AAPS PHARMSCITECH
·
2021
·Vol. 22
·期 7
·1-13
·
IF 3.246
Qin Tingting,Yan Libiao,Wang Xin,Lin Siqi,Zeng Qingbing
The postprandial glycemic regulation is essential for diabetic patients to reduce the risk of long-term microvascular and macrovascular complications. Herein, we designed a glucose-responsive oral insulin delivery system based on polyelectrolyte complexes (PECs) for controlling the increasing postprandial glucose concentrations. Briefly, alginate-g-3-aminophenylboronic acid (ALG-g-APBA) and chitosan-g-3-fluoro-4-carboxyphenylboronic acid (CS-g-FPBA) were wrapped on mesoporous silica (MSN) to form the negative charged ALG-g-APBA@MSN and the positive charged CS-g-FPBA@MSN nanoparticles, with an optimum insulin loading capacity of 124 mg/g and 295 mg/g, respectively. ALG-g-APBA@MSN was further cross-linked with CS-g-FPBA@MSN to form PECs through electrostatic interaction and borate esters. The dense polyelectrolyte network wrapped on MSN was capable of preventing insulin from diffusion and regulating its release. The in vitro insulin release of PECs demonstrated an obvious glucose response profile in different glucose concentrations (0 mg/mL, 2 mg/mL, 5 mg/mL) and presented a switch “on” and “off” release regulation at hyperglycemic or normal state. The CCK-8 assay showed that none of the MSN, ALG-g-APBA@MSN, CS-g-FPBA@MSN, and PECs possessed cytotoxicity to Caco-2 cells. For in vivo tests, the oral PECs exhibited a significant hypoglycemic effect and maintained in the euglycemic levels up to approximately 12 h on diabetic rats. Overall, the PECs directly triggered by postprandial glucose in the intestine have a good potential to be applied in intelligent insulin delivery by the oral route.
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 18
·23189-23205
·
IF 2.478
Chen Piao,Zhang Zhi,Yang Shuijin,Yang Yun,Sun Yong
In this study, a novel oxygen vacancy-rich BiOCl/ZnMoO 4 composites were successfully prepared by a simple two-step method. Experimental results indicated that the content of BiOCl with oxygen vacancies played an important role in photocatalytic performance of OBZM heterostructures. OBZM-5 exhibited a highly enhanced photocatalytic activity under visible light irradiation compared to pure BiOCl, Ov-BiOCl, ZnMoO 4 and other OBZM composites, which can be attributed to the efficient separation and transfer of photogenerated charge carrier. The photocatalytic degradation efficiency of rhodamine B (RhB) can reach 99% within 40 min and almost all of norfloxacin (NOR) can be degradated after 100 min by OBZM-5. In addition, OBZM-5 displayed a good stability during the photocatalytic process, which favored a long-term use. Moreover, a possible photocatalytic mechanism was proposed based on the active species trapping experiments and electron spin resonance (ESR) tests, verifying that the photogenerated holes (h + ) and · O 2 − radicals were the dominating active species.
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Journal of Advanced Ceramics
·
2021
·Vol. 10
·期 5
·1129-1139
·
IF 6.707
Wu Pengfei,Shi Benyang,Tu Huibin,Guo Changqing,Liu Anhua,Yan Guan,Yu Zhaoju
Severe volume expansion and inherently poor lithium ion transmission are two major problems of silicon anodes. To address these issues, we proposed a pomegranate-type Si/C composite anode with highly dispersed tiny silicon particles as the core assisted by small amount of SiC. Skillfully exploiting the high heat from magnesiothermic reduction, SiC can assist the good dispersion of silicon and provide good interface compatibility and chemical stability. The silicon anchored to the carbon shell provides multipoint contact mode, that together with the carbon shell frame, significantly promoting the transfer of dual charge. Besides, the pomegranate-type microcluster structure also improves the tap density of the electrode, reduces the direct contact area between active material and electrolyte, and enhances the electrochemical performance.
