Nature Energy
·
2023
·Vol. 8
·期 10
·1158-1167
·
IF 56.7
Yan Luyao,Huang Hao,Cui Peng,Du Shuxian,Lan Zhineng,Yang Yingying,Qu Shujie,Wang Xinxin,Zhang Qiang,Liu Benyu,Yue Xiaopeng,Zhao Xing,Li Yingfeng,Li Haifang,Ji Jun,Li Meicheng
The fabrication of perovskite solar cells (PSCs) in ambient air can accelerate their industrialization. However, moisture induces severe decomposition of the perovskite layer, limiting the device efficiency. Here we show that sites near vacancy defects absorb water molecules and trigger the hydration of the perovskite, eventually leading to the degradation of the material. We demonstrate that guanabenz acetate salt eliminates both cation and anion vacancies, blocking the perovskite hydration and allowing the crystallization of a high-quality film in ambient air. With guanabenz acetate salt, we prepare PSCs in ambient air with a certified efficiency of 25.08%. The PSCs without encapsulation maintain around 96% of their initial efficiency after 2,000 hours of ageing in ambient air and after 500 hours of operating at the maximum power point under simulated air mass (AM) 1.5 G solar light in a N 2 atmosphere. The encapsulated devices retained 85% of their initial efficiency after 300 hours under damp heat conditions (85 °C and 85% relative humidity).
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Signal Transduction and Targeted Therapy
·
2025
·Vol. 10
·期 1
·1-17
·
IF 52.7
Tang Yu,Luo Zhiyuan,Ma Zhanni,Han Lingling,Zhou Yurong,Liang Tianci,Yang Kangsen,Zhao Lei,Chen Xiaoyuan,Zhang Pengfei
The variety and functionality of current clinical vaccine adjuvants remain limited. Conventional aluminum-based adjuvants predominantly induce Th2-biased humoral immunity but exhibit a limited capacity to elicit Th1-mediated cellular immune responses, particularly tumor antigen-specific cytotoxic CD8 + T lymphocytes (CTLs), which are essential for effective cancer vaccine performance. Inspired by natural biomolecular condensates, we developed a versatile noncovalent protein self-assembly strategy distinct from traditional approaches requiring structural domain modifications or bifunctional crosslinkers. Our methodology employs amphiphilic molecules (sodium myristate/SMA and sodium dodecyl thiolate/SDT) as molecular bridges to mediate protein‒protein interactions through hydrophobic forces and disulfide bond formation. This process generates nanoscale protein condensate (PCD) vaccines with exceptional stability. As a novel adjuvant system, these synthetic condensates significantly enhance antigen cross-presentation by optimizing key parameters: antigen loading capacity, lymph node targeting, cytosolic delivery, and lysosomal escape. Consequently, they induce robust antigen-specific CTL responses and humoral immunity, demonstrating potent antitumor efficacy. Importantly, we found that the synthetic protein condensate (PCD) alone can act as a nanoadjuvant. By increasing mitochondrial membrane permeability, PCD induces mitochondrial DNA leakage into the cytosol, activating the cGAS‒STING pathway and promoting DC maturation. This safe and scalable platform eliminates the need for complex covalent modifications or genetic engineering, and it facilitates the design of diverse modular antigens, including neoantigens and viral antigens. Given its straightforward manufacturing process and superior immunogenicity, this synthetic PCD vaccine adjuvant has significant potential for clinical application and translation.
