RSC Advances
·
2019
·Vol. 9
·期 68
·39561-39571
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IF 3.049
Fahim A. Qaraah,Samah A. Mahyoub,Mahmoud Elsayed Hafez,Guangli Xiu
Herein, we fabricated a C and N co-modified Nb2O5 nanonet structure (C–N/Nb2O5NNs) from niobium oxalate using 2-methylimidazole (Hmim) as a source for C and N via a simple hydrothermal route. The obtained nanonets are robust and cost-effective with excellent recycling stability. Compared with N-doped TiO2 (N-TiO2) and a Nb2O5 control sample (Nb2O5-CS), the resulting nanonets exhibited the highest performance toward the photocatalytic degradation of Rhodamine B (RhB) upon visible light irradiation (λ > 420 nm). Through this study, we revealed that the synergetic effects of C and N on the nanonet surface, which were effectively incorporated into the surface of the Nb2O5 nanonet structure, not only remarkably enhanced the visible light response by decreasing the bandgap to 2.9 eV but also improved the light utilization efficiency and photo-induced electron–hole pair separation efficiency of our nanonet structure. We also proposed that the presence of carbonate species (COx) and nitrogen species (NOx) increased the population of generated holes (h+) that had the key role in the photodegradation mechanism of RhB, suggesting reasonable importance for the modification of Nb2O5 with C and N. This synergism offers a new view to reveal the origin of photodegradation processes, introducing h+ as a key intermediate. Our approach provides a new insight to design 2D nanostructures with potential applications in catalysis, solar energy conversion, and environmental protection.
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THERMOCHIMICA ACTA
·
2019
·
IF 2.251
Shijie Zhang,Jiaoqiang Zhang,Huimin Shi,Zhenguo Gao,Kaichang Kou
The polyacrylonitrile- b -poly(hydroxyethyl acrylate) (PAN- b -PHEA) was synthesized of polyacrylonitrile-TeMe (PAN-TeMe) and 2-Hydroxyethyl acrylate (HEA) via organotellurium-mediated living radical polymerization (TERP), and the PAN-TeMe and PAN- b -PHEA were characterized by several methods. A Calvet micro-calorimeter was used to investigate the polymerization of PAN-TeMe and HEA at different temperatures (358.15 K, 363.15 K, 368.15 K, 373.15 K, 378.15 K and 383.15 K). The kinetic equations of polymerization at different temperatures were obtained, and the apparent activation energy ( E ) of polymerization is 16.43±0.17 kJ∙mol −1 and the pre-exponential factor ( A ) is 0.6845±0.0366 s −1 . Furthermore, the thermodynamic parameters including the standard molar Gibbs free energy of activation ( Δ G ≠ θ ), the standard molar enthalpy of activation ( Δ H ≠ θ ) and the standard molar entropy of activation ( Δ S ≠ θ ) are acquired.
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Journal of Analysis and Testing
·
2022
·Vol. 7
·期 2
·147-156
·
IF 0
Yang Xiaohua,Zhang Peigang,Tan Jie,Li Xuebing,Zhang Weidong,Bian Wei,Choi Martin M. F.
Owing to the excellent stability, biocompatibility and photoluminescence property, graphene quantum dots (GQDs) are emerging as a kind of potential materials to be applied in a series of fields ranging from sensor to drug delivery. As the growing concern for human and environmental safety, selective detection of metal ions has been paid more and more attention. GQDs, as nanoparticles with superior optical properties, have been attracting growing attention in the field of metal ions detection. In this work, glutathione(GSH) functionalized boron doped graphene quantum dots (B-GQDs@GSH) were successfully synthesized with stable bright blue fluorescence and has been used for the detection of Fe 3+ . A good linear relationship between 1/( F 0 ‒ F ) and 1/ c with the concentration ranging from 0.70 to 53 μmol/L was obtained with a detection limit of 5.5 nmol/L. The application of B-GQDs@GSH for Fe 3+ detection in water samples was demonstrated and the quenching mechanism was further explored. Due to low cytotoxicity and favorable biocompatibility, B-GQDs@GSH were successfully applied for cell fluorescence imaging and intracellular determination of Fe 3+ .
