Food & Function
·
2021
·Vol. 12
·期 10
·4582-4590
·
IF 5.396
Xue-Yan Dai,Yi Zhao,Jing Ge,Shi-Yong Zhu,Mu-Zi Li,Milton Talukder,Jin-Long Li
Lycopene (Lyc) has been discussed as a potential effector in the prevention and therapy of various diseases. Di(2-ethylhexyl) phthalate (DEHP) is regarded as a universal environmental pollutant. To clarify the potential protective effect of Lyc on DEHP-induced splenic injury, 140 male mice were randomized into seven groups: control (distilled water), vehicle control (corn oil per day), Lyc (5 mg per kg BW per day), DEHP (500 or 1000 mg per kg BW per day), and DEHP combined Lyc group, respectively. All experimental animals were treated by oral gavage for 28 days. The results that showed DEHP exposure significantly up-regulated the mRNA and protein expression of the sirtuin family (except SIRT4-5), PGC-1α, OPA1, Drp1, MFN1/2, NRF1, TFAM, Parkin and PINK in DEHP-treated alone groups and the SOD2 and LC3-II protein expression were also in accordance with the above changes. These were accompanied with an increase of the number of inflammatory cells and rate of mitochondrial damage, and autophagosome formation in the spleen. Notably, Lyc supplementation facilitated all these changes to effectively return to the normal level, indicating that Lyc exerts protective effects against DEHP-induced splenic toxicity. Altogether, the protective effects of Lyc may be a strategy to ameliorate DEHP-induced spleen damage.
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高影响因子
MATERIALS RESEARCH BULLETIN
·
2021
·
IF 4.641
Mei-Hong Liu,De-Long Zhang
Er 3+ /Yb 3+ -codoped NaLa(WO 4 ) 2 phosphor samples with different Er 3+ and Yb 3+ doping levels were synthesized by solid-state chemical reaction for optical thermometry and fully characterized. The results show that each phosphor sample mainly consists of NaLa(WO 4 ) 2 crystalline phase and has a nominally stoichiometric chemical composition. The phosphor grains have massive polyhedron morphology, good size homogeneity with a mean value of ∼5 μm and a cutoff phonon energy of 927 cm −1 . The 530 and 550 nm upconversion fluorescence of Er 3+ in the phosphor samples and their temperature characteristics were investigated under 980 nm excitation. The results show that the phosphor exhibits strong upconversion fluorescence and the maximum fluorescence intensity is observed at the optimal Er 3+ and Yb 3+ doping levels of 5 and 20 mol%, respectively. The two-photon process is responsible for the upconversion fluorescence. The spectral structure of either 530 or 550 nm fluorescence band is thermally stable. The peak absolute thermal sensitivity is observed at ∼490 K and has a peak value of ∼9 × 10 -3 K -1 . As expected, Er 3+ or Yb 3+ doping level has little effect on the thermal sensitivity. The phosphor displays a wide dynamical response range of thermal sensitivity from 293 to 800 K, where the sensitivity varies within (6.5–9.0) × 10 -3 K -1 . A comparison study shows that the temperature characteristics obtained from the cooling procedure are almost the same as those obtained from the heating procedure. Besides, the effects of Er 3+ /Yb 3+ doping level and heating/cooling on fluorescence color chromaticity were also studied. Based on the results, the Er 3+ /Yb 3+ -codoped NaLa(WO 4 ) 2 phosphor shows strong fluorescence, good thermal stability, high thermal sensitivity and broad response range of thermal sensitivity. Thus, it is a promising material for thermal detection over a wide temperature range of 293−800 K.
