COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Jixing Wang,Huan Yang,Zhu Meng,Binqiang Xie,Xiaorong Yu,Gaoshen Su,Li Wang
A pH-responsive epoxy composite coating was obtained by adding a benzotriazole-containing with pH-responsive nanocontainer to the epoxy coating. The release experimental results of benzotriazole in benzotriazole-loaded nanocontainer show that the cumulative release of benzotriazole increases with the decrease of pH value of the 3.5 wt% NaCl solution. The cumulative release of benzotriazole from nanocontainer in 60 h with different pH are 50.6%, 63.1%, 76.3% and 80.2% for pH = 6.8, 6.0, 5.5 and 5.0, respectively, indicating that benzotriazole has obvious release behavior under weak acid condition, which ensures that the coating with nanocontainer can show active repair performance in different acidic environments. Moreover, the EIS results show that the epoxy coating with benzotriazole-loaded nanocontainer exhibits excellent anticorrosion and active repair properties, and the more severe the corrosion environment, the stronger the repair ability of the coating.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2021
·
IF 3.981
Bo Fu,Can Tao,Nian Chen,Jie-Rou Lin,Ping Zhao
Chemotherapeutical agents have been frequently reported to have adverse side effects which reduce their application in clinic. Herein, we reported a mesoporous silica nanoparticles (MSNs)-based drug delivery system (DDS) capped with zinc oxide quantum dots (ZnO QD) which has glutathione (GSH)/pH dual-responsive controlled release in the cancer cells. The drug loaded DDS have higher cellular inhibition than the free drug because of the synergistic effect of payload DNM and the Zn 2+ dissolved from ZnO QD. The anti-cancer mechanism research indicates that the designed drug loaded DDS can cause mitochondrial damage, arrest the cell cycle and induce the cell apoptosis and autophagy. The combination of excellent biocompatibility , selective release performance, synergistic cellular cytotoxicity, endowed the DDS with the potential of utilization in cancer treatment.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Materials Interfaces
·
2021
·Vol. 9
·期 4
·2101633
·
IF 6.147
Yi Cai,Minghao Wang,Mengxian Liu,Jing Zhang,Yong Zhao
An optical fiber sensing platform based on the nitrogen-doped carbon dots (N-CDs) for online detection of pH value in real time has been developed. The pH-sensitive N-CDs are synthesized by a one-pot hydrothermal method. To compose the sensing probe, the N-CDs are immobilized on the surface of the fiber tip by the biocompatible hydrogel. According to the results of optical simulation, the fiber tip is designed to be tapered for efficient excitation and fluorescence collection. The assembling process of the sensing probe can be accomplished by the method of in-situ polymerization without any mold in seconds. The fluorescence of the sensing probe can be enhanced or quenched by pH value variation in a certain range and transmits to the spectrometer. The maximum diameter of the proposed sensing probe is only 450 µ m. Therefore, the sensing platform with rapid response has great potential application for remote monitoring in the narrow space. Besides, the proposed platform is portable and provides a new photonic-sensing method for emergency analysis.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Siwen Wu,Yuling Yang,Shihan Wang,Chunyan Dong,Xueyan Zhang,Rui Zhang,Li Yang
Traumatic multidrug-resistant (MDR) bacterial infections are deadly threat to the public. To combat MDR bacteria, we developed a dual functional pH-sensitive hydrogel based on peptide DP7 (VQWRIRVAVIRK) and oxidized dextran (DP7-ODEX hydrogel). As an antimicrobial peptide , DP7 can synergize with many antibiotics; thus, we loaded ceftazidime into DP7-ODEX hydrogel, which showed an obvious advantage in MDR P. aeruginosa inhibition. Additionally, due to the interaction between aldehyde groups in oxidized dextran and amine groups from wound tissue, the hydrogel could extend on the irregular surface of skin defects and promote epithelial cells adhesion . DP7 could also be used as a wound-healing peptide and accelerate the healing process. We confirmed that the DP7-ODEX hydrogel exerted formidable therapeutic effects in normal or diabetic wound infection model. According to histomorphology analysis we found that DP7 hydrogel also have a scarless wound healing ability. In summary, we developed a hydrogel fabricated by the dual functional peptide DP7 that can kill multidrug-resistant bacteria colonizing the wound bed and boost scarless wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2021
