CHINESE JOURNAL OF CATALYSIS
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2026
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IF 17.2
Han Xiang,Lu Lin,Yu Li,Qisong Yi,Chaoran Jiang,Rui Chen,Yuanshuai Liu,Na Sai,Jinlu He,Fenghua Bai,Wenhao Luo
Selective hydrogenation of furfural (FFL) to furfuryl alcohol (FAL) represents a pivotal paradigm in sustainable biomass valorization. In this work, nanoscale Cu clusters were encapsulated in silicalite-1 (S-1) zeolite using in-situ synthesis, and further modified by a rare-earth element of La for regulating the catalyst microenvironment. The obtained La-Cu@S-1 can provide an enhanced performance in the FFL-to-FAL transformations, with 98.6% conversion of FFL and 99% selectivity of FAL at 110 °C, 20 bar H 2 , and 3 h. Besides, La-Cu@S-1 shows a good stability without apparent catalyst deactivation upon four consecutive runs. Extensive characterization research reveals that La addition could provide anchoring sites for Cu nanoclusters via an enhanced electronic interaction, thereby effectively suppressing metal leaching and agglomeration during the liquid-phase catalysis. Additionally, La addition could modulate the zeolite microenvironment of encapsulated Cu nanoparticles and notably stabilize the conventionally unstable Cu + species at a high proportion, even in a reductive H 2 atmosphere during catalysis, accounting for the enhanced activity and stability. This study showcases La modification as an efficient approach to rationally develop metal-zeolite combinations with enhanced performance, promoting potential utilization and development of rare-earth elements in the valorization of biomass and other renewable energy.
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Nature Communications
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2026
·
IF 18.1
Tang Jiawen,Zhang Junyu,Liu Jiacheng,Li Yunsong,Shao Ahu,Wang Zhiqiao,Wang Xin,Jia Qiurong,Liu Ting,Liu Zhe,Wang Jian-Gan,Wang Zhaohui,Xu Fei,Ma Yue
Practical implementation of solid polymer electrolytes is constrained by interfacial instability and manufacturing scalability. Here, we report a roll-to-roll compatible, 9.6-μm-thick solid polymer electrolyte membrane synthesized via in situ 1,3-dioxolane polymerization catalyzed by Lewis-acidic Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 on a polyethylene matrix, achieving a 99.1% conversion rate. The resulting membrane demonstrates 191.7 MPa mechanical strength and 418.7 mS ionic conductance at 25 °C. To resolve multiscale interfacial incompatibilities, a dual-additive strategy is employed: tris(4-fluorophenyl) phosphine constructs a fluorine-rich interphase extending positive electrode tolerance to 4.8 V, while Mg(TFSI) 2 forms a Li–Mg alloy lowering the negative electrode Li⁺ diffusion barrier to 0.127 eV. Validated in 1.2 Ah pouch cells, this system attains specific energy and energy density of 456.7 Wh kg⁻ 1 and 911.1 Wh L⁻ 1 (based on the total mass and volume of the pouch cell, respectively), stable wide-temperature cycling (−20 to 55 °C), and prevents thermal propagation under abuse conditions.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Xijia Zhang,Xiaojian Fei,Hongbin Pu,Weibin Zhao,Qingyi Wei,Zhiwei Zhu
In situ HKUST-1 growth created a hierarchically porous hydrocolloid aerogel. • Polymer macropores and MOF pore domains jointly regulated carvacrol loading and release. • Humidity build-up triggered sustained rather than front-loaded carvacrol release. • Vapour phase carvacrol effectively inhibited bacterial and Botrytis cinerea growth. • PCTH@CAR delayed strawberry deterioration by maintaining texture and water status. Excessive moisture sensitivity of pristine HKUST-1 often causes rapid framework collapse and burst release under highly humid conditions, limiting its use as a humidity-triggered carrier for volatile antimicrobials. Here, we report a hierarchically porous composite aerogel constructed by in situ growth of HKUST-1 within a poly (vinyl alcohol)/carboxymethyl chitosan/TEMPO-oxidised cellulose nanofiber network, followed by carvacrol (CAR) loading to obtain PCTH@CAR. This confined growth architecture regulated metal organic framework (MOF) distribution, helped moderate moisture-induced structural disruption, and coupled polymer-derived macropores with MOF micropores, thereby improving cargo accommodation and release control. The cumulative CAR release reached 54.32% after 12 d even at 15% RH, while at 98% RH it reached 34.61% after 2 d and 81.99% after 12 d, with release sustained throughout storage rather than concentrated at the initial stage. The aerogel also showed effective vapour phase antimicrobial activity against Escherichia coli , Staphylococcus aureus , and Botrytis cinerea . In strawberry packaging, PCTH@CAR delayed visible spoilage and reduced weight loss from 20.45% to 2.04% after 8 d, whereas untreated strawberries had already lost marketability by day 4 owing to evident mould growth and softening. These results support in situ grown HKUST-1 within a hierarchically porous biopolymer aerogel as a practical route to non-contact, humidity-adaptive active packaging for postharvest preservation. Download: Download high-res image (211KB) Download: Download full-size image
