AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
·
2025
·
IF 5.3
Mingzhi Luo,Xiangrong Zhang,Jia Guo,Rong Gu,Youyuan Qin,Kai Ni,Lei Liu,Yan Pan,Jingjing Li,Honglei Shi,Linhong Deng
Bronchodilators that relax airway smooth muscle cells (ASMCs) are essential for treating constrictive airway diseases such as asthma. However, the existing bronchodilators are often unable to control symptoms of severe asthmatic patients, leaving a pressing need to search for alternatives. Recent studies indicate that the transmembrane mechanosensitive channel, Piezo1 may provide a novel target for bronchodilation as it mediates ASMCs relaxation via calcium signaling and activation of large-conductance calcium-activated potassium channels (BKCa), and Piezo1 specific agonist Yoda1 has been shown to reduce cell stiffness and traction force in cultured ASMCs after 24 h incubation. Thus in this study, we further explored the potential of Yoda1 for inducing rapid ASMCs relaxation and bronchodilation. We treated either cultured ASMCs or allergen-induced mouse models of asthma with Yoda1 at various doses, and then assessed the resulting variations in cell stiffness, traction force, and molecular signaling of cultured ASMCs, as well as in airway resistance of the mouse models. We found that exposure to Yoda1 rapidly decreased cell stiffness, traction force in association with induced calcium signaling and BKCa activation in cultured ASMCs, and reduced airway resistance in methacholine-challenged mice in a dose-dependent manner. These results indicate that chemical activation of Piezo1 with specific agonist Yoda1 was indeed capable of inducing bronchodilation by relaxing ASMCs, and thus provide insights into development of Piezo1 agonist-based novel bronchodilators for treating constrictive airway disorders such as asthma.
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International Review of Financial Analysis
·
2024
·
IF 7.5
Shengpeng Zhang,Yaokuang Li,Yu He,Ruixin Liang
In this study, we investigate whether vocal cues expressed by management in IPO online roadshows in the SSE STAR Market play an information role. Using deep learning techniques, we classify the emotional tendencies of vocal cues in IPO online roadshows and construct quantitative proxy variables. After a series of empirical analyses, we find that vocal emotions are positively associated with first-day stock returns after IPO. In addition, we find that vocal emotions have predictive power for future operating performance after IPO. Our findings still hold after a series of robustness checks. Through additional analyses, we provide evidence that information content in the prospectus and investor sentiment play moderating and mediating roles, respectively, in the relationship between vocal emotions and the first-day stock returns after IPO. Moreover, we find that the vocal emotions expressed in the presentation section and the management tone in the Q&A section develop synergistic effects. Finally, we find that the information role played by vocal emotions exhibits timeliness. Our findings elucidate the information role of vocal cues and highlight the importance of IPO online roadshows in the SSE STAR Market.
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MOLECULAR DIVERSITY
·
2026
·
IF 3.8
Xia Hailun,Wu Jun,Fu Haoxin,Wang Peiqi,Li Ruibin,Cao Lu,Liu Ya-nan,Shi Lu,Xu Ren-ai
Escitalopram, a selective serotonin reuptake inhibitor (SSRI), treats depression and related anxiety symptoms by enhancing the physiological effects of serotonin (5-HT). This study explored the potential drug-drug interactions (DDIs) of combining escitalopram with flavonoid compounds (kaempferol and quercetin). The inhibitory effects of flavonoids on escitalopram metabolism were studied using human liver microsomes (HLM), rat liver microsomes (RLM) and Sprague–Dawley rats. The concentration of escitalopram and its metabolites were detected by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Our findings revealed that the half-maximal inhibitory concentration (IC 50 ) of kaempferol against escitalopram in HLM and RLM were 14.34 and 8.69 μM, respectively, and both were mixed inhibitory mechanisms, consisting of competitive and non-competitive inhibition in HLM and non-competitive and un-competitive inhibition in RLM, respectively. Moreover, the IC 50 of quercetin against escitalopram in HLM and RLM were 11.25 and 8.14 μM, respectively, and the inhibitory mechanisms were both mixed inhibitory mechanisms consisting of non-competitive and un-competitive inhibition. The in vivo results showed that quercetin significantly increased the AUC (0-t) , AUC (0-∞) and C max of escitalopram by 0.91-, 0.90- and 1.83-fold, respectively, while kaempferol and quercetin significantly reduced the CL z/F by 41.3% and 44.7%, respectively. In addition, kaempferol reduced the C max of N-desmethyl escitalopram by 62.1%. Therefore, the inhibitory effects of kaempferol and quercetin on the metabolism of escitalopram carries the risk of causing DDI and requires caution in combination.
