MOLECULAR PHARMACEUTICS
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2024
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IF 4.5
Lixin Ding,Feng Wang,Zilei Wang,Yongxiang Pan,Teli Liu,Liansheng Cheng,Wenting Liu,Kuke Ding,Hua Zhu,Zhi Yang
Lymphocyte activation gene 3 (LAG-3) has attracted much attention as a potentially valuable immune checkpoint. Individual identification of LAG-3 expression at screening and during treatment could improve the successful implementation of anti-LAG-3 therapies. HuL13 is a human IgG1 monoclonal antibody that binds to the LAG-3 receptor in T cells. Here, we used [89Zr]Zr-labeled HuL13 to delineate LAG-3+ T-cell infiltration into tumors via positron emission tomography (PET) imaging. A549/LAG-3 cells, which stably express LAG-3, were generated by infection with lentivirus. The uptake of [89Zr]Zr-DFO-HuL13 in A549/LAG-3 cells was greater than that in the negative control (A549/NC) cells at each time point. The equilibrium dissociation constant (Kd) of [89Zr]Zr-DFO-HuL13 for the LAG-3 receptor was 8.22 nM. PET imaging revealed significant uptake in the tumor areas of A549/LAG-3 tumor-bearing mice from 24 h after injection (SUVmax = 2.43 ± 0.06 at 24 h). As a proof of concept, PET imaging of the [89Zr]Zr-DFO-HuL13 tracer was further investigated in an MC38 tumor-bearing humanized LAG-3 mouse model. PET imaging revealed that the [89Zr]Zr-DFO-HuL13 tracer specifically targets human LAG-3 expressed on tumor-infiltrating lymphocytes (TILs). In addition to the tumors, the spleen was also noticeably visible. Tumor uptake of the [89Zr]Zr-DFO-HuL13 tracer was lower than its uptake in the spleen, but high uptake in the spleen could be reduced by coinjection of unlabeled antibodies. Coinjection of unlabeled antibodies increases tracer activity in the blood pool, thereby improving tumor uptake. Dosimetry evaluation of the healthy mouse models revealed that the highest absorbed radiation dose was in the spleen, followed by the liver and heart wall. In summary, these studies demonstrate the feasibility of using the [89Zr]Zr-DFO-HuL13 tracer for the detection of LAG-3 expression on TILs. Further clinical evaluation of the [89Zr]Zr-DFO-HuL13 tracer may be of significant help in the stratification and management of patients suitable for anti-LAG-3 therapy.
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PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Yongqiang Xu,Menglin Guo,Chenge Zhang,Keyu Meng,Fuqiang Liang,Jiayi Shi
Pumpkin seed protein (PSP), a valuable byproduct of pumpkin seed oil extraction, is abundant in essential amino acids but exhibits weak functional properties, limiting its processing and application potential. This study aimed to evaluate the effects of covalent modification with epigallocatechin-3-gallate (EGCG) at varying concentrations on the structural, functional and in vitro digestion properties of PSP. Sulfhydryl and free amino acid content analyses, combined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis, confirmed the formation of covalent complexes through C-S and C-N bond formation between EGCG and PSP. Upon binding with EGCG, the secondary structure of PSP was predominantly shifted from a β-sheet (from 40.70 % to 11.70 %) to a random coil (from 23.70 % to 46.80 %), accompanied by enhanced flexibility and a 52.59 % reduction in surface hydrophobicity. The solubility of the PSP-EGCG covalent complexes increased by 66.07 %, while the maximum emulsifying activity reached 421.91 m 2 /g. However, protein digestibility decreased by up to 25.50 % with higher EGCG concentrations. These findings provide a theoretical foundation for improving PSP properties and applying its complexes in specialised functional foods.
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SOLAR ENERGY
·
2024
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IF 6
Zhi-Ping Huang,Hui-Li,Wei-Ze Wang,Hu Li,Li-Mei Lin,Zhi-Gao Huang,Shui-Yuan Chen,Gui-Lin Chen
Sb 2 (S,Se) 3 is a promising photovoltaic material due to its tunable bandgap, high thermal stability, and low-cost production potential. However, films produced by close-spaced sublimation (CSS) often suffer from defects that reduce efficiency. In this work, lithium (Li) doping was introduced to improve crystal quality, carrier concentration, and conductivity. The lithium was incorporated into the sublimation source via molten salt treatment, resulting in a uniform Li-Sb 2 (S,Se) 3 thin film. The resulting ITO/CdS/Li-Sb 2 (S,Se) 3 /PbS/Carbon solar cell achieved a power conversion efficiency of 6.18%, a significant improvement over undoped devices. The study further investigates the optoelectronic properties, revealing that Li doping effectively reduces non-radiative recombination, improves carrier extraction, and increases the valence band maximum (VBM), optimizing energy level alignment for enhanced hole transport. Additionally, the improved surface conductivity and higher carrier concentration due to Li doping contributed to enhanced carrier transport and reduced recombination.This research demonstrates that alkali metal doping can enhance the optoelectronic properties of Sb 2 (S,Se) 3 films, providing a pathway for further efficiency improvements in antimony-based thin-film solar cells.
