JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2024
·
IF 1.5
Guo Dingge,Xiao Jing,Ning Yang,Yu Hongchao,Jin Tianxiang,Huang Bin,Qian Yong
The efficient removal of thorium from the environment is critical due to the risks it poses to organisms. Metal–organic frameworks are favored by scholars because of their potential to effectively adsorb a variety of heavy metal ions in wastewater treatment. In this work, the interaction of UiO-66-NH 2 surface with graphene, enhances adsorption capacity of MOFs. Optimal adsorption conditions have been identified, and a detailed adsorption mechanism has also been comprehensively discussed. The theoretical maximum adsorption capacity exhibited by UiO-66-GO is 119.57 mg g −1 . Moreover, it shows a fast adsorption rate and reached equilibrium within 20 min. The development of materials with good adsorption performance and fast adsorption for Th(IV) plays an important role in the development of Th(IV) adsorption in the future.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-13
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IF 3.8
Dezhakam Ehsan,Vayghan Roya Faraghi,Dehghani Sarina,Kafili-Hajlari Taha,Naseri Abdolhossein,Dadashpour Mehdi,Khalilzadeh Balal,Kanberoglu Gulsah Saydan
Nowadays, rapid and facile diagnosis of cancer using user friendly processes has attracted much attention. In this regard, an electrochemical (EC) biosensor with high sensitivity was fabricated by merging MIL156 MOF@COF nanocomposite with Au nanoparticles for the detection of CA15-3. Herein, metal clusters of MIL-156 as a Metal organic frameworks (MOF) were coated by a crystalline covalent organic frameworks (COF) through covalent bonding and created core-shell-like structures. The active part of the working electrode was modified in two consecutive steps. First, MIL-156 MOF@COF and then Au nanoparticles were electrodeposited on the glassy carbon electrode (GCE). The porosity of nanocomposite has significantly increased the surface area and improved the conductivity. Au nanoparticles also form an acceptable substrate for bonding antibodies due to their high affinity with amino groups. In addition, Au nanoparticles amplify the EC signal of the biosensor with their undeniable conductivity. Nanocomposite was characterized with XRD, SEM, and EDAX techniques. To investigate the proposed biosensor, differential pulse voltammetry (DPV) was used as an analytical technique. The CA15-3 calibration provided a linear range between concentrations of 30 and 100 nU/mL, thus expressing the powerful diagnostic potential of the designed biosensor. Furthermore, the suggested biosensor has been used in serum samples and discriminate breast cancer sufferers from healthy individuals with high confidence levels.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2024
·Vol. 39
·期 4
·1053-1060
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IF 1.3
Wu Zhengsen,Huang Biwu,Liu Yuansheng,Shen Han
The reactive diluent prepared by siloxane modified Trimethylene oxide can improve the performance of the UV curing system. Therefore, 1,7-bis [(3-ethyl-3-methoxyoxacylobutane) propyl] octadecylosiloxane (BEMOPOMTS) was synthesized from diethyl carbonate, trimethylopropanes, allyl bromide, and 1,1,3,3,5,5,7,7-octadecylosiloxane as the main raw materials. BEMOPOMTS can be used as reactive diluents in the field of cationic UV curing. It has good thermal stability, and the addition of BEMOPOMTS significantly improves the tensile strength and elongation at break of epoxy resin. Compared with the pure epoxy resin, adding 20% BEMOPOMTS increased the elastic modulus by 25% to 677 MPa.
