MICROCHIMICA ACTA
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2025
·Vol. 192
·期 8
·1-10
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IF 5.3
Liu Yadi,Li Shu,Guo Xinyuan,Wang Tong,Yang Dawei,Zhan Jinhua,Chen Jing
A solid-phase microextraction-SERS (SPME-SERS) analysis system was enhanced by the synergistic integration of azo reaction and electroextraction (Azo/EEx/SPME-SERS) to directly determine aromatic amines in serum and urine. Azo reactions selectively converted aromatic amines (e.g., aniline) into positively charged derivatives, which were selectively absorbed onto a rough silver SERS substrate via charge-selective electroextraction (- 0.2 V), excluding anionic interferents. Electroextraction-accelerated mass transfer and real-time SERS detection enabled rapid preconcentration and spectral acquisition under 3 min. The azo reaction increased the Raman scattering cross-section of aniline, and electroextraction reduced the distance of azo aniline to the SERS hot spots. This enabled low detection limits (aniline, 0.005 µg·mL −1 ). The Azo/EEx/SPME-SERS method achieved dual-dimensional interference exclusion through chemical derivatization (azo reaction) and physical charge-selective electroextraction, granting aromatic amines competitive adsorption advantage over serum metabolites at SERS hotspots. This synergy allows for the direct detemination of aniline in urine/serum with only 5–10 fold dilutions. It avoids the need for tedious pretreatments, while maintaining recoveries of 92–107%, accuracy of 97.33% (urine) and 94.89% (serum), and method detection limits of 0.05 µg·mL −1 (urine) and 0.5 µg·mL −1 (serum). Graphical
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Meng Jin,Ge Gao,Zeyu Liu,Xiao Meng,Haiyan Wei,Wenwen Chen,Hui Pan,Mengping Zhang,Qiang Jia,Cuijuan Wang
Public concern regarding the illicit addition of diphenhydramine (DPH) to children’s cosmetics highlights the urgent need for robust point-of-use (POU) detection strategies. In addressing this concern, we present a surface-enhanced Raman scattering (SERS)-based method for rapidly identifying and quantifying DPH in children’s creams. Our approach utilizes a multifunctional sensor comprising a cellulose nanofibrils (CNFs) film modified with metal-organic framework-801 (MOF-801) and hedgehog-like gold nanoparticles (GHPs). The synthesized GHPs/MOF-801/CNF sensor functions as both a SERS-active substrate and a sorbent, leveraging abundant nanogaps and sharp tips of the GHPs to amplify SERS signals. The porous CNF and MOF-801 ensure efficient and selective extraction, while the SERS-active GHPs significantly enhance detection sensitivity. The correlation between SERS intensity and logarithmic concentration yielded R-values between 0.926 and 0.978, with the detection limit as low as 0.4 ppb, making it suitable for detecting prohibited DPH additives. This method was successfully applied to two brands of cream samples, with results closely aligning with those from routine chromatography. This method’s key advantage is its exceptional efficiency, completing the detection process within 11 min, making it a user-friendly POU assay for detecting prohibited additives in children’s cosmetics.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Kaiyue Li,Wenhui Li,Ping Huang,Yuquan Zhuo,Ziwen Yang,Bo Wang,Runru Liu,Bing Liu,Enzhu Hou,Shuo Yang,Donglai Han
To address the challenge of achieving simultaneous pollutant removal and real-time monitoring in water remediation, Z-scheme Cu 2 O/g-C 3 N 4 /Ag heterostructures with integrated functionalities for synergistic adsorption, photocatalytic degradation, and surface-enhanced Raman scattering (SERS) detection were developed—hereafter referred to as APS-Hs (adsorption–photocatalysis–SERS heterostructures). Particular emphasis was placed on the Cu 2 O/g-C 3 N 4 /Ag-1.5 APS-Hs, incorporating an optimized 1.5 wt% Ag loading. Optical and electrochemical tests demonstrated that the Cu 2 O/g-C 3 N 4 /Ag-1.5 APS-Hs significantly enhanced charge separation efficiency and reduced charge transfer resistance. Under visible-light irradiation, the Cu 2 O/g-C 3 N 4 /Ag-1.5 APS-Hs attained a removal efficiency of 98.1 % for methyl orange (MO) within 45 min and sustained an efficiency of 84.0 % after three consecutive cycles. XRD and SEM analyses conducted before and after photocatalytic cycling confirmed the composite's outstanding structural and morphological stability. Notably, the Cu 2 O/g-C 3 N 4 /Ag-1.5 APS-Hs demonstrated the highest adsorption capacity (21.34 mg/g) among all samples. Zeta potential measurements revealed a surface charge reversal from + 22.35 mV to −10.29 mV, indicative of strong electrostatic interactions with anionic pollutants. Pseudo-second-order (PSO) kinetic modeling (R 2 =0.971) further established physisorption as the dominant mechanism. Radical trapping experiments verified that the enhanced photocatalytic performance originates from the Z-scheme charge transfer pathway. Additionally, the Cu 2 O/g-C 3 N 4 /Ag-1.5 APS-Hs substrate achieved a SERS enhancement factor of 3.1 × 10 6 and a broadband self-cleaning capability, underscoring its potential for integrated environmental remediation and sensing applications.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zixuan Wang,Wei Ran,Juan Shen,Yuanyuan Cao,Zhongzhong Wang,Simeng Zhang,Rongzhang Hao