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FOOD CHEMISTRY
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2026
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IF 10.4
Maratab Ali,Huizhi Chen,Weijie Wu,Ben Niu,Xiangjun Fang,Chaoyi Shen,Guannan Wang,Hangjun Chen,Ting Huang,Ming Yin,Ruiling Liu,Haiyan Gao
1-MCP upregulated the sugar and organic acid metabolism in goji berry. • Malic and fructose were main organic acid and sugar in goji berry. • 1-MCP interlinked sugar-acid homeostasis with extended shelf life of goji berry. • Molecular docking showed possible 1-MCP led modulations in enzyme function. • 1-MCP maintained postharvest quality and storage potential of goji berries. This study investigated postharvest quality and shelf life of “Ningnongqi 17” goji berries under 1-MCP-mediated sugar-acid metabolism. The results showed that 1-MCP-treated goji berries exhibited delayed firmness loss, TA loss, and color, along with a slower increase in TSS/TA ratio, weight loss, decay rate, and EL than control (CK). 1-MCP enhanced citric, succinic, fumaric, and malic acids accumulation by upregulating PEPC, CS, and NAD-MDH and suppressing ACL, ACO, and SDH enzymes and their transcription. Meanwhile, sucrose levels increased, and glucose and fructose remained lower via downregulated AI, NI, SS-c, and upregulated SPS and SPP enzymes and their transcription. Notably, malic acid and fructose were identified as the main organic acid and sugar in berries. Correlation analysis linked elevated malic, succinic, and sucrose levels with improved firmness, color, TSS, and lower weight loss, decay rate, and EL in treated berries. In conclusion, 1-MCP delayed ripening and senescence by maintaining optimal sugar-acid homeostasis, resulted in improved quality and extended shelf life of fresh goji berries. Download: Download high-res image (250KB) Download: Download full-size image
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Stem Cell Research & Therapy
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2026
·Vol. 17
·期 1
·123
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IF 7.8
Du Mengxian,Guo Fengyi,Liu Xinna,Zhang Shiqi,Zhang Di,Qiu Leyi,Zhang Jingyang,Li Baoqiang,Yuan Huiping
Background Normal tension glaucoma (NTG) causes progressive retinal ganglion cell (RGC) loss without elevated intraocular pressure, and currently lacks effective neuroprotective therapies. OPTN(E50K) mutation, a pathogenic gene of NTG, compromises paracrine trophic capacity in bone marrow (BM) stem cells. Allogeneic young BM stem cells can provide trophic support and exhibit therapeutic potential; however, their clinical application is limited by immunogenic rejection and tumorigenic risks, prompting a renewed interest in rejuvenate autologous BM stem cells strategy. Methods To address these challenges, we developed a composite chitosan-rapamycin (RAPA) carbon dots (CRCD) to restore the reparative potential of autologous BM stem cells. BM stem cells from aged OPTN(E50K) mice were isolated, clustered and treated with CRCD before validated their changes of neurotrophic factors expression as well as oxidative stress and autophagy indicators. Then we assessed their impact on co-cultured retinas in vitro. Transplantation were performed into lethally irradiated age-matched OPTN(E50K) hosts with CRCD-pretreated autologous BM stem cells via tail vein injection, and generated stable chimeric models. Neurotrophic factors and neuron apoptosis analyses were performed, followed by the visual behavioral tests. Results Our results demonstrated that CRCD pretreatment enhanced autophagy, reduced oxidative stress, and augmented paracrine neurotrophic release. In vitro, these cells reduced retinal ganglion cell apoptosis and promoted neurotrophic factor expression in co-cultured retinal explants. In vivo, comparative analysis revealed that CRCD intervention significantly elevated neurotrophic factor expression in retinal tissues compared to RAPA-treated and untreated chimeras. Functional assessments further confirmed superior visual performance in CRCD-Sca-1 + chimeras, correlating with improved RGC survival. Conclusion These findings suggest that CRCD improved paracrine neurotrophic support of autologous BM stem cells by enhancing their autophagy and paracrine functions, leading to structural and functional rescue of the glaucomatous retina. This approach offered a clinically relevant strategy for NTG, providing sustained neuroprotection while avoiding the risks of allogeneic transplantation and repeated intravitreal drug delivery. Graphical The alternative text for this image may have been generated using AI.