·Vol. 13
·期 8
·1205
·
IF 6.321
Shuang Ba,Mingxi Qiao,Li Jia,Jiulong Zhang,Xiuli Zhao,Haiyang Hu,Dawei Chen
Cancer stem-like cells (CSLCs) have been considered to be one of the main problems in tumor treatment owing to high tumorigenicity and chemotherapy resistance. In this study, we synthesized a novel mitochondria-target derivate, triphentlphosphonium-resveratrol (TPP-Res), and simultaneously encapsulated it with doxorubicin (Dox) in pH-sensitive liposomes (PSL (Dox/TPP-Res)), to reverse chemotherapeutic resistance of CSLCs. PSL (Dox/TPP-Res) was approximately 165 nm in size with high encapsulation efficiency for both Dox and TPP-Res. Cytotoxicity assay showed that the optimal synergistic effect was the drug ratio of 1:1 for TPP-Res and Dox. Cellular uptake and intracellular trafficking assay indicated that PSL (Dox/TPP-Res) could release drugs in acidic endosomes, followed by mitochondrial targeting of TPP-Res and nucleus transports for Dox. The mechanisms for reversing the resistance in CSLCs were mainly attributed to a synergistic effect for reduction of mitochondrial membrane potential, activation of caspase cascade reaction, reduction of ATP level and suppression of the Wnt/β-catenin pathway. Further, in vivo assay results demonstrated that the constructed liposomes could efficiently accumulate in the tumor region and possess excellent antineoplastic activity in an orthotopic xenograft tumor model with no evident systemic toxicity. The above experimental results determined that PSL (Dox/TPP-Res) provides a new method for the treatment of heterogenecity tumors.Keywords:TPP conjugate;hierarchical targetability;cancer stem-like cells
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2021
·
IF 19.503
Shiqiang Wang,Yali Cao,Wei Jia,Zhenjiang Lu,Dianzeng Jia
Electrochemical water splitting has been highly considered as a promising technology to produce hydrogen with high purity and large quantity. Herein, a cage-confinement strategy is proposed to encapsulate H 3 PMo 12 O 40 clusters into cavities of ZIF-67. The ZIF-67 with cavity diameter of 1.16 nm and cavity window of 0.34 nm can appropriately confine H 3 PMo 12 O 40 with diameter of 1.0 nm. The H 3 PMo 12 O 40 served as guest species were also homogeneously encapsulated in well-defined cavities of ZIF-67 host without destroying the structure of ZIF-67. This cage-confinement strategy endow Mo 6 Co 6 C nanoparticles uniformly embedded in carbon matrix without aggregation and exposed abundant active sites during pyrolysis process. Furthermore, the heterojunction of Pt-Mo 6 Co 6 C was fabricated through galvanic replacement with H 2 PtCl 6 . The prepared Pt-PMo/ZIF-67-800 electrocatalyst with a low Pt amount of 3.0 % exhibits excellent HER activity and stability and even superior to commercial Pt/C in PH-universal solutions. Density functional theory (DFT) calculation reveals that Pt-Mo 6 Co 6 C heterostructure results in a lower hydrogen adsorption free energy than commercial Pt/C and thus enhances its intrinsic catalytic activity. The outstanding HER performance of Pt-Mo 6 Co 6 C heterostructure confined on dodecahedron carbon matrix opens new perspectives for rational design polyoxometalate (POM) based catalyst for hydrogen evolution.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Qin Wang,Li-Bing Lü,Zhu Tao,Tao Sun,Qing Tang,Ying Huang
In the present work, we have investigated the effect of pH and mercury ions on the host–guest complex formed between cucurbit[7]uril (Q[7]) and Hoechst 33342 (H33342). 1 H NMR, UV–vis and fluorescence spectroscopy revealed that acid/base stimulation could change the binding stoichiometry between Q[7] and H33342. The results suggest that two complexation equilibria (1:1 and 2:1) may exist between H33342 and Q[7] at pH 2.0 and 4.5, respectively. However, a 1:1 host–guest complex was formed between H33342 and Q[7] at pH 7.0 and 10.0. Q[7] shows differential affinities for the protonated and neutral forms of H33342 dye. Moreover, the switching between H33342∙2H + @2Q[7](1:2) at pH 4.5 and H33342∙H + @Q[7](1:1) at pH 7.0 was reversible. Furthermore, as a metal stimulus, Hg 2+ ions could push (i) Q[7] from the piperazine ring to the benzimidazole position with a 1:1 guest–host ratio and (ii) a second Q[7] onto the ethyl position with a 1:2 guest–host stoichiometry. This stimulus response system will have potential applications in the field of molecular switch design.
