CHINESE JOURNAL OF CATALYSIS
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2026
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IF 17.2
Han Xiang,Lu Lin,Yu Li,Qisong Yi,Chaoran Jiang,Rui Chen,Yuanshuai Liu,Na Sai,Jinlu He,Fenghua Bai,Wenhao Luo
Selective hydrogenation of furfural (FFL) to furfuryl alcohol (FAL) represents a pivotal paradigm in sustainable biomass valorization. In this work, nanoscale Cu clusters were encapsulated in silicalite-1 (S-1) zeolite using in-situ synthesis, and further modified by a rare-earth element of La for regulating the catalyst microenvironment. The obtained La-Cu@S-1 can provide an enhanced performance in the FFL-to-FAL transformations, with 98.6% conversion of FFL and 99% selectivity of FAL at 110 °C, 20 bar H 2 , and 3 h. Besides, La-Cu@S-1 shows a good stability without apparent catalyst deactivation upon four consecutive runs. Extensive characterization research reveals that La addition could provide anchoring sites for Cu nanoclusters via an enhanced electronic interaction, thereby effectively suppressing metal leaching and agglomeration during the liquid-phase catalysis. Additionally, La addition could modulate the zeolite microenvironment of encapsulated Cu nanoparticles and notably stabilize the conventionally unstable Cu + species at a high proportion, even in a reductive H 2 atmosphere during catalysis, accounting for the enhanced activity and stability. This study showcases La modification as an efficient approach to rationally develop metal-zeolite combinations with enhanced performance, promoting potential utilization and development of rare-earth elements in the valorization of biomass and other renewable energy.
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Nature Communications
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2026
·
IF 18.1
Tang Jiawen,Zhang Junyu,Liu Jiacheng,Li Yunsong,Shao Ahu,Wang Zhiqiao,Wang Xin,Jia Qiurong,Liu Ting,Liu Zhe,Wang Jian-Gan,Wang Zhaohui,Xu Fei,Ma Yue
Practical implementation of solid polymer electrolytes is constrained by interfacial instability and manufacturing scalability. Here, we report a roll-to-roll compatible, 9.6-μm-thick solid polymer electrolyte membrane synthesized via in situ 1,3-dioxolane polymerization catalyzed by Lewis-acidic Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 on a polyethylene matrix, achieving a 99.1% conversion rate. The resulting membrane demonstrates 191.7 MPa mechanical strength and 418.7 mS ionic conductance at 25 °C. To resolve multiscale interfacial incompatibilities, a dual-additive strategy is employed: tris(4-fluorophenyl) phosphine constructs a fluorine-rich interphase extending positive electrode tolerance to 4.8 V, while Mg(TFSI) 2 forms a Li–Mg alloy lowering the negative electrode Li⁺ diffusion barrier to 0.127 eV. Validated in 1.2 Ah pouch cells, this system attains specific energy and energy density of 456.7 Wh kg⁻ 1 and 911.1 Wh L⁻ 1 (based on the total mass and volume of the pouch cell, respectively), stable wide-temperature cycling (−20 to 55 °C), and prevents thermal propagation under abuse conditions.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Xijia Zhang,Xiaojian Fei,Hongbin Pu,Weibin Zhao,Qingyi Wei,Zhiwei Zhu
In situ HKUST-1 growth created a hierarchically porous hydrocolloid aerogel. • Polymer macropores and MOF pore domains jointly regulated carvacrol loading and release. • Humidity build-up triggered sustained rather than front-loaded carvacrol release. • Vapour phase carvacrol effectively inhibited bacterial and Botrytis cinerea growth. • PCTH@CAR delayed strawberry deterioration by maintaining texture and water status. Excessive moisture sensitivity of pristine HKUST-1 often causes rapid framework collapse and burst release under highly humid conditions, limiting its use as a humidity-triggered carrier for volatile antimicrobials. Here, we report a hierarchically porous composite aerogel constructed by in situ growth of HKUST-1 within a poly (vinyl alcohol)/carboxymethyl chitosan/TEMPO-oxidised cellulose nanofiber network, followed by carvacrol (CAR) loading to obtain PCTH@CAR. This confined growth architecture