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Journal of the Taiwan Institute of Chemical Engineers
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2026
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IF 6.9
Yulin Zhou,Shuang Tan,Qiangqiang Liu,Xingwen Zheng,Bochuan Tan,Riadh Marzouki
Background Q235 steel is susceptible to severe corrosion during the pickling process, especially in hydrochloric acid media, which not only shortens the service life of the equipment, but also may cause safety hazards and environmental pollution. Methods : A bis-triazole Schiff base carboxylic acid (BTSCA) was synthesized, named the 5-((4-(4H-1,2,4-triazol-4-yl) benzylidene) amino)-1H-1,2,4-triazole-3-carboxylic acid. The present study investigates the inhibitory performance of Q235 steel in a 1 M HCl solution containing BTSCA. The experimental methods adopted were weight loss method and electrochemical method. Significant findings : The results show that BTSCA has a good inhibitory efficiency on Q235 steel in 1 M HCl solution, which can reach 98.98%. Kinetic and thermodynamic analyses explained inhibitory mechanism of the compound, and the results showed that the adsorption behavior was in accordance with the Langmuir isotherm. The surface morphology of Q235 steel was characterized by scanning electron microscope (SEM) and atomic force microscope (AFM). Density functional theory (DFT) was used to analyze the inhibitory mechanism of BTSCA. Combined with molecular dynamics simulation (MD), the most stable configuration, adsorption sites and adsorption energy of BTSCA on the steel surface were determined.
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FOOD AND CHEMICAL TOXICOLOGY
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2026
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IF 3.2
Yuzhen Xia,Fang Wang,Lisha Zhao,Bingfeng Lin,Pingcui Xu,Lingmin Lu,Nani Wang
Nanoplastics (NPs) induce ferroptosis in endothelial cells and zebrafish. • NPs disrupt unsaturated fatty acid metabolism in zebrafish. • NPs downregulate GPX4 and induce lipid peroxidation in vitro and in vivo. • Targeting ferroptosis mitigates NPs-related cardiovascular injury. Nanoplastics (NPs) are widespread environmental pollutants, and their potential cardiovascular toxicity has raised growing concern. This study aimed to investigate whether NPs impair angiogenesis through ferroptosis induction. Zebrafish larvae were exposed to NPs (10-1000 μg/L) or erastin (5 μM) for 48 h. Rescue experiments were performed by co-treatment with ferrostatin-1 (Fer-1, 1 μM). Human microvascular endothelial cell line-1 were treated with NPs at 100 μg/mL for 24 h, with or without Fer-1 (1 μM). NPs exposure resulted in reduced body length, impaired intersegmental vessel formation, and downregulated expression of key angiogenesis-related genes in zebrafish larvae. Additionally, NPs inhibited tube formation, migration, and vascular endothelial growth factor A expression in HMEC-1 cells. Transcriptomic and metabolomic analyses revealed that NPs exposure disrupted unsaturated fatty acid metabolism. NPs induced lipid peroxidation, reactive oxygen species accumulation, elevated malondialdehyde levels, and downregulation of glutathione peroxidase 4 expression, all of which were reversed by treatment with the ferroptosis inhibitor Fer-1. Intervention with Fer-1 not only rescued NPs-induced intersegmental vessel defects but also upregulated the expression of angiogenesis-related genes, thereby effectively ameliorating NPs-induced vascular damage. These findings indicate that ferroptosis is a key mechanism underlying NPs-mediated vascular dysfunction.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Keke Zhang,Shiqi Li,Xiaocan Sun,Hongkun Ma,Ying Li,Yu Pan,Jingruo Liu,Xianru Geng,Yingchao Wan,Dan Wu
Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver injury. Thrombospondin-1 (Thbs-1) is associated with NAFLD and has the potential to reduce lipid accumulation in hepatocytes. The aim of the study was to construct and screen truncated Thbs-1 polypeptide, and to investigate the function in palmitic acid (PA)-induced AML12 cells and High-fat diet (HFD)-induced C57BL/6 mice. The recombinant truncated Thbs-1 plasmids were constructed and the polypeptides were purified. The effects of the polypeptides were investigated in PA-induced AML12 cells and HFD-induced mice to screen the target polypeptide. The results showed that TSRC could alleviate the histopathological changes of NAFLD mice, reduce the expression of inflammatory factors and lipid metabolism-related factors. In conclusion, TSRC could ameliorate inflammation and lipid accumulation in PA-induced AML12 cells, relieve liver pathological changes, improve liver function, and effectively alleviate NAFLD in HFD-induced C57BL/6 mice.
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高影响因子
ACS Nano
·
2025
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IF 16
Xiao Sun,Yufang Gong,Haiyan Ge,Guiqi Ma,Tianxing Yang,Mengyao Mu,Le Zhang,Chenyu Wang,Bowen Shen,Xiaohui Dai,Zhengyan Wu,Xinyu Zhang,Qing Fan,Hongzan Sun
Visualizing tumor programmed cell death ligand 1 (PD-L1) expression and synchronously using this target for effective tumor therapy present great prospects for clinical application. In this study, a gadolinium-hybridized platinum nanoplatform with dimeric PD-L1-antagonistic affibody (ZPD-L1) (GPPZ) was constructed. Leveraging the specific binding between ZPD-L1 and the tumor surface, ZPD-L1 could endow this nanoplatform with efficient PD-L1 targeting, enabling the efficient magnetic resonance imaging (MRI) visualization of PD-L1 expression. GPPZ, through its catalase- and peroxidase-like activities, can catalyze the production of O2 and the production of •OH, respectively, sensitizing radiotherapy and enhancing immunogenic cell death. In addition, ZPD-L1 can also terminate T cells’ immune suppression by effectively inhibiting interactions of PD-1/PD-L1 to further enhance tumor immunotherapy. Systemic delivery of GPPZ resulted in MRI contrast enhancement of tumors with high levels of PD-L1 expression. Importantly, no obvious side effects can be observed in both histological and hematology examination. Therefore, this nanoplatform demonstrated promise for enhanced MRI visualization of tumor PD-L1 level and synergistic radio immunotherapy.
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PubMed
高影响因子
APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Xiaofei Zhang,Zhaozhu Qu,Xiaohui Sun,Wei Wu,Xiangpeng Guan,Qirong Xu,Jianwei Wu,Guohua Wu,Bo Wang,Ruihui Peng,Nana Liu,Xiangwei Wang,Xuyang Zhang
This study synthesizes mixed-phase vanadium oxide (V x O 2x+1 ) thin films with dual electrochromic and capacitive functionalities through a synergistic combination of sol–gel processing, electrochemical deposition, and thermal annealing. The VO-350 film, annealed at 350 °C, exhibits a hierarchically ordered “dense-layer/porous-interior” architecture, achieving exceptional areal capacitance and superior optical modulation. This single-material system exhibits an unparalleled four-state multicolor switching capability (yellow, green, blue and brown) with rapid kinetics (<20 s) and ultrahigh cycling stability, retaining 51.29% of its initial capacitance and exhibiting zero optical modulation decay after 2,000 cycles. When integrated into VO-350/WO 3 electrochromic devices, the system delivers dual-band high modulation (58.39% @750 nm and 59.11% @1000 nm after 3000 cycles) alongside enhanced switching dynamics. This work pioneers a methodology that precisely orchestrates reduction potentials and thermal annealing strategies to directionally regulate vanadium oxidation states, crystallographic phases, and morphological features, this establishes a standardized paradigm for designing dual-functional electrochromic capacitors.
