FirePhysChem
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2026
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IF 5.1
Ying Kang,Kaiyuan Sun,Haiting Liu,Jiani Dong,Guoliang Liu,Lianqiang Li,Haixia Zhao,Erhai An,Xiong Cao
(H 2 dabco) [NH 4 (ClO 4 ) 3 ] (DAP-4) is a multi-ionic energetic material with strong oxidizing and detonation capabilities, but its high decomposition temperature (380 °C) limits its practical use. Cobalt-doped carbon nanotube composites (Co/CNTs) with different Co loadings (0.05, 0.5, 5 mmol) were hydrothermally prepared. Their morphologies and structures were characterized, and the influence of Co/CNTs-(1-3) on the thermolysis process and combustion performance of DAP-4 was comprehensively examined. Among them, Co/CNTs-2 exhibited the strongest catalytic activity in terms of DAP-4′s thermal decomposition and combustion. It decreased the activation energy by 57.1 kJ/mol and the decomposition temperature by 32.2 °C, respectively. Furthermore, the combustion heat of DAP-4/Co/CNTs-2 was 14947 kJ/kg, which was significantly more than that of DAP-4. The addition of Co/CNTs increased the flame area and intensity of DAP-4 while shortening the flame duration and accelerating the energy release rate.
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高影响因子
Nature Communications
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2026
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IF 18.1
Li Chao,Chen Zehao,Li Wentao,Deng Ronghui,Huang Lingan,Song Yifan,Wang Yiqun,Cui Guoqing,Liu Huawei,Yu Jiakuo
Excessive transforming growth factor-β1 (TGF-β1) signaling is a key driver of the pathological processes of fibrosis and matrix disorganization in tendinopathy, yet current treatments do not directly target this fibrotic microenvironment. Here we show that a self-assembling peptide composed entirely of natural amino acids, AsPep-FTSQ, can locally capture TGF-β1 and remodel the pathological tendon niche. Injecting AsPep-FTSQ into rat and beagle models of tendinopathy resulted in the formation of an interconnected nanofibrous network in situ that selectively sequesters excess TGF-β1. This network suppresses pro-fibrotic signaling, limits pathological tendon cell (TC) state transitions, and promotes collagen realignment. These effects improve tendon structure and functional repair across species. This fully natural, self-assembling peptide composed of amino acids provides a modular strategy for local cytokine sequestration and suggests a therapeutic approach for tendinopathy and potentially other fibrotic soft-tissue disorders.
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高影响因子
Phenomics
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2026
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IF 5.5
Li Zhiyao,Fang Mengyuan,Wang Yu,Chen Yunqiu,Liu Yuying,Chen Yijia,Li Xuewen,Meng Fangzhou,Qian Xiaoyang,He Zhen Ning Tony,Yang Qing
Prolonged immunosuppression is a major risk factor for sepsis death. The mechanism of sepsis-associated immunosuppression remains unclear, hindering timely and targeted immunotherapy. The immunomodulatory enzyme, indoleamine-2,3-dioxygenase 1 (IDO1), is overactivated in patients with sepsis; however, its role in sepsis-associated immunosuppression remains unclear. In this study, we defined the time window when cecal ligation puncture (CLP) mice, a gold-standard sepsis model, entered the immunosuppressive state and confirmed elevated IDO1 activity during this phase. The IDO1 inhibitor prevented the occurrence of immunosuppression in CLP mice by decreasing the concentration of interleukin-10 (IL-10), the number of regulatory T cells and myeloid-derived suppressor cells, and increasing the proportion of M1 macrophages, which led to clearance of pathogenic bacteria in the peritoneal cavity. The IDO1 inhibitor enhanced resistance to infection and improved the survival of septic mice during secondary infection with Staphylococcus aureus . Finally, we explored the potential role of IDO1 in macrophages, key participants in the progression of sepsis. IDO1 preferentially promoted IL-10 production in septic macrophages through the aryl hydrocarbon receptor–STAT3 axis. In macrophages, IDO1 inhibited the mammalian target of rapamycin pathway by depleting ambient tryptophan, leading to the downregulation of the mitochondrial biogenesis regulator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and the metabolic reprogramming mediator hypoxia-inducible factor 1-alpha (HIF-1α). The downregulation of PGC-1α and HIF-1α inhibited mitochondrial biogenesis and glycolysis, respectively, both of which were essential for immune defense. These results demonstrate that IDO1 is a crucial mediator of sepsis-associated immunosuppression, and that targeting IDO1 could serve as a therapeutic strategy for sepsis.