CHEMOSPHERE
·
2017
·
IF 4.208
Xiaoxue Pan,Liqing Yan,Ruijuan Qu,Zunyao Wang
The goals of this study were to bring forward new data and insights into the effect of activation methods, operational variables and reaction pathways during sulfate radicals-based oxidation of benzophenone-3 (BP-3) in aqueous solution. Heat, transition metal ions (Fe 2+ , Cu 2+ , Co 2+ ), UV and visible light irradiation were used to activate persulfate (PS) to degrade BP-3. The results showed that these three activation methods can remarkably enhance BP-3 removal efficiency. Under the conditions of [BP-3] 0 : [PS] 0 = 1: 500, pH = 7.0, and 40 °C, complete removal of BP-3 (1.31 μM) was observed in 3 h. In the pH range of 3.0–9.0, the degradation of BP-3 decreased with increasing pH. Increasing the PS dosage accelerated the reaction, while the presence of humic acid (HA) significantly inhibited the efficiency of BP-3 removal. Based on electron paramagnetic resonance (EPR) and radical quenching studies, sulfate and hydroxyl radicals contributed to the oxidation process. According to the evolution of BP-3 and its 7 by-products, as well as frontier electron densities (FED) calculation, two routes were proposed involving hydroxylation, demethylation and direct oxidation. On the whole, this work is a unique contribution to the systematic elucidation of BP-3 removal by PS.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Hairui Fang,Jiawei Zhang,Eryang Shang,Hong Chen,Xiao Ma,Xingyu Kang,Huizhang Zhao,Yuxia Liu,Dong Wang
Metal oxides are widely used because of their simple structure, low price, and excellent gas-sensitive properties. But now, the metal oxide sensor faces two challenges. One is that when the detection limit of the sensor is low, it will be affected by a high concentration of gas and fail in practical applications. Second, the metal oxide sensor is susceptible to temperature changes, resulting in inaccurate measurement results. To address the above problems, the performance of metal oxides is enhanced through doping. Indium oxide doped with various levels of indium molybdate was prepared using a two-step hydrothermal method resulting in a composite material with an n-n heterostructure. The interaction formed by the n-n heterostructure enhances the redox reaction between NO 2 gas and the sensor, and the unique nano cluster structure provides more active sites for the sensor, significantly improving the gas performance of the sensor towards NO 2 . Sensors based on In 2 (MoO 4 ) 3 with a doping ratio of 4 % (the sample IM3) showed excellent gas sensitivity. The lower and upper detection limits of the sensor are 200 ppb (response is 1.46) and 150 ppm (response is 515.94), respectively. And the sensor has good resistance to ultra-high concentration (10000 ppm) nitrogen dioxide (NO 2 ) impact. In the range of 130–170°C, the temperature has a small and linear effect on the sensor response, which is very beneficial for temperature correction of gas sensors. The sensor prepared by In 2 (MoO 4 ) 3 doped In 2 O 3 composite material has a good potential for application in engineering practice.
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Soft Matter
·
2015
·Vol. 11
·期 23
·4717-4722
·
IF 4.029
Tianxiang Yin,Jiequn Wu,Shuzhen Wang,Weiguo Shen
The aggregation behaviors of surface active ionic liquid 1-butyl-3-methylimidazolium bis(2-ethylhexyl) sulfosuccinate in aqueous solutions were investigated by conductometry, densimetry, fluorimetry, 1H nuclear magnetic resonance (1H NMR) spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM), which confirmed two distinguished critical concentrations. The first critical concentration was believed to be the critical aggregation concentration (CAC), where two different types of aggregates were formed, namely, micelles with the size of 10 nm and vesicles with the size of 100 nm. The second critical concentration at two-fold CAC was suggested to be resulting from the insertion of the imidazolium cations into aggregates.