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JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 28
·15937-15949
·
IF 4.22
Sun Na,Li Xiangqing
Application of phase change materials (PCMs)-based thermal management technology in flexible electronic devices has been inhibited due to the leakage and strong rigidity of PCMs. A novel flexible composite PCMs with ultrahigh extensibility was developed in this paper. Concretely, a kind of paraffin@copper (PA@Cu) microcapsule with paraffin as core and nano-Cu particle as “flexible” metal shell was prepared by a simple Pickering emulsion method in an aqueous medium. The encapsulation ratio of paraffin reached 98wt%. Then the PA@Cu microcapsules were introduced into uncured liquid silicone to fabricate flexible composite PCMs (PA@Cu/SE). SEM results demonstrated that the microcapsules were tightly and uniformly wrapped in the three-dimensional network structure of silicone elastomer matrix. Owing to the good compatibility of PA@Cu with the polymer elastomer and a barrier for the melted PA provided by the “flexible” nano-Cu shell, the resulting composite PCMs present superior flexibility and thermal reliability. Tensile tests showed that the flexible composites with a relative higher loading of PA@Cu (40wt%) exhibit outstandingly larger extensibility (> 730%) than many reported literatures. In addition, the composites presenting superior thermal protection for biological tissue make them well-suited for thermal management in wearable electronics. Graphical abstract
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 8
·1-9
·
IF 5.833
Ran Fanpeng,Ma Chen,Xiang Yueci,Xu Yixuan,Liu Xiaoyan,Zhang Haixia
A colorimetric and fluorescent dual-channel detection method for acid phosphatase (ACP) activity has been constructed, based on the internal filtering effect between oxidized 3,3′,5,5′-tetramethylbenzidine (oxTMB) and rhodamine B (RB). Au 3+ , which in situ form gold nanoparticles (AuNPs), can oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to oxTMB (blue color). The fluorescence of RB can be quenched by oxTMB due to the spectral overlap of emission of RB and absorption of oxTMB. By means of the above process, ACP can be determined because ACP promotes the hydrolysis of 2-phospho- l -ascorbic acid trisodium salt (AAP) to generate ascorbic acid (AA), which can inhibit the internal filtering effect between RB and oxTMB. No material preparation was needed for the determination of ACP. The colorimetric and fluorimetric methods can quantify ACP in the range 0.06–5.0 mU/mL and 0.03–5.0 mU/mL, respectively. Furthermore, a smartphone-assisted sensing platform has been constructed for on-site monitoring of ACP in the range 0.75–50 mU/mL, and the detection limit is 0.3 mU/mL. The methods developed can measure ACP in human serum successfully. Graphical abstract
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高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 8
·1-9
·
IF 5.833
Chen Ruipeng,Li Shuang,Sun Yunfeng,Huo Bingyang,Xia Yating,Qin Yingkai,Li Shuning,Shi Baodi,He Defu,Liang Jun,Gao Zhixian
The design and fabrication of a surface-enhanced Raman scattering (SERS) aptasensor for simultaneous detection of zearalenone (ZEN) and ochratoxin A (OTA) in wheat and corn samples is described. The capture and reporter probes were SH-cDNA-modified gold nanorods and SH-Apt-modified Au@Ag core-shell nanoparticles, respectively. After recognizing OTA and ZEN aptamers and complementary strands (SH-cDNA), the reporter probe generated a strong SERS signal. The preferred binding of OTA and ZEN aptamers to OTA and ZEN, respectively, caused reporter probes to release the capture probes, resulting in a linear decrease in SERS intensity. The detection of OTA showed good linearity with an R 2 value of 0.986, which could be maintained across a wide concentration range (0.01 to 100 ng/mL), with the limit of detection of 0.018 ng/mL. For detection of ZEN, good linearity with an R 2 value of 0.987 could be maintained across a wide concentration range (0.05 to 500 ng/mL), with 0.054 ng/mL as the limit of detection. Good accuracy (relative standard deviation < 4.2%) during mycotoxin determination as well as excellent quantitative recoveries (96.0–110.7%) during the analysis of spiked real samples was achieved. The proposed SERS aptasensor exhibited excellent performance in the detection of OTA and ZEN in real food samples. Hence, by simply changing the aptamer, this new model can be applied to the detection of multiple mycotoxins in the food industry. Graphical abstract
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PubMed
高影响因子
METALS AND MATERIALS INTERNATIONAL
·
2021
·Vol. 27
·期 12
·5389-5398
·
IF 3.642
Hong S. F.,Lu Z. C.,Liu Y. H.,He Q. M.,Jiang W.,Zeng M. Q.
Abstract Supersaturated solid–solutions in a W–Cr alloy system were fabricated by conventional milling and plasma milling. The different extension mechanisms of the solid solubility that were created by ball milling with and without discharge plasma were studied. The solid–solubility of Cr in W for the P-milling W–Cr alloy system was higher, which indicates that plasma milling promotes the formation of W(Cr) solid–solution more easily than conventional milling. According to Miedema’s model, in the W–Cr alloy system, the free-energy change to form a W(Cr) solid solution by plasma milling is reduced compared with conventional milling because of the heating effect of the discharge plasma. Therefore, a higher stored energy in the grain boundaries and dislocations of the W–Cr nanograins during plasma milling makes it easier to overcome the thermodynamic barrier in the formation of a solid–solution, when compared with conventional milling. Graphic Abstract
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FIBERS AND POLYMERS
·
2021
·Vol. 22
·期 10
·2869-2877
·
IF 2.153
Wu Hongming,Xu Dinghong,Zhou Ying,Guo Jianbing,He Weidi,He Yong,Yi Yuan,Qin Shuhao
Hemp fibers-reinforced polypropylene (HP/PP) composite is strengthened and toughened by chemical treatment in a melt-blending process. The surface characters of the hemp fibers (HFs) treated by alkaline, γ-valerolactone (GVL) and dodecyl bromide (C12) are studied by FTIR. To evaluate the effect of each chemical treatment on HP/PP composites, the thermal stability, crystalline property, microstructure, mechanical property and rheology property have been studied. It is found that the composites with chemical treatment have improved mechanical property and thermal stability. Among those composites, the tensile modulus and maximum decomposition temperature (T max ) of the dodecyl bromide treated composites are highest, and increase 18 % and 10 °C when compared with raw HFs. It is reveals that dodecyl bromide treatment could improve the mechanical and thermal properties of the composites. A possible reinforcing mechanical that hemp fibers react with dodecyl bromide in the composites have been proposed.