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TRANSPORTATION RESEARCH RECORD
·
2019
·
IF 0.748
Yan Xia,Jie Yang,Zhiyuan Liu,Jing Dong
This paper investigates the economic viability of plug-in hybrid electric vehicles (PHEV) in Shanghai, China based on a real-world in-use PHEV dataset. To quantify PHEV drivers’ gross profit compared with internal combustion engine vehicle (ICEV) owners, a total cost of ownership (TCO) model is adopted taking account of vehicle retail price, tax credits, subsidies, insurance, maintenance, energy prices, and resale value. The impact of the determinants for gross profit are examined in relation to vehicle distance traveled (VDT) electrically, gasoline price, electricity price, and car-buying cost. It is found that: (1) only 10% of the deployment of PHEVs (i.e., BYD Qin) is economically viable if the benefit from a free license plate is exempt; (2) the 100-kilometer gross profit of PHEVs increases linearly with the electric driving distance, while the saving of energy cost per kilometer decreases with the total VDT; (3) PHEVs’ profit could be significantly improved by reducing the car-buying cost—a decrease of 10% in car-buying cost makes 80% of the PHEV deployment feasible; and (4) if switching the daytime charges to off-peak hours, 50% of the PHEV deployment will become feasible.
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ACS Applied Electronic Materials
·
2026
·
IF 4.7
Zhaoyue Yang,Yujian Du,Yian Hu,Yanfeng Miao,Yuljae Cho
Self-powered photodetectors (SPPDs), operating without an external bias, hold significant potential for next-generation optoelectronic systems. Their performance, however, is intrinsically constrained by the heterojunction interface, since charge extraction depends solely on the built-in potential. Here, we report a strategy to enhance the built-in potential and device performance in quasi-2D perovskite (PVK)-based SPPDs through energy landscape engineering at the heterojunction interface. By incorporating self-assembled molecules (SAMs) onto a hole transport layer (HTL), we achieve suppression of low-n phase of quasi-2D PVK, reduced interfacial recombination, and an enhanced built-in electric field. Systematic characterization reveals that the SAM promotes favorable energy alignment, passivates interfacial defects, and promotes improved PVK film growth. The SPPDs exhibit a high responsivity of 0.373 A/W, a specific detectivity of 8.34 × 1012 Jones at 560 nm, and an external quantum efficiency exceeding 70% across wavelengths of 460–610 nm with a peak of 82% at 560 nm. Furthermore, the devices demonstrate rapid response times of 7.25/3.68 μs and improved operational stability, retaining 96.4% of their initial performance over 4200 h. This work demonstrates interfacial energy landscape engineering as an effective strategy for improving the potential of quasi-2D PVKs for self-powered optoelectronic devices.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zichen Shangguan,Xingzhong Yuan,Longbo Jiang,Chencheng Qin,Xiangyan Chen,Jing Bai,Zhiyan Feng,Jingyi Wang,Hou Wang,Hui Wang
A Co Mn atomic switch reconstructs radical and non-radical PMC activation pathways. • Nominal waste O 2 is valorized into selective 1 O 2 via a unique cascade. • The non-radical route yields 13.3-fold rate hike and effluent detoxification. • High robustness is proven over 100-h continuous flow operation in real water matrices. Advanced oxidation processes (AOPs) hold great promise for pollutant abatement, yet selectively triggering non-radical pathways remains a formidable challenge, as radical and non-radical routes often compete kinetically. Here, by exploiting the confined framework of Silicalite-1 zeolites, we engineer bimetallic Co Mn sites where tailoring the Co/Mn ratio drives a structural evolution from isolated diatomic to nanoclusters, functioning as an atomic-scale switch to govern this competition in peroxymonocarbonate (PMC) activation. A