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MOLECULAR PHARMACEUTICS
·
2024
·
IF 4.5
Lixin Ding,Feng Wang,Zilei Wang,Yongxiang Pan,Teli Liu,Liansheng Cheng,Wenting Liu,Kuke Ding,Hua Zhu,Zhi Yang
Lymphocyte activation gene 3 (LAG-3) has attracted much attention as a potentially valuable immune checkpoint. Individual identification of LAG-3 expression at screening and during treatment could improve the successful implementation of anti-LAG-3 therapies. HuL13 is a human IgG1 monoclonal antibody that binds to the LAG-3 receptor in T cells. Here, we used [89Zr]Zr-labeled HuL13 to delineate LAG-3+ T-cell infiltration into tumors via positron emission tomography (PET) imaging. A549/LAG-3 cells, which stably express LAG-3, were generated by infection with lentivirus. The uptake of [89Zr]Zr-DFO-HuL13 in A549/LAG-3 cells was greater than that in the negative control (A549/NC) cells at each time point. The equilibrium dissociation constant (Kd) of [89Zr]Zr-DFO-HuL13 for the LAG-3 receptor was 8.22 nM. PET imaging revealed significant uptake in the tumor areas of A549/LAG-3 tumor-bearing mice from 24 h after injection (SUVmax = 2.43 ± 0.06 at 24 h). As a proof of concept, PET imaging of the [89Zr]Zr-DFO-HuL13 tracer was further investigated in an MC38 tumor-bearing humanized LAG-3 mouse model. PET imaging revealed that the [89Zr]Zr-DFO-HuL13 tracer specifically targets human LAG-3 expressed on tumor-infiltrating lymphocytes (TILs). In addition to the tumors, the spleen was also noticeably visible. Tumor uptake of the [89Zr]Zr-DFO-HuL13 tracer was lower than its uptake in the spleen, but high uptake in the spleen could be reduced by coinjection of unlabeled antibodies. Coinjection of unlabeled antibodies increases tracer activity in the blood pool, thereby improving tumor uptake. Dosimetry evaluation of the healthy mouse models revealed that the highest absorbed radiation dose was in the spleen, followed by the liver and heart wall. In summary, these studies demonstrate the feasibility of using the [89Zr]Zr-DFO-HuL13 tracer for the detection of LAG-3 expression on TILs. Further clinical evaluation of the [89Zr]Zr-DFO-HuL13 tracer may be of significant help in the stratification and management of patients suitable for anti-LAG-3 therapy.
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MATERIALS CHEMISTRY AND PHYSICS
·
2016
·
IF 2.101
Gen Liu,Chaochao Wu,Xia Zhang,Yufeng Liu,Hao Meng,Junli Xu,Yide Han,Xinxin Xu,Yan Xu
Surface functionalization of zirconium dioxide (ZrO 2 ) nano-adsorbents was carried out by using 3-aminopropyl triethoxysilane (APTES) as the modifier. The addition amount of APTES was varied to determine the optimum modification extent, and the bulk ZrO 2 microparticles were also modified by APTES for comparison. Some means, such as TEM, XRD , FT-IR, XPS and TG-DSC were used to character these ZrO 2 particles. The results showed that the APTES molecules were chemically immobilized on the surface of ZrO 2 nanoparticles via Zr O Si bonds, and the nano-ZrO 2 samples showed larger special surface area. In the adsorption of bovine serum albumin (BSA), nano-ZrO 2 samples exhibited enhanced adsorption activity, and APTES modified nano-ZrO 2 with proper APTES content presented the best adsorption property. Under the same adsorption conditions, the equilibrium adsorption capacity of BSA on APTES-ZrO 2 -2 was almost 2.3 times as that on pristine nano-ZrO 2 and 3.0 times as on bulk ZrO 2 microparticles. The increased adsorption capacity of APTES-ZrO 2 nano-adsorbents can be attributed to the chemical interaction between amino and carboxyl groups at APTES-ZrO 2 /BSA interface. The pH-dependent experiments showed that the optimum pH value for the adsorption and desorption was 5.0 and 9.0, respectively, which suggested that the adsorption and release of BSA could be controlled simply by adjusting the solution pH condition.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2016
·
IF 2.76
Juntao Gu,Shaojun Yuan,Wanting Shu,Wei Jiang,Shengwei Tang,Bin Liang,Simo Olavi Pehkonen
A novel pH-sensitive polystyrene (PS)-type resin was developed by grafting of poly(3-sulfopropyl methacrylate) (PSPMA) brushes onto a cross-linked poly(vinylbenzyl chloride) (PVBC) microsphere via surface-initiated atom transfer radical polymerization (ATRP), and was further utilized as a highly efficient and recyclable sorbent to remove Pb(II) ions from aqueous solutions. The as-synthesized PSPMA-grafted PVBC microspheres were characterized by ATR-FTIR, XPS and SEM. Batch adsorption results revealed that the solution pH had an evident effect on the adsorption capacity of the PSPMA-grafted microspheres towards Pb(II) ions with an optimal sorption pH of above 5.0. The PSPMA-grafted microspheres had rapid adsorption kinetics of Pb(II) ions to reach adsorption equilibrium within 60 min. The Langmuir-fitted adsorption isotherms at pH 5.0 with an initial Pb(II) concentration range of 0.12–0.97 mmol L −1 (i.e. 50–200 mg L −1 ) revealed a maximum capacity of Pb(II) ions of 0.82 mmol g −1 . The calculated thermodynamic parameters demonstrated an endothermic and spontaneous adsorption process of Pb(II) ions on the PSPMA-grafted microspheres. With the inherent stability, high adsorption capacity and good regenerability, the PSPMA-grafted PVBC microsphere resin provides a novel promising PS-type adsorbent for effective removal of heavy metal ions from aqueous solution.
