JOURNAL OF NANOPARTICLE RESEARCH
·
2022
·Vol. 24
·期 6
·1-16
·
IF 2.533
Yang Yuhang,Zhu Zhongan,Adu-Frimpong Michael,Liu Jing,Wang Yaping,Chen Lin,Toreniyazov Elmurat,Ji Hao,Cao Xia,Shi Feng,Wang Qilong,Yu Jiangnan,Xu Ximing
Licorice chalcone A (LCA) possesses a variety of pharmacological activities amid poor solubility in water which consequently restricts its clinical application. In this study, LCA micelles (LCA-M) and LCA micelles modified with TPGS (LCA-M-T) were prepared, wherein in vitro, in vivo, and hepatoprotection potential of the formulations were evaluated. LCA-M-T and LCA-M were prepared by thin-film dispersion method and characterized by a transmission electron microscope (TEM). The encapsulation efficiency, in vitro release, and stability of LCA-M-T and LCA-M were detected by HPLC and UV, respectively. The pharmacokinetics, tissue distribution studies, and pharmacodynamics research were also carried out after oral administration. The sizes of micellar particles were 34.02 ± 0.29 nm (LCA-M) and 62.46 ± 0.51 nm (LCA-M-T) with 0.223 ± 0.021 (LCA-M) and 0.343 ± 0.006 (LCA-M-T) polydispersities, − 35.06 ± 2.27 mV (LCA-M) and − 38.58 ± 1.69 mV (LCA-M-T) zeta potentials, and 95.2 ± 0.27% (LCA-M) and 90.34 ± 0.31% (LCA-M-T) encapsulation efficiencies. The drug loadings were 8.56 ± 0.27% (LCA-M) and 8.04 ± 0.19% (LCA-M-T). The two preparations released quickly and reached over 95% in the four-dissolution media (pH = 1.2 pH = 6.8 pH = 7 pH = 7.4). The preparations of LCA showed significant elevation of cumulative release compared with the free LCA and more importantly 119% (LCA-M) and 285% (LCA-M-T) increments in the relative oral bioavailability of the drug. Preparations of LCA may act as a promising approach to improve solubility and enhance bioavailability and liver protective activity of LCA.
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COMPOSITES COMMUNICATIONS
·
2026
·
IF 8.6
Wei Zhang,Zhiqin Zhao,Lanlan Wei,Kai Zhang,Min Shi,Yang Chen,Lijun Wang
Microcellular polymer composites with an excellent conductivity are greatly desired for electromagnetic interference (EMI) shielding applications, but it still remains a great challenge to fabricate conductive composite foams with intelligent EMI shielding performance at minimal amounts of functional filler. Herein, a novel and facile technology is developed for in-situ creating poly(3,4-ethylenedioxythiophene)/ferroferric oxide (PEDOT/Fe 3 O 4 ) in the closed-cells of bulk epoxy foams without sacrificing the lightweight and mechanical properties. Via vapor phase polymerization of EDOT monomer using FeCl 3 as oxidant and followed by alkali treatment, the in-situ generated PEDOT/Fe 3 O 4 composites densely pack at the inner walls of closed-cells to form the highly conductive islands. These islands are linked by the nanofiller/PEDOT conductive chains in cell walls, thus constructing the unique “island-chain” segregated conductive nanostructure. This architecture endows the resultant composite foams with good conductivity, outstanding EMI shielding effectiveness, highly effective absorbance (A eff ), epsilon-negative (ε′ < 0) response and considerable compressive strength, showcasing obvious advantages as compared to conventional design in open-cells. Moreover, these functional composite foams display a repeatably pH-sensitive EMI shielding performance with a significant difference of 14 dB, providing a potential approach for intelligent EMI shielding.
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Plants-Basel
·
2026
·Vol. 15
·期 5
·706
·
IF 4.7
Zhuoya Zhang,Junrong Guo,Zurun Huang,Xiuyan Zheng,Ping Xiong
Cinnamomum cassia essential oil production generates substantial waste, and the therapeutic potential of non-volatile constituents from cinnamomum cassia leaves in ulcerative colitis (UC) has not been fully explored. This research focused on identifying the principal components of cinnamomum cassia leaf extract (CCLE) through ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS), and its anti-inflammatory potential was verified in vitro. A lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage model was employed, with assessments performed through cell viability assays, Griess assay, fluorescent probe detection, wound healing, and Transwell migration assays. Network pharmacology analysis combined with molecular docking revealed that CCLE exerts therapeutic effects against UC by targeting key molecules including TNF, TLR4, STAT3, SRC, PTGS2, NFKB1, MMP9, EGFR, BCL2, and AKT1, with high binding affinity between these targets and CCLE components (especially Quercetin, Catechin, Naringenin, 3′,4′-dimethoxyflavonol, Procyanidin Bl, and Caffeic acid). Enrichment analysis indicated that the therapeutic effect of CCLE on UC was significantly associated with the PI3K-Akt signaling pathway, B cell receptor signaling pathway, NF-κB signaling pathway, TNF signaling pathway, and JAK-STAT signaling pathway. The experimental results demonstrated that CCLE markedly reduced the production of nitric oxide (NO) and reactive oxygen species (ROS) (*p< 0.05) and inhibited macrophage migration (*p< 0.05). In conclusion, CCLE appears to ameliorate UC via a multi-target regulatory mechanism involving inflammatory signaling pathways. These outcomes offer a scientific foundation for the further development of CCLE.
