ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19
Shanhu Wang,Jiachang Bi,Shuya Liu,Jiyang Xie,Yihan Lei,Zihao Lin,Yang He,Hao Fan,Jiayi Qin,Wenyan Zha,Sheng'an Yang,Ji Ma,Hui Zhang,Qingming Chen,Jiangnan Li,Yanwei Cao,Changjian Li,Wanbiao Hu,Liang Wu
Self-assembled nanocomposites typically form through the phase separation of immiscible components, yet controllable synthesis with tailored functionalities remains challenging. Here, we demonstrate a substrate-directed self-assembled 2-(1-3)-structured nanocomposite via topotactic phase separation, preserving the crystallographic orientation from the substrate. It comprises a horizontal antiferromagnetic (AFM) rocksalt layer (2) at the substrate and vertical rocksalt nanopillars (1) embedded in a ferrimagnetic (FiM) spinel matrix (3). The nanopillars arise from kinetic trapping of late-arriving rocksalt species unable to diffuse through the growing spinel layer, forming “frozen diffusion channels” under continuous pulsed laser deposition. Importantly, the comparable magnitudes of AFM anisotropy and AFM-FiM interfacial exchange coupling enable two phenomena: switching between coercivity enhancement and exchange bias regimes, and field-free manipulation of AFM order. This approach offers precise control of magnetic interactions in self-assembled nanocomposites for advanced spintronic applications.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Xiaofei Zhang,Zhaozhu Qu,Xiaohui Sun,Wei Wu,Xiangpeng Guan,Qirong Xu,Jianwei Wu,Guohua Wu,Bo Wang,Ruihui Peng,Nana Liu,Xiangwei Wang,Xuyang Zhang
This study synthesizes mixed-phase vanadium oxide (V x O 2x+1 ) thin films with dual electrochromic and capacitive functionalities through a synergistic combination of sol–gel processing, electrochemical deposition, and thermal annealing. The VO-350 film, annealed at 350 °C, exhibits a hierarchically ordered “dense-layer/porous-interior” architecture, achieving exceptional areal capacitance and superior optical modulation. This single-material system exhibits an unparalleled four-state multicolor switching capability (yellow, green, blue and brown) with rapid kinetics (<20 s) and ultrahigh cycling stability, retaining 51.29% of its initial capacitance and exhibiting zero optical modulation decay after 2,000 cycles. When integrated into VO-350/WO 3 electrochromic devices, the system delivers dual-band high modulation (58.39% @750 nm and 59.11% @1000 nm after 3000 cycles) alongside enhanced switching dynamics. This work pioneers a methodology that precisely orchestrates reduction potentials and thermal annealing strategies to directionally regulate vanadium oxidation states, crystallographic phases, and morphological features, this establishes a standardized paradigm for designing dual-functional electrochromic capacitors.
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Journal of the Taiwan Institute of Chemical Engineers
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2026
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IF 6.9
Yulin Zhou,Shuang Tan,Qiangqiang Liu,Xingwen Zheng,Bochuan Tan,Riadh Marzouki
Background Q235 steel is susceptible to severe corrosion during the pickling process, especially in hydrochloric acid media, which not only shortens the service life of the equipment, but also may cause safety hazards and environmental pollution. Methods : A bis-triazole Schiff base carboxylic acid (BTSCA) was synthesized, named the 5-((4-(4H-1,2,4-triazol-4-yl) benzylidene) amino)-1H-1,2,4-triazole-3-carboxylic acid. The present study investigates the inhibitory performance of Q235 steel in a 1 M HCl solution containing BTSCA. The experimental methods adopted were weight loss method and electrochemical method. Significant findings : The results show that BTSCA has a good inhibitory efficiency on Q235 steel in 1 M HCl solution, which can reach 98.98%. Kinetic and thermodynamic analyses explained inhibitory mechanism of the compound, and the results showed that the adsorption behavior was in accordance with the Langmuir isotherm. The surface morphology of Q235 steel was characterized by scanning electron microscope (SEM) and atomic force microscope (AFM). Density functional theory (DFT) was used to analyze the inhibitory mechanism of BTSCA. Combined with molecular dynamics simulation (MD), the most stable configuration, adsorption sites and adsorption energy of BTSCA on the steel surface were determined.