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CATALYSIS LETTERS
·
2024
·
IF 2.3
Xiong Ying,Jia Yushan,Yang Ruixi,Wang Peng,Feng Xiaogeng,Cui Junshuo,Lou Zhenning,Shan Weijun,Yu Haibiao
In this paper, the foam-like multi-stage porous 3wt%Al-KIT-6-4T(WI) catalyst was prepared and employed for efficient catalyzing biomass-derived GVL to butene. It is found that the prepared 3wt%Al-KIT-6-4T(WI) catalyst possess abundant mesoporous and presented the foam-like microstructure. Due to this, the 3wt%Al-KIT-6-4T(WI) catalyst has large specific surface area (517.09 m 2 ·g −1 ) and adequate amount of surface acid sites (both Brønsted and Lewis acid site). The special microstructure further improves the mass transfer efficiency of reactants and products. Under the optimized reaction conditions, the butene yield over the 3wt%Al-KIT-6-4T(WI) catalyst can up to 93.78% at 300 °C, after reacting 240 min. Moreover, the 3wt%Al-KIT-6-4T(WI) catalyst still showed excellent regeneration stability, and above 72% butene yield can be maintained after 7th cycle tests. Graphical Abstract
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 4
·1-16
·
IF 3.8
Wang Hongyu,Xie Yi,Xiao Henglin,Li Lu,Zhang Shujia,Wang Bin,Jiang Can,Hu Xiaoling,Zhou Dao,Nan Dongyun
Ecotoxicity of diclofenac sodium (DS) even at low concentrations makes it urgent to remove DS from water. In this work, chitosan microspheres were prepared by one-step reversed-phase emulsion method, and then, polyethyleneimine (PEI) was successfully grafted to form CS/PEI composites. The CS/PEI was characterized by Fourier infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). Effects of different influencing factors like material composition, dosage, pH, co-existing anions, and humic acid were investigated, and adsorption behavior of CS/PEI was explored by model simulation analysis. Results showed that adsorption process fits well with pseudo-second-order kinetic model and Langmuir adsorption isotherm model, indicating homogeneous and monolayer adsorption nature, and maximum Langmuir adsorption capacity was 364.12 mg/g at pH 6. The reusability of CS/PEI was confirmed by cyclic adsorption-desorption experiments, and electrostatic attraction and hydrogen bonding were the main mechanism for DS uptake by CS/PEI. Therefore, CS/PEI microspheres can be regarded as an efficient and convenient adsorbent for DS removal from aqueous media. Graphical Abstract
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Journal of Sustainable Metallurgy
·
2025
·
IF 3.2
Ma Kaihui,Wu Qinghui,Fang YunPeng,Deng Junyi,Zheng Kui,Qiu Shuxing,Chen Mao,Xu Jian
The issue of carbon emissions in the iron-making process is receiving increasing attention, and the utilization of hydrogen (H 2 )-reduced iron ore presents an appealing prospect for application. Iron oxides are the primary components involved in the iron-making process, and their reduction in H 2 holds significant research value. In this work, the softening–melting behaviors of quaternary/quinary-FeO-rich oxides in four different gases, namely 100%N 2 , 10%H 2 + 90%N 2 , 40%CO + 60%N 2 , and 10H 2 + 40%CO + 50%N 2 , above 900°C are studied by simulating the cohesive zone of blast furnace. Compared to CO, H 2 exhibits a higher reducing capacity and can achieve a faster reduction of metal iron. However, due to its inability to promote carburizing and further liquation of metal iron, iron remains in a dense metallic state within the packed bed, hindering its further reduction into iron oxide particles and consequently slowing down the shrinkage of the packed bed. Delaying the initial temperature of reaccelerated shrinkage to more than 1300°C also reduces the pressure drop within the packed bed. Its limited ability for liquid phase generation plays a positive role in influencing both the height contraction and permeability reduction of the packed bed. Furthermore, the formed spinel phase in H 2 with high melting point did not shrink until the temperature was increased to 1400°C, and a sudden increase in shrinkage rate (SR) to 0.12%/°C or above was observed. Graphical
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 9
·1-10
·
IF 2.6
Luo Shi-He,Xiao Ying,Gao Juan-Juan,Cao Xi-Ying,Fang Yong-Gan,Lin Jian-Yun,Li Huan-Qing,Wang Zhao-Yang
Polylactic acid (PLA) is one of promising biocompatible and biodegradable polyester. Poly(2-hydroxyethyl methacrylate) (PHEMA) is a polymer with good hydrophilicity. The hydrophilic PHEMA may improve PLA’s amphiphilic properties. Hence, directly starting from hydroxyethyl methacrylate (HEMA), lactic acid (LA), maleic anhydride (MAH) and 2,2'-azobis(2-methyl-propionitrile) (AIBN), a series of new amphiphilic copolymers PLA 20 MH n were obtained through direct melt polycondensation (DMP) and subsequent free radical polymerization (FRP) in one pot. The results show that PLA 20 MH n can self-assemble in aqueous solution to form stable spherical micelles and dissolve hydrophobic pyrene molecules. What’s more, The CMC value can be adjusted by the polymerization ratio. Therefore, this method is expected to further realize the encapsulation and controlled release of hydrophobic drug molecules for systemic circulation in vivo.