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Journal of Integrative Agriculture
·
2016
·
IF 0.724
Ai-yong QI,Pei-pei ZHANG,Yue ZHOU,Zhan-jun YAO,Zai-feng LI,Da-qun LIU
Wheat leaf rust is a destructive foliar disease of common wheat ( Triticum aestivum L.) worldwide. The most effective, economical s to control the disease is growing resistant cultivars with adult plant resistance (APR). The Chinese wheat lines W014204 and Fuyu 3 showed high leaf rust resistance in the field. To identify leaf rust APR genes in the two lines, two mapping populations with 215 and 163 F 2:3 lines from the crosses W014204/Zhengzhou 5389 and Fuyu 3/Zhengzhou 5389, respectively, were phenotyped for leaf rust severities during the 2010–2011, 2011–2012 and 2012–2013 cropping seasons in the field at Baoding, Hebei Province, China. A total of 1 215 SSR markers were used to identify the quantitative trait loci (QTLs) for leaf rust APR in the two populations. In the W014204/Zhengzhou 5389 population, three QTLs were detected and designated as QLr.hbu-1BL.1, QLr.hbu-2BS.1 and QLr.hbu-7DS, and explained 2.9–8.4, 11.5–38.3 and 8.5–44.5% of the phenotypic variance, respectively; all the resistance alleles at these loci were derived from W014204. In the Fuyu 3/Zhengzhou 5389 population, three QTLs, QLr.hbu-1BL.2, QLr.hbu-2BS.2 and QLr.hbu-7BL, explained 12.0–19.2, 22.3–38.9 and 4.1–4.3% of the phenotypic variance, respectively, and all resistance alleles were contributed by Fuyu 3. Based on chromosome positions of closely linked markers, both QLr.hbu-1BL.1 and QLr.hbu-1BL.2 are Lr46, and QLr.hbu-7DS is Lr34. QLr.hbu-7BL was mapped on chromosome 7BL near to Lr68 and they are likely the same gene. Based on chromosome positions, pedigree and field reactions, the two 2BS QTLs are different from all the known APR genes and are likely to be new APR QTL for leaf rust. These QTLs and their closely linked markers are potentially useful for improving leaf rust resistance in wheat breeding.
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JOURNAL OF MATERIALS SCIENCE
·
2016
·Vol. 51
·期 8
·4088-4095
·
IF 2.302
Zhao Xiong-wei,Zang Chong-guang,Ma Qing-kun,Wen Yu-quan,Jiao Qing-jie
In this paper, (3-mercaptopropyl)trimethoxysilane (MPTS)- and copper-coated carbon fiber (M–Cu-CF) was obtained by electroless plating method. The M–Cu-CF was evaluated by FTIR, XRD, TGA, and SEM. It was found that the MPTS and Cu were coated on the fiber surface successfully. The M–Cu-CF was utilized as a conductive filler in silicone rubber (SR) for thermal and electrical conductivity applications and exhibited good dispersion and compatibility with the matrix. The effect of M–Cu-CF content on the thermal conductivity and volume resistivity of silicone rubber composites was investigated. The results showed that the thermal conductivity of the M–Cu-CF/SR composites reached 1.99 W (m K) −1 with only 4.0 wt% filler loading, approximately 2.10 times higher than that of raw-CF/SR composites at the same loading. And with the increase of M–Cu-CF loading, the least volume resistivity of M–Cu-CF/SR composites was 3.5 × 10 3 Ω cm.
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MOLECULAR NEUROBIOLOGY
·
2016
·Vol. 54
·期 1
·392-405
·
IF 5.397
Chen Ying,Huang Liyong,Zhang Huiyong,Diao Xiling,Zhao Shuyang,Zhou Wenke
Mitochondrial dysfunction and subsequent autophagy, which are common features in central nervous system (CNS) disorders, were found to contribute to neuronal cell injury after subarachnoid hemorrhage (SAH). (-)-Epigallocatechin-3-gallate (EGCG), the main biological active of tea catechin, is well known for its beneficial effects in the treatment of CNS diseases. Here, the ability of EGCG to rescue cellular injury and mitochondrial function following the improvement of autophagic flux after SAH was investigated. As expected, EGCG-protected mitochondrial function depended on the inhibition of cytosolic Ca 2+ concentration ([Ca 2+ ] i ) influx via voltage-gated calcium channels (VGCCs) and, consequently, mitochondrial Ca 2+ concentration ([Ca 2+ ] m ) overload via mitochondrial Ca 2+ uniporter (MCU). The attenuated [Ca 2+ ] i and [Ca 2+ ] m levels observed in the EGCG-treated group likely lessened oxyhemoglobin (OxyHb)-induced mitochondrial dysfunction, including mitochondrial membrane potential depolarization, mitochondrial membrane permeability transition pore (mPTP) opening, reactive oxygen species (ROS), and cytochrosome c (cyt c) releasing. Subsequently, EGCG can restore the disrupted autophagy flux after SAH both at the initiation and formation stages by regulating Atg5 , LC3B , and Becn-1 ( Beclin-1 ) mRNA expressions. Thus, precondition EGCG resulted in autophagosomes and more autolysosomes compared with SAH group. As a result, EGCG pre-treatment increased the neurological score and decreased cell death. This study suggested that the mitochondrial dysfunction and abnormal autophagy flux synergistically contribute to SAH pathogenesis. Thus, EGCG can be regarded as a new pharmacological agent that targets both mitochondria and altered autophagy in SAH therapy.
