LANGMUIR
·
2022
·
IF 4.331
Zhenyu Zhao,Xuting Wang,Shifu Wang,Zuoyi Xiao,Shangru Zhai,Jiliang Ma,Xiaoli Dong,Haodong Sun,Qingda An
The development of g-C3N4-based photocatalysts with abundant active sites is of great significance for photocatalytic reactions. Herein, a smart and robust strategy was presented to fabricate three-dimensional (3D) g-C3N4 nanosheet-coated alginate-based hierarchical porous carbon (g-C3N4@HPC), including coating melamine on calcium alginate (CA) hydrogel beads, freeze-drying hydrogel beads as well as pyrolysis at high temperatures. The resulting photocatalyst possessed a significantly high surface area and a large amount of interconnected macropores compared with porous carbon without the melamine coating. The unique structural features could effectively inhibit the curling and agglomeration of g-C3N4 nanosheets, provide abundant photocatalytic active sites, and promote mass diffusion. Therefore, the g-C3N4@HPC composite exhibited remarkable photocatalytic activity and outstanding stability toward the photoreduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) by NaBH4 under natural sunlight and simulated visible-light irradiation (λ > 420 nm) using a 300 W xenon lamp. Moreover, the mechanism toward the photocatalytic reaction was extensively studied by quenching experiments and electron spin resonance (ESR) experiments. The results showed that active hydrogen species were able to be achieved by following a dual-channel pathway in the NaBH4 system, which included photocatalytic reduction of H+ ions and photocatalytic oxidation of BH4– ions. This work not only opens up a new way to design efficient photocatalysts for various reactions but also provides a reference for an in-depth study of the photoreduction mechanism.
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高影响因子
RSC Advances
·
2021
·Vol. 11
·期 28
·16955-16961
·
IF 3.361
Zeng-Feng Wei,Li-Jie Ni,Heng Quan,Jiang Duan
4-Substituted catechols with different CC bonds as urushiol analogues were synthesized through the a three-step route including reductive amination reaction of 3,4-dihydroxybenzaldehyde with N-Boc-piperazine, Boc deprotection, and amidation with various fatty acids. Electrochemical polymerization of these analogues on a copper surface afforded robust coatings with desirable adhesive force, hydrophobicity and thermal stability. Cyclic voltammetry and infrared spectroscopic characterizations revealed that the coating formation of urushiol analogues resulted from the electrooxidation-induced radical coupling of phenoxyl radicals with a phenyl ring and the side chain CC bond. The coating of the urushiol analogue bearing only one side chain CC bond exhibited the best performance in copper corrosion inhibition, with an inhibition efficiency of 99.99% and long-term effect (99.9% after 4 weeks of immersion in 3.5 wt% NaCl). The desired performance of these urushiol analogues suggests that they could be of practical applications as an alternative to the resource-limited natural urushiol.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
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IF 3.232
Zhiming Guo,Alberta Osei Barimah,Chuang Guo,Akwasi A. Agyekum,Viswadevarayalu Annavaram,Hesham R. El-Seedi,Xiaobo Zou,Quansheng Chen
Black tea like other food crops is prone to mercury ion (Hg 2+ ) contamination right from cultivation to industrial processing. Due to the dangerous health effects posed even in trace contents, sensitive detection and quantification sensors are required. This study employed the surface-enhanced Raman scattering (SERS) enhancement property of 4-aminothiophenol (4-ATP) as a signal turn off approach functionalized on Ag-Au alloyed nanoparticle to firstly detect Hg 2+ in standard solutions and spiked tea samples. Different chemometric algorithms were applied on the acquired SERS and inductively coupled plasma-mass spectrometry (ICP-MS) chemical reference data to select effective wavelengths and