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FOOD AND CHEMICAL TOXICOLOGY
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2026
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IF 3.2
Yuzhen Xia,Fang Wang,Lisha Zhao,Bingfeng Lin,Pingcui Xu,Lingmin Lu,Nani Wang
Nanoplastics (NPs) induce ferroptosis in endothelial cells and zebrafish. • NPs disrupt unsaturated fatty acid metabolism in zebrafish. • NPs downregulate GPX4 and induce lipid peroxidation in vitro and in vivo. • Targeting ferroptosis mitigates NPs-related cardiovascular injury. Nanoplastics (NPs) are widespread environmental pollutants, and their potential cardiovascular toxicity has raised growing concern. This study aimed to investigate whether NPs impair angiogenesis through ferroptosis induction. Zebrafish larvae were exposed to NPs (10-1000 μg/L) or erastin (5 μM) for 48 h. Rescue experiments were performed by co-treatment with ferrostatin-1 (Fer-1, 1 μM). Human microvascular endothelial cell line-1 were treated with NPs at 100 μg/mL for 24 h, with or without Fer-1 (1 μM). NPs exposure resulted in reduced body length, impaired intersegmental vessel formation, and downregulated expression of key angiogenesis-related genes in zebrafish larvae. Additionally, NPs inhibited tube formation, migration, and vascular endothelial growth factor A expression in HMEC-1 cells. Transcriptomic and metabolomic analyses revealed that NPs exposure disrupted unsaturated fatty acid metabolism. NPs induced lipid peroxidation, reactive oxygen species accumulation, elevated malondialdehyde levels, and downregulation of glutathione peroxidase 4 expression, all of which were reversed by treatment with the ferroptosis inhibitor Fer-1. Intervention with Fer-1 not only rescued NPs-induced intersegmental vessel defects but also upregulated the expression of angiogenesis-related genes, thereby effectively ameliorating NPs-induced vascular damage. These findings indicate that ferroptosis is a key mechanism underlying NPs-mediated vascular dysfunction.
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高影响因子
Scientific Reports
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2026
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IF 4.9
Xiang Qingqing,Yu Rong,Huang Li,Liu Qingqing,Qin Nuo,Wang Li,Wu Yan,Fu Hang
Due to a lack of complete mechanistic understanding, there are no specific therapeutics for necrotizing enterocolitis (NEC), a deadly gastrointestinal disease affecting premature newborns. While sodium butyrate offers intestinal protection, its efficacy is strictly dose-dependent, and the underlying mechanisms regulating intestinal epithelial cell (IEC) survival remain elusive. Here, using neonatal murine NEC models and human IECs, we demonstrate that moderate-dose butyrate (50 mg/kg) significantly attenuates mucosal injury and improves survival, whereas high-dose butyrate (250 mg/kg) exacerbates mortality by inducing complex cell death pathways including necroptosis and ferroptosis. Mechanistically, moderate butyrate suppresses glycolysis and intracellular lactate production, which restores expression of the translational regulator PABPC1; PABPC1 then binds to YB-1 mRNA to enhance YB-1 protein synthesis without altering transcription. Elevated YB-1 subsequently binds BCL-2 mRNA, increasing BCL-2 protein levels to inhibit intrinsic mitochondrial apoptosis. Functional validation shows that YB-1 knockdown abolishes butyrate-mediated protection and exacerbates TNF-α-induced apoptosis, while YB-1 overexpression rescues cell viability, and exogenous lactate supplementation reverses these effects by suppressing the PABPC1-YB-1 axis. These findings elucidate a novel Lactate-PABPC1-YB-1-BCL-2 signaling axis through which butyrate safeguards the intestinal epithelium, highlighting precise dosing and the modulation of epithelial translational control as promising therapeutic strategies for NEC.
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PubMed
高影响因子
ANALYST
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2026
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IF 3.6
Xiaojing Zhang,Hongyang Guo,Li Sin Wong,Hangming Xiong,Liubing Kong,Li Zhang,Yanjie Hu,Yong Zhou,Hao Wan,Ping Wang
Decentralized biomarker testing is pivotal for cancer screening, risk evaluation, and longitudinal surveillance, yet most established assays remain laboratory-centric that are not suitable for point-of-care testing (POCT). Saliva has attracted extensive attentions owing to its redundant bioinformation, non-invasive collection and easy sampling for disease screening. Herein, we developed a highly sensitive Love-wave surface acoustic wave (Love-SAW) immunosensor for the quantification of Cyfra21-1 in saliva, a clinically established cytokeratin-19 fragment widely used in epithelial cancer management, and advanced it toward a chip-scale sensing platform that can be readily integrated into portable POCT devices. The immunosensor employs a sandwich immunoassay, with signal amplification by gold nanoparticle–labeled antibodies. The sensing interface is engineered via cysteamine self-assembly on gold through Au–S coupling, followed by glutaraldehyde activation to enable covalent immobilization of the Cyfra21-1 coating antibody. Cyfra21-1 was measured in both PBS and artificial saliva samples, with a total assay time of approximately 20 min per sample. The Love-SAW immunosensor provided a dynamic detection range of 7.81–62.5 ng/mL and a limit of detection of 4.9 ng/mL for Cyfra21-1 detection in PBS, and demonstrated matrix-tolerant detection in spiked artificial saliva (15.62–125 ng/mL, LOD: 13.9 ng/mL). Quantification in spiked artificial saliva agreed well with ELISA, yielding good recoveries of 82.36%–106.60%. These results demonstrate that the gold-enhanced Love-SAW immunosensor enables highly sensitive, rapid and portable quantification of salivary biomarkers, providing a promising foundation for the development of compact and non-invasive POCT systems for disease screening.