The detection of volatile organic compounds (VOCs) markers in exhaled breath based on surface-enhanced Raman scattering (SERS) technology is expected to become a non-invasive diagnosis method for lung cancer patients. However, the inherently low Raman scattering efficiency of trace VOCs in exhaled breath, coupled with the inadequate stability and uniformity of conventional Raman substrates, has hampered the practical application of SERS technologies for lung cancer biomarker detection. Additionally, the development of nanomaterials that simultaneously exhibit superior electromagnetic enhancement capabilities and efficient molecular enrichment functions remains a significant challenge. Herein, we have reported a size-effect-driven strategy for constructing Au nanocube (Au NC) @ zeolite imidazolate framework-8 (ZIF-8) core-shell nanoparticles. Tunability of Au NC@ZIF-8 shell thickness from 3 nm to 40 nm was achieved through cetyltrimethylammonium bromide (CTAB) concentration gradient control (0.5–2 mL) and ice bath kinetics control. This method requires no harsh conditions, featuring simple operation, mild reaction, and short synthesis time, successfully fabricating thin ZIF-8 shell layers with controllable structural properties. This unique architecture integrates the strong localized surface plasmon resonance (LSPR) effect of Au NCs with the porous adsorption capability of ZIF-8, realizing ultrasensitive detection of benzaldehyde (BA) with a limit of detection (LOD) of 2.5 ppb. As a straightforward approach for synthesizing homogeneous and controllable core-shell SERS-active nanoparticles, this method not only offers valuable insights for the preparation of analogous core-shell materials but also provides a robust material foundation and technical support for the non-invasive screening of lung cancer.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 10
·1-15
·
IF 5.3
Yang Rong,Wang Qian,Zhu Ling,Shen Xiaodong,Cao Yang,Wang Yifeng,Xin Wenbo
A facile, one-pot synthesis method is proposed for the in situ growth of multibranched gold (Au) mesocrystals on polydopamine (PDA)-modified three-dimensional (3D) carbon nanotube (CNT) foams using cetyltrimethylammonium bromide (CTAB) and silver nitrate (AgNO 3 ) as shape-directing agents. The synthesized Au mesocrystals exhibit complex 3D architectures composed of ultra-long branches (exceeding 1 μm) with sharp tips and serrated edges. Their morphology can be precisely tuned on CNT foams by adjusting the concentrations of CTAB and AgNO 3 in the growth solutions. The resulting CNT foam-multibranched Au mesocrystal hybrids exhibit high surface-enhanced Raman scattering (SERS) sensitivity, enabling the detection of rhodamine 6G and thiram at concentrations as low as 1 × 10 –11 M and 1 × 10 –10 M, respectively. Additionally, the 3D SERS substrates exhibit excellent uniformity, reproducibility, and long-term stability, maintaining high SERS activity after 10 weeks of storage. Importantly, the SERS substrates achieve sensitive detection of thiram on apple peels down to 2.4 ng/cm 2 . This work provides a promising strategy for the efficient fabrication of high-performance 3D SERS platforms for practical sensing applications. Graphical
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Quanhong Ou,Yehao Zuo,Yunhua Li,Xuan He,Lun Li,Gang Liu,Junqi Tang,Weibin Zhang