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2016
·
IF 3.902
Hong-Jin Tang,Xiao-Wei Zhang,Lin Yang,Wei Li,Jia-Huang Li,Jin-Xin Wang,Jun Chen
Xanthine oxidase (XO) is the key enzyme in humans which is related to a variety of diseases such as gout, hyperuricemia and cardiovascular diseases. In this work, a series of 2-arylbenzo[ b ]furan derivatives were synthesized based on salvianolic acid C, and they were evaluated for xanthine oxidase inhibitory and antioxidant activities. Compounds 5b , 6a , 6e and 6f showed potent xanthine oxidase inhibitory activities with IC 50 values ranging from 3.99 to 6.36 μM, which were comparable with that of allopurinol . Lineweaver-Burk plots analysis revealed that the representative derivative 6e could bind to either xanthine oxidase or the xanthine oxidase-xanthine complex, which exhibited a mixed-type competitive mechanism. A DPPH radical scavenging assay showed most of the hydroxyl-functionalized 2-arylbenzo[ b ]furan derivatives possessed the potent antioxidant activity, which was further validated on LPS-stimulated RAW 264.7 macrophages model. The structure-activity relationships were preliminary analyzed and indicated that the structural skeleton of 2-arylbenzo[ b ]furan and phenolic hydroxyl groups played an important role in maintaining xanthine oxidase inhibitory effect and antioxidant property for the series of derivatives. Meanwhile, molecular docking studies were performed to further confirm the structure-activity relationships and investigate the proposed binding mechanisms of compounds 5d , 6d and 10d binding to the protein.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Changjun Zhang,Ke Yang,Sihang Yu,Jing Su,Shengli Yuan,Jiaxin Han,Yan Chen,Jinping Gu,Tao Zhou,Renren Bai,Yuanyuan Xie
A series of hybrids of hydroxypyridinone and coumarin were rationally designed, synthesized and biologically evaluated for their iron ion chelating and MAO-B inhibitory activities. Most of the compounds displayed excellent iron ion chelating effects and moderate to good anti-MAO-B activities. Compound 27a exhibited the most potent activity against MAO-B, with an IC 50 value of 14.7 nM. Importantly, 27a showed good U251 cell protective effect and significantly ameliorated the cognitive dysfunction of scopolamine-induced AD mice. Moreover, molecular docking was performed to elucidate the probable ligand-receptor interaction, and the structure-activity relationships were also summarized.
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BIOORGANIC & MEDICINAL CHEMISTRY
·
2020
·
IF 3.073
Xiaoying Jiang,Jianan Guo,Yangjing Lv,Chuansheng Yao,Changjun Zhang,Zhisheng Mi,Yuan Shi,Jinping Gu,Tao Zhou,Renren Bai,Yuanyuan Xie
A series of (3-hydroxypyridin-4-one)-coumarin hybrids were developed and investigated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through the incorporation of iron-chelating and monoamine oxidase B (MAO-B) inhibition. This combination endowed the hybrids with good capacity to inhibit MAO-B as well as excellent iron-chelating effects. The pFe 3+ values of the compounds were ranging from 16.91 to 20.16, comparable to more potent than the reference drug deferiprone (DFP). Among them, compound 18d exhibited the most promising activity against MAO-B, with an IC 50 value of 87.9 nM. Moreover, compound 18d exerted favorable antioxidant activity, significantly reversed the amyloid- β 1-42 (A β 1-42 ) induced PC12 cell damage. More importantly, 18d remarkably ameliorated the cognitive dysfunction in a scopolamine-induced mice AD model. In brief, a series of hybrids with potential anti-AD effect were successfully obtained, indicating that the design of iron chelators with MAO-B inhibitory and antioxidant activities is an attractive strategy against AD progression.
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Arabian Journal of Chemistry
·
2023
·
IF 6
Peng Lei,Zhirong Zhou,Jierong Pei,Li Jia,Lifeng Han,Miaomiao Jiang
Alisol B 23-acetate (AB23A) is an important pharmacodynamic compound found in Alismatis Rhizoma. In this study, response surface methodology (RSM) and Box- Behnken design (BBD) were used to optimize the extraction parameters of the AB23A. The optimal conditions included a solid–liquid ratio of 1:13, a reflux extraction of 70% ethanol, an extraction time of 2 h, and an extraction cycle of 3 cycles. Furthermore, a rat model of acute liver injury was established using carbon tetrachloride (CCl 4 ), and a comprehensive analysis combining histopathology, lipidomics, and metabolomics was conducted to elucidate the hepatoprotective effect of AB23A. The findings revealed that AB23A significantly reduced the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), and restored the abnormal morphology of hepatocytes. Furthermore, AB23A exhibited the ability to attenuate CCl 4 -induced lipid peroxidation, as evidenced by the upregulation of glutathione (GSH) and glutathione peroxidase 4 (GPX4) levels, along with a reduction in malondialdehyde (MDA) content in the liver. Omics results and immunohistochemistry analyses demonstrated a decrease in inflammatory reaction and oxidized phospholipid levels following AB23A administration, indicating an enhanced anti-inflammatory and antioxidant capacities of hepatocytes. Differential metabolite analysis revealed that AB23A improved anti-inflammatory and antioxidant capacities by modulating liver sphingolipid metabolism and purine metabolism, thereby enhancing hepatocyte recovery and counteracting acute liver injury induced by CCl 4 .
