CURRENT MICROBIOLOGY
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2026
·Vol. 83
·期 8
·424
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IF 2.8
Xu Jialin,Yan Bohu,Fu Qifu,Li Haoyu,Jiang Zonghan,Zhou Rushun,Chen Xiaojun,Sun Zhiliang,Wang Yanan,Li Jiyun
In response to the critical challenge of colistin resistance in animal production, we examined the occurrence and genetic features of mcr-1 -positive E. coli isolates collected from livestock in Hunan province, China, between 2016 and 2021. A total of 1,358 animal samples from chickens and pigs were collected and screened. Monitoring data indicates that nineteen mcr-1 -positive E. coli isolates (1.40%) were identified, and all were resistant to colistin and tetracycline. The prevalence rate of mcr-1 positive E. coli has significantly declined since 2017 and has remained consistently low. Most isolates (89.47%) exhibited multidrug resistance and carried multiple antibiotic resistance genes, including tet (A) , sul3, bla TEM-1B, while a subset of strains (21.05%) harbored quinolone resistance-associated point mutations in gyrA , parC , and parE . Multi-locus sequence typing identified 14 sequence types, with ST48 being the most frequent (21.05%), and five clonal complexes, with CC10 as the predominant lineage (52.63%). Plasmid analysis revealed that 68.42% of the isolates carried plasmids, predominantly IncX4 (36.84%), and 57.89% of isolates harbored conjugative plasmids with complete relaxase and MPF system components. The mcr-1 gene was found within three main genetic arrangements: (i) mcr-1-pap2, (ii)IS Apl1-mcr-1-pap2, and (iii) IS Apl1-mcr-1-pap2- IS Apl1 . These findings highlight the potential for dissemination of mcr-1 in animal-derived E. coli and underscore the importance of monitoring and controlling antimicrobial resistance in livestock.
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PubMed
高影响因子
Journal of Cannabis Research
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2026
·Vol. 8
·期 1
·90
·
IF 3.8
Nichols Niara A.,Dane A. John,Musah Rabi A.
Background Cannabidiol (CBD) is one of over 100 naturally occurring phytocannabinoids in Cannabis . While extensive research has evaluated the effects that CBD and other phytocannabinoids have on consumers, less attention has been directed towards studying the health impacts of the compounds formed when cannabinoids are burned. Such an investigation is highly desirable, as smoking remains the most common form of Cannabis consumption. Previous research has investigated the structures of CBD pyrolysis products that are of a molecular mass similar to or greater than CBD. However, studies of the lower molecular weight products formed when CBD is pyrolyzed at the temperatures of a burning cigarette are limited. This work investigated the identities of the small-molecule cracking products formed from the pyrolysis of CBD. Methods CBD standards were pyrolyzed within the temperature range of 400 °C – 800 °C and analyzed using two-dimensional gas chromatography – high-resolution mass spectrometry. A combination of mass spectral fragmentation patterns, retention index data, GC retention times, and comparison of the profiles of detected compounds with those of authentic standards were used to identify cracking products that eluted during the first 19 min of a 90-min analysis. Results This investigation revealed a mixture of pyrolysis products whose complexity increased with increasing temperature. A total of 86 compounds were detected, 81 of which were identified. They spanned the alkane (both cyclic and acyclic), alkene (both cyclic and acyclic), alkyne, substituted benzene, aromatic heterocycle, phenol, and ketone compound classes. Seventy-eight of the identified molecules are reported here for the first time as CBD pyrolysis products. Several are known to have adverse health effects, including genotoxicity and neurotoxicity. Others have been reported to possess health benefits such as anti-inflammatory and antioxidant properties. Conclusions The pyrolysis of CBD revealed a complex mixture of 86 C 3 - C 10 cracking products across all five temperatures analyzed. The largest number of compounds were formed at 800 °C, while the smallest number of products was observed at 400 °C. The vast majority of these compounds have not been reported in previous studies of CBD pyrolysis. Many of the identified products are known to have impacts on human health.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Chunyu Zhao,Di Gao,Yuxuan Weng,Liquan Xiong,DongSheng Chen,Ying Wang