Co-rich composition stabilizes atomically dispersed heteronuclear Co Mn sites featuring Mn-promoted Co(II) centers. This precise configuration kinetically inhibits direct peroxide cleavage and instead promotes interfacial single-electron transfer to oxygen (O 2 ), thereby valorizing this traditionally wasted byproduct into the non-radical singlet oxygen ( 1 O 2 ) generation. Conversely, a Mn-rich composition induces aggregated nanoclusters with abundant electron-deficient oxygen vacancies, which facilitate peroxy-bond dissociation and shift the reaction toward radical pathways. Corroborated by density functional theory and comprehensive experimental validations, this composition-dependent pathway regulation affords the optimized non-radical system a 13.3-fold kinetic enhancement and stable continuous-flow operation over 102 h. Download: Download high-res image (130KB) Download: Download full-size image
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Physiological Reports
·
2026
·Vol. 14
·期 11
·e70975
·
IF 2.1
Yunxian Wang,Fenglan Chu,Yanhua Gong,Ruihong Guo,Hui Dong
Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short-circuit current ( I sc ) in the murine ileum, which was significantly reduced by extracellular Cl − , Na + , and Ca 2+ removal. Mechanistically, MSG-induced I sc was significantly attenuated by pharmacological inhibition of key transporters (NCX, SGLT1, NKA) and secretory channels (CaCC, CFTR, IK Ca ). Furthermore, disrupting intracellular Ca 2+ homeostasis via endoplasmic reticulum (ER) chelation or blockade of IP 3 R, RyR, SOCE/CRAC, and VGCC significantly suppressed both the ileal I sc and MSG-stimulated Ca 2+ signaling in IECs. Importantly, MSG triggered a simultaneous elevation in intracellular Ca 2+ and a reduction in Na + , which were abolished by the blockers of NCX and SGLT1. In vivo, MSG-induced Ca 2+ -dependent ion transports were significantly reduced in irritable bowel syndrome with diarrhea (IBS-D) mice. Our findings indicate that MSG drives Ca 2+ -dependent intestinal ion transports through a complex network orchestrated by SGLT1 and NCX under healthy state, which is markedly attenuated in IBS-D. This study provides novel insights into the gastrointestinal impact of dietary MSG in both health and bowel disease.
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Small
·
2026
·
IF 11.8
Hui Wang,Xiang Li,Zitong Jiang,Qing Xu,Qiaoqin Guo,Chaozheng He,Junjun Zhang,Yaming Liu,Mingshang Jin
Direct ethanol fuel cells are promising clean energy devices, but the difficulty in cleaving the C─C bond of ethanol leads to low C1 pathway selectivity (typically ∼10%) and incomplete energy conversion. To address this challenge, we synthesized a porous multiphase Pd-based metallene nanocatalyst co-doped with oxygen-philic Cu and W. Temperature was identified as the key factor regulating the crystal structure: low temperatures yielded amorphous phases, high temperatures produced crystalline phases, and intermediate temperatures formed the desired crystalline/amorphous mixed multiphase structure. This multiphase structure provided abundant active sites. The optimal PdCuW metallene exhibited exceptional performance for ethanol electrooxidation: a record-high C1 pathway selectivity of 72.6% (1.6 times that of undoped Pd metallene and 10.2 times that of commercial Pd/C), a mass activity of 4301.6 mA/mg Pd (4.7 times that of commercial Pd/C), and superior stability (only 7.3% activity decay vs. 67.9% for commercial Pd/C). Mechanistic studies (In situ ATR-FTIR, DFT calculations) revealed that synergistic Cu-W doping reduced the C─C bond cleavage energy barrier, enhanced OH * adsorption, and weakened the poisoning effect of intermediate CO * . The work offers a rational design strategy for high-selectivity electrocatalysts, advancing ethanol's full energy utilization and holding broad implications for Pd-based catalyst systems in energy conversion technologies.