regulated metal organic framework (MOF) distribution, helped moderate moisture-induced structural disruption, and coupled polymer-derived macropores with MOF micropores, thereby improving cargo accommodation and release control. The cumulative CAR release reached 54.32% after 12 d even at 15% RH, while at 98% RH it reached 34.61% after 2 d and 81.99% after 12 d, with release sustained throughout storage rather than concentrated at the initial stage. The aerogel also showed effective vapour phase antimicrobial activity against Escherichia coli , Staphylococcus aureus , and Botrytis cinerea . In strawberry packaging, PCTH@CAR delayed visible spoilage and reduced weight loss from 20.45% to 2.04% after 8 d, whereas untreated strawberries had already lost marketability by day 4 owing to evident mould growth and softening. These results support in situ grown HKUST-1 within a hierarchically porous biopolymer aerogel as a practical route to non-contact, humidity-adaptive active packaging for postharvest preservation. Download: Download high-res image (211KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Keke Zhang,Shiqi Li,Xiaocan Sun,Hongkun Ma,Ying Li,Yu Pan,Jingruo Liu,Xianru Geng,Yingchao Wan,Dan Wu
Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver injury. Thrombospondin-1 (Thbs-1) is associated with NAFLD and has the potential to reduce lipid accumulation in hepatocytes. The aim of the study was to construct and screen truncated Thbs-1 polypeptide, and to investigate the function in palmitic acid (PA)-induced AML12 cells and High-fat diet (HFD)-induced C57BL/6 mice. The recombinant truncated Thbs-1 plasmids were constructed and the polypeptides were purified. The effects of the polypeptides were investigated in PA-induced AML12 cells and HFD-induced mice to screen the target polypeptide. The results showed that TSRC could alleviate the histopathological changes of NAFLD mice, reduce the expression of inflammatory factors and lipid metabolism-related factors. In conclusion, TSRC could ameliorate inflammation and lipid accumulation in PA-induced AML12 cells, relieve liver pathological changes, improve liver function, and effectively alleviate NAFLD in HFD-induced C57BL/6 mice.
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PubMed
高影响因子
MEDICINE
·
2026
·Vol. 105
·期 5
·e47341
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IF 1.4
He Mingjie,Wen Jie,Zou Yan,Jiang Qiong,Zhong Aimin
Hyperhomocysteinemia has been identified as a potential metabolic risk factor for type 1 diabetes-related nephropathy (T1DN). However, the causal relationship between homocysteine (Hcy) and T1DN remains unclear. We performed univariable Mendelian randomization (MR) and multivariable MR analyses to investigate the causal effects of Hcy and B vitamins (vitamin B6, B12, and folate) on T1DN in a cohort of 19,406 individuals. Linkage disequilibrium score regression and colocalization analyses were conducted to examine genetic correlations. Additionally, 2-step MR analysis was employed to identify potential mediating factors. Our MR findings revealed that elevated Hcy levels were causally associated with the late stage of T1DN (OR = 1.33, 95% CI: 1.08–1.64; P < .0001; false discovery rate < 0.05). Multivariable MR analysis further confirmed that Hcy remained significantly associated with increased risk of late-stage T1DN (OR = 1.215; false discovery rate < 0.05), even after adjusting for kidney function and vitamin B6 levels. Two-step MR analysis suggested that estimated glomerular filtration rate mediated 3.21% of the effect of Hcy on T1DN. No causal relationship was observed between Hcy and the microalbuminuria stage of T1DN (OR = 0.963, 95% CI: 0.717–1.293). Furthermore, folate, vitamin B6, and vitamin B12 were not significantly associated with T1DN. Experimental results showed that Hcy inhibited HK-2 cell viability and induced cellular injury. Notably, treatment with losartan and sinomenine alleviated Hcy-induced cytotoxicity, indicating their potential protective effects. The findings of this study suggest that elevated Hcy levels represent an important risk factor contributing to the development of T1DN.