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Xiaorui Chen,Xiao Xiao,Wei Zhao,Bin Liu,Hongzhou Lian,He Ding,Piaoping Yang,Ping'an Ma,Lingjie Song,Shifang Luan,Ziyong Cheng,Jun Lin
Biomineralization of bacterial as a ultrasound (US)-triggered CO generator. • Engineered bacteria can decompose through acid-response in tumor microenvironment. • Self-supplying H 2 O 2 , amelioration of hypoxia, Ca 2+ -induced mitochondria damage. • US-triggered CO release for apoptosis in tumor cells. • Activating anti-tumor immune responses for significant inhibition of tumor growth. Carbon monoxide (CO) gas therapy is emerging as a highly promising strategy in cancer treatment. However, the tumor-targeted delivery and on-demand release of CO remain formidable challenges, and monotherapeutic efficacy is inherently limited. To address these issues, we report a self-guided “CO-releasing bomb” constructed by armoring Escherichia coli ( E. coli ) with 3-hydroxyflavone-D-alanine (HF-D-Ala) and calcium peroxide (CaO 2 ) nanoparticles (EHC). Upon reaching the acidic, hypoxic tumor microenvironment (TME), CaO 2 instantly generates Ca 2+ and H 2 O 2 ; the bacterium then self-catalyzes H 2 O 2 to produce a local O 2 burst. Subsequent ultrasound irradiation triggers HF-D-Ala to liberate a high concentration of CO owing to the O 2 -rich environment, selectively damaging tumor-cell mitochondria and inducing apoptotic death. Moreover, the O 2 generation alleviates tumor hypoxia and reverses the immunosuppressive TME. Concurrently, E. coli antigens promote dendritic cell maturation and enhance T-lymphocyte recruitment and infiltration. In vivo studies demonstrate that the EHC under US irradiation significantly suppresses tumor growth and potently activates antitumor immunity. These findings provide compelling evidence to support the potential application of combined CO gas therapy and immunotherapy for in vivo tumor treatment. Download: Download high-res image (58KB) Download: Download full-size image
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COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2026
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IF 8.2
Feng Li,ZeZhou He,JiaHao Li,SiChao Zhang,Jun Xia,Liu Wang,HengAn Wu,YinBo Zhu
Layered graphene oxide (GO) films are promising structural materials, but their strength and ductility are limited by weak, porous interfaces that lose load transfer during interlayer sliding. Here we report a nacre-like reduced graphene oxide/melamine (rGO/Mel) film coupling dense lamellar stacking with strong, constrained yet dynamically reconfigurable noncovalent interactions. Melamine is introduced between GO sheets and retained after hydroiodic acid reduction, while the reduced sheets form flatter, more compact stacks with smaller interlayer spacing. Melamine’s triazine rings interact with graphitic domains through π–π stacking, and its amine groups form reversible hydrogen bonds with residual oxygen-containing groups, sustaining shear transfer while allowing controlled sliding. Under tensile loading, rGO/Mel exhibits pronounced post-yield strain hardening associated with nanosheet straightening, interfacial reorientation and continued molecular bridging. The optimized film reaches a tensile strength of 262.7 MPa, a strain at break of 5.0 % and a toughness of 6.0 MJ m⁻ 3 . These values represent increases of 538 %, 317 % and 2900 % over pure GO, respectively. Molecular dynamics simulations support this picture by showing more stable interlayer contact and melamine-assisted shear transfer in rGO/Mel. This work shows that constrained noncovalent interfaces can turn interlayer sliding from a failure pathway into a source of strain hardening in layered nanocomposites.