✓ 已验证
DOI
PubMed
高影响因子
Pharmaceutics
·
2021
·Vol. 13
·期 3
·338
·
IF 6.321
Ahmed M. Omer,Maha S. Ahmed,Gehan M. El-Subruiti,Randa E. Khalifa,Abdelazeem S. Eltaweil
To develop an effective pH-sensitive drug carrier, alginate (Alg), carboxymethyl chitosan (CMCs), and aminated chitosan (AmCs) derivatives were employed in this study. A simple ionic gelation technique was employed to formulate Alg-CMCs@AmCs dual polyelectrolyte complexes (PECs) microcapsules as a pH-sensitive carrier for efficient encapsulation and release of diclofenac sodium (DS) drug. The developed microcapsules were characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analyzer (TGA), and scanning electron microscope (SEM). The results clarified that formation of dual PECs significantly protected Alg microcapsules from rapid disintegration at colon conditions (pH 7.4), and greatly reduced their porosity. In addition, the dual PECs microcapsules can effectively encapsulate 95.4% of DS-drug compared to 86.3 and 68.6% for Alg and Alg-CMCs microcapsules, respectively. Higher DS-release values were achieved in simulated colonic fluid [SCF; pH 7.4] compared to those obtained in simulated gastric fluid [SGF; pH 1.2]. Moreover, the drug burst release was prevented and a sustained DS-release was achieved as the AmCs concentration increased. The results confirmed also that the developed microcapsules were biodegradable in the presence of the lysozyme enzyme. These findings emphasize that the formulated pH-sensitive microcapsules could be applied for the delivery of diclofenac sodium.Keywords:alginate;carboxymethyl chitosan;aminated chitosan;pH-sensitive microcapsules;polyelectrolyte complex;drug release
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 31
·10838-10844
·
IF 4.39
Xia Xu,Meirong Fu,Penghui Li,Min Yang
While photothermal therapy is widely applied in phototherapy, there are still challenges in developing new generation phototherapy materials with precise diagnostic functions. Here we report the construction of a pH responsive upconversion fluorescence imaging precisely guided photothermal therapy system, namely NaYF4:Yb3+/Er3+@NaYF4@MnO2@Au nanocomposites, which can effectively avoid light damage to non-target tissues. Owing to the fluorescence resonance energy transfer between the upconversion nanocrystal donor and MnO2 and Au acceptor, the upconversion fluorescence is completely quenched. However, in pH 5.3 PBS buffer, MnO2 is gradually broken down, and the upconversion fluorescence is partially recovered, which could be used for upconversion fluorescence imaging to precisely guide photothermal therapy under 980 nm excitation. Simultaneously, due to the absorption of 980 nm excitation light and the emission bands of Er3+ (2H11/2 → 4I15/2 and 4S3/2 → 4I15/2 transition), temperature increment of core@shell@MnO2@Au could reach 35.5 °C under 980 nm excitation at 0.8 W cm−2. The core@shell@MnO2@Au nanocomposites are supposed to contribute significantly in the biological applications of photoluminescence imaging and photothermal therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Liangliang Dai,Xiang Li,Xinmin Zheng,Zhenxiang Fu,Mengjiao Yao,Siyu Meng,Jiangong Zhang,Binbin Han,Quanli Gao,Jing Chang,Kaiyong Cai,Hui Yang