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ACTA PHARMACOLOGICA SINICA
·
2021
·Vol. 43
·期 1
·96-110
·
IF 6.15
Liu Xue-qi,Jiang Ling,Li Yuan-yuan,Huang Yue-bo,Hu Xue-ru,Zhu Wei,Wang Xian,Wu Yong-gui,Meng Xiao-ming,Qi Xiang-ming
Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options. Wogonin is a flavonoid derived from the root of Scutellaria baicalensis Georgi, which has shown a potent renoprotective effect. But the mechanisms of action in DKD are not fully elucidated. In this study, we investigated the effects of wogonin on glomerular podocytes in DKD using mouse podocyte clone 5 (MPC5) cells and diabetic mice model. MPC5 cells were treated with high glucose (30 mM). We showed that wogonin (4, 8, 16 μM) dose-dependently alleviated high glucose (HG)-induced MPC5 cell damage, accompanied by increased expression of WT-1, nephrin, and podocin proteins, and decreased expression of TNF-α, MCP-1, IL-1β as well as phosphorylated p65. Furthermore, wogonin treatment significantly inhibited HG-induced apoptosis in MPC5 cells. Wogonin reversed HG-suppressed autophagy in MPC5 cells, evidenced by increased ATG7, LC3-II, and Beclin-1 protein, and decreased p62 protein. We demonstrated that wogonin directly bound to Bcl-2 in MPC5 cells. In HG-treated MPC5 cells, knockdown of Bcl-2 abolished the beneficial effects of wogonin, whereas overexpression of Bcl-2 mimicked the protective effects of wogonin. Interestingly, we found that the expression of Bcl-2 was significantly decreased in biopsy renal tissue of diabetic nephropathy patients. In vivo experiments were conducted in STZ-induced diabetic mice, which were administered wogonin (10, 20, 40 mg · kg −1 · d −1 , i.g.) every other day for 12 weeks. We showed that wogonin administration significantly alleviated albuminuria, histopathological lesions, and p65 NF-κB-mediated renal inflammatory response. Wogonin administration dose-dependently inhibited podocyte apoptosis and promoted podocyte autophagy in STZ-induced diabetic mice. This study for the first time demonstrates a novel action of wogonin in mitigating glomerulopathy and podocytes injury by regulating Bcl-2-mediated crosstalk between autophagy and apoptosis. Wogonin may be a potential therapeutic drug against DKD.
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高影响因子
Advanced Materials Interfaces
·
2021
·Vol. 8
·期 11
·2100308
·
IF 6.147
Weiwei Zhao,Tiantian Chen,Weikang Wang,Shuaihang Bi,Mengyue Jiang,Kenneth Yin Zhang,Shujuan Liu,Wei Huang,Qiang Zhao
2D conductive metal–organic frameworks (2D c-MOFs) naturally possess high active sites, large specific surface areas, and fast ion transport for energy-storage devices. However, the intelligent exploration of 2D c-MOFs for the emerging flexible transparent supercapacitors (FTSCs) with excellent photoelectric property and electrochemical activity is rarely implemented. Herein, 2D conductive ultrathin Cu 3 (HHTP) 2 (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) film is synthesized on the indium tin oxide/polyethylene terephthalate (ITO/PET) substrate for flexible transparent conductive electrodes (FTCEs) through the layer-by-layer assembly method. The interconnected conductive frameworks possess the cooperative superiority of low internal resistance, fast electrolyte ion diffusion, and quick electron transfer. Cu 3 (HHTP) 2 -15/ITO/PET FTCEs show high photoelectric property of T 550 nm = 82.2% and R s = 49.1 Ω sq −1 , and high areal capacitance ( C A ) of 1700 µF cm −2 . The corresponding symmetrical FTSCs ( T 550 nm = 62.1%) exhibit excellent C A of 939.2 µF cm −2 at the current density of 7 µA cm −2 , superior rate capability (63.9% at 150 µA cm −2 ), long-term cycling stability (85% after 3000 cycles), and mechanical flexibility under different bending angles. This work provides key insights into the design and synthesis of 2D c-MOF films for flexible transparent energy-storage devices.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Yanling Li,Jinfu Ma,Shaolin Yang,Lihua Cui,Hui Lu
Material defects play an important role in metal oxide-based or hydroxide-based supercapacitors . Oxygen vacancies as anion vacancy defects can not only offer a high electron conductivity by act as shallow donors but also can adjust the materials’ surface properties. Herein, we synthesis a novel oxygen-vacancy-rich Co(OH) 2 /SnOᵪ/C hybrid nanosheets which are prepared by using a facile one-step hydrothermal route. Possessing special petal-like nanosheets and rich oxygen vacancies, the as-prepared dual ligand hybrid nanosheets (marked Co(OH) 2 /SnOᵪ/C) present a high specific capacitance of 806.36 F g −1 at 1 A g −1 , much higher than single ligand compound (338.36 F g −1 or 450.00 F g −1 ). The solid-state asymmetrical supercapacitors assembled with Co(OH) 2 /SnOᵪ/C show energy density of 49.73 Wh kg −1 with a power density of 1599.98 W kg −1 , and good cycle stability with 64.43% capacitance retention after 20,000 cycles at the current density of 1 A g −1 .