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高影响因子
Advanced Science
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2026
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IF 14.1
Bolun Xu,Xuan Lu,Yuquan Wang,Haihua Ji,Ying Zhang,Yiqun Wan,Hao Wan
Immunogenic cell death (ICD)-based whole-cell personalized cancer immunotherapies present full tumor antigens but suffer from poor immunogenicity, early clearance, and a glutathione (GSH)-rich immunosuppressive tumor microenvironment (TME). Here, we report a TME-responsive immunotherapeutic platform, DTBEI@CS@MnO 2 , which integrates immunogenicity-enhanced dead tumor cell bodies (DTBEI) with Mn 2 + -potentiated innate immunity. Tumor cells preloaded with indocyanine green (ICG) are sequentially functionalized with a chitosan (CS) interlayer followed by MnO 2 adsorption (CS@MnO 2 ) via electrostatic interactions. Upon near-infrared laser irradiation, ICG-mediated photodynamic/photothermal effect induces potent ICD, generating DTBEI. Within the acidic and GSH-enriched TME, the CS@MnO 2 coating disassembles to release DTBEI and MnO 2 . DTBEI provides endogenous antigens and ICD-associated danger signals, while MnO 2 is reduced by GSH to Mn 2 + . The resulting Mn 2 + amplifies DTBEI- and tumor-derived deoxyribonucleic acid-triggered cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) activation and downstream immune-stimulatory effects, thereby synergistically promoting dendritic cell maturation, antigen cross-presentation, and tumor-specific T-cell priming. Consequently, DTBEI@CS@MnO 2 elicits durable anti-tumor immunity, effectively inhibiting tumor growth and suppressing recurrence and metastasis, while establishing T-cell memory responses. Importantly, this strategy shows broad applicability in multiple tumor models, including CT26 colon cancer, 4T1 breast cancer, and B16F10 melanoma, while maintaining favorable biocompatibility. Overall, these findings highlight a materials-based approach for personalized cancer immunotherapy.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Yaning Gong,Dingyu Qiu,Xingchen He,Junhui Shao,Najun Li,Dongyun Chen,Hua Li,Qingfeng Xu,Jianmei Lu
Hybrid HfO 2 -PMA subnanobelts are synthesized by cluster–nuclei co-assembly. • Subnanometer belt morphology enhances piezoelectric polarization response. • Hf-O-Mo interfacial orbital coupling enhances charge separation. • PMA redox pairs act as electron buffers for efficient CO 2 activation. • Dilute CO 2 is efficiently converted into syngas via piezocatalysis. Efficient piezocatalytic conversion of dilute CO 2 into syngas offers a sustainable route for industrial flue gas valorization, yet conventional piezoelectric materials are often constrained by lattice rigidity and rapid charge recombination under weak mechanical stress. Herein, we constructed ultrathin 1D HfO 2 -phosphomolybdic acid (PMA) hybrid subnanobelts (SNBs) via cluster-nuclei co-assembly. The subnanometer architecture and flexible morphology induce an intense polarization response by leveraging the piezoelectric size effect, enabling HfO 2 -PMA SNBs to achieve remarkable CO and H 2 production rates of 4.5 and 5.8 mmol g −1 h −1 , respectively. In-situ FTIR spectra and density functional theory (DFT) calculations reveal that the asymmetric Hf-O-Mo interfacial coordination induces spontaneous electron transfer from HfO 2 to PMA, constructing a robust built-in electric field. Concurrently, the reversible redox properties of PMA clusters further enrich interfacial electron density and facilitate CO 2 adsorption and activation through Hf-O-Mo coupling, lowering the formation energy barrier of the key *COOH intermediates. This interfacial electronic structure engineering strategy establishes a novel paradigm for mechanical-energy-driven CO 2 conversion and offers a new approach for designing emerging sub-nanometer piezocatalysts. Download: Download high-res image (202KB) Download: Download full-size image
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Jing Wang,Jiaqi He,Silei Bai,Yixiong Wang,Hengbin Yao,Xuehui Liu,Junhui He,Anhong Liu,Chao Wang,Zhonghua Liu,Jianan Huang
Fresh leaves from seven regions were processed under identical conditions. • Processing reshaped aroma composition and amplified regional differences. • OAV and multivariate analysis identified 17 region-specific odorants. • Molecular docking suggested different receptor binding capacities among key odorants. Whether standardized tea processing homogenizes regional raw material differences or reconstructs them into distinct aroma profiles of raw Anhua dark tea (RADT) remains unclear. In this study, fresh leaves from seven regions were processed under identical manufacturing conditions to separate the effects of raw material origin from manufacturing process. Sensory evaluation showed that standardized processing did not eliminate regional aroma differences; instead, the