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高影响因子
Signal Transduction and Targeted Therapy
·
2025
·Vol. 10
·期 1
·1-19
·
IF 52.7
Wang Baile,Liu Jie,Wang Qin,Arhatte Malika,Cheong Lai Yee,Glogowska Edyta,Jiang Xue,Chung Sookja Kim,Jin Leigang,Hu Qianxing,Wang Yu,Honoré Eric,Xu Aimin
With aging or osteoporosis, bone marrow adipogenesis is increased and inversely correlates with the loss of bone mass. Bone marrow adipocytes are derived from multipotent bone marrow mesenchymal stem cells (BMMSCs), which can differentiate into either fat or bone. BMMSCs are mechanosensitive cells, but how mechanical loading is implicated in the in vivo regulation of bone marrow adipogenesis and its impact on bone remodeling remain poorly understood. Here, we identify the mechanosensitive cationic channel Piezo1 in BMMSCs as a key suppressor of bone marrow adipogenesis by preventing local inflammation, thereby enhancing osteoblast differentiation and bone formation. Mice with a specific Piezo1 invalidation in BMMSCs exhibit osteoporosis and marrow adiposity, together with resistance to the beneficial effects of exercise on bone health. Accordingly, Piezo1-deficient BMMSCs in vitro preferentially differentiate into adipocytes rather than osteoblasts. Invalidation of Piezo1 in BMMSCs enhances the autocrine activation of CCR2 by Ccl2, which further induces lipocalin-2 (Lcn2) production via NF-κB activation, thereby promoting adipocyte differentiation. Conversely, Piezo1 opening induces Klf2 expression through CaMKII, preventing c-Jun activation, Ccl2 production and bone marrow adipogenesis. These findings demonstrate that Piezo1 activation in BMMSCs suppresses bone marrow adipogenesis to maintain bone strength by preventing the Ccl2-Lcn2 inflammatory autocrine loop, thus uncovering a previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
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NATURE
·
2025
·Vol. 647
·期 8091
·889-896
·
IF 48.5
Xue Yaoting,Cao Jiasheng,Feng Tao,Zhang Kaihang,Li Siyang,Hu Jiahao,Guo Haotian,Zhang Jinming,Song Yaoxian,Wang Zhuofan,Wang Lei,Huang Qishan,Zhou Haofei,Zhou Fanghao,Shen Jiliang,Fan Yaowei,Wang Zhe,Li Xinge,Wong Jie-Wei,Chen Zhiwei,Ruan Dongrui,Miao Zhikun,Zhang Bin,Zhou Enjie,Gan Letian,Wang Xuanqi,Cao Ertai,Chen Tong,Zou Weifeng,Zhang Junhui,Lu Haojian,Zhang Qinghai,Liu Song,Dong Huixu,Xiong Shiying,Peng Shuyou,Wong Tuck-Whye,Chen Yuanjie,Li Tiefeng,Chen Mingyu,Yang Xuxu,Yang Wei,Cai Xiujun
Mechanical transmission is essential in force-related activities ranging from the daily tying of shoe laces 1 to sophisticated surgical 2 and robotic operations 3 , 4 . Modern machines and robots typically use complex electronic devices designed to sense and limit force 5 , some of which still face challenges when operating space is limited (for example, in minimally invasive surgeries) 6 or when resources are scarce (for example, operations in remote areas without electricity). Here we describe an alternative slipknot-based mechanical transmission mechanism to control the intelligent operation of both human and robotic systems. Through topological design, slipknot tying and release can encode and deliver force with a consistency of 95.4% in repeating operations, which circumvents the need for additional sensors and controllers. When applied to surgical repair, this mechanism helped inexperienced surgeons to improve their knotting-force precision by 121%, enabling them to perform surgical knots as good as those of experienced surgeons. Moreover, blood supply and tissue healing after surgery were improved. The mechano-intelligence exhibited in slipknots may inspire investigations of knotted structures across multiple length scales. This slipknot-gauged mechanical transmission strategy can be widely deployed, opening up opportunities for resource-limited healthcare, science education and field exploration.