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高影响因子
Journal of Energy Storage
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2026
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IF 10.7
Feng Ye,Shujing Yang,Ruyi Liu,Xinwang Niu,Siteng Zhou,Tian-Hu Wang,Chao Xu
Vanadium flow batteries (VFBs) are considered a promising technology for grid-scale energy storage owing to their intrinsic safety, flexible design, and long cycle life. However, their practical deployment remains constrained by the selectivity–conductivity dilemma of benchmark membranes such as Nafion, leading to capacity decay and efficiency loss. Herein, we propose and experimentally fabricate a hybrid membrane integrating a sulfonated polymer of intrinsic microporosity (sPIM-1) into Nafion. Through systematic optimization of sPIM-1 loading, the optimal 7% sPIM-1/Nafion membrane achieves an exceptional ion selectivity (1.95 × 10 5 S min cm −3 , 2.87 times larger than conventional Nafion), while retaining high proton conductivity (210.96 mS cm −1 ). As a result, VFBs assembled with the composite membrane exhibit a markedly prolonged self-discharge time (70.7% extension) and outstanding cycling durability, retaining an energy efficiency of 86.6% after 1000 cycles, substantially outperforming Nafion-based systems. The improvement is rationalized by the synergistic coupling of chemical (-SO₃H mediated) and physical (rigid-porous-network) proton transport pathways, concurrent with a size-sieving effect that selectively blocks vanadium ions. This work not only demonstrates the efficacy of sPIM-1/Nafion composite membrane strategy for high-performance VFB, but also establishes an advanced membrane design avenue in energy storage devices.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Tianqi Wang,Shaoze Jing,Ke Ma,Fan Zhang,Bing Wang,Yu Lei,Jun Zhang
Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by articular cartilage degradation, persistent oxidative stress, and chronic inflammation. Targeting oxidative damage within the joint microenvironment represents a promising avenue for disease modification, offering potential to preserve cartilage integrity, alleviate inflammatory cascades, and ultimately delay structural progression. Lipid nanoparticles were prepared by thin-film hydration and extrusion, then embedded into GelMA microspheres via a microfluidic droplet platform with UV crosslinking to form a sustained-release system. Biocompatibility, ROS-scavenging, anti-inflammatory, and chondroprotective effects were evaluated in vitro and in vivo, while transcriptome sequencing was applied to elucidate system-induced molecular alterations. In vitro , Api-LNP@GMS markedly attenuated ROS accumulation and inflammatory responses in IL-1β-stimulated chondrocytes, as demonstrated by ROS fluorescence imaging, immunofluorescence, Western blotting, and qRT-PCR analyses. In vivo , intra-articular administration in anterior cruciate ligament transection (ACLT) rats effectively alleviated joint inflammation while preserving cartilage integrity and functional capacity. Moreover, transcriptome-wide RNA sequencing, integrated with pathway enrichment analysis and validated by molecular assays, revealed robust activation of the Nrf2–HO-1 antioxidant signaling axis. Api-LNP@GMS is a multifunctional antioxidant biomaterial platform that integrates a natural therapeutic with a sustained-release delivery system, offering a safe and effective strategy to reprogram the osteoarthritic microenvironment and mitigate disease progression. Download: Download high-res image (281KB) Download: Download full-size image
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高影响因子
APPLIED CATALYSIS A-GENERAL
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2026
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IF 4.8
Jingyi Chen,Shuangfeng Ren,Luyao Guo,Tongtong Feng,Xiaoling Mou,Jiaxu Liu,Li Yan,Ronghe Lin,Yunjie Ding