resulting tea infusions retained distinct aroma attributes across regions, including roasty/smoky, stale/woody, floral, fruity, and green/fatty notes. GC-O/MS and quantitative analysis identified 48 odorants in fresh leaves and 82 odorants in RADT infusions, indicating that processing substantially reshaped the aroma composition. Alcohols, aldehydes, and terpenoids derived from fresh leaves generally decreased, whereas processing associated acids, phenols, lactones, and heterocyclics increased. Multivariate analysis identified 45 processing responsive odorants, including newly formed heterocyclics, ( E , E )-2,4-heptadienal, and ( E )- β -ionone. By integrating odor activity value with multivariate discrimination, 17 regional key odorants were identified, demonstrating that standardized processing reconfigured regional raw material differences into distinct aroma-active compound combinations rather than homogenizing them. Molecular docking revealed different predicted binding capacities between representative key odorants and selected olfactory receptors, with cedrol and ( E )- β -ionone showing stronger predicted receptor interactions than smaller linear aldehydes, suggesting that regional aroma differences in RADT may also involve receptor level recognition. Overall, these findings reveal that standardized processing acts as a transformative filter that reshapes regional raw material differences into distinct aroma profiles in RADT. Download: Download high-res image (184KB) Download: Download full-size image
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高影响因子
OPTICS AND LASER TECHNOLOGY
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2026
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IF 5.2
Hao Chen,Min Li,Jichuan Gai,Jiyuan Wei,Zengshan Yu,Shan Guo,Zelong Li,Yanjun Wu,Xue Han,Kuihua Li,Guochao Shi
A double-antibody sandwich SERS immunoassay was developed for the highly specific capture of NSE in clinical serum. • The interpretable 1D-CNN model achieved an AUC of 0.9704, significantly outperforming DNN and RNN architectures. • SHAP and saliency maps deciphered the “black box”, identifying key Raman shifts at 607 and 1078 cm -1 as biomarkers. • A high-performance PSS@Cu-Ag@Ag SERS substrate with core-shell structure was fabricated using magnetron sputtering. • The periodic array provided dense “hot spots” with superior reproducibility, achieving RSD values below 6.4%. To address the issues of low imaging sensitivity in the clinical diagnosis of ischemic stroke (IS) and the cumbersome procedures associated with traditional Neuron-Specific Enolase (NSE) testing methods, this study proposes a rapid diagnostic approach which integrates Surface-enhanced Raman scattering (SERS) immunonanosensing technology with deep learning. Using magnetron sputtering, a periodic core–shell structured PSS@Cu-Ag@Ag active substrate was fabricated on a periodic microsphere array (PSS). The NSE biomarker in serum was specifically captured via a double-antibody sandwich immunoassay, and the spectra were subjected to deep feature extraction using a one-dimensional convolutional neural network (1D-CNN). Results showed that the model achieved an area under the curve average AUC of 0.9704 under five-fold cross-validation, and the SHapley Additive exPlanations (SHAP) interpreter successfully identified key differential Raman shift such as 607 cm −1 and 1078 cm −1 , enhancing the interpretability of the algorithm. This approach enables robust and transparent classification of clinically heterogeneous samples, providing a highly sensitive and intelligent medical solution with great potential for practical clinical implementation in the auxiliary diagnosis of IS. Download: Download high-res image (125KB) Download: Download full-size image
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DESALINATION
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2026
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IF 9.9
Longbin Yuan,Mingjie Chen,Yi Wei,Zhihan Xu,Ruizhe Zhou,Zhongxin Liu,Huihui Wang
A thermo-adaptive hydrogel evaporator achieves autonomous salt self-cleaning. • The hydrogel network shrinks autonomously during the daytime to enhance evaporation rate, and recovers at night to reflux the accumulated salt. • The hydrogel anisotropic structure decouples the water and heat transport pathways • A high water evaporation rate of 3.15 kg m -2 h -1 under one sun could be obtained. Solar-driven interfacial evaporation (SDIE) offers a sustainable and economic solution for water purification. However, the efficiency and long-term stability degradation resulting from the salt fouling still hamper the development of SDIE. This study presents a thermo-adaptive hydrogel evaporator with an excellent salt self-cleaning performance. The hydrogel network mesh size and surface amphiphilicity autonomously switch between day and night to reflux the accumulated salt. In detail, the hydrogel network shrinks reducing water supply to enhance water evaporation rate at daytime, while the network mesh size autonomously recovers drawing bulk water to reflux the accumulated salt at night. As a result, the evaporation rate of the hydrogel evaporator is up to 3.15 kg m −2 h −1 under one sun in 3.5 wt% of seawater, and it works stably in 25.0 wt% hypersaline brine lasting for 8 days without salt crystallization. This work provides a new perspective for designing autonomous anti-salt solar evaporators with an excellent evaporation performance. Download: Download high-res image (114KB) Download: Download full-size image