Size-controlled cubic–octahedral HKUST-1 is synthesized for modifying both inner and outer walls of hollow microtubes. • The Mn 3 O 4 -derived MnO 2 @HKUST-1 hollow composite micromotor integrates pollutant adsorption-enrichment with redox-mediated catalytic degradation within a unified platform. • Controlled HKUST-1 crystal size and deposition enabled uniform coating on hollow MnO₂ microtubes, enhancing pollutant enrichment while preserving catalytic sites and self-propulsion. In this study, cotton was employed as a biological template, and a size-controlled octahedral HKUST-1 structure was constructed via a combined calcination and hydrothermal process. Subsequently, a hollow tubular MnO 2 @HKUST-1 composite micromotor, derived from Mn 3 O 4 , was successfully fabricated. Under H 2 O 2 -driven conditions, the as-prepared micromotor exhibits stable autonomous motion and enables efficient removal of methylene blue (MB). Under optimized reaction conditions, a 90.4% removal efficiency was achieved within 10 min, and complete degradation was reached within 40 min. Kinetic and mechanistic analyses indicate that HKUST-1 primarily contributes to pollutant enrichment via its porous structure, whereas MnO 2 is responsible for H 2 O 2 activation and reactive oxygen species (ROS) generation. This work, for the first time, proposes a structural design principle for MOF-based micromotors that differs fundamentally from conventional MOF-coating strategies. Rather than improving performance by increasing MOF coverage or forming dense, continuous MOF coatings, the crystal size and deposition behavior of HKUST-1 were deliberately regulated to achieve a uniform yet non-continuous distribution over the inner and outer surfaces of hollow MnO 2 microtubes. This architecture simultaneously enhances pollutant enrichment, preserves the accessibility of MnO 2 catalytic sites, and maintains autonomous micromotor propulsion, thereby establishing a rational design principle for integrating adsorption, catalytic activity, and self-propulsion in multifunctional MOF-based environmental micromotors. Download: Download high-res image (318KB) Download: Download full-size image
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高影响因子
ACS Applied Nano Materials
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2026
·
IF 5.8
Saifei Du,Lei Ding,Shuqi Li,Kun Wang,Baojiang Liu,Wei Wang,Dan Yu,Chunyan Hu
MXene-based aerogels are promising for electromagnetic interference (EMI) shielding due to their lightweight nature and high conductivity. However, their practical application is often hindered by severe impedance mismatch and excessive secondary reflection. To overcome this limitation, we developed a multifunctional ternary composite aerogel (MTCA) via a synergistic self-assembly strategy. In this architecture, TpPa-1 covalent organic framework (COF) was grown in situ and integrated with MXene nanosheets within a chitosan matrix. The resulting hierarchical porous structure significantly optimizes impedance matching. Consequently, the optimized MTCA achieves an EMI shielding efficiency of 39.93 dB in the X-band, operating via an absorption-dominated mechanism. This performance stems from enhanced interfacial polarization at the MXene/COF heterojunctions and prolonged microwave propagation paths facilitated by multiple scattering within the porous network. Furthermore, the aerogel exhibits multispectral stealth capabilities: it demonstrates low infrared emissivity (ε = 0.50), superior thermal insulation (surface temperature of 28.7 °C under an 80 °C heat source), and effective visual camouflage adaptable to environmental backgrounds. This work presents a robust strategy for designing advanced stealth materials that integrate efficient absorption-dominant EMI shielding with multispectral compatibility.
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高影响因子
CANCER LETTERS
·
2026
·
IF 11.8
Jie Wang,Huihao Ma,Baozhi Feng,Yan Fu,Chunlin Lu,Mingyang Fei,Yuxin Zhang,Bin Dong,Ying Li,Jing Liu