Hydrothermal defect healing selectively stabilizes catalytically active Pt ensembles by removing weakly anchored species in Silicalite-1. • Confined Pt ensembles exhibit enhanced intrinsic activity, lower activation energy, and improved oxygen activation in aerobic alcohol oxidation. • Catalysis occurs on externally accessible Pt sites and mesoporous regions, enabling efficient oxidation of bulky alcohol molecules. • Defect-healing-induced restructuring provides a general strategy to optimize active site stability and catalytic efficiency in heterogeneous oxidation catalysts. The development of robust Pt catalysts that simultaneously achieve efficient O 2 activation, high intrinsic activity, and structural stability remains a central challenge in aerobic alcohol oxidation. Herein, we report a hydrothermal defect-healing strategy to restructure impregnated weakly anchored Pt species in Silicalite-1 zeolite into highly stable Pt ensembles confined within the zeolite framework (Pt@S-1). Spectroscopic and microscopic analyses reveal that hydrothermal treatment heals silanol defects and drives controlled restructuring of isolated Pt atoms into small ensembles strongly stabilized by the zeolitic microenvironment. The resulting Pt@S-1 catalyst exhibits markedly enhanced intrinsic activity, achieving a turnover frequency of 5560 h −1 in aqueous aerobic oxidation of 3,5,5-trimethylhexanol, exceeding conventional nanoparticle and impregnated analogues by over one order of magnitude despite significantly lower Pt loading. Kinetic studies demonstrate a reduced apparent activation energy (65.7 kJ mol −1 ) and nearly first-order dependence on O 2 pressure, indicating facilitated O 2 activation and optimized competitive adsorption between oxygen and alcohol substrates. The zeolite confinement and aqueous reaction medium synergistically promote selective formation of isononanoic acid and ester while suppressing catalyst sintering and thermal runaway. Furthermore, the catalyst shows excellent stability without requiring hydrogen pretreatment or additional base. This work establishes defect-healing-induced restructuring as an effective approach to generate stable and highly active catalytic ensembles from labile atomically dispersed precursors and provides fundamental insights into structure–activity relationships governing selective aerobic alcohol oxidation. Download: Download high-res image (150KB) Download: Download full-size image A hydrophilic zeolite-supported Pt catalyst cooperates with water to drive base-free and H 2 -free aerobic oxidation of long-chain alcohols under mild aqueous conditions, achieving selective acid formation while suppressing energy demand, metal sintering, and organic solvent use.
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高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
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2026
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IF 5.2
Zhuohua Cao,Siyu Men,Zhenhua Li,Gang Liu,Qingying Su,Xinran Chen,Xianhua Che,Hanyong Jin
Organophosphate esters (OPEs) are widespread environmental contaminants increasingly recognized for their metabolic-disruption potential. However, systematic cross-structure comparisons of their inhibitory effects on human carboxylesterase 1 (hCES1), an enzyme involved in xenobiotic metabolism and lipid homeostasis, remain limited. Here, we established an OPE-centered cross-structure inhibition dataset for hCES1 using 25 structurally diverse organophosphate compounds, revealing a pronounced structure-dependent potency pattern across the series (IC 50 : 2.538 nM to > 600 μM). More potent inhibition was enriched among compounds bearing P=O motifs and aryl-containing substituents, although the overall activity pattern could not be explained by any single empirical structural label. To resolve the determinants underlying this stratification, we developed complementary QSAR models. The 2D-QSAR models captured global descriptor-level trends but showed only moderate predictive ability ( R 2 ≥ 0.918, q 2 ≥ 0.508), whereas the scaffold-based 3D-QSAR models (CoMFA and CoMSIA) offered a more spatially informative explanation of activity variation ( R 2 ≥ 0.947, q 2 ≥ 0.374, RMSE ≤ 0.420), indicating that steric, electrostatic, hydrophobic, and hydrogen-bonding effects jointly shape hCES1 inhibition. Molecular docking further showed that more potent aryl-rich compounds achieved broader hydrophobic occupancy and denser nonpolar contacts within the hCES1 catalytic cavity. Complementary quantum-chemical analyses indicated that the phosphorus center was the major electron-deficient site, while phosphorus-centered bonding environments and side-chain features contributed differently to electrophilic susceptibility and pocket recognition. Overall, hCES1 inhibition by organophosphate compounds can be interpreted within a layered SAR framework in which side-chain-mediated cavity recognition and phosphorus-centered electronic effects jointly shape inhibitory activity.