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yongtang Wang,Lan Chen,Zhanfeng Zhou,Yuhan Liang,Tong Zhang,Rongbang Sun,Yueling Tian,Yang Liu,Yifu Fu,Huihan Wang,Guang Feng,Jianhua Miao,Xinhui Zheng,Kai Yang
This work fabricated FeOOH/arginine composite coatings firmly bonded onto Mg alloy substrates, which greatly enhanced the corrosion resistance of biodegradable magnesium implants. • The composite coating achieves NIR and TME dual-responsive controlled NO release, and the PTT-CDT-NO synergistic therapy suppresses core oncogenic signaling pathways to induce efficient osteosarcoma cell death, while low-concentration NO facilitates anti-inflammation and angiogenesis. • By utilizing the concentration-dependent bidirectional effects of NO, the constructed multifunctional coating offers a simple and low-cost design strategy for intelligent magnesium alloy implants toward clinical postoperative bone tumor therapy. Osteosarcoma is prone to recurrence after surgery and is accompanied by extensive bone defects. Traditional treatment methods struggle to achieve tumor suppression and bone repair simultaneously. Degradable magnesium alloys are ideal bone implant materials, yet they have drawbacks, including overly rapid degradation and a lack of anti-tumor activity. Although nitric oxide (NO) shows promise for its anti-inflammatory and regenerative properties, its clinical translation is limited by its short half-life and uncontrolled release, which do not meet the postoperative requirements for osteosarcoma. Herein, in this work, a porous PEO (plasma electrolytic oxidation) coating was first prepared on Mg alloys to improve corrosion resistance, and then Fe 2+ and L-arginine were simultaneously introduced to synthesize the FeOOH-Arg coating in situ, which was then coated with polydopamine to obtain a responsive composite coating. This composite coating achieved interfacial bonding and seals the PEO porous structure through covalent bonding, and can realize the controllable release of NO and reactive oxygen species (ROS) with near-infrared light irradiation and tumor microenvironment, not only synergistically combining the photothermal therapy (PTT) and chemodynamic therapy (CDT) to induce the apoptosis of osteosarcoma cells efficiently, but also regulate the immune microenvironment and promote angiogenesis both in vitro and in vivo. This work offers a novel, feasible, multifunctional modified magnesium alloy implant for integrated anti-tumor and bone-regeneration treatment following osteosarcoma surgery.
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高影响因子
ACS Photonics
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2026
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IF 6
Ou Lihao,Li Siqi,Wang Minge,Yu Hong,Zhang Ning,Wang Yichen,Li Fei,Zhang Youzhi,Kuai Yan,Liu Xue,Jiang Yuxuan,Zhen Shenglai,Hu Zhijia,Gao Yesheng,Yu Benli
Chiral fiber lasers, owing to their unique circularly
polarized
laser output, are crucial in frontier fields such as spin photonics,
quantum information processing, and high-sensitivity chiral sensing.
Current fabrication methods, relying on mechanical twisting or complex
multicore structures, are limited by poor torsional strain tolerance,
structural instability, and difficulties in achieving precise intercore
coupling. To address these bottlenecks, we propose and demonstrate
an innovative fabrication strategy using chiral supramolecular glasses
(SGs) as the optical fiber core material. This approach leverages
the intrinsic chirality of SGs to impart macroscopic chirality to
the fiber. By integrating high-performance gain dyes, we successfully
construct and characterize a chiral fiber laser. The readily designable
chiral motifs of SGs and their near-room-temperature glass transition
temperature simplify fabrication and enhance structural controllability.
The resulting chiral fiber laser stably emits narrow-line width circularly
polarized laser output with an asymmetry value ( g lum ) of approximately 0.31. This work establishes chiral
SG-based systems as a high-performance, highly designable class of
chiral laser gain media, paving a new technological path for next-generation
functionalized fiber lasers.
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危险品化学品经营许可证（带存储）