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ACS Nano
·
2026
·
IF 17.3
Hao Li,Shanghao Xiao,Yarong Liu,Yifan Zheng,Chongchong Chen,Wenjia Wu,Wenxiu Yang,Jingtao Wang
Precisely defining proton transport channels and regulating the chemical microenvironment of proton carriers are critical for high-performance proton exchange membranes (PEMs). Beyond optimizing carrier type and density, modulation of electron density distribution offers an underexplored route to enhance intrinsic proton conductivity. Herein, a series of ZnM-BDC-COOH nanosheets are synthesized by partial substitution of Zn2+ with a second metal ion in Zn-BDC frameworks and subsequent −COOH modification. The optimized ZnCu-BDC-COOH achieves a high intrinsic proton conductivity of 361.5 mS cm–1 over 16 times that of the pristine Zn-BDC (22.2 mS cm–1) at 80 °C and 98% RH using comb electrodes. Density functional theory and molecular dynamics simulations reveal that the introduced Cu2+, with higher electronegativity, withdraws more electrons from adjacent −COOH groups and Zn ions, generating asymmetric electron cloud distribution within the O–H bonds and the heterogeneous Zn3CuO(COO)6 nodes. This electron asymmetry facilitates rapid H+ release and establishes a strong local potential gradient that lowers the proton transport barrier. The resulting ZnCu-BDC-COOH lamellar membrane achieves a peak power density of 0.92 W cm–2, outperforming Nafion-117 (0.28 W cm–2), and maintains good durability over 100 h of open-circuit voltage (OCV) under 80 °C and 100% RH in fuel cells.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Tiwen Xu,Ruijie Ren,Junjie He,Fei Yan,Shuxin Guan,Shuyan Jiang,Junye Huang,Jingshui Xu,Ying Yang,Kaiyang Huang
Silica-hybridized carbon black (CB-SiO 2 ) shows a promising eco-friendly filler for tread rubber, combining the advantages of both potentially. Here, in situ hydrolyzed nano-SiO 2 anchored on CB particles was prepared by varying the tetraethyl orthosilicate (TEOS) dosage, and its effect on the properties of natural rubber (NR) composites was studied. Results demonstrated the existence of hydrogen bond between CB and SiO 2 , and increasing the anchored SiO 2 delayed curing, yet enhanced tensile strength by 35.6% and lowered rolling resistance (tan δ @60°C) by 22.7% while maintaining wear resistance (8 mL TEOS/10 g CB, no coupling agent). The improvement is attributed to the hybrid's higher specific surface area, favorable particle-size distribution, and surface protrusions, which strengthen rubber-filler interaction despite the reduced dispersive free energy ( γ s d $$ {\gamma}_s^d $$ ). This work presents a green and sustainable strategy for designing high-performance CB in its production process.