Aldo-keto reductase family 1 member C3 (AKR1C3) is a pivotal metabolic enzyme involved in arachidonic acid (AA) metabolism and cancer metabolic reprogramming, which plays a critical role in the initiation and progression of glioblastoma (GBM). We integrated single-cell and transcriptome data to characterize AA metabolism features in GBM and identify the key gene AKR1C3. Using CCK8 assays, wound-healing assays, transwell assays, and mouse tumor formation experiments, we elucidated the effects of AKR1C3. Dual-luciferase reporter assays and ChIP-PCR experiments were performed to investigate the regulation of transcription factor JUN on AKR1C3 expression. RNA-seq analysis, combined with rescue experiments, demonstrated that AKR1C3 significantly regulates the RhoA/ROCK pathway. Arachidonic acid metabolism is closely associated with clinical outcomes in glioma, with AKR1C3 identified as a key gene within this pathway. AKR1C3 knockdown enhanced tumor cell proliferation, migration, and invasion, whereas AKR1C3 overexpression suppressed these malignant behaviors. In vivo experiments further confirmed the inhibitory effect of AKR1C3 on glioma progression. Dual-luciferase reporter and ChIP-PCR assays demonstrated that JUN acts as an upstream regulator of AKR1C3. ELISA results indicated that AKR1C3 overexpression reduced cellular PGD2 levels. RNA-seq analysis suggested that the RhoA/ROCK pathway was a downstream effector of AKR1C3, and exogenous PGD2 supplementation could reverse AKR1C3-mediated regulation of this pathway. We identified curcumin, a natural product with anti-cancer metabolic regulatory activity, as an upstream modulator that suppresses JUN expression, thereby activating the JUN/AKR1C3 axis and inhibiting malignant phenotypes in GBM cells. JUN/AKR1C3 axis influences glioma progression via modulating PGD2-mediated RhoA/ROCK Signaling.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9.1
Zemin Li,Rongbo Li,Benxing Li,Yuqi Zhu,Jiale Lin,Chongqing Wang,Rujing Hou,Yichang Pan
The separation of hexane isomers in petrochemical engineering is energy-intensive, driving the need for membrane-based alternatives to conventional thermal processes. Mixed-matrix membranes (MMMs) offer a material platform by combining the processability of polymer matrices with the high structural tunability of porous fillers. In this work, we fabricate UiO-66-Tix/tPIM-1 MMMs by incorporating Ti-regulated bimetallic Zr/Ti-UiO-66 fillers into a thermally treated polymer of intrinsic microporosity (tPIM-1) matrix. At low Ti contents, the UiO-66-type crystallinity is largely preserved, while Ti introduction produces measurable changes in the pore characteristics and nHex/22DMB adsorption kinetics. Membrane-level sorption measurements show preferential nHex uptake, while adsorption-kinetic analysis and molecular dynamics simulations of both the isolated frameworks and the UiO-66-Ti 0.2 /tPIM-1 composite environment indicate stronger diffusion restriction toward bulky 22DMB than toward linear nHex. Collectively, these results support an adsorption–diffusion transport mechanism for the observed separation behavior. Among the Ti contents and filler loadings investigated, the selected 5 wt% UiO-66-Ti 0.2 /tPIM-1 membrane achieves a flux of 515 g·m −2 ·h −1 and a separation factor of 7.9 for nHex/22DMB separation. The membrane also maintained relatively stable performance during 84 h of continuous operation and preferentially enriched nHex from multicomponent C6 isomer mixtures, showing competitive separation performance among reported MMMs for hexane isomer separation. These results indicate that controlled Ti introduction provides a route to modify the pore characteristics of UiO-66 and improve nHex/22DMB discrimination in thermally treated PIM-1-based MMMs.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
·
IF 2.4
Yuexin Chu,Xianming Zhang,Guojun Ji,Yunfei Wang,Ruifeng Wang,Yongli Wu,Jianmin Wang,Hongyu Peng
The production of C8 linear α-olefins via Fischer–Tropsch (F-T) synthesis represents a promising alternative approach. However, purifying α-olefins from F-T synthesis oil presents considerable technical challenges, particularly with respect to the removal of oxygenated compounds. In this work, propylene carbonate (PC) was used as extractant, and 1-pentanol, n-valeraldehyde, 2-hexanone, and ethyl acetate were selected as representative substances of oxygenated compounds. Liquid–liquid equilibrium (LLE) for the binary system of 1-octene + PC, and the ternary systems of 1-octene + 1-pentanol + PC, 1-octene + n-valeraldehyde + PC, 1-octene + 2-hexanone + PC, and 1-octene + ethyl acetate + PC were measured at 298.15, 303.15, and 313.15 K under 101.3 kPa using a jacketed equilibrium cell. The phase diagrams for the ternary systems were classified as Treybal’s Type I behavior. The distribution coefficient (D) and selectivity (S) were calculated to investigate the efficiency of PC as an extractant. Moreover, the temperature dependencies of D and S were investigated in this study. The experimental LLE data were correlated using the NRTL and UNIQUAC models with the interaction parameters optimized. The RMSD values between the experimental and calculated data indicate that these models can accurately correlate the experimental data for the study systems.