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高影响因子
ELECTROCHIMICA ACTA
·
2025
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IF 5.6
Hongdi Zheng,Liuyan Zhang,Yingying Li,Binkai Yuan,Shixuan Wang,Zeyi Guan,Gengzhe Shen,Guibin Tan,Yanmei Zhang
A honeycomb-like porous self-supporting Ni-Al(G) electrode was successfully prepared by low-pressure cold spraying combined with heat treatment. The main components of the electrode were Ni and NiAl. Graphene was uniformly dispersed throughout the electrode, exhibiting a 3-D distribution, which increased the active site of electrode and improved the electron exchange rate. The electrochemical properties of the Ni-Al(G) electrode were characterized using 6 M KOH. As a result, the Ni-Al(G) electrode requires only an overpotential of 130 mV to achieve a current density of 100 mA cm −2 , and a Tafel slope of 35.5 mV dec −1 . In addition, the electrode exhibited excellent stability. The addition of graphene and the honeycomb-like porous structure of the Ni-Al(G) electrode resulted in an excellent hydrogen evolution activity. This study provides a simple and rapid technique for building high-performance, low-cost, and industrially available electrodes for the efficient alkaline HER.
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高影响因子
CHEMICAL PHYSICS LETTERS
·
2024
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IF 2.8
Lu Li,Weiyi Chen,Meng Wang,Xinjiang Shi,Shiming Zhang,Debao Xiao
In this paper, we present the first application of organic hole-transporting semiconductors 4,4′,4′'-tris(carbazol-9-yl)triphenylamine (TCTA) and 4,4′-cyclohexylbis[N,N-bis(4-methylphenyl) aniline] (TAPC) in electrochromism area, demonstrating that TCTA or TAPC is suitable for use as hole-transporting materials on the anode of 1,1′-bis(3-sulfopropyl) viologen (SPV)-based electrochromic devices. For such devices, we obtain a decreased driving voltage of SPV-based electrochromic devices down to −2.0 V in the presence of TCTA or TAPC with comparison to that of ca. −2.5 V in the absence of the hole-transporting material. The optical contrast of the device increased from 57.19 % (without hole-transport layer) to 66.41 % (TCTA) or 62.97 % (TAPC) at 533 nm. The response time of 66.2 s in the absence of hole-transporting layer can decrease to 30.6 s with TCTA and 62.7 s with TAPC, respectively. The coloration efficiency of the as-fabricated devices at 533 nm can reach from 67.3 cm 2 /C (SPV-only) up to 153.2 cm 2 /C (TCTA) and 80.5 cm 2 /C (TAPC). This work paved a new way for boosting electrochromic performances of viologen-based devices via electrode modification of anode by hole-transporting material TCTA and TAPC which have been used effectively and efficiently in organic electroluminescent devices and solar cells.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Hui Li,Rui Da,Li-Quan Yao,Hu Li,Peng Tang,Jin-Rui Cai,Li-Mei Lin,Shui-Yuan Chen,Dong Wei,Li-Ping Cai,Gui-Lin Chen
Sulfoselenide Sb 2 (S,Se) 3 , as a potential light-harvester, possesses a flexibly tunable bandgap of 1.1–1.7 eV to match solar radiation spectrum. However, the preparation of a homogenous Sb 2 (S,Se) 3 film is still challenging due to the different growth kinetics in sulfide and selenide compound, which consequentially leads to phase separation, lattice disorder and unfavored band level. This dilemma also occurs in the simple and well-established close space sublimation (CSS) method, and poses a devastating carrier recombination in Sb 2 (S,Se) 3 solar cells. Herein, alloyed powders of Sb 2 (S,Se) 3 are exquisitely synthesized by a thorough gas-solid reaction, delivering a uniform and single phase composition distribution as well as finely-tunable S/Se ratio. Compared with a physically mixed powder source (Sb 2 S 3 /Sb 2 Se 3 ), this alloyed Sb 2 (S,Se) 3 source allows for the fabrication of a homogeneous Sb 2 (S,Se) 3 thin film by CSS, rendering improved ( hk1 ) orientation, dense morphology, a more consistent longitudinal S/Se ratio, and enhanced energy level arrangement. These advancements contribute to enhance carrier transport and reduce carrier recombination. As a result, the efficiency of the solar cell is remarkably boosted from 2.59% to 5.46%, which is among of the highest PCE of full-inorganic Sb 2 (S,Se) 3 devices fabricated through the CSS method.