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PubMed
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Liang Ye,Wenming Liu,Bo Yao,Guobo Li,Lizhi Zhang,Jian Ji,Yupeng Liu,Jia Li,Fangruo Ding,Jingda Li,Ying Zhang,Honggen Peng
Dry reforming of methane (DRM) to produce syngas can effectively address environmental issues caused by the greenhouse effect. Nevertheless, sintering and coking of catalysts under high-temperature operating conditions continue to be critical challenges that hinder practical applications. Herein, this work develops a CoRh alloy catalyst (Co 7 Rh 3 /DMS) confined in dendritic mesoporous silica (DMS) that displays an 89.1 % CH 4 and 92.4 % CO 2 conversion, approaching the thermodynamic equilibrium limit. Under a continuous operation at 800 °C for 100 h, the Co 7 Rh 3 /DMS catalyst shows a CH 4 and CO 2 deactivation rates of merely 0.022 %·h −1 and 0.011 %·h −1 , respectively, with negligible coke formation (<0.1 wt%) and metal sintering. Notably, the surface spatial confined structures of DMS effectively suppress the migration and agglomeration of active sites. Comprehensive mechanistic investigations indicate that the synergistic mechanism of CoRh alloy reduces the CH 4 dissociation energy barrier and promotes CO 2 activation, thereby facilitating the in-situ elimination of carbonaceous precursors. This work provides a rational design strategy for advancing the efficient resource utilization of greenhouse gases.
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TALANTA
·
2026
·
IF 6.7
Jingjing Yin,Yuehua Wang,Shanshan Zhu,Xiaoxue Liu,Yujie Sun,Hong Yang,Yifei Ma,Jinhua Liu
The development of wavelength-tunable fluorescence immunoassays for sensitive biomarker detection remains a significant challenge in clinical diagnostics. In this work, we present an HRP-induced in situ fluorogenic immunoassay platform based on the rapid reaction between p-phenylenediamine (PPD) analogues and 6-hydroxyquinoline (6-Hy). The proposed mechanism involves HRP-catalyzed generation of hydroxyl radicals from H 2 O 2 , which subsequently oxidize PPD to form fluorescent copolymer nanoparticles (FCNPs) with 6-Hy. By strategically modifying the PPD structure with various substituents, we achieved discrete and tunable emission of FCNPs, with maxima spanning from 380 to 600 nm (Δλ ≈ 220 nm). Using cardiac troponin I (cTnI) as a model antigen and zinc-coordination nanoparticles (ZnNPs) as carriers, the immunoassay demonstrated exceptional performance, with a wide dynamic range (0.5-125 ng/mL) and an ultralow detection limit (0.17 ng/mL) for cTnI. The platform was successfully validated in human serum samples, showing excellent correlation with clinical standards. This work not only establishes a novel strategy for wavelength-programmable immunoassays but also provides a versatile platform for advancing biomarker detection in clinical diagnostics.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Zihui Liu,Wenting Feng,Jianhang Yang,Xinru Wei,Yunbo Zhang,Chenyu Ma,Yiming Sun,Han Wang,Haolin Wu,Debin Kong,Changming Mao
The escalating demand for high-energy-density storage has intensified research on Li-Cl 2 batteries, which exhibit ultrahigh energy density but suffer from rapid failure due to the poor ionic conductivity and mechanical fragility of naturally formed LiCl interphases on Li metal. Here, we design an organic–inorganic hybrid protective layer (Li 3 Sb/LiF/PVDF, denoted as LSLP@Li) via in situ interfacial engineering. This designed layer effectively isolates the Li anode from corrosive SOCl 2 electrolyte and suppresses parasitic reactions. The synergistic Li 3 Sb/LiF phase ensures high ionic conductivity and guides uniform Li deposition, while the flexible PVDF matrix accommodates cycling-induced volumetric strain. As a result, the LSLP@Li anode maintains structural integrity for over 48 h in corrosive electrolyte (<2 h for bare Li), enabling Li-Cl 2 batteries to maintain over 400 cycles at 1000 mA g −1 . The study advances the understanding of naturally formed LiCl layer on SOCl 2 -based battery and provide valuable strategy to achieve the interfacial stability.