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高影响因子
Animals
·
2026
·Vol. 16
·期 11
·1606
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IF 3.2
Yiping Gu,Hongzuo Duan,Congyun Ji,Hanyu Lin,Yuxin Lai,Jianwei Zhang,Cun Zhang,Suxin Huo,Zheng Ni,Tao Yun,Weicheng Ye,Jionggang Hua,Liu Chen,Yuan Fu,Yinchu Zhu,Zihao Pan
Simple SummaryBovine herpesvirus type 1 (BoHV-1) causes severe respiratory disease and reproductive disorders in cattle, leading to major economic losses worldwide. Current vaccines in China have limitations, as they cannot distinguish vaccinated animals from infected ones. In this study, we developed two new live vaccines by removing three viral genes (rBoHV-∆gG-∆gE/gI and rBoHV-∆TK-∆gE/gI). We tested their safety and effectiveness in rabbits. The results show that both vaccines were safe and induced strong immune responses. After exposure to the virus, vaccinated rabbits showed no fever, significantly reduced virus shedding, and less lung damage. Notably, the rBoHV-∆TK-∆gE/gI vaccine worked best at a high dose, while the rBoHV-∆gG-∆gE/gI vaccine was effective even at a low dose. These findings suggest that our new vaccines could help control BoHV-1 infections and support eradication programs by allowing differentiation between vaccinated and naturally infected animals.Bovine herpesvirus type 1 (BoHV-1) causes severe respiratory and reproductive diseases in cattle, leading to significant economic losses worldwide. Current inactivated vaccines in China fail to induce robust cellular immunity and cannot differentiate infected from vaccinated animals (DIVA). To address these limitations, we constructed two triple-gene-deleted BoHV-1 vaccine candidates, ∆T3 (∆TK-∆gE/gI) and ∆g3 (∆gG-∆gE/gI), using Red/ET two-step recombination technology based on an infectious BAC clone. Their safety and immunogenicity were evaluated in a rabbit model. Both deletion mutants exhibited growth kinetics similar to the wild-type strain but with significantly reduced viral titers and plaque areas. The triple-gene deletion mutants showed superior safety compared with single-gene deletion mutants, with minimal clinical signs and low viral shedding. Immunization with ∆T3 and ∆g3 induced robustgB-specific and neutralizing antibody responses. Following challenge with the virulent BoHV-1 BC01 strain, vaccinated rabbits maintained normal body temperatures, showed significantly reduced viral shedding (approximately 100-fold), and exhibited milder pulmonary lesions. These findings demonstrate that ∆T3 high-dose and ∆g3 low-dose regimens are promising DIVA-compatible vaccine candidates, offering an effective strategy for IBR control and eradication programs.
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高影响因子
MOLECULAR THERAPY
·
2026
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IF 11.4
Yang Yang,Jiannan Wang,Hong Yu,Zhen Quan,Zhujiao Zhang,Jingran Guo,Haoxuan Wu,Shanshan Liu,Xiaoqian Li,Xinxin Hu,Hongyan Zou,Mengyuan Zhu,Tianyi Wang,Zijian Zhou,Jiaying Liu,Jing Wang,Kai Wang,Lili Yang,Zhaoguo Han,Xilin Sun
The costimulatory receptor CD28 is indispensable for regulating T-cell effector function, and the absence of co-stimulation is associated with poor immunotherapy response. However, longitudinal molecular imaging studies targeting CD28 as a costimulatory biomarker using positron emission tomography (PET) have not been reported. Here, we developed the co-stimulation-associated radiotracer [ 89 Zr]Zr-DFO-anti-CD28 to enable early prediction of therapeutic response by identifying recovery of T-cell responsiveness following programmed cell death protein 1 (PD-1) blockade in lung cancer. [ 89 Zr]Zr-DFO-anti-CD28 demonstrated high specificity for CD28 + tumor-infiltrating lymphocytes (TILs) in vitro and in vivo. By monitoring CD28 expression and its loss within the tumor microenvironment, [ 89 Zr]Zr-DFO-anti-CD28 PET identified responses to anti-PD-1 therapy earlier than changes in tumor volume observed at day 5, and increased radiotracer uptake correlated with more favorable treatment responses. Repeated PET imaging was performed to monitor dynamic changes in CD28 + TILs induced by different immunotherapies at day 14, and [ 89 Zr]Zr-DFO-anti-CD28 PET captured the CD28-dependent restoration of T-cell effector function, further supporting its potential for early prediction. Taken together, costimulatory biomarker-specific CD28 PET molecular imaging may enable noninvasive early prediction of responses to multiple immunotherapies and facilitate the application of precision medicine in lung cancer.
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