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Yu Luo,Zijun Yan,Fenglei Wang,Zining Wang,Min Zhou,Yongdong Jin,Yuanhua Wang,Chuanqin Xia
The reduction of environmental pollution and the exploration of economic values require the efficient separation and purification of xenon (Xe) and krypton (Kr) from radioactive gases generated during nuclear fission processes. To address this issue, we have synthesized three thieno[3,2-b]thiophene-based porous organic polymers (POP-ch-ET, POP-ch-SP and POP-ch-ME) via high yield C–H direct arylation reaction, all of which exhibited excellent thermal and acid-base stability. Notably, the three-dimensional (3D) structures of POP-ch-SP and POP-ch-ME allowed higher Xe capacity compared to the two-dimensional (2D) structure of POP-ch-ET. Density functional theory (DFT) calculations confirmed that thieno[3,2-b]thiophene moieties contributed to a more negative adsorption energy for Xe than benzene. Among them, POP-ch-SP with fixed group showed superior Xe capacity (2.37 mmol/g) at 298 K and 1.0 bar and the highest ideal adsorption solution theory (IAST) selectivity (11.5). This superior performance is attributed to its 3D ultra-micropore structure, which enables closer proximity between aromatic rings, thereby enhancing Xe interaction. The DFT calculation further revealed that the adsorption energy of Xe in POP-ch-SP was more negative compared to other POPs , indicating a stronger interaction. In addition, POP-ch-SP exhibited the largest ΔQ st (14.2 kJ/mol) between Xe and Kr , highlighting a marked affinity difference. In dynamic breakthrough experiments, POP-ch-SP demonstrated robust Xe/Kr separation efficiency under both low (400 ppm Xe and 40 ppm Kr in dry air) and high concentration scenarios (Xe/Kr, v/v, 20/80), underscoring its promising potential for practical applications in radioactive gas management.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2023
·
IF 3.8
Mingliang Zhang,Fangfang Duo,Chubei Wang,Jianwei Zhou,Liangliang Chu,Jihong Lan,Junwei Li,Lixiang Li
Semiconductor photocatalysis has driven considerable interests for its desirable potential to tackle the worldwide energy shortage and environmental pollution. In this paper, a novel Bi 5 O 7 I/Bi 2 SiO 5 Z-scheme heterojunction photocatalyst was in situ synthesized via a co-crystallization process and partial anion exchange strategy. The XRD and FT-IR pattern validated the successful preparation of the heterojunction. The optimal Bi 5 O 7 I/Bi 2 SiO 5 heterojunction displayed an excellent photocatalytic activity towards the ciprofloxacin under the simulated solar light, and the rate constant (0.46021 h −1 ) was 2 and 7.8 times higher than that of pure BiOI (0.22967 h −1 ) and Bi 2 SiO 5 (0.05877 h −1 ). Similarly, the degradation efficiency on rhodamine B (RhB) reached 94%, which was much higher than that of the single photocatalysis. The enhanced photocatalytic performance of the heterojunction photocatalyst could be attributed to the formation of the direct Z-scheme heterojunction between the Bi 5 O 7 I and Bi 2 SiO 5 , which was favorable for retarding the recombination of photoinduced electron-hole pairs. Moreover, the bacteriostatic activity testing illustrated the toxicity of drug solutions decreased sharply after the photocatalytic degradation with the Bi 5 O 7 I/Bi 2 SiO 5 -3. The ESR characterization analysis and the free radical trapping experiments synergistically determined the Z-scheme electron transfer path of the heterojunction. The possible photocatalytic mechanism of Bi 5 O 7 I/Bi 2 SiO 5 heterojunction was proposed. Overall, the well-designed Bi 5 O 7 I/Bi 2 SiO 5 heterojunction depicted great practical promise in efficient treatment of organic pollutants.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Jiawei Lu,Ying-Nan Li,Youran Li,Huilin Zhu,Guiyang Shi