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高影响因子
INORGANIC CHEMISTRY
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2025
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IF 4.7
Miaomiao Chen,Huili Zhao,Han Xue,Yan Liang,Min Ji,Min Wang
B(C6F5)3-based frustrated Lewis pairs (FLPs) have made remarkable progress in metal-free catalytic reduction. However, the high affinity of B(C6F5)3 for oxygen makes it susceptible to irreversible poisoning when exposed to H2O, limiting its widespread application in reductive amination. To overcome the influence of H2O, a hydrophobic catalyst, B(C6F5)3@Rn–1-MIL-101 (n = 3, 5, 7), was developed by confining B(C6F5)3 within the nanocages of metal–organic frameworks (MOFs) modified with alkyl chains. The hydrophobic strength of the catalyst could be adjusted by varying the length of the alkyl chain. At n = 3, the alkyl chain was too short to be hydrophobic, while the excessively long alkyl chain blocked the pore channels and adversely affected the loading of B(C6F5)3 at n = 7. Only the catalyst B(C6F5)3@R4-MIL-101 synthesized at n = 5 could effectively facilitate the reductive amination of aldehydes or ketones with amines in a “wet solvent.” The strategy of combining hydrophobic MOFs with B(C6F5)3 to prepare heterogeneous catalysts for FLP catalysis not only provides a fresh avenue for investigating catalytic systems for reductive amination but also represents an innovative approach to advancing FLP chemistry.
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Huiyuan Cheng,Jingwei Hu,Zihan Liu,Guangping Lei,Guojun Xi,Yayun Zhang,Hantao Liu,Xuhuan Guo,Huiyun Ren
Developing novel adsorbents for CO 2 capture and separation offers an efficient approach to relieving global environmental problems. To promote CO 2 capture from flue gas, novel Cr 3 O@MIL-101(Cr) composites was synthesized through packing [Cr 3 O(HCOO) 6 (H 2 O) 3 ]NO 3 into MIL-101(Cr) cages. The resultant composite Cr 3 O@MIL-101(Cr) presents higher CO 2 uptakes at lower pressure ranges, benefiting from the increased content of unsaturated Cr(III) ions and micropores relative to MIL-101(Cr). Meanwhile, IAST selectivity for CO 2 /N 2 mixture reached 50.2 under standard temperature and pressure, outperforming most of the reported materials. Further GCMC simulations reveal that the synergistic effect of [Cr 3 O(HCOO) 6 (H 2 O) 3 ] + , NO 3 − and MIL-101 (Cr) could effectively facilitate the interactions with CO 2 molecules and hinder N 2 molecules from approaching the optimal adsorption sites. Thus the [Cr 3 O(HCOO) 6 (H 2 O) 3 ]NO 3 encapsulated MIL-101(Cr) can be recommended as a promising adsorbent for superior CO 2 /N 2 separation.