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Food Bioscience
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2026
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IF 6.2
Shiyu Zhang,Xinzhuan Yao,Yanxia Wang,Muhammad Safiullah Virk,Shiyu Tian,Zhenkedai Yuan,Qihong Zou,Linlin Li,Shenyuan Ye,Hu Tang,Litang Lu
This study comprehensively evaluated Baiye No.1 (BY1H), a temperature-sensitive tea cultivar. Normally, it whitens in early spring and gradually regreens in autumn, accompanied by declining free amino acids and rising catechin and caffeine levels. We reevaluated the common belief that autumn tea is inferior. The feasibility of producing premium yellow tea from autumn-harvested BY1H was assessed, and the mechanisms underlying its quality formation were elucidated. The menhuang yellowing step played a central role. Driven by non-enzymatic thermal oxidation and hydrolysis, it reduced typical autumn defects by lowering phenolic and caffeine levels and increasing sweet-tasting free amino acids. Sensory evaluation, targeted metabolite profiling, and multivariate statistics were integrated to compare BY1H with four reference yellow teas (Ya’an Yellow Tea, Weishan Maojian, Yuan’an Luyuan Yellow Tea, and Pingyang Huangtang). BY1H yellow tea exhibited superior sensory attributes for its mellow-sweet taste and layered floral bouquet. Chemically, this profile was supported by a high water-extract yield, low levels of caffeine and ester-catechins, and abundant serine and phenylalanine. Together, these components contributed to its mellow-sweet taste. Gas Chromatography-Mass Spectrometry (GC-MS) analysis further identified 18 key volatiles, among which benzaldehyde, β-ionone, and methyl 2-(2-methylpropoxy)benzoate were the major contributors to the sweet-floral aroma. Partial Least-Squares Discriminant Analysis (PLS-DA) and Mantel tests confirmed BY1H’s unique chemical signature, clearly separating it from the other traditional yellow teas. These findings demonstrate that autumn BY1H leaves can be valorized through yellow tea processing, providing a scientific basis for cultivar innovation and sustainable utilization of seasonal tea resources.
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BIOCHEMICAL ENGINEERING JOURNAL
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2016
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IF 2.463
Hui-Li Lu,Dong-Qiang Lin,Qi-Lei Zhang,Shan-Jing Yao
Hydrophobic charge-induction chromatography (HCIC) with 2-mercapto-1-methyl-imidazole (MMI) ligands shows promising results in antibody purification. In this study, competitive adsorption processes between bovine immunoglobulin G (IgG) and bovine serum albumin (BSA) were investigated with MMI resins. Adsorption isotherms of IgG, BSA and IgG/BSA mixtures at various mass ratios were measured, and the Langmuir-Freundlich model was used to fit the adsorption experimental data. The results indicated that IgG could be preferentially adsorbed by MMI resins, and MMI-B-4FF-100 resin with the pore size of 43.2 nm and the ligand density of 101 μmol/g gel showed the best adsorption selectivity of IgG over BSA. In addition, binding behaviors of IgG and BSA in column were studied with MMI-B-4FF-100 at various pH values, and the optimized separation conditions were obtained as loading at pH 7.0 and elution at pH 4.0. Furthermore, IgG was effectively separated from IgG/BSA protein mixtures with MMI-B-4FF-100. The purities of IgG monomer reached above 95%, and the recovery kept about 90%. The results indicated that MMI-B-4FF-100 with high ligand density and moderate pore size would be a promising HCIC resin for IgG purification.
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Journal of Saudi Chemical Society
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2016
·Vol. 21
·期 3
·315-323
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IF 1.978
Pei-Yi Wang,Ling Chen,Jian Zhou,He-Shu Fang,Zhi-Bing Wu,Bao-An Song,Song Yang
In this paper, a variety of 1-aryl-4-hydroxy-1 H -pyrrol-2(5 H )-one derivatives bearing 1,3,4-oxadiazole moiety were designed and synthesized. Preliminary bioassays suggested that these compounds not only exhibited favorable antibacterial activity toward plant pathogenic bacteria including Xanthomonas oryzae pv. oryzae ( Xoo ), Ralstonia solanacearum ( R. solanacearum ), and Xanthomonas axonopodis pv. citri. ( Xac ), but also demonstrated certain curative and protective activities against Tobacco mosaic virus (TMV). Further studies revealed that compounds 8a and 8l exerted the best inhibition effect against Xoo with the half-maximal effective concentration (EC 50 ) values of 8.6 and 7.3 μg/mL, respectively, which were better than that of commercial agricultural antibacterial bismerthiazol (EC 50 = 92.6 μg/mL). Given the above results, this kind of compounds can be further studied and explored as alternative antibacterial agents.