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ANNALS OF BIOMEDICAL ENGINEERING
·
2026
·
IF 5.2
Gao Zanhua,Lin Haoming,Yu Zhifan,Xu Huiqin,Chen Xin,Zhang Xinyu,Shen Yuanyuan
Purpose The development and progression of gliomas are intimately linked to abnormal tumor angiogenesis. Different grades of gliomas exhibit distinct vascular distribution and structural characteristics. Therefore, analyzing vascular architecture and hemodynamics can provide crucial insights into tumor growth and invasion. Methods Ultrasound localization microscopy (ULM) was applied to image the cerebrovascular changes in an orthotopic glioma mouse model at two different stages of tumor progression (14- and 21-days post-implantation). A total of twenty mice with intracranial glioma were imaged on the 14th day (n = 9) and on the 21st day (n = 11) after implantation. Pathological staining, vascular endothelial immunofluorescence examinations, and fluorescence dye perfusion were conducted to compare the ULM imaging results of the microvascular network morphology. Results By separating slow and fast blood flow signals, the ULM images revealed distinct vascular changes that visually correlated with H&E-derived pathological features. The vascular densities in glioma regions showed a significant increase compared to the contralateral side: 30.4% on day 14 (39.91% ± 4.09% vs. 30.60% ± 3.17%, p < 0.001) and 56.5% on day 21 (42.54% ± 3.78% vs. 27.17% ± 4.56%, p < 0.001) post-glioma implantation. The vascular densities obtained from ULM images correlated strongly and significantly with pathological and vascular perfusion results (CD31 and DiI perfusion). ULM-derived multiparametric analysis further revealed significantly reduced average vessel length in glioma regions at both Day 14 (123.72 ± 28.06 μm vs. 192.90 ± 27.75 μm, p < 0.001) and Day 21 (87.07 ± 22.92 μm vs. 233.79 ± 38.94 μm, p < 0.001), decreased blood flow velocity at Day 21 (3.70 ± 0.66 mm/s vs. 4.64 ± 0.82 mm/s, p < 0.001), and increased flow-orientation heterogeneity at both Day 14 (0.838 ± 0.082 vs. 0.595 ± 0.174, p < 0.001) and Day 21 (0.812 ± 0.086 vs. 0.625 ± 0.083, p < 0.001). Conclusion ULM imaging modality enables in vivo simultaneous structural-functional imaging of glioma microvasculature at micron-level resolution, capturing microcirculatory alterations across glioma regions. Its feasibility and reliability in visualizing vascular abnormalities were validated against ex vivo pathological and vascular perfusion, providing preclinical evidence for research and clinical applications in glioma therapy assessment and aggressiveness monitoring.
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ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 29
·21546-21557
·
IF 7.3
Fan Qingao,Wang Zijun,Xu Jing,Jia Yixin,Sun Tian,Li Tianbao,Yuan Mao-sen,Wang Jinyi,Tu Qin
Wearable
microneedle biosensors have garnered significant attention
for in situ analysis of biomarkers in interstitial fluid (ISF), providing
a minimally invasive approach for continuous health monitoring. Nevertheless,
there has been little advancement in the field of cancer diagnostics,
especially in the early diagnosis of skin cancer. Here, we introduce
a wearable microneedle patch with integrated Bluetooth connectivity
for the transdermal detection of tyrosinase (Tyr), a key biomarker
associated with melanoma. The platform integrates a highly swellable
hydrogel microneedle array for efficient ISF extraction, a high-sensitivity
electrochemical sensor (screen-printed carbon electrode modified with
catechol) for in situ analysis, and a miniaturized Bluetooth module
for wireless transmission of measured current signals. The hydrogel
microneedle patch successfully extracted 8.2 μL of ISF in 4
min, and the electrochemical sensor provided quantitative Tyr detection
with a sensitivity of 68.8 μA·mL·mg –1 and a low detection limit of 2.7 μg·mL –1 . Furthermore, the sensor exhibited excellent selectivity against
common interfering substances found in ISF. System validation using
agarose gel, porcine skin (in vitro), and rat skin (ex vivo) demonstrated
strong calibration linearities with R 2 = 0.985, 0.981, and 0.984, respectively. Recovery
rates relative to standard solutions exceeded 74.4% in vitro and 81.3%
ex vivo. Consequently, this microneedle-based platform represents
a promising and viable approach for the continuous, minimally invasive
monitoring of cutaneous biomarkers, with the potential to enable earlier
detection and more timely intervention for skin pathologies.
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