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ADVANCED MATERIALS
·
2021
·Vol. 33
·期 34
·2101707
·
IF 30.849
Min Li,Sanpeng Li,Yixuan Huang,Haixia Chen,Songya Zhang,Zhicheng Zhang,Weigang Wu,Xiaobin Zeng,Boping Zhou,Bin Li
The transfer of foreign synthetic messenger RNA (mRNA) into cells is essential for mRNA-based protein-replacement therapies. Prophylactic mRNA COVID-19 vaccines commonly utilize nanotechnology to deliver mRNA encoding SARS-CoV-2 vaccine antigens, thereby triggering the body's immune response and preventing infections. In this study, a new combinatorial library of symmetric lipid-like compounds is constructed, and among which a lead compound is selected to prepare lipid-like nanoassemblies (LLNs) for intracellular delivery of mRNA. After multiround optimization, the mRNA formulated into core–shell-structured LLNs exhibits more than three orders of magnitude higher resistance to serum than the unprotected mRNA, and leads to sustained and high-level protein expression in mammalian cells. A single intravenous injection of LLNs into mice achieves over 95% mRNA translation in the spleen, without causing significant hematological and histological changes. Delivery of in-vitro-transcribed mRNA that encodes high-affinity truncated ACE2 variants (tACE2v mRNA) through LLNs induces elevated expression and secretion of tACE2v decoys, which is able to effectively block the binding of the receptor-binding domain of the SARS-CoV-2 to the human ACE2 receptor. The robust neutralization activity in vitro suggests that intracellular delivery of mRNA encoding ACE2 receptor mimics via LLNs may represent a potential intervention strategy for COVID-19.
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高影响因子
CRYSTAL GROWTH & DESIGN
·
2021
·
IF 4.076
Xiaoqing Jiang,Hongping Wu,Hongwei Yu,Zhanggui Hu,Jiyang Wang,Yicheng Wu
Iodates capable of exhibiting large second-harmonic-generation (SHG) response, wide transparent windows, and ease in crystal growth are an ideal materials class for the design of mid-infrared (IR) nonlinear optical (NLO) crystals. In previous research, we have presented a new strategy for effectively designing noncentrosymmetric iodates on the basis of the structure-directing properties of d0 transition-metal (TM) oxide fluoride anions. However, due to the d–d electronic transition of TM cations, the band gaps of these TM-containing iodates are relatively small. In this study, we substituted TM cations of β-Ba[VFO2(IO3)2] (BVIF) with In3+ cations and successfully synthesized the first F–-containing indium iodate, Ba[InF3(IO3)2]. It has a similar structure and exhibits an SHG response equivalent with that of BVIF. Remarkably, however, the band gap of Ba[InF3(IO3)2] is larger than that of BVIF. The analysis of the structure–property relationship indicates that the enlarged band gap mainly originates from the removal of TM cations. In addition, due to the strong anisotropic polarization of the [IO3]− groups, Ba[InF3(IO3)2] can also exhibit a large birefringence (0.172@1064 nm), which not only is helpful for the phase-matching ability of Ba[InF3(IO3)2] in a wide wavelength range but also suggests that Ba[InF3(IO3)2] may be a potential birefringent crystal.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 30
·13592-13598
·
IF 3.591
Chengfa Wu,Junwei Feng,Feng Yu
A new rare earth borate Na2La2B10O19 was successfully synthesized by spontaneous crystallization in a high temperature solution. It crystallizes in the centrosymmetric (CS) space group C2/c with an infinite two-dimensional (2D) double layer which is composed of the fundamental building block (FBB) [B5O12]9−. The calculated birefringence of the compound is 0.06 @1064 nm which mainly originates from the contributions of the B–O anion group according to the first-principles study.