The reusability of immobilized lipases, including their hydrolysis activity, is greatly affected by lipase leakage, mass transfer channel blockage, and compound deposition on the outside surface. In this study, Candida antarctica lipase B (CALB) was immobilized on Fe3O4 nanoparticle-polyacrylonitrile (PAN) composite magnetic beads through phase inversion (L/FP). The hydrolysis activity of lipase was investigated using p-nitrophenyl palmitate (p-npp) as a model ester. To overcome the limitations of immobilized lipase in ester hydrolysis, three modification strategies were employed. First, lipase was covalently immobilized on Fe3O4 nanoparticles modified with methallyl (M9) and chloro (M13) silane modifiers, which exhibited faster immobilization with reduced lipase leaching and higher activity expression and stability. Second, poly(ethylene glycol) (PEG6000) and polylactic acid (PLA) were added to the precursors to physically modify the composite structures of L/FP, resulting in modified beads with larger specific surface area (15.26 m2·g–1) and smaller average pore size (19 nm). The modified beads, L/FP-9-M and L/FP-13-M, demonstrated superior reusability in long-term hydrolysis activity over 250 cycles. L/FP-9-M retained 63 and 34% of the initial activity at the 100th cycle and the 250th cycle, respectively. L/FP-13-M retained 55 and 36% of the initial activity at the 100th cycle and the 250th cycle, respectively. Furthermore, even after 250 repeated uses, the unit activities (U·gsupport–1) of both L/FP-9-M and L/FP-13-M remained higher than the initial activity of Novo 435.
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ANALYTICAL LETTERS
·
2024
·
IF 1.6
Zixuan Wang,Ganghui Chu,Juan Peng,Shiyi Chen
Internal reference probes can effectively eliminate internal and external interferences. Hence, finding a suitable internal reference probe is the key to ratiometric electrochemistry. In this study, a simple and sensitive ratiometric electrochemical sensor for the determination of rutin was prepared for the first time using rhodamine B (Rh B) as an internal reference probe. The modified electrochemical sensor was constructed by electrodepositing gold nanoparticles (AuNPs) on a glassy carbon electrode followed by drop-coating chitosan-immobilized rhodamine B (CS@Rh B). Rh B has a dual function in that it has a stable electrochemical signal (1.18 V) (vs. Ag/AgCl) that is completely separated from the oxidation peak of rutin (0.52 V) to serve as an internal reference probe. At the same time, it synergistically enhances the electrochemical signal of rutin with AuNPs. When differential pulse voltammetry was used for the determination of rutin, the current ratio of IRutin/IRh B was employed as the signal for rutin determination with a wide linear range (0.1 to 70 μM) and a low detection line (0.028 μM). The recoveries for the determination of rutin in Coreopsis tinctoria and Buckwheat tea were 95.4%–106% and 95.3%–104%, respectively. This work successfully demonstrated the feasibility of Rh B as an internal reference probe.
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Polymers
·
2023
·Vol. 16
·期 1
·97
·
IF 5
Ouyang Shi,Peng Li,Chao Yang,Haitian Jiang,Liyue Qin,Wentao Liu,Xiaolin Li,Zhenming Chen
In this experiment, a series of poly(propylene 2,5-furan dicarboxylate)-b-poly(ethylene glycol) (PPFEG) copolymers with different ratios were synthesized using melt polycondensation of dimethylfuran-2,5-dicarboxylate (DMFD), 1,3-propanediol (PDO) and poly(ethylene glycol) (PEG). The effect of PEG content on the crystallization behavior of the poly(propylene 2,5-furan dicarboxylate) (PPF) copolymers was investigated. For PPF, the nucleation density of theβ-crystals was higher than that ofα-crystals. AsTcincreases, theβcrystals are suppressed more, but atTc= 140 °C, the bulk of PPF has already been converted toαcrystals, which crystallize faster at higher nucleation densities, resulting in a difference in polymer properties. For this case, we chose to add a soft segment material, PEG, which led to an early multi–melt crystallization behavior of the PPF. The addition of PEG led to a decrease in the crystallization temperature of PPF, as well as a decrease in the cold crystallization peak of PPF. From the crystalline morphology, it can be seen that the addition of PEG caused the transformation of the PPF crystalline form to occur earlier. From the crystalline morphology of PPF at 155 °C, it can be observed that the ring-banded spherical crystals of the PPF appear slowly with increasing time. With the addition of PEG, spherical crystals of the ring band appeared earlier, and even appeared first, and then disappeared slowly.
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