spectral variables in order to develop models to predict the Hg 2+ . Results indicated that Ag-Au/4-ATP SERS sensor combined with ant colony optimization partial least squares (ACO-PLS) exhibited the best correlation efficient and minimum errors for Hg 2+ standard solutions (R c = 0.984, R p = 0.974, RMSEC = 0.157 μg/mL, RMSEP = 0.211 μg/mL) and spiked tea samples (R c = 0.979, R p = 0.963, RMSEC = 0.181 μg/g and RMSEP = 0.210 μg/g). The limit of detection of the proposed sensor was 4.12 × 10 −7 μg/mL for Hg 2+ standard solutions and 2.83 × 10 −5 μg/g for Hg 2+ spiked tea samples. High stability and reproducibility with relative standard deviation of 1.14% and 0.84% were detected. The potent strong relationship between the SERS sensor and the chemical reference method encourages the application of the developed chemometrics coupled SERS system for future monitoring and evaluation of Hg 2+ in tea.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Bo Luo,Yacong Zhao,Jing Zhang,Wei Li,Mengxing Liu,Miaomiao Yang,Lulu Wei,Yijing Liu,Bingjie Wen,Lailiang Qu
A series of novel pyrazole-4-carboxamides bearing an ether group were designed and synthesized on the basis of the structure of commercial succinate dehydrogenase inhibitor (SDHI) fungicide flubeneteram via scaffold hopping and evaluated for their antifungal activities against five fungi. The bioassay results showed that most of the target compounds exhibited excellent in vitro antifungal activity against Rhizoctonia solani and some compounds exerted remarkable antifungal activities against Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium graminearum, and Alternaria alternate. Particularly, compounds 7d and 12b displayed outstanding antifungal activity against R. solani, with an EC50 value of 0.046 μg/mL, far superior to that of boscalid (EC50 = 0.741 μg/mL) and fluxapyroxad (EC50 = 0.103 μg/mL). Meanwhile, compound 12b also presented a broader fungicidal spectrum than other compounds. Moreover, in vivo anti-R. solani results showed that compounds 7d and 12b could significantly inhibit the growth of R. solani in rice leaves with excellent protective and curative efficacies. In addition, the results of the succinate dehydrogenase (SDH) enzymatic inhibition assay showed that compound 7d generated significant SDH inhibition, with an IC50 value of 3.293 μM, which was about 2 times better than that of boscalid (IC50 = 7.507 μM) and fluxapyroxad (IC50 = 5.991 μM). Furthermore, scanning electron microscopy (SEM) analysis indicated that compounds 7d and 12b significantly destroyed the typical structure and morphology of R. solani hyphae. The molecular docking study revealed that compounds 7d and 12b could embed into the binding pocket of SDH and form hydrogen bond interactions with TRP173 and TRY58 at the activity site of SDH, which was in line with fluxapyroxad, indicating that they had a similar mechanism of action. These results demonstrated that compounds 7d and 12b could be promising candidates of SDHI fungicides, which deserved further investigation.
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高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Yuting Sun,Bin Yao,Yuhong Jiang,Yongfeng Li,Xiaobo Du,Zhanhui Ding,Jiayong Zhang,Chunkai Wang,Ding Ma,Mengge Li,Yan Zhu,Xiaofei Sun,Ning Ding,Liyuan Shi
It is well known that the improvement of crystal quality and photoelectric properties of Cu2ZnSn(S,Se)4 (CZTSSe) is one of the key issues in enhancing power conversion efficiency (PCE). To resolve this problem, we selected Li2CO3 as a Li source to prepare Li-doped CZTSSe by annealing Li-doped Cu2ZnSnS4 (CZTS) precursor films in air, followed by selenization (CZTSSe-Li-A). It is interesting that the air annealing leads to the incorporation of Li and O into CZTSSe in the form of Li-O pairs, which improves the crystal quality and absorption coefficient (α) of CZTSSe-Li-A and decreases its hole concentration and resistivity compared with Li-doped CZTSSe prepared using