VGCC significantly suppressed both the ileal I sc and MSG-stimulated Ca 2+ signaling in IECs. Importantly, MSG triggered a simultaneous elevation in intracellular Ca 2+ and a reduction in Na + , which were abolished by the blockers of NCX and SGLT1. In vivo, MSG-induced Ca 2+ -dependent ion transports were significantly reduced in irritable bowel syndrome with diarrhea (IBS-D) mice. Our findings indicate that MSG drives Ca 2+ -dependent intestinal ion transports through a complex network orchestrated by SGLT1 and NCX under healthy state, which is markedly attenuated in IBS-D. This study provides novel insights into the gastrointestinal impact of dietary MSG in both health and bowel disease.
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2026
·
IF 11.8
Hui Wang,Xiang Li,Zitong Jiang,Qing Xu,Qiaoqin Guo,Chaozheng He,Junjun Zhang,Yaming Liu,Mingshang Jin
Direct ethanol fuel cells are promising clean energy devices, but the difficulty in cleaving the C─C bond of ethanol leads to low C1 pathway selectivity (typically ∼10%) and incomplete energy conversion. To address this challenge, we synthesized a porous multiphase Pd-based metallene nanocatalyst co-doped with oxygen-philic Cu and W. Temperature was identified as the key factor regulating the crystal structure: low temperatures yielded amorphous phases, high temperatures produced crystalline phases, and intermediate temperatures formed the desired crystalline/amorphous mixed multiphase structure. This multiphase structure provided abundant active sites. The optimal PdCuW metallene exhibited exceptional performance for ethanol electrooxidation: a record-high C1 pathway selectivity of 72.6% (1.6 times that of undoped Pd metallene and 10.2 times that of commercial Pd/C), a mass activity of 4301.6 mA/mg Pd (4.7 times that of commercial Pd/C), and superior stability (only 7.3% activity decay vs. 67.9% for commercial Pd/C). Mechanistic studies (In situ ATR-FTIR, DFT calculations) revealed that synergistic Cu-W doping reduced the C─C bond cleavage energy barrier, enhanced OH * adsorption, and weakened the poisoning effect of intermediate CO * . The work offers a rational design strategy for high-selectivity electrocatalysts, advancing ethanol's full energy utilization and holding broad implications for Pd-based catalyst systems in energy conversion technologies.
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2026
·
IF 17.3
Hao Li,Shanghao Xiao,Yarong Liu,Yifan Zheng,Chongchong Chen,Wenjia Wu,Wenxiu Yang,Jingtao Wang
Precisely defining proton transport channels and regulating the chemical microenvironment of proton carriers are critical for high-performance proton exchange membranes (PEMs). Beyond optimizing carrier type and density, modulation of electron density distribution offers an underexplored route to enhance intrinsic proton conductivity. Herein, a series of ZnM-BDC-COOH nanosheets are synthesized by partial substitution of Zn2+ with a second metal ion in Zn-BDC frameworks and subsequent −COOH modification. The optimized ZnCu-BDC-COOH achieves a high intrinsic proton conductivity of 361.5 mS cm–1 over 16 times that of the pristine Zn-BDC (22.2 mS cm–1) at 80 °C and 98% RH using comb electrodes. Density functional theory and molecular dynamics simulations reveal that the introduced Cu2+, with higher electronegativity, withdraws more electrons from adjacent −COOH groups and Zn ions, generating asymmetric electron cloud distribution within the O–H bonds and the heterogeneous Zn3CuO(COO)6 nodes. This electron asymmetry facilitates rapid H+ release and establishes a strong local potential gradient that lowers the proton transport barrier. The resulting ZnCu-BDC-COOH lamellar membrane achieves a peak power density of 0.92 W cm–2, outperforming Nafion-117 (0.28 W cm–2), and maintains good durability over 100 h of open-circuit voltage (OCV) under 80 °C and 100% RH in fuel cells.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Tiwen Xu,Ruijie Ren,Junjie He,Fei Yan,Shuxin Guan,Shuyan Jiang,Junye Huang,Jingshui Xu,Ying Yang,Kaiyang Huang