Immunosuppressive tumor microenvironment and low delivery efficiency severely impede the tumor chemotherapy effect. To address this issue, we develop a pH/ROS cascade-responsive prodrug micelle to deliver siTGF-β with size-shrinkage and charge-reversal property, leading to synergistical tumor microenvironment remodeling. The nanosystem highly improved endocytosis efficiency and tumor penetration depth through charge reversal and size reduction upon exposure to weakly acidic tumor microenvironment. Moreover, the nanocarrier would rapidly escape from endo/lysosome, disassemble and release siTGF-β and hydroxycamptothecin in response to high intracellular ROS. Furthermore, the nanosystem significantly boosted antitumor immune response and reduced immune tolerance with remodeling tumor microenvironment, which significantly prolonged the survival time of tumor-bearing mice (75% survival rate upon 35 days). It is realized by the combined effects of chemotherapy-enhanced immunogenicity and recruitment of effector T cells , TGF-β-blockade immunotherapy-activated inhibition immunosuppressive tumor microenvironment and epithelial-to-mesenchymal transition (EMT), and regulation physical tumor microenvironment via reducing the dense tumor extracellular matrix and the high tumor interstitial pressure obstacles. To this end, the nanosystem not only overcame biobarriers and reinforced antitumor immune response, but also effectively inhibited tumor growth, metastasis and recurrence in vivo .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2021
·
IF 19.503
Hongbo Lu,Chunli Wang,Xueming Liu,Jing Zhang,Zhang Lin,Zhengping Hao,Gang Pan
Arsenic sulfide sludge (ASS) is a typical precipitation product of acid smelting wastewater. Previous study reported that when exposed to sunlight, the release and oxidation of As(III) in ASS were markedly accelerated. However, the key factor to trigger the photocatalytic transformation of ASS is still unclear. Herein, we revealed that the coexisting Fe(II)/Fe(III) ions were critical to promote the photo-oxidation of released As(III) under visible light. We further validated that Fe(II)-stimulated photo-oxidation mechanism of As(III) in ASS was pH-dependent. In acid conditions, OH and SO 4 − were promoted by Fe(II)/Fe(III) cycling catalysis with the assistance of the reductive sulfur species from ASS, e.g. S 2− and SO 3 2− , and thus accelerated the oxidation of As(III). While in neutral conditions, the nascent ferric hydroxide colloids enhanced the oxidation rate of As(III) via photo-induced ligand-to-metal-charge transfer (LMCT) mechanism. These findings help in predicting and controlling the fate of real arsenic-containing sludge in sunlit environments.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2021
·Vol. 12
·期 1
·1-10
·
IF 14.919
Zhang Lufeng,Zhang Liang,Deng Hui,Li Huan,Tang Wentao,Guan Luyao,Qiu Ye,Donovan Michael J.,Chen Zhuo,Tan Weihong
Helicobacter pylori infection is a major etiological factor in gastric diseases. However, clinical antibiotic therapy for H. pylori is limited by continuously decreased therapeutic efficacy and side effects to symbiotic bacteria. Herein, we develop an in vivo activatable pH-responsive graphitic nanozyme, PtCo@Graphene (PtCo@G), for selective treatment of H. pylori . Such nanozymes can resist gastric acid corrosion, exhibit oxidase-like activity to stably generate reactive oxygen species only in acidic gastric milieu and demonstrate superior selective bactericidal property. C 18 -PEG n -Benzeneboronic acid molecules are modified on PtCo@G, improving its targeting capability. Under acidic gastric pH, graphitic nanozymes show notable bactericidal activity toward H. pylori , while no bacterial killing is observed under intestinal conditions. In mouse model, high antibacterial capability toward H. pylori and negligible side effects toward normal tissues and symbiotic bacteria are achieved. Graphitic nanozyme displays the desired enzyme-like activities at corresponding physiological sites and may address critical issues in clinical treatment of H. pylori infections.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）