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Advanced Healthcare Materials
·
2026
·
IF 9.6
Hai Zhou,Chaoyang Huang,Yanqi Chen,Tingzi Zhao,Fengyi Zhu,Gong Jun,Jinrong Zhang,Yingsong Pan,Qiulan Wen,Lei Yang,Huihui Zhang,Lianglong Chen
Diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and susceptibility to infection, posing significant clinical challenges. Here, we report an intelligent shape-memory sponge (P 1 A 3 @B-MOF) engineered for the programmable modulation of the diabetic wound microenvironment. The dressing consists of an interpenetrating network of oxidized pullulan and acellular dermal matrix, incorporating zeolitic imidazolate framework-8 (ZIF-8) metal–organic frameworks encapsulated with salvianolic acid B (SalB) via in situ self-assembly. This design enables exudate-triggered shape recovery and pH-responsive drug release, targeting the acidic pathological environment. We demonstrate that the released Zn 2+ and SalB exert synergistic effects: conferring broad-spectrum antibacterial activity, orchestrating macrophage repolarization from proinflammatory M1 to regenerative M2 phenotypes, and activating the hypoxia-inducible factor 1-alpha (Hif-1α)/vascular endothelial growth factor (VEGF) pathway to restore vascularization. In a diabetic rat model, the sponge accelerated wound closure with a 98.5% healing rate by day 14 and modulated collagen deposition via the transforming growth factor-β (TGF-β)/Smad signaling axis, thereby effectively mitigating scar formation. This integrated strategy offers a promising modality for restoring immune homeostasis and promoting functional skin regeneration.
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PHYTOMEDICINE
·
2026
·
IF 8.3
Yin-Chao Tong,Huan Lin,Yang Yang,Zhi-fu Zhou,Yi-Ning Zhang,Juan Wang,Wu-ren Ma,Yongsheng Wang,Wei-Min Zhang,Su-Zhu Qing
Background Antimicrobial resistance (AMR) infection is attracting increasing attention, especially superbug infections. As a result, finding ways to reduce AMR is essential. For the time being, natural compound therapy for reducing AMR is an ideal choice. Purpose This study aims to investigate the mechanism of magnolol reducing the AMR of E. coli in vitro and vivo . Methods The morphology and function of E. coli under magnolol treatment were assessed using a scanning electron microscope, qPCR, RNA-seq, and other methods. Moreover, the in vivo treatment effects of magnolol combined with antibiotics were evaluated by HE and IHC staining. Results In this study, we found that magnolol reduced the resistance of ESBL E. coli to the fourth-generation cephalosporin in vitro via two main mechanisms. Firstly, magnolol disrupts iron ion metabolism by increasing environmental iron uptake significantly (P ≤ 0.01), leading to a significant increase in intracellular ROS (P ≤ 0.01) and membrane damage. Secondly, magnolol significantly inhibits the relative mRNA expression of blaCTX-M-1 (P ≤ 0.01) and the CTX-M-1 enzyme activity in ESBL E. coli. Furthermore, we find that magnolol can inhibit ESBL E. coli in vivo by significantly reducing the TLR4-NFκB p65 pathway ( P ≤ 0.01). Conclusion In a word, our results indicate that magnolol is a natural antibacterial adjuvant with potent inhibitory activity against bacterial resistance and exerts this activity through multiple pathways, which has particular significance for the further study of the AMR mechanism.
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Journal of Materials Chemistry B
·
2026
·
IF 5.7
Lingling Wei,Haoyu Jin,Zhongke Ji,Haoyang Tian,Jiayang Han,Yanyan Liu,Wanjia Li,Di Liu,Hui Song
Oral squamous cell carcinoma (OSCC) remains a challenging malignancy with high recurrence and metastasis rates, often limited by insufficient immunogenicity and a suppressive tumor microenvironment. Immunogenic cell death (ICD) offers a promising approach to convert cell death into antitumor immunity, yet its efficacy depends on precise modulation of autophagy and endoplasmic reticulum stress (ERS). Here, we report that combining the BET inhibitor JQ1 with the autophagy inhibitor chloroquine (CQ) synergistically amplifies ERS, leading to enhanced ICD in OSCC models. This combination promotes robust damage-associated molecular pattern (DAMP) release, dendritic cell activation, and antigen-specific CD8⁺ T-cell responses. To enable localized and efficient delivery, we engineered self-assembled JQ1/CQ nanoparticles stabilized through π–π stacking and integrated them into dissolvable cryomicroneedles. This minimally invasive platform ensures sustained drug release, improves tumor accumulation, and minimizes systemic exposure. Our study not only elucidates a druggable autophagy–ERS–ICD axis but also provides a versatile transdermal delivery strategy with potential applicability to a range of solid tumors.