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CELL RESEARCH
·
2022
·Vol. 32
·期 7
·638-658
·
IF 46.297
Wang Xiaomin,Chen Ziqi,Xu Jun,Tang Shuai,An Nan,Jiang Lei,Zhang Yixiang,Zhang Shaoying,Zhang Qingli,Shen Yanyan,Chen Shijie,Lan Xiaojing,Wang Ting,Zhai Linhui,Cao Siyuwei,Guo Siqi,Liu Yingluo,Bi Aiwei,Chen Yuehong,Gai Xiameng,Duan Yichen,Zheng Ying,Fu Yixian,Li Yize,Yuan Liang,Tong Linjiang,Mo Kun,Wang Mingcheng,Lin Shu-Hai,Tan Minjia,Luo Cheng,Chen Yi,Liu Jia,Zhang Qiansen,Li Leping,Huang Min
Mutant isocitrate dehydrogenase 1 (mIDH1) drives tumorigenesis via producing oncometabolite R-2-hydroxyglutarate (R-2-HG) across various tumor types. However, mIDH1 inhibitors appear only effective in hematological tumors. The therapeutic benefit in solid tumors remains elusive, likely due to the complex tumor microenvironment. In this study, we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis, conferring a therapeutic vulnerability in IDH1-mutant solid tumors. Mechanistically, SLC1A1, a Na + -dependent glutamate transporter that is preferentially expressed in endothelial cells, facilitates the influx of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria. R-2-HG hijacks SLC1A1 to promote mitochondrial Na + /Ca 2+ exchange, which activates the mitochondrial respiratory chain and fuels vascular endothelial cell migration in tumor angiogenesis. SLC1A1 deficiency in mice abolishes mIDH1-promoted tumor angiogenesis as well as the therapeutic benefit of mIDH1 inhibitor in solid tumors. Moreover, we report that HH2301, a newly discovered mIDH1 inhibitor, shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models. Together, we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular endothelial cells, and demonstrate the therapeutic potential of mIDH1 inhibitors in treating IDH1-mutant solid tumors via disrupting R-2-HG-promoted tumor angiogenesis.
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Nature Electronics
·
2025
·
IF 40.9
He Jing,Ge Jifeng,Xue Junying,Xia Tingyi,Dai Yongping,Wang Shengqi,Li Wenjie,Lin Zhaoyang
Solution-processed two-dimensional semiconductors could be used to create electronic devices on large scales and at low cost. However, the electronic performance of devices based on such materials is typically below that of devices based on materials grown via high-temperature chemical vapour deposition. Here we report the fabrication of indium selenide (InSe) semiconductor thin films using a colloidal solution of monolayer nanosheets (monolayer purity more than 98%). The InSe thin films are assembled on 4-inch wafers with conformal and intimate van der Waals contacts between the monolayer building blocks. We use the solution-processed films to fabricate InSe transistors that exhibit electron mobilities of 90–120 cm 2 V −1 s −1 , current on/off ratios of up to 10 7 and a small current hysteresis. We also show that InSe transistors with oxide encapsulation can remain stable in air for 3 months.
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Nature Sustainability
·
2022
·Vol. 5
·期 12
·1080-1091
·
IF 27.157
Xia Yongsheng,Cao Hongyan,Xu Fang,Chen Yuxin,Xia Yu,Zhang Dezhu,Dai Liheng,Qu Kai,Lian Cheng,Huang Kang,Xing Weihong,Jin Wanqin,Xu Zhi
Membrane technologies with low environmental impacts and ease of use have a wide spectrum of applications, with the potential to provide more sustainable solutions in domains such as water, energy and pollution treatment. However, the design of membranes is subject to a trade-off between ion conductivity and selectivity. Here we show a composite polymeric membrane that breaks this dilemma and supports both high proton conductivity (80.1 mS cm −1 ) and good vanadium ion selectivity (2.01 × 10 5 S min cm −3 ). Underlying this synthetic success is a flow-processing technique through which zeolite nanosheet fillers are oriented in a preferred direction throughout a polymer Nafion matrix. As a result, pairing this aligned membrane with a vanadium flow battery leads to a high energy efficiency of >80% at 200 mA cm −2 and remarkable stability over 1,000 cycles. This work enables the design of membranes that combine otherwise mutually exclusively properties for many possible applications beyond energy storage.