研究领域:
药物化学
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农业化学
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抗菌剂
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病毒学
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有机合成
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JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
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2026
·Vol. 40
·期 1
·e70661
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IF 2.8
Li Yao,Xin-ze Qiu,Jun Zou,Jing-rong Liang,Meng-bin Qin,Jin-xiu Zhang,Peng Peng,Jie-an Huang
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a leading cause of chronic liver disease with no available therapies. Currently, the pathogenesis of MASLD remains to be further elucidated. Ferroptosis and ferroptosis-related genes may play a vital role in the development of MASLD. Thus, this study investigated the role of heme oxygenase-1 (HMOX1/HO-1) in ferroptosis associated with MASLD. Here, we applied bioinformatics to identify ferroptosis-related genes. HMOX1 expression was validated by immunohistochemistry. Mice fed a methionine-choline-deficient diet for 8 weeks were treated with hemin, followed by biochemical and histological analyses. HL7702 cells were transfected to overexpress HMOX1, exposed to oleic acid, and treated with erastin or AZD1480. Iron, ROS, lipid peroxidation, and mitochondrial damage were assessed by ELISA, flow cytometry, and electron microscopy. Western blotting explored molecular mechanisms. HMOX1 was identified as a ferroptosis-related hub gene in MASLD datasets and was decreased in patient liver tissues. MCD-fed mice developed hepatic steatosis with elevated ALT, AST, TG, LDL, Fe²⁺, MDA, and ROS, along with reduced HMOX1 and GSH. Hemin ameliorated MASLD and inhibited ferroptosis. Cell experiments showed JAK/STAT pathway activation in MASLD. HMOX1 upregulation reduced lipid peroxidation, inhibited ferroptosis, and downregulated JAK/STAT, whereas erastin reversed these effects. AZD1480 reversed the effects of erastin and improved MASLD. Collectively, our results suggest that HMOX1 protects against MASLD by suppressing ferroptosis through JAK/STAT pathway inhibition.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2026
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IF 2.2
Jianjun Chen,Jian Ma,Jichao Hu,Pan Zhang,Dong Fu,Lemeng Wang
In this study, we investigated the viscosity data of carbonated aqueous blends of 1-dimethylamino-2-propanol (DMA2P) and piperazine (PZ) over a temperature range of 303.2 to 323.2 K at atmospheric pressure. The concentration of DMA2P and PZ ranged from 30 wt% to 50 wt% and 2.5 wt% to 7.5 wt%, respectively. The experimental viscosities were calculated and predicted using the Weiland equation. The calculations showed good agreement with the experimental results, yielding an average relative deviation of 2.18%. Furthermore, the viscosity activation energy ( E a) and the estimated diffusion coefficient of CO 2 ( D CO2 ) into the carbonated DMA2P-PZ aqueous blends were derived using the Arrhenius-type expression and the modified Stokes-Einstein equation, respectively. The results indicate that the DMA2P-PZ absorbent exhibits promising potential for industrial application in CO 2 capture processes.
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Scientific Reports
·
2026
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IF 3.9
Liao Xuemei,Zhuang Ruirong,Zhuang Tangting,Xie Meijiao,Zhou Beidou
In this study, 45 2-benzylidene-1-indolone compounds were synthesized and their antitumor activities were evaluated. Experimental results demonstrated that these compounds exhibited varying degrees of inhibition against cancer cell proliferation. Notably, compound 20 showed significant activity against HGC-27 gastric cancer cells, with a half-maximal inhibitory concentration (IC 50 ) as low as 2.57 µM. Finally, the antitumor mechanism of compound 20 was investigated through network pharmacology and molecular docking, and 12 key genes and 21 related tumor signaling pathways were obtained. These findings suggest that compound 20 , as a potential lead compound, may provide a new direction for the development of antitumor drugs after structural optimization.
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高影响因子
Nature Energy
·
2026
·
IF 60.1
Wen Xin,Li Zongbao,Lu Wenbo,Li Jianjun,Xie Weiwei,Wei Zhouqing,Liu Shunchang,Liu Qingxiang,An Xiaoyan,Feng Mingjie,Liu Gang,Hu Jin-Song,Hou Yi,Xue Ding-Jiang,Wan Li-Jun
Selenium (Se), the world’s oldest photovoltaic material, is experiencing a resurgence in interest due to its intrinsic wide bandgap of approximately 1.9 eV, making it an ideal photoabsorber for the top cell in tandem solar cells and for indoor photovoltaics. However, the power conversion efficiency of Se solar cells remains constrained by severe non-radiative recombination losses caused by the small grain size (~500 nm) of conventionally thermally annealed Se films. Here we report an illumination-assisted annealing strategy that enables photo-induced crystallization at ambient temperature while suppressing dewetting, followed by subsequent thermal annealing, to fabricate Se films with large grains (~2.7 μm), a low trap-state density (6.9 × 10¹⁴ cm⁻³) and a long carrier lifetime (22.9 ns). The resultant Se solar cells achieve a certified power conversion efficiency of 10.3% with a 1.03 V open-circuit voltage. Unencapsulated devices exhibit negligible performance loss after 1,000 h under maximum power point tracking in ambient conditions.
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