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高影响因子
BIOMACROMOLECULES
·
2021
·
IF 6.988
Panpan Song,Nannan Song,Li Li,Minghao Wu,Zhongxia Lu,Xia Zhao
Glioblastoma (GBM) is a fatal brain tumor with poor prognosis. Blood–brain barrier (BBB) prevents the effective delivery of chemotherapeutic agents to GBM. Herein, we developed a pH/reduction-sensitive carboxymethyl chitosan nanogel (CMCSN) modified by targeting peptide angiopep-2 (ANG) and loaded with doxorubicin (DOX). The multifunctional nanogel (DOX-ANG-CMCSN) exhibited good pH and reduction sensitivity, ideal stability, and biocompatibility. Its hydrodynamic diameter was 190 nm, drug loading was 12.7%, and the cumulative release rate of 24 h was 82.3% under the simulated tumor microenvironment. More importantly, the modification of ANG significantly enhanced BBB penetration and tumor targeting ability both in vivo and in vitro. DOX-ANG-CMCSN achieved 2–3-fold higher uptake and an enhanced antitumor activity compared with nontargeted DOX-CMCSN. Therefore, the targeted nanogels with the pH/reduction dual-stimuli response may provide a promising platform for GBM-targeted chemotherapy.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 56
·期 2
·1577-1589
·
IF 3.553
Li Zhaohua,Hu Rui,Ye Shuai,Song Jun,Liu Liwei,Qu Junle
Abstract We report herein a versatile new approach for improving the photodegradation performance of UiO-66 by introducing 2-methylimidazole through a straightforward in situ one-pot solvothermal method. The resultant complex UiO-66-M-0.7 has demonstrated a reaction rate constant of 0.0183 min −1 in the photodegradation of rhodamine B under visible light, which is 69.4% higher than that with unmodulated UiO-66. Further investigation has confirmed that the improved activity can be attributed to enhanced adsorption of the dye by the photocatalyst during the adsorption–desorption equilibrium. The main active species involved in the photodegradation process have been identified as h + and O 2 − ·. In addition, the complex has shown ideal stability in recycling tests and excellent activity in the degradation of methylene blue. This study provides a novel perspective for the future design of various photocatalysts with superior performance. Graphic abstract 2-Methylimidazole-modulated UiO-66 exhibits increased catalytic performance in the photodegradation of rhodamine B (RhB) under visible light because of enhanced adsorption of RhB on the catalyst during the adsorption-desorption equilibrium.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2021
·
IF 3.575
Wei Wei,Yuanyuan Yao,Hongyuan Bi,Wenxin Xu,Yan Gao
Our previous findings revealed that hsa_circ_0068,888 was markedly down-regulated in the plasma of patients with sepsis-associated acute kidney injury (AKI). However, its molecular mechanism in AKI remains unclear. Herein, we explored the role of hsa_circ_0068,888 in AKI. Human renal proximal tubular cell line HK-2 was stimulated with lipopolysaccharide (LPS) to mimic AKI in vitro . Decreased hsa_circ_0068,888 expression was observed in AKI cell model. The overexpression of hsa_circ_0068,888 significantly increased the viability of LPS-stimulated HK-2 cells, whereas hsa_circ_0068,888 downregulation showed the opposite effect. Furthermore, LPS triggered inflammatory response and oxidative stress , which was inhibited by hsa_circ_0068,888 overexpression and enhanced by hsa_circ_0068,888 down-regulation. Hsa_circ_0068,888 overexpression suppressed the activation of nuclear factor-κB (NF-κB) pathway triggered by LPS as evidenced by decreased p-p65 protein level and nuclear translocation of p65 in hsa_circ_0068,888 overexpressed cells. Additionally, we proved that hsa_circ_0068,888 targeted microRNA-21–5p (miR-21–5p). The expression of miR-21–5p was markedly increased and was negatively regulated by hsa_circ_0068,888 in LPS-stimulated HK-2 cells. Furthermore, we demonstrated that miR-21–5p overexpression reversed the effects on cell viability , inflammatory response, oxidative stress, and NF-κB pathway induced by hsa_circ_0068,888 overexpression in LPS-stimulated HK-2 cells. Overall, these results implied that hsa_circ_0068,888 shows a protective effect on AKI by sponging miR-21–5p. Hence, up-regulation of hsa_circ_0068,888 might be a potential strategy in treatment for AKI.
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高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Hang Liu,Hua Yin,Shaoyu Tang,Hui Peng,Xiaolong Yu,Guining Lu,Zhi Dang
In this work, the prepared mesoporous TiO 2 was employed to eliminate the environmental risk induced by the combined pollution (tris-(2-chloroisopropyl) phosphate (TCPP) and Cd 2+ ). The prepared material was characterized by X-ray diffraction (XRD), UV–vis diffuse reflectance spectra (UV-DRS), Raman imaging spectrometer (Raman), N 2 adsorption/desorption isotherm and X-ray photoelectron spectroscopy (XPS). In the combined pollution system, the prepared TiO 2 simultaneously exhibited a higher adsorption and photocatalytic activity for Cd 2+ and TCPP at neutral condition, respectively. The adsorption of Cd 2+ and photo-degradation of TCPP by mesoporous TiO 2 followed pseudo-second-order and pseudo-first-order kinetics model, respectively. The removal efficiency of TCPP was improved from 67% to 100% when the concentration of co-existed Cd 2+ increased from 0.5 mg L −1 to 2 mg L −1 , due to the fact that the adsorbed Cd 2+ on the surface of TiO 2 scavenged electron and thus inhibited the photo-generated electron-hole pairs recombination. In addition, six degradation intermediates were determined by high resolution mass spectrum (HRMS) and potential transformation pathways of TCPP under the co-existence of Cd 2+ were proposed. The results suggested that rapid and high-efficient simultaneous removal of Cd 2+ and TCPP was feasible, which laid the basis for the remediation of other combined pollution in the future.
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高影响因子
危险品化学品经营许可证（带存储）