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Scientific Reports
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2026
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IF 4.9
Xiang Qingqing,Yu Rong,Huang Li,Liu Qingqing,Qin Nuo,Wang Li,Wu Yan,Fu Hang
Due to a lack of complete mechanistic understanding, there are no specific therapeutics for necrotizing enterocolitis (NEC), a deadly gastrointestinal disease affecting premature newborns. While sodium butyrate offers intestinal protection, its efficacy is strictly dose-dependent, and the underlying mechanisms regulating intestinal epithelial cell (IEC) survival remain elusive. Here, using neonatal murine NEC models and human IECs, we demonstrate that moderate-dose butyrate (50 mg/kg) significantly attenuates mucosal injury and improves survival, whereas high-dose butyrate (250 mg/kg) exacerbates mortality by inducing complex cell death pathways including necroptosis and ferroptosis. Mechanistically, moderate butyrate suppresses glycolysis and intracellular lactate production, which restores expression of the translational regulator PABPC1; PABPC1 then binds to YB-1 mRNA to enhance YB-1 protein synthesis without altering transcription. Elevated YB-1 subsequently binds BCL-2 mRNA, increasing BCL-2 protein levels to inhibit intrinsic mitochondrial apoptosis. Functional validation shows that YB-1 knockdown abolishes butyrate-mediated protection and exacerbates TNF-α-induced apoptosis, while YB-1 overexpression rescues cell viability, and exogenous lactate supplementation reverses these effects by suppressing the PABPC1-YB-1 axis. These findings elucidate a novel Lactate-PABPC1-YB-1-BCL-2 signaling axis through which butyrate safeguards the intestinal epithelium, highlighting precise dosing and the modulation of epithelial translational control as promising therapeutic strategies for NEC.
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PubMed
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
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2026
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IF 5.2
Zhuohua Cao,Siyu Men,Zhenhua Li,Gang Liu,Qingying Su,Xinran Chen,Xianhua Che,Hanyong Jin
Organophosphate esters (OPEs) are widespread environmental contaminants increasingly recognized for their metabolic-disruption potential. However, systematic cross-structure comparisons of their inhibitory effects on human carboxylesterase 1 (hCES1), an enzyme involved in xenobiotic metabolism and lipid homeostasis, remain limited. Here, we established an OPE-centered cross-structure inhibition dataset for hCES1 using 25 structurally diverse organophosphate compounds, revealing a pronounced structure-dependent potency pattern across the series (IC 50 : 2.538 nM to > 600 μM). More potent inhibition was enriched among compounds bearing P=O motifs and aryl-containing substituents, although the overall activity pattern could not be explained by any single empirical structural label. To resolve the determinants underlying this stratification, we developed complementary QSAR models. The 2D-QSAR models captured global descriptor-level trends but showed only moderate predictive ability ( R 2 ≥ 0.918, q 2 ≥ 0.508), whereas the scaffold-based 3D-QSAR models (CoMFA and CoMSIA) offered a more spatially informative explanation of activity variation ( R 2 ≥ 0.947, q 2 ≥ 0.374, RMSE ≤ 0.420), indicating that steric, electrostatic, hydrophobic, and hydrogen-bonding effects jointly shape hCES1 inhibition. Molecular docking further showed that more potent aryl-rich compounds achieved broader hydrophobic occupancy and denser nonpolar contacts within the hCES1 catalytic cavity. Complementary quantum-chemical analyses indicated that the phosphorus center was the major electron-deficient site, while phosphorus-centered bonding environments and side-chain features contributed differently to electrophilic susceptibility and pocket recognition. Overall, hCES1 inhibition by organophosphate compounds can be interpreted within a layered SAR framework in which side-chain-mediated cavity recognition and phosphorus-centered electronic effects jointly shape inhibitory activity.
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高影响因子
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