The integration of noble metals onto semiconductor surfaces has become a key focus in advancing surface-enhanced Raman spectroscopy (SERS) research. Two-dimensional materials such as MoS 2 are valued for their exceptional thermal and chemical stability, making them promising candidates for advanced SERS sensor development. In this study, we synthesized flower-like MoS 2 microspheres (~380 nm in diameter) through a facile hydrothermal method and functionalized their surfaces with gold nanoparticles (AuNPs) to produce MoS 2 @Au composites. Rhodamine 6G, used as a Raman probe, revealed that the enhancement factor of the MoS 2 @Au system increased substantially from 2.78 × 10 5 to 3.79 × 10 7 , and the detection limit improved to an impressive 3.13 × 10 −10 mol/L—exhibiting a two-order-of-magnitude improvement in sensitivity compared with pristine MoS 2 . Detecting trace tramadol hydrochloride holds immense significance. It enables the precise identification of minuscule drug quantities, facilitating early detection of abuse. This provides crucial support for clinical treatment, rehabilitation interventions, and holds vital importance in judicial appraisal and related fields. The composite demonstrated exceptional proficiency in detecting tramadol hydrochloride, achieving an unprecedented detection limit of 10 −10 mol/L, well below clinically relevant thresholds. Finite-difference time-domain simulations revealed the spatial distribution of the electromagnetic field, while density functional theory calculations elucidated the intricacies of charge transfer and bandgap modulation upon tramadol adsorption. These theoretical insights uncovered the fundamental mechanisms driving the observed SERS enhancement. Experimental validation confirmed that AuNP modification substantially enhanced charge transfer efficiency, highlighting the synergistic contributions of electromagnetic and chemical enhancement effects in improving SERS sensitivity. This work not only deepens our understanding of SERS phenomena but also broadens its potential applications in biomedical sensing.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Tianna Wu,Shuo Yang,Wei Feng,Kaiyue Li,Yanru Li,Lili Wang,Rui Chen,Xiaodong Yang,Lulu Liu,Donglai Han
Equipped with surface-enhanced Raman scattering (SERS) effect and magnetic manipulation capacity, a new paradigm of recyclable SERS substrates based on Fe 3 O 4 nanoparticles (NPs) @SiO 2 @PEI-DTC adhesive layer @Au-Ag alloy quantum dots (QDs) were successfully prepared via engineering hydrothermal and seed deposition techniques. The SERS performance and uniformity of those substrates with different gold-silver (Au-Ag) weight ratios were evaluated by 4-aminothiophenol (4-ATP) molecules, revealing that the relative standard deviations (RSDs) of all substrates were less than 12 %, with the optimal SERS substrate achieving an enhancement factor (EF) of up to 1.39 × 10 5 . This phenomenon can be attributed to the magnetic core and plasmonic resonance properties of Au-Ag alloy QDs, which result in abundant interparticle hotspots in the Fe 3 O 4 @SiO 2 @PEI-DTC@Au-Ag (FSPAA) nanocomposites. Furthermore, the optimal FSPAA nanocomposite was employed as a SERS substrate for rapid non-destructive detection of thiram on fruit surfaces. The SERS signal intensity exhibited a robust manifesting a linear association with thiram concentration within the span of 1 × 10 −4 to 1 × 10 −9 M, and the minimal detectable concentration was 1.04 × 10 −10 M. The FSPAA core–shell nanocomposites exhibit high reusability and reliability and hold great promise for the practical applications in on-site assessment of food/environmental safety, as well as in spectroscopic identification of molecules adsorbed onto fruit surfaces.
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Analytical Methods
·
2025
·Vol. 17
·期 8
·1884-1891
·
IF 2.6
Hongjun Wang,Ziyang Bian,Yue Wang,Huijuan Niu,Zhenshan Yang,Hefu Li
Ensuring food safety necessitates rapid identification of pesticide residues on fruits. Herein, we developed a shape-adaptable flexible surface-enhanced Raman scattering (SERS) substrate, combined with a deep learning algorithm, to quickly detect and quantitatively analyze thiram on fruit surfaces. This SERS substrate was fabricated by depositing silver nanoparticles (Ag NPs) onto a thin, corrugated polydimethylsiloxane (PDMS) film. This innovative design improves physical flexibility, ensuring conformal contact with curved surfaces while achieving high sensitivity, reproducibility, and mechanical robustness. The corrugated Ag NPs@PDMS thin film was able to directly detect thiram at concentrations as low as 10−7 M on tomato and blueberry peels, exhibiting consistent SERS activity with small interference from the fruit's shape. Furthermore, we developed a one-dimensional convolutional neural network (1D CNN) model, trained using a dataset of SERS signals from thiram, for quantitative analysis. The developed model achieved high prediction accuracy, with a coefficient of determination (R2) of 0.9905 and a root mean square error (RMSE) of 0.1364. The integration of our flexible SERS substrate, which adapts well to irregular surfaces, with the 1D CNN algorithm for quantitative analysis, holds great potential for rapid thiram detection in fruits.