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Journal of Food Measurement and Characterization
·
2024
·
IF 2.9
Wang Jin,Ren Qiao,Zhou Houqin,He Chenghao,Huang Qinwan
Red ginseng, a processed product of ginseng, has been shown to possess various pharmacological effects. To investigate the changes in ginsenosides during the processing of ginseng into red ginseng and to visualize their spatial distribution characteristics in tissues, ultra-high performance liquid chromatography coupled with hybrid quadrupole-orbitrap high-resolution mass spectrometry (UPLC-Q-Orbitrap HRMS) was used to detect and identify the extracts of ginseng and red ginseng. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used to visually analyze the spatial distribution and temporal changes of prototype ginsenosides and their metabolites in ginseng. The UPLC-Q-Orbitrap HRMS results showed the identification of 42 major ginsenosides in both ginseng and red ginseng. Additionally, PCA and OPLS-DA analyses identified the processing-related markers for ginseng and red ginseng. During the processing of ginseng into red ginseng, the content of protopanaxadiol ginsenosides decreased (Rb1, Rc, Rd, etc.), while the types and content of rare ginsenosides increased (Rg3, Rg5, Rh1, etc.). The MALDI-MSI tissue distribution results demonstrated that ginsenosides in ginseng were mainly distributed in the cambium and phloem, while the processing led to the transformation of ginsenosides and an increase in distribution in the xylem and medulla. This study comprehensively reveals the chemical diversity and dynamic transformation patterns during the processing of ginseng, providing more substantial foundational information for research on red ginseng processing techniques. The transformation of these rare ginsenosides also indicates that ginseng is more beneficial for pharmacological applications such as anti-tumor, anti-allergic, and liver protection after being processed into red ginseng. Graphical abstract
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Forensic Toxicology
·
2024
·
IF 2.8
Zhang Xiaolong,Chen Yuxuan,Liu Jinlei,Wang Mengchao,Dai Yinyin,Zhao Kundi,Gu Jie,Zhang Huimin,Wurita Amin,Hasegawa Koutaro
Purpose Distribution and abuse of imidazole-derived γ-aminobutyric acid (GABA) agonists, such as etomidate and metomidate, and their analogs have been encountered frequently especially in China. The aim of this study was to identify etomidate, metomidate, propoxate, and isopropoxate more accurately by establishing a gas chromatography–mass spectrometry (GC–MS) and liquid chromatography tandem mass spectrometry (LC–MS/MS) method and applying it to real forensic cases. Methods One mg of the seized powder was dissolved in 1 mL of methanol, and subjected to GC–MS and LC–MS/MS. Hair samples were washed and cut into approximately 2 mm sections, then ground to powder by a low-temperature grinder. Twenty mg of the hair powder was extracted with 1 mL of methanol, and the supernatant was subjected to LC–MS/MS. Results Etomidate, metomidate, propoxate, and isopropoxate were chromatographically separated and each mass spectrum was obtained by GC–MS. For LC–MS/MS, tested validation data were all satisfactory. The seized powder samples contained isopropoxate, with an approximate content of 30.9%. Etomidate, etomidate acid, metomidate, and isopropoxate could be determined in the submitted hairs, ranging from 2.89 to 8.09 ng/mg, 0.0591–0.177 ng/mg, 0.342–2.77 ng/mg, and 33.2–130 ng/mg, respectively. Conclusions Mass spectra and ion chromatograms of etomidate, metomidate, isopropoxate, and propoxate were obtained by GC–MS. We have also established a simultaneous and reliable analytical method for etomidate, etomidate acid, metomidate, and isopropoxate in human hair by LC–MS/MS. This is the first report to present analytical results of a novel imidazole-derived GABA agonist isopropoxate in drug abuse cases.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
He Keting,Wei Dongfan,Liu Qiuhong,Liu Xiaoli,Zhou Diwenxin,Chen Shangci,Zhu Danhua,Xu Xiaowei