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高影响因子
ACS Applied Materials & Interfaces
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2026
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IF 7.8
Xiaoqiong Li,Yunruo Xu,Luming Xu,Qilin Li,Yiwei Zhao,Chunyu Wei,Yuyu Li,Lin Wang,Zheng Wang
Surgery is the mainstay of treatment for patients with solid tumors. However, the intricate inflammatory and immunosuppressive tumor microenvironment after surgery is recognized as a primary cause of tumor recurrence and metastasis. Here, we design and construct an in situ injectable therapeutic hydrogel encapsulating 1-methyl-d-tryptophan (1-d-MT), a small-molecule competitive inhibitor of indoleamine 2,3-dioxygenase, and meloxicam, a selective inhibitor of cyclooxygenase-2 (Ge1MT/Mel hydrogel) to prevent postoperative tumor metastasis and relapse. In this hydrogel system, 1-d-MT increases cytotoxic T lymphocytes and decreases regulatory T cells, thereby reversing the tumor immune tolerance microenvironment, while released meloxicam reduces inflammation caused by postoperative trauma via the COX-2/PGE2 pathway. When delivered into the resected tumor cavity, the hydrogel system mimics a “hot” tumor-immunity niche to attack residual tumor cells and significantly suppresses the postoperative recurrence of colorectal cancer. In the model of postoperative breast cancer and colorectal cancer recurrence and metastasis, the Ge1MT/Mel hydrogel substantially reduces the volume of recurrent tumors and demonstrates 85.1% and 66.7% inhibition rates of metastases, respectively. Importantly, the Ge1MT/Mel hydrogel markedly stimulates a potent antitumor immune response in the cancer lesion microenvironment, increasing antitumor immune cells including CD8+ T cells, as well as elevating antitumor cytokines such as interferon-γ. Overall, combination immunotherapy via the Ge1MT/Mel hydrogel after surgery represents a promising strategy to minimize residual tumor burden and reduce recurrence risk following tumor resection.
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PubMed
高影响因子
CERAMICS INTERNATIONAL
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2026
·
IF 6
Kunqi Liu,Junxia Wang,Jin Wang,Long Kang,Jun Li,Die Liu,Yuan Liu,Qing Tao
To explore the application potential of ceramic waste forms for immobilizing multiple nuclides in high-level waste, a systematic study was conducted on (1- x )Sr 0.5 Zr 2 (PO 4 ) 3 - x Ce 0.5 Sm 0.5 PO 4 ( x = 0, 0.5, and 1) ceramics, focusing on their chemical and irradiation stability. The composite ceramics can simultaneously immobilize multiple nuclides (Sr, Ce, and Sm), while retaining a homogeneous microstructure and high relative density (>97%). Static leaching experiment indicated low normalized leaching rates: LR Sr ∼ 10 -4 -10 -3 g·m -2 ·d -1 , LR Ce ∼ 10 -8 -10 -7 g·m -2 ·d -1 , and LR Sm ∼ 10 -7 -10 -6 g·m -2 ·d -1 . Different leaching behaviors of nuclides (Sr, Ce, Sm) were further identified using the de Groot and van der Sloot model. With 5 MeV Xe 20+ irradiation at a fluence of 2.5×10 15 ions/cm 2 , Sr 0.5 Zr 2 (PO 4 ) 3 phase in the composite ceramics can still maintain part of its crystal structure, while Ce 0.5 Sm 0.5 PO 4 phase tends to amorphize. Interestingly, subsequent TEM observation further vitrificated the Xe 20+ -induced amorphous Ce 0.5 Sm 0.5 PO 4 phase recrystallizes under electron-beam (e-beam) irradiation.
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高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Feng Ye,Shujing Yang,Ruyi Liu,Xinwang Niu,Siteng Zhou,Tian-Hu Wang,Chao Xu
Vanadium flow batteries (VFBs) are considered a promising technology for grid-scale energy storage owing to their intrinsic safety, flexible design, and long cycle life. However, their practical deployment remains constrained by the selectivity–conductivity dilemma of benchmark membranes such as Nafion, leading to capacity decay and efficiency loss. Herein, we propose and experimentally fabricate a hybrid membrane integrating a sulfonated polymer of intrinsic microporosity (sPIM-1) into Nafion. Through systematic optimization of sPIM-1 loading, the optimal 7% sPIM-1/Nafion membrane achieves an exceptional ion selectivity (1.95 × 10 5 S min cm −3 , 2.87 times larger than conventional Nafion), while retaining high proton conductivity (210.96 mS cm −1 ). As a result, VFBs assembled with the composite membrane exhibit a markedly prolonged self-discharge time (70.7% extension) and outstanding cycling durability, retaining an energy efficiency of 86.6% after 1000 cycles, substantially outperforming Nafion-based systems. The improvement is rationalized by the synergistic coupling of chemical (-SO₃H mediated) and physical (rigid-porous-network) proton transport pathways, concurrent with a size-sieving effect that selectively blocks vanadium ions. This work not only demonstrates the efficacy of sPIM-1/Nafion composite membrane strategy for high-performance VFB, but also establishes an advanced membrane design avenue in energy storage devices.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Tianqi Wang,Shaoze Jing,Ke Ma,Fan Zhang,Bing Wang,Yu Lei,Jun Zhang
Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by articular cartilage degradation, persistent oxidative stress, and chronic inflammation. Targeting oxidative damage within the joint microenvironment represents a promising avenue for disease modification, offering potential to preserve cartilage integrity, alleviate inflammatory cascades, and ultimately delay structural progression. Lipid nanoparticles were prepared by thin-film hydration and extrusion, then embedded into GelMA microspheres via a microfluidic droplet platform with UV crosslinking to form a sustained-release system. Biocompatibility, ROS-scavenging, anti-inflammatory, and chondroprotective effects were evaluated in vitro and in vivo, while transcriptome sequencing was applied to elucidate system-induced molecular alterations. In vitro , Api-LNP@GMS markedly attenuated ROS accumulation and inflammatory responses in IL-1β-stimulated chondrocytes, as demonstrated by ROS fluorescence imaging, immunofluorescence, Western blotting, and qRT-PCR analyses. In vivo , intra-articular administration in anterior cruciate ligament transection (ACLT) rats effectively alleviated joint inflammation while preserving cartilage integrity and functional capacity. Moreover, transcriptome-wide RNA sequencing, integrated with pathway enrichment analysis and validated by molecular assays, revealed robust activation of the Nrf2–HO-1 antioxidant signaling axis. Api-LNP@GMS is a multifunctional antioxidant biomaterial platform that integrates a natural therapeutic with a sustained-release delivery system, offering a safe and effective strategy to reprogram the osteoarthritic microenvironment and mitigate disease progression. Download: Download high-res image (281KB) Download: Download full-size image
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高影响因子
APPLIED CATALYSIS A-GENERAL
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2026
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IF 4.8
Jingyi Chen,Shuangfeng Ren,Luyao Guo,Tongtong Feng,Xiaoling Mou,Jiaxu Liu,Li Yan,Ronghe Lin,Yunjie Ding
Hydrothermal defect healing selectively stabilizes catalytically active Pt ensembles by removing weakly anchored species in Silicalite-1. • Confined Pt ensembles exhibit enhanced intrinsic activity, lower activation energy, and improved oxygen activation in aerobic alcohol oxidation. • Catalysis occurs on externally accessible Pt sites and mesoporous regions, enabling efficient oxidation of bulky alcohol molecules. • Defect-healing-induced restructuring provides a general strategy to optimize active site stability and catalytic efficiency in heterogeneous oxidation catalysts. The development of robust Pt catalysts that simultaneously achieve efficient O 2 activation, high intrinsic activity, and structural stability remains a central challenge in aerobic alcohol oxidation. Herein, we report a hydrothermal defect-healing strategy to restructure impregnated weakly anchored Pt species in Silicalite-1 zeolite into highly stable Pt ensembles confined within the zeolite framework (Pt@S-1). Spectroscopic and microscopic analyses reveal that hydrothermal treatment heals silanol defects and drives controlled restructuring of isolated Pt atoms into small ensembles strongly stabilized by the zeolitic microenvironment. The resulting Pt@S-1 catalyst exhibits markedly enhanced intrinsic activity, achieving a turnover frequency of 5560 h −1 in aqueous aerobic oxidation of 3,5,5-trimethylhexanol, exceeding conventional nanoparticle and impregnated analogues by over one order of magnitude despite significantly lower Pt loading. Kinetic studies demonstrate a reduced apparent activation energy (65.7 kJ mol −1 ) and nearly first-order dependence on O 2 pressure, indicating facilitated O 2 activation and optimized competitive adsorption between oxygen and alcohol substrates. The zeolite confinement and aqueous reaction medium synergistically promote selective formation of isononanoic acid and ester while suppressing catalyst sintering and thermal runaway. Furthermore, the catalyst shows excellent stability without requiring hydrogen pretreatment or additional base. This work establishes defect-healing-induced restructuring as an effective approach to generate stable and highly active catalytic ensembles from labile atomically dispersed precursors and provides fundamental insights into structure–activity relationships governing selective aerobic alcohol oxidation. Download: Download high-res image (150KB) Download: Download full-size image A hydrophilic zeolite-supported Pt catalyst cooperates with water to drive base-free and H 2 -free aerobic oxidation of long-chain alcohols under mild aqueous conditions, achieving selective acid formation while suppressing energy demand, metal sintering, and organic solvent use.
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