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JOURNAL OF HAZARDOUS MATERIALS
·
2017
·
IF 6.065
Xiulei Fan,Chao Wang,Peifang Wang,Bin Hu,Xun Wang
Most studies investigating the influence of TiO 2 NPs on heavy metal bioavailability have focused on the aqueous phase; however, few have examined the sediments containing more nanoparticles. Here, we investigated the effects of TiO 2 NPs on heavy metal bioavailability in C. fluminea in sediments. The interactions between the TiO 2 NPs and metals in sediments, the influence of TiO 2 NPs on metals levels in aqueous phase and geochemical speciation were also explored. The results indicated the large adsorption capacity of TiO 2 NPs and the strong adsorption affinity to metals caused the metals adsorbed on nanoparticles, which decreased the metals concentrations in water phase. Changes in metal speciation caused by metals in EXC, CAR, and IMO partly transported from sediments to TiO 2 NPs during the aging of sediments. Heavy metals contents in C. fluminea tissues were in the order of gill > visceral mass > mantle > foot and increased with the increasing TiO 2 NPs contents in sediments. TiO 2 NPs enhanced the bioavailability of metals in the speciation of EXC, CAR, and IMO in sediments by the Trojan horse effects. The results can facilitate a more realistic evaluation of the environmental risks of TiO 2 NPs to benthic organisms in heavy metal-contaminated sediments.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2023
·
IF 6
Bingyang Li,Meiqian Chen
Massive spent ion exchange resins (SIERs) containing radionuclides are produced in nuclear power plants , which need to be treated reasonably. The migration mechanism of nuclides in SIER in both pyrolysis and gasification was evaluated from the chemical equilibrium analysis based on the Gibbs free energy minimization. The maximum volatility degrees of Co, Sr and Cs at 400–600 °C and 0.1 MPa were 0.01%, 0% and 0.1% in the pyrolysis . The maximum volatility degrees of Co, Sr and Cs were 0.015%, 0% and 100% at 600–1300 °C and 0.1 MPa in the gasification, and the steam concentration should be set mainly how to limit the volatilization of radionuclides . To reduce the volatility of nuclides as much as possible, the temperatures should be kept below 600 °C and 870 °C in the pyrolysis and gasification, respectively. The volatilization of Cs was greatly inhibited with lifting the pressure from 0.1 MPa to 1.5 MPa, which decreased from 0.103% to 0.007% in the pyrolysis (600 °C) and from 4.80% to 0.30% in the gasification (715 °C), respectively. Based on preventing the nuclides leakage, the negative pressure in the gasification should be controlled between 0.097 and 0.099 MPa. The volatilization of radionuclides was effectively weakened by adding a fixative, Zr(HPO 4 ) 2 ·H 2 O, since it could be helpful to reduce the gaseous cesium-based products in the pyrolysis and gasification. The volatility degree of Cs was close to 0 if Zr/Cs was great than or equal to 0.5. This study could provide basic data for the pyrolysis and gasification treatment of SIER.
研究领域:
核化学
·
环境工程
·
放射化学
·
废物处理
·
热力学分析
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PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2020
·Vol. 37
·期 2
·1900445
·
IF 3.099
Artem Yakovliev,Tymish Y. Ohulchanskyy,Roman Ziniuk,Tereza Dias,Xin Wang,Hao Xu,Guanying Chen,Junle Qu,Anderson S. L. Gomes
In this work, the application of near infrared (NIR)-emitting NaYbF 4 :1%Tm 3+ @NaLuF 4 :30%Nd 3+ core–shell nanoparticles is reported for noninvasive probing and monitoring the temperature during photopolymerization of dental materials. When excited at 808 nm, the synthesized nanoparticles emit NIR photoluminescence (PL) with two distinctive peaks at 865 and 980 nm which correspond to radiative transitions from the doped Nd 3+ and Yb 3+ ions, respectively. Luminescence intensity ratio between these two bands is found to vary with temperature due to temperature-dependent electronic excitation energy transfer between Nd 3+ and Yb 3+ ions at the core/shell interface. This finding allows luminescence ratiometric evaluation of the in situ temperature during photopolymerization of resin cement (doped with nanoparticles) in a veneer placement procedure. In addition, the NIR emission also enables PL imaging of the distribution of the adhesive under the veneer. The results highlight that rare-earth ions–doped nanoparticles with both excitation and emission in the NIR spectral range are advantageous for both PL-based nanothermometry and imaging due to the reduced attenuation of NIR light by dental ceramics.
研究领域:
生物医学工程
·
牙体牙髓病学
·
纳米医学
·
光学成像
·
生物材料
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危险品化学品经营许可证（带存储）