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Food Chemistry-X
·
2024
·
IF 6.5
Mengmeng Zhang,Jingbo Liu,Yu Gao,Bing Zhao,Meng-Lei Xu,Ting Zhang
A Se site targeted-two circles antioxidant of polyphenols EGCG and genistein in glutathione peroxidase 4 (GPx4)–like catalytic peroxide H 2 O 2 and cumene hydroperoxide degradation was demonstrated by surface-enhanced Raman scattering (SERS). Se atom's active center is presenting a ‘low-oxidation’ and a ‘high-oxidation’ catalytic cycle. The former is oxidized to selenenic acid (SeO − ) with a Raman bond at 619/ 610 cm −1 assigned to the νO − Se by the hydroperoxide substrate at 544/ 551 cm −1 assigned to ωHSeC decreased. Under oxidative stress, the enzyme shifted to ‘high-oxidation’ catalytic cycle, in which GPx4 shuttles between R-SeO − and R-SeOO − with a Raman intensity of bond at 840/ 860 cm −1 assigned to νO Se. EGCG could act as a reducing agent both in H 2 O 2 and Cu-OOH degradation, while, genistein can only reduce Cu-OOH, because it binds more readily to the selenium site in GPx4 than EGCG with a closer proximity, therefore may affect its simultaneous binding to coenzymes.
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ANALYST
·
2025
·
IF 3.3
Jianying Huang,Yayue Huang,Ling Xia,Xiaohua Xiao,Gongke Li
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool to acquire the fingerprint information of molecules rapidly, sensitively, and noninvasively. Its application in sample analysis, however, suffers from low repeatability due to the interference of the sample matrix. To address this issue, a microfluidic device was developed to realize all-in-one sample preparation and SERS detection for the online analysis of deltamethrin in meat products. This device was constructed using a microfluidic sample preparation unit and a droplet SERS detection unit. Through flow rate control, analytes at appropriate concentrations can be continuously encapsulated into online-generated microdroplets with SERS substrate Ag nanoparticle-coated Au nanoparticles. Stronger intensities with smaller relative standard deviations were observed by accumulating the Raman signals of microdroplets. Using the microfluidic SERS device, the enhancement factors of rhodamine 6G and deltamethrin were 2.7 × 107 and 3.8 × 105, respectively, with RSDs less than 4.0% (n = 19). Moreover, this device can be reused more than 7 times through simple cleaning procedures. The established microfluidic SERS analytical method has a linear range of 30.0–500 μg L−1 with a correlation coefficient of 0.9953, and the limit of detection was 11.6 μg L−1 (S/N = 3). The established microfluidic SERS method was applied to deltamethrin analysis in chicken skin, chicken and grass carp; 32.8 μg kg−1 of deltamethrin was found in the chicken skin sample. The accuracy and precision of the method were confirmed by high-performance liquid chromatography and recovery test results, indicating its potential for application in food safety.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Yue Mao,Borong Yu,Huijiao Zhang,Yuanyuan Ma,Fangwei Han,Binbin Zhou,Lili Yang,Zhangang Han
The work reported on the preparation of expanded graphite (EG) coupled with Ag nanoparticles for quick water contaminant adsorption, followed by trace molecules sensing using SERS technique. The surfactant-free composites of Ag/EG were obtained by a simple and controllable “mix-and-heat” mechanochemical method. Most of the analytes were found to be adsorbed within 15 min without any additional physical or chemical activation and its adsorption behavior at room temperature fitted pseudo-second-order kinetic models. As SERS enhanced substrate, less than 10 ppb of crystal violet (CV) and methylene blue (MB) could be determined via Ag/EG. What’s more, the Ag/EG substrate could adapt to strong acid and alkali environment and could be stored for as long as 120 days. Therefore, the composites Ag/EG could be used as a reliable SERS active substrate. Moreover, the substrate could be reused at least four times. In addition, ‘adsorption-filtration’ was conducted through a homemade filter and the filter membrane was employed as substrate support instead of silicon wafers. Such results reveal that Ag/EG as a solid SERS substrate has great potential value for practical applications. And the study provides a new strategy for the development of high-performance sensing of the target analyte in the future.
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Nanomaterials
·
2019
·Vol. 9
·期 3
·480
·
IF 4.034
Xiaozhen Feng,Chongning Li,Aihui Liang,Yanghe Luo,Zhiliang Jiang
The as-prepared co-doped N/Ag carbon dot (CDNAg) has strong catalysis of H2O2oxidation of 3,3′-dimethylbiphenyl-4,4′-diamine (DBD). It forms an oxidation product (DBDox) with surface-enhanced Raman scattering (SERS) activity at 1605 cm−1in the silver nanosol substrate, and a CDNAgcatalytic amplification with SERS analytical platform can be structured based on aptamer (Apt) with the DBD oxidizing reaction. For example, the aptamer (Apt) of acetamiprid (ACT) can be adsorbed on the surface of CDNAg, resulting in inhibited catalytic activity, the reduced generation of DBDox, and a weakened SERS intensity. When the target molecule ACT was added, it formed a stable Apt-ACT complex and free CDNAgthat restored catalytic activity and linearly enhanced the SERS signal. Based on this, we proposed a new quantitative SERS analysis method for the determination of 0.01–1.5 μg ACT with a detection limit of 0.006 μg/L.Keywords:acetamiprid;aptamer;carbon dot catalytic;DBD;SERS
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