Li-doped CZTS that is not annealed in air (CZTSSe-Li). By optimizing Li doping concentration, annealing temperature and time, the highest PCE of CZTSSe-Li-A solar cell without MgF anti-reflection layer reaches 11.13%, which is larger than the highest PCE of CZTSSe-Li solar cell (10.21%). Quantitative analysis indicates that the increased PCE of CZTSSe-Li-A solar cell compared to CZTSSe-Li solar cell is mainly attributed to the decrease in reverse saturation current density (J0) and series resistance (Rs) caused by thermal effect of the air annealing, followed by an increase in photogeneration density (JL) and shunt resistance (Rsh). The decreased J0 is due to a reduction in interfacial defect density, increased JL is due to increase in α and depletion region width, and decreased Rs and increased Rsh are due to improve crystal quality. This work offers a route for the improvement of PCE of CZTSSe solar cells.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Shuxin Wang,Hui Li,Gen Zhou,Jingmei Xu,Baoju Li,Xiangzi Wei,Zhe Wang
Traditional proton exchange membranes (PEMs), such as Nafion, often rely on perfluorosulfonic acid, posing ecological risks. To address this, sulfonated poly(arylene ether ketone sulfone) containing amino group (Am-SPAEKS) membranes were created as an eco-friendly alternative. This study further innovates by incorporating sulfonatocalix[4]arene (SC4A)-functionalized UiO-66-NH2 (SC4A@UiO-66-NH2) into Am-SPAEKS to produce ASUS-X wt % hybrid membranes. This combination not only boosts proton conductivity without sacrificing mechanical properties but also leverages the unique functionalities of supramolecular macrocycles and metal–organic frameworks (MOFs) to create efficient proton transport channels. The resultant hybrid membrane ASUS-6 wt % exhibits remarkable properties, including a swelling ratio of 16.75% at 80 °C, tensile strength of 41.08 MPa, and proton conductivity of 163.11 mS cm–1 at 80 °C and 100% RH, 89.13% higher than pristine Am-SPAEKS, with over 86% conductivity remaining after 432 h. Remarkably, the maximum power density reaches 392.73 mW cm–2, twice that of pristine Am-SPAEKS. The unique properties of supramolecular macrocycles and MOFs can provide tailored functionalities to address key challenges in PEMs applications.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Xin Wang,Kaiyan Mao,Jianqing Ma,Huining Zhang,Yongxing Qian,Huixia Jin,Kefeng Zhang
Nitrogen-doping is an effective strategy for enhancing peroxymonosulfate (PMS) activation efficiency by carbon-based catalysts, yet its impact on pollutant adsorption remains largely unexplored. Here, N-doped biochar (CNC) was synthesized via pyrolysis of sodium lignosulfonate, melamine, and activated carbon. The CNC/PMS system exhibited excellent efficiency for 4-chlorophenol (4-CP) removal, following a pseudo-second-order kinetic model with an observed rate constant of 0.0134 L·mg –1 ·min –1 . This process relied on synergistic adsorption and catalytic degradation processes. N-doping improved the graphitization of the carbon skeleton and introduced defects that facilitated PMS activation via non-radical pathways. However, excessive pyridinic N reduced 4-CP adsorption due to increased hydrophilicity, emphasizing the need for balanced doping. Mechanistic analysis of the CNC/PMS/4-CP system revealed that electron transfer pathways dominated the degradation process, with C=O groups and pyrrolic N on the CNC surface serving as primary active sites. Degradation pathways of 4-CP involved hydroxylation, dechlorination, and polymerization, with many intermediates adsorbed onto CNC, thereby minimizing ecological risks. The system achieved over 95 % removal efficiency both in tap and river water and maintained effectiveness over seven cycles, demonstrating robust anti-interference capability and stability. These findings advance understanding of electron transfer pathway control and broaden N-doped biochar applications in water treatment.