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JOURNAL OF SEPARATION SCIENCE
·
2016
·Vol. 39
·期 19
·3736-3744
·
IF 2.741
Li Peng,Manman Zhu,Lingyi Zhang,Haiyan Liu,Weibing Zhang
A 3 m zwitterionic polymeric porous layer open tubular column (3 m × 25 μm id × 375 μm od) with a polymeric porous layer thickness of 4 μm was fabricated by the copolymerization of [2-(methacryloyloxy)ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide and N , N ’-methylenebis(acrylamide). The effects of the diameter of the capillary, reaction temperature, and polymerization time on the preparation of the open tubular column were investigated. Characterized by scanning electron microscopy, the zwitterionic layer was observed to be rough and throughout the fused-silica capillary homogenously, which increased the phase ratio. The separation of neutral, basic, and acidic compounds demonstrates the strong hydrophilicity of the poly[2-(methacryloyloxy)ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide coating. In addition, the poly[2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide porous layer open tubular column was applied for the analysis of flavonoids from the rootstalk of licorice, revealing the potential in separating complex samples. The relative standard deviation of retention time for run-to-run ( n = 5), day-to-day ( n = 3), and column-to-column ( n = 3) of toluene, N , N -dimethylformamide, formamide, and thiourea were below 1.2%, exhibiting good repeatability.
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POLYMER
·
2012
·
IF 3.438
Xu-Cheng Zhang,Xi Xiong,Jian Yu,Zhao-Xia Guo
Amine-functionalized thermoplastic polyurethane (TPU) electrospun fibers with controllable number of amine groups on fiber surfaces are prepared by co-electrospinning of TPU and 3-aminopropyltriethoxysilane (APS) in DMF/THF 4:6, followed by thermal treatment at 60 °C in a ventilated oven for 24 h. The morphology of the fibers was observed by Field Emission Scanning Electron Microscopy (FESEM), showing a decrease in average fiber diameter with increasing APS content, resulted from significantly increased solution conductivity. The amine groups are homogeneously distributed on the fiber surfaces, as revealed by energy dispersive X-ray spectroscopy (EDX) Si-mapping. Both the Si content measured by X-ray photoelectron spectroscopy (XPS) and NH 2 content obtained by chemical titration show an enrichment of APS condensate on the fiber surfaces, which is explained by the higher mobility of APS to TPU during electrospinning. Gold nanoparticles of 16 nm are homogeneously adsorbed on the amine-functionalized TPU fibers. A conductive gold layer with a surface resistivity of 0.3 Ω/sq is formed after electroless plating using the adsorbed gold nanoparticles as the seeds, demonstrating the usefulness of the amine groups in the preparation of TPU fibers with added functionalities.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2015
·
IF 2.999
Yuexin Wang,Yanhua Song,Xiuqing Zhou,Keyan Zheng,Ye Sheng,Pingchuan Ma,Bowen Zhang,Meiqi Chang,Haifeng Zou
Uniform Lu 2 (C 4 H 4 O 6 ) 3 ·6H 2 O cauliflower-like microspheres have been synthesized via a direct precipitation method at room temperature, without any templates and catalysts. The solvent-dependent morphological evolution and the formation mechanism of the Lu 2 (C 4 H 4 O 6 ) 3 ·6H 2 O cauliflower-like microspheres were investigated in detail. Furthermore, Eu 3+ /Tb 3+ -doped Lu 2 O 3 inherited their parents' morphology were obtained through a direct annealing process. The Lu 2 (C 4 H 4 O 6 ) 3 ·6H 2 O:Eu 3+ , Lu 2 O 3 :Eu 3+ exhibit strong red emission corresponding to the 5 D 0 - 7 F j transition of the Eu 3+ ions. The Lu 2 (C 4 H 4 O 6 ) 3 ·6H 2 O:Tb 3+ , Lu 2 O 3 :Tb 3+ exhibit strong green emission corresponding to the 5 D 4 - 7 F j transition of the Tb 3+ ions under UV light excitation. The samples may have potential applications in the fields, such as light-emitting phosphors, advanced flat panel displays, or biological labeling.
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危险品化学品经营许可证（带存储）