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Nature Biomedical Engineering
·
2025
·
IF 26.6
Zhang Xiaoguang,Feng Xiaobo,Ma Liang,Lei Jie,Li Gaocai,Zhang Weifeng,Liang Huaizhen,Tong Bide,Wu Di,Yang Cao,Tan Lei
The antimicrobial effect of antimicrobial peptides is typically slow; they can be rapidly biodegraded and often have non-selective toxicity and elaborate sequences. Here we report a short peptide that is activated by ultrasound, that shows high broad-spectrum antibacterial efficiency (>99%) against clinically isolated methicillin-resistant bacteria (specifically, Staphylococcus aureus , Escherichia coli , Staphylococcus epidermidis , Enterobacter cancerogenus and Pseudomonas aeruginosa ) with 15 min of ultrasound irradiation, and that has negligible toxicity and low self-antibacterial activity. We selected the peptide, FFRKSKEK (a segment from the human host-defence LL-37 peptide), from a library of peptides with piezoelectric diphenylalanine (FF) sequences, low toxicity, hydrophobicity and net positive charge. We show via all-atom molecular dynamics simulations that ultrasound amplifies the membrane-penetrating ability of peptides with FF sequences and that its piezoelectric polarization generates reactive-oxygen species and disturbs bacterial electron-transport chains. In a goat model of hard-to-treat intervertebral infection, the sonosensitive peptide led to better outcomes than vancomycin. Antimicrobial peptides activated by ultrasound may offer a clinically relevant strategy for combating antibiotic-resistant infections.
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Nano-Micro Letters
·
2023
·Vol. 16
·期 1
·1-16
·
IF 26.6
Yang Ya’nan,Wang Jiaqi,Wang Zhe,Shao Changxiang,Han Yuyang,Wang Ying,Liu Xiaoting,Sun Xiaotong,Wang Liru,Li Yuanyuan,Guo Qiang,Wu Wenpeng,Chen Nan,Qu Liangti
AbstractSection
Highlights
An efficient moist-electric generator with ultra-fast electric response to moisture is achieved by triggering Grotthuss protons hopping in the moisture-electric–moisture-sensitive heterostructure.
The moist-electric generator produces a quick response (0.435 s), an unprecedented ultra-fast response rate of 972.4 mV s −1 to alternating moisture stimulation and stable output for 8 h.
An obstructive sleep apnea hypoventilation syndrome diagnostic system based on a moist-electric generator was developed to monitor hypopnea and apnea in real time and successfully diagnose them with early warning.
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Nano-Micro Letters
·
2023
·Vol. 15
·期 1
·1-16
·
IF 26.6
Luo Zhen,Xia Yufan,Chen Shuang,Wu Xingxing,Zeng Ran,Zhang Xuan,Pan Hongge,Yan Mi,Shi Tingting,Tao Kai,Xu Ben Bin,Jiang Yinzhu
The synergistic “anchor-capture” mechanism of polar groups on Zn stripping/plating process is firstly proposed.
The amino group firmly anchors on Zn surface and the carboxyl group strongly captures Zn 2+ , constructing a robust anode–electrolyte interface and inducing uniform Zn deposition.
The ultra-stable cycle lifespan of Zn–Zn symmetric cell (over 2800 h) and high utilization rate of Zn anode (the depth of discharge up to 68% for 200 h) are achieved under the proposal of synergistic “anchor-capture.”
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Nano-Micro Letters
·
2023
·Vol. 16
·期 1
·1-13
·
IF 26.6
Lu Wenjiang,Deng Qixuan,Liu Minsu,Ding Baofu,Xiong Zhiyuan,Qiu Ling
A core-sheath structured coaxial composite fiber with highly aligned and densely stacked boron nitride nanosheets arrangements in the sheath was successfully fabricated.
The coaxial fibers have an ultrahigh axial Herman orientation parameter of 0.81, thermal conductivity of 17.2 W m −1 K −1 , and tensile strength of 192.5 MPa.
The coaxial fibers exhibit intensively potential applications in the wearable thermal management textile.
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Nano-Micro Letters
·
2023
·Vol. 16
·期 1
·1-13
·
IF 26.6
Xiao Guang,Li Hao,Yu Zhizhou,Niu Haoting,Yao Yagang
Highly thermally conductive composite films with elimination of graphene nanosheet wrinkles prepared by a constrained drying strategy of in-plane stretching.
Reveals the mechanism of graphene nanosheet wrinkle elimination to improve the thermal conductivity of composite films and demonstrates its use as a heat sink film for cooling flexible LED chips and smartphones.
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