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Nanoscale
·
2018
·Vol. 10
·期 9
·4500-4514
·
IF 7.233
Xin Liang,Lei Shen
In2O3(ZnO)k natural superlattices (where k is an integer), consisting of relatively earth abundant and non-toxic elements with coarsening-resistant nanostructures, are environmentally friendly materials with the potential for high temperature thermoelectric applications. Herein, we report our investigation of the high temperature thermoelectric properties of the In2O3(ZnO)4 superlattice bulk polycrystals that were singly and dually doped with Al and Ce. Transport property measurements revealed that Al and Ce did not only enter the ZnO blocks but also modified the InO2 single atomic layers. The effective electron potential barrier height of the superlattice interfaces can be adjusted by doping, and the optimal value that maximizes the power factor is of the order of kBT above the Fermi level. The interfacial thermal (Kapitza) resistance of the InO2 atomic sheets dramatically increased with doping, primarily accounting for the bulk thermal conductivity reduction. At the optimal crossing of the interfacial thermal resistance and the effective potential barrier height, a maximum ZT of ≈0.22 was achieved at 800 °C in the 1.6 mol% Al-doped superlattice, which was an enhancement of ∼200% over the pristine In2O3(ZnO)4. This work provides a new perspective on enhancing the high temperature thermoelectric performance of nanostructured oxides by synergistically optimizing the interfacial phonon and electron transport properties.
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Pharmaceuticals
·
2026
·Vol. 19
·期 8
·1166
·
IF 5.7
Xu Huang,Qingyang Nian,Xizhe Sun,Yuheng Zhou,Yuxin Wang,Jiayin Yue,Fanhao Meng,Jingwei Liang
Background:Cyclin-dependent kinase 4 (CDK4) is a key regulator of cell-cycle progression and an established therapeutic target for breast cancer. Although the unique architecture of its ATP-binding site has enabled the development of highly selective inhibitors, the emergence of acquired resistance highlights the need for alternative therapeutic strategies targeting protein conformational regulation.Methods:The conformational landscape of CDK4 was investigated in this study using accelerated molecular dynamics (aMD) simulations combined with Markov state model (MSM) analysis to identify cryptic conformational states and potential allosteric binding sites. Particular attention was given to the glycine-rich loop (G-loop), a critical structural element that shapes the ATP-binding pocket, and to the effects of compound8i(1-(2-(3-chlorobenzoyl)hydrazine-1- carbonyl)-N-(pyridin-3-yl)pyrrolidine-2-carboxamide), previously synthesized in our laboratory, on CDK4 dynamics.Results:A distinct conformational transition was identified in which the G-loop shifted toward the N-terminus, resulting in the exposure of a previously unrecognized allosteric pocket adjacent to the catalytic site. Compound 8i interacted with Leu147 and was associated with stabilization of conformational states that favor exposure of the cryptic pocket.Conclusions:These observations suggest that ligand binding may modulate the conformational landscape of CDK4 and favor formation of a cryptic pocket with potential allosteric characteristics. The identified conformational mechanism provides new insights into the dynamic regulation of CDK4 and suggests that stabilization of transient allosteric states represents a promising strategy for the rational design of next-generation CDK4 inhibitors with the potential to overcome resistance in breast cancer therapy.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2026
·
IF 3.5
Linlin Zhang,Yanfen Chen,Fangyu Wu,Aoxing Feng,Jiaqi Zhang,Tianyu Zhang,Xuenan Yang,Sisi Li,Qilin Lu,Jingjing Hou,Yuanhui Tang,Lixin Yu,Xiaolin Wang,Yakai Lin