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Zonghan Wang,Yingchen Fan,Ying Luo,Chao Guo,Yuanyuan Hu,Xiaoming Guo,Dayong Zhou,Beiwei Zhu
This work aimed to elucidate the deterioration mechanisms of shrimp surimi gels during refrigerated storage, and the regulatory mechanisms of epigallocatechin-3-gallate loaded cyclodextrin-based metal−organic framework (EGCG@CD-MOF) as a model antioxidant. Labele-free proteomics provided a quantitative analysis of the differential proteomic signatures of degraded proteins. Structural proteins, like myosin, paramyosin, titin, laminin, and α-actinin, along with calcium regulatory proteins, like calcineurin and sarcoplasmic calcium-binding protein were found to be highly susceptible to oxidative degradation during refrigeration. In contrast, EGCG@CD-MOF significantly mitigated protein degradation. Electron spin resonance (ESR) data demonstrated that EGCG@CD-MOF efficiently inhibited free radical accumulation over the 8-week refrigeration period. Scanning electron microscopy (SEM) further confirmed its ability to prevent network structural deterioration. Additionally, rheological, infrared, and molecular dynamics analyses supported the sustained interaction between EGCG@CD-MOF and proteins, with key interaction sites identified at residues ASP-131, ARG-92, SER-97, ASP-98, Lys-12, Gly-168, Glu-170, Arg-8, and Gly-6.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Zhiyin Huang,Yuqin Peng,Lixin Xing,Mijia Xu,Meng Fang,Huiqi Xie,Jiamin Li,Yangdong Zhou,Puwei Wu,Ning Wang,Chunmei Tang,Mingjie Wu,Liguang Wang,Siyu Ye,Lei Du
Platinum (Pt) is inevitably employed to facilitate various electrocatalysis including hydrogen oxidation/evolution and oxygen reduction reactions (HOR/HER/ORR), the foundation for renewable energy conversion and storage. Pt-based high-entropy-alloy (HEA) catalysts have been recently presenting promises to improve intrinsic activity of unit mass Pt. However, their current synthesis methods always produce large particles—some can control small size but have to use complicated recipe and/or highly toxic and expensive chemicals. Alternatively, a facile microenvironment regulation strategy is herein proposed to tune solvent polarity and nanoparticle-support interactions within the precursors for carbon-thermal shock pyrolysis. We found that the decreased solvent polarity and enhanced particle-support affinity can jointly control the nanoparticle size ultimately to ∼2.68 nm with ∼10 wt% Pt loading. The compressed lattice fringe in such HEA particles leads to electron accumulation at Pt atoms and build a moderate charge density rearrangement, showing superior multifunctional HER/HOR/ORR activity to Pt/C in acidic media.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2018
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IF 3.52
Yumeng Zhang,Lin Chen,Yuanqi Lv,Shuangxi Wang,Zhiyao Suo,Xingguang Cheng,Xinglian Xu,Guanghong Zhou,Zhixi Li,Xianchao Feng
High levels of polyphenols can interact with myofibrillar proteins (MPs), causing damage to a MP emulsion gel. In this study, β -cyclodextrins were used to reduce covalent and non-covalent interaction between epigallocatechin-3-gallate (EGCG) and MPs under oxidative stress. The loss of both thiol and free amine groups and the unfolding of MPs caused by EGCG (80 μM/g protein) were significantly prevented by β -cyclodextrins, and the structural stability and solubility were improved. MP emulsion gel treated with EGCG (80 μM/g protein) had the highest cooking loss (68.64%) and gel strength (0.51 N). Addition of β -cyclodextrins significantly reduced cooking loss (26.24–58.20%) and improved gel strength (0.31–0.41 N) of MP emulsion gel jeopardized by EGCG under oxidative stress. Damage to the emulsifying properties of MPs caused by EGCG was significantly prevented by addition of β -cyclodextrins. β -cyclodextrins reduced interaction between EGCG and MPs in the order Methyl- β -cyclodextrin > (2-Hydroxypropyl)- β -cyclodextrin > β -cyclodextrin. In absence of EGCG, addition of β -cyclodextrins partly protected MPs from oxidative attack and improved its solubility. It is concluded that β -cyclodextrins does not markedly reduce the antioxidant ability of EGCG according to carbonyl analysis, and can effectively increase EGCG loading to potentially provide more durable antioxidant effect for meat products during processing, transportation and storage.
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高影响因子
POWDER TECHNOLOGY
·
2018
·
IF 3.23
Weiwei Chu,Zhenzhen Lu,Ruiqin Tan,Shihui Tang,Wei Xu,Weijie Song,Junhua Zhao
In this work, β-SrHPO 4 , Sr 3 (PO 4 ) 2 , and Sr 5 (PO 4 ) 3 (OH) (SrHAp) powders were successfully prepared by a controllable hydrothermal method and were utilized in removal of lead ion (Pb 2+ ). The effects of pH value, contact time and initial ion concentration on the immobilization of Pb 2+ were investigated systematically. Results showed that β-SrHPO 4 exhibited a capacity of 1438 ± 45 mg/g for Pb 2+ , while Sr 3 (PO 4 ) 2 and SrHAp showed values of 1223 ± 45 mg/g and 543 ± 45 mg/g respectively under the optimum conditions. The XRD , SEM and EDX results revealed that the mechanism of Pb 2+ immobilization by β-SrHPO 4 , Sr 3 (PO 4 ) 2 and SrHAp was mainly due to a process of dissolution and precipitation in the acidic solution. Comparing the immobilization behavior and capacities of β-SrHPO 4 , Sr 3 (PO 4 ) 2 and SrHAp for Pb 2+ removal, it is shown that β-SrHPO 4 is an effective and eco-friendly material for the removal of Pb 2+ from acidic aqueous solutions among strontium phosphates materials.
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高影响因子
危险品化学品经营许可证（带存储）