Silica-hybridized carbon black (CB-SiO 2 ) shows a promising eco-friendly filler for tread rubber, combining the advantages of both potentially. Here, in situ hydrolyzed nano-SiO 2 anchored on CB particles was prepared by varying the tetraethyl orthosilicate (TEOS) dosage, and its effect on the properties of natural rubber (NR) composites was studied. Results demonstrated the existence of hydrogen bond between CB and SiO 2 , and increasing the anchored SiO 2 delayed curing, yet enhanced tensile strength by 35.6% and lowered rolling resistance (tan δ @60°C) by 22.7% while maintaining wear resistance (8 mL TEOS/10 g CB, no coupling agent). The improvement is attributed to the hybrid's higher specific surface area, favorable particle-size distribution, and surface protrusions, which strengthen rubber-filler interaction despite the reduced dispersive free energy ( γ s d $$ {\gamma}_s^d $$ ). This work presents a green and sustainable strategy for designing high-performance CB in its production process.
✓ 已验证
DOI
高影响因子
ANNALS OF BIOMEDICAL ENGINEERING
·
2026
·
IF 5.2
Gao Zanhua,Lin Haoming,Yu Zhifan,Xu Huiqin,Chen Xin,Zhang Xinyu,Shen Yuanyuan
Purpose The development and progression of gliomas are intimately linked to abnormal tumor angiogenesis. Different grades of gliomas exhibit distinct vascular distribution and structural characteristics. Therefore, analyzing vascular architecture and hemodynamics can provide crucial insights into tumor growth and invasion. Methods Ultrasound localization microscopy (ULM) was applied to image the cerebrovascular changes in an orthotopic glioma mouse model at two different stages of tumor progression (14- and 21-days post-implantation). A total of twenty mice with intracranial glioma were imaged on the 14th day (n = 9) and on the 21st day (n = 11) after implantation. Pathological staining, vascular endothelial immunofluorescence examinations, and fluorescence dye perfusion were conducted to compare the ULM imaging results of the microvascular network morphology. Results By separating slow and fast blood flow signals, the ULM images revealed distinct vascular changes that visually correlated with H&E-derived pathological features. The vascular densities in glioma regions showed a significant increase compared to the contralateral side: 30.4% on day 14 (39.91% ± 4.09% vs. 30.60% ± 3.17%, p < 0.001) and 56.5% on day 21 (42.54% ± 3.78% vs. 27.17% ± 4.56%, p < 0.001) post-glioma implantation. The vascular densities obtained from ULM images correlated strongly and significantly with pathological and vascular perfusion results (CD31 and DiI perfusion). ULM-derived multiparametric analysis further revealed significantly reduced average vessel length in glioma regions at both Day 14 (123.72 ± 28.06 μm vs. 192.90 ± 27.75 μm, p < 0.001) and Day 21 (87.07 ± 22.92 μm vs. 233.79 ± 38.94 μm, p < 0.001), decreased blood flow velocity at Day 21 (3.70 ± 0.66 mm/s vs. 4.64 ± 0.82 mm/s, p < 0.001), and increased flow-orientation heterogeneity at both Day 14 (0.838 ± 0.082 vs. 0.595 ± 0.174, p < 0.001) and Day 21 (0.812 ± 0.086 vs. 0.625 ± 0.083, p < 0.001). Conclusion ULM imaging modality enables in vivo simultaneous structural-functional imaging of glioma microvasculature at micron-level resolution, capturing microcirculatory alterations across glioma regions. Its feasibility and reliability in visualizing vascular abnormalities were validated against ex vivo pathological and vascular perfusion, providing preclinical evidence for research and clinical applications in glioma therapy assessment and aggressiveness monitoring.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）