Plasma leakage and thrombosis remain critical challenges limiting the long-term performance of poly(4-methyl-1-pentene) (PMP) hollow fiber membranes (HFMs) in extracorporeal membrane oxygenation (ECMO). In this work, a hierarchical hydrophobic modification strategy was developed to construct a stable anti-wetting interface on PMP HFMs. Surface hydroxyl groups were first generated via Fenton-induced oxidation, followed by interfacial coupling with trimesoyl chloride (TMC). Subsequently, SiO 2 nanoparticles were grafted to create a micro/nano-structured rough surface, and further modified with 1H,1H,2H,2H-perfluorodecyltrimethoxysilane (17-FAS) to reduce surface energy. Under the optimized conditions (120 min Fenton pre-treatment, 60 min TMC reaction, and 0.1% (mass) SiO 2 nanoparticles), the modified PMP–SiO 2 /17-FAS membrane exhibited a high N 2 flux of 54.1 ml·cm –2 ·min –1 ·MPa –1 , while the plasma leakage resistance time was significantly prolonged from 5910 to 8775 min. In addition, bovine serum albumin adsorption was reduced by approximately 50%, indicating enhanced antifouling performance. Coagulation tests further revealed a selective prolongation of activated partial thromboplastin time, while prothrombin time, thrombin time, and international normalized ratio remained nearly unchanged, suggesting suppressed contact-induced coagulation activation without disturbing normal coagulation pathways. The enhanced performance could be attributed to the synergistic effect of micro/nano-structured roughness and the fluorinated low-surface-energy layer, which stabilizes a non-wetting interfacial state and reduces protein-surface interactions. This work provides a feasible strategy for simultaneously improving plasma leakage resistance and hemocompatibility of PMP-based oxygenation membranes. Download: Download high-res image (297KB) Download: Download full-size image
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Shuhuan Yun,Xianzhe Sheng,Weiran Tang,Handong Luo,Zhonglei Ma,Guangcheng Zhang
Lightweight, high-temperature resistant copolymerized polyimide foams (CPIFs) were fabricated via a “stepwise heating-holding” thermal foaming process using 3,3′,4,4′-biphenyltetracarboxylic dianhydride (s-BPDA) and 2,3,3′,4′-biphenyltetracarboxylic dianhydride (α-BPDA) as codianhydrides and p-phenylenediamine (PDA) as the diamine. Asymmetric α-BPDA rigidifies molecular chains to endow superior thermal resistance. The CPIFs possess a three-dimensional open-cell structure (open-cell content >99%), ultralow densities (<10 kg·m–3), excellent heat resistance (Tg ranging from 373.8 to 405.6 °C), and high thermal stability (T5% > 588 °C), substantially outperforming previously reported counterparts. Benefiting from the unique cellular architecture, the CPIFs exhibit thermal conductivities below 0.06 W·m–1·K–1 at room temperature and approximately 0.08 W·m–1·K–1 at 200 °C, and excellent sound absorption (NRC ≥ 0.4), along with outstanding flame retardancy (LOI > 44%, UL-94 V-0 rating). Moreover, the CPIFs remain flexible and thermal insulating even in liquid nitrogen. This work provides a robust strategy for high-performance polyimide foams integrating heat resistance, flexibility, thermal insulation, and acoustic absorption, promising for aerospace and extreme-environment applications.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Rui-Lin Zhang,Jia-Qing Wang,Sara Taha Abdelkhalek,Shan-Cheng Yi,Yuping Zha,Man-Qun Wang
The olfactory system is pivotal for insect behavior, with odorant-binding proteins (OBPs) serving as primary detectors for semiochemicals. Previous studies demonstrated that DhelOBP4 in Dastarcus helophoroides is essential for detecting herbivore-induced plant volatiles (HIPVs). Here, we demonstrated through dual-luciferase reporter assays, yeast one-hybrid (Y1H) assays, and electrophoretic mobility shift assays (EMSA) that transcription factors BarH1/2 directly activate DhelOBP4 expression by binding to its promoter. RNAi knockdown revealed sex-specific regulation: BarH1 silencing significantly reduced DhelOBP4 expression only in females, whereas BarH2 knockdown affected both sexes. Y-tube olfactometer assays showed that BarH1 depletion abolished female attraction to α-pinene and 2-undecyloxy-1-ethanol, as well as male attraction to α-pinene. BarH2 knockdown eliminated attraction in both sexes and reversed the female response to α-pinene from attraction to repulsion. These findings establish DhelOBP4 as a key detector of these volatiles, under sex-specific regulation by BarH1/2 to modulate behavior, revealing novel mechanisms in tritrophic interactions.
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