Acute liver injury (ALI) presents a challenging problem worldwide, prompting extensive research efforts. Cellular senescence has been found to be induced following ALI, and targeting cellular senescence has shown therapeutic potential. Therefore, understanding the expression of senescence-related genes in ALI can help to explore pathogenesis and treatment of this common disease. Carbon tetrachloride (CCl 4 ) is commonly used to study ALI. Although polymerase chain reaction (PCR) is a convenient and economical molecular biology technique widely used in basic medicine, research on selecting suitable reference genes to obtain objective and reproducible PCR data is scarce. Moreover, evidence supporting the choice of reference genes for experimental studies of CCl4-induced ALI and hepatic senescence in mice is limited. In this study, we obtained murine livers at four time points (0, 12, 24, and 48 h) following CCl4 treatment. We used five algorithms (geNorm, BestKeeper, NormFinder, delta Ct, and RefFinder) to rank 12 candidate genes in real-time reverse-transcription quantitative PCR (RT-qPCR) experiments. Focusing on cellular senescence in this model, we adopted four senescence-associated secretory phenotype (SASP) genes ( Il6 , Il1b , Ccl2 , and Ccl5 ) as target genes. Our results confirmed Gapdh and Tbp as suitable reference genes in murine CCl 4 -induced ALI models. Furthermore, we provide a table of published studies recommending reference genes for various liver disease models. This study provides a valuable reference for enhancing the reliability and reproducibility of ALI molecular findings.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-15
·
IF 12.6
Liu Yu,Zhang Jia,Lai Chunyu,Wang Wenjun,Huang Yangyue,Bao Xuanwen,Yan Haimeng,Sun Xuqi,Liu Qiqi,Chen Dong,Dai Xiaomeng,Qian Xinyu,Zhao Peng
Immunotherapy, exemplified by immune checkpoint blockade (ICB), has been extensively employed in antitumor treatments. Nevertheless, its efficacy in addressing low-immunogenic tumors has not yielded satisfactory results, primarily due to the depletion and inadequate infiltration of effector T cells within the tumor microenvironment (TME). Here, we construct an injectable water-in-oil emulsion hydrogel to load clinically used Celastrol (Gel@Cel), which addresses the limitations of Cel’s hydrophobicity. Cel can both inhibit tumor cell proliferation and promote tumor cell apoptosis, while simultaneously inducing immunogenic cell death, through activation of the AKT and MAPK pathways. In a model of clinically refractory hepatocellular carcinoma with malignant ascites, intraperitoneal administration of Gel@Cel significantly inhibits tumor progression and activates antitumor immune effects through lipase-controlled release of Cel, as compared to free Cel. Intriguingly, the Gel@Cel induces the activation of dendritic cells, resulting in the infiltration of cytotoxic T cells in the TME of ascites. Furthermore, the administration of Cel increases the expression of programmed cell death protein ligand-1 (PD-L1) in tumor cells. Moreover, combining the PD-1 antibody (αPD-1) with Gel@Cel further enhances the antitumor effect and amplifies the immune activation. In conclusion, Gel@Cel exhibits promising therapeutic potential in the treatment of low-immunogenic tumors, especially when combined with ICB therapy.
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JOURNAL OF SOILS AND SEDIMENTS
·
2024
·Vol. 24
·期 9
·3195-3207
·
IF 2.8
Gu Meixia,Yin Xiaoshuang,Feng Xiaoning,Shi Nan,Zhu Wei,Guo Shuhai,Li Min,Wu Bo,Li Gang,Cong Xingshun,Lou Bin,Wen Fushan,Liu Dong
Purpose In order to investigate the desorption effect and mechanism of petroleum from petroleum contaminated soil (PCS) in surfactant solution (SAA-solution). Method In this study, the desorption effect of SAA-solution cleaning of PCS was systematically analyzed by using orthogonal experiments. In addition, the petroleum mechanism of desorption from the PCS surface was further explored by kinetic and thermodynamic studies. Results The results indicated that the petroleum removal efficiency (Re) gradually decreased with the increase of PCS particle size and PCS aging time. The highest petroleum Re was 82.13% under optimum conditions. Subsequently, FT-IR and petroleum component analysis showed the petroleum light components were easily removed from PCS, while the petroleum heavy components limited the desorption of petroleum. The kinetic studies revealed that the petroleum desorption was well depicted by the pseudo-first-order kinetic model, and the desorption rate increased with the decrease of PCS particle size. Meanwhile, the petroleum desorption equilibrium was well described by the Langmuir isotherm model and proceeded by a chemical mechanism. The thermodynamic studies demonstrated that the petroleum desorption from PCS was a viable, spontaneous, and endothermic process. Conclusion The study provided theoretical guidance to apply SAA-solution cleaning industrial PCS. Graphical Abstract
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