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FIBERS AND POLYMERS
·
2021
·Vol. 22
·期 10
·2656-2663
·
IF 2.153
Shi Huili,Zhao Wenjing,Zhao Xiaowei,Li Zhiwei,Li Xiaohong,Zhang Zhijun
A novel green composite flame retardant, bismuth oxychloride nanosheet decorated with chitosan and phytic acid (BiOCl@CS-PA) was prepared in order to improve the fire safety of flexible poly(vinyl chloride) (PVC). Introducing phytic acid (PA) is aimed at promoting the flame retardancy of BiOCl nanosheets in condensed phase using the synergistic effects. Chitosan (CS) not only acts as a bridge between BiOCl and PA, but also increases residue as a charring agent. Adequate characterizations verified that the BiOCl@CS-PA has been prepared successfully. When 3 wt.% of BiOCl@CS-PA was imparted into the PVC matrix, the resultant PVC composite can pass V-0 rating in the UL-94 test. Additionally, cone calorimetry test demonstrated that 3 wt.% of BiOCl@CS-PA reduced the first peak heat release rate and inhibited the pronounced peak heat release rate of PVC matrix between 300–400 s in comparison with the BiOCl nanosheets, indicating a further improvement in flame retardancy of PVC/BiOCl@CS-PA composite with the help of PA in the condensed phase. Microstructure and morphology of the char residue of PVC/BiOCl@CS-PA were analyzed to reveal the flame retardant mechanism. The results indicated that the joint action of PA and CS improves the quality of the char layer, which contributes to improving the flame retardancy in condensed-phase.
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FIBERS AND POLYMERS
·
2021
·Vol. 22
·期 11
·3025-3034
·
IF 2.153
Li Chengcai,Tang Tao,Zheng Tao,Hong Wei,Wang Feng,Liu Guojin,Lei Caihong,Yu Yuan,Zhu Hailin,Guo Yuhai
A new hydrophilicity and negatively charged polytetrafluoroethylene (PTFE) fiber membrane has been developed and characterized. Specifically, the dopamine (DA) and polyethylenimine (PEI) were co-deposited onto the PTFE fiber membrane surface via covalent connection. Then the amine groups of the membrane surface were reacted with anhydride groups of poly(ethylene-alt-maleic anhydride) (PEMA). Last, unreacted anhydride groups have hydrolysis and ionization. The preparation membrane has been investigated and confirmed by using XPS, ATR-FTIR, SEM, Zeta potential analyzer, pore size analyzer water contact angle, respectively. The results showed that the membranes were endowed with excellent hydrophilicity and negatively charged. It has high separation efficiency and permeation flux for oil-in-water emulsion containing cationic emulsifiers, and excellent anti-fouling property.
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高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2021
·Vol. 99
·期 1
·132-139
·
IF 2.326
Duan Chenguang,Liu Huating,Huang Zongyu,Qiao Hui,Zhou Yang,Liao Gengcheng,Liu Yundan,Qi Xiang
Electrocatalytic hydrogen evolution is an exercisable way to achieve large-scale application of hydrogen energy. It is of great significance to develop an effect, stable, and cost-effective electrocatalyst. Here, we applied the two-dimensional (2D) bismuth (Bi) to the electrocatalytic hydrogen evolution, and proposed the strategies to enhance the catalytic performance of the catalyst. Due to more active sites located along the edges of 2D structure, Bi nanosheets revealed a higher electrocatalytic activity (overpotential of −958 mV vs RHE at 10 mA cm −2 , Tafel slope of 122 mV/dec) than the bulk counterpart. To further evaluate the electrocatalytic performance of Bi nanosheets, the typical parameters measured in different H + concentration (C[H + ]) are carried out. The improved catalytic activity obtained in 0.5 M H 2 SO 4 is attributed to enhancing the hydrogen adsorption and accelerating the charge transport on the surface of catalyst. Moreover, the durability of Bi nanosheets has been texted, where the current is not evident fluctuation during the 40,000 s electrolysis measurement indicating its excellent stability. The present work expands the application of Bi in the catalysis and provides the simple strategies to improve its hydrogen evolution performance.
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MRS Communications
·
2021
·Vol. 11
·期 4
·418-424
·
IF 2.566
Liu Heguang,Jing Ruixuan,Wang Zilu,You Caiyin
Abstract FeS 2 is thought to be a kind of promising anode materials used for lithium-ion batteries (LIBs), but the intrinsic low electrical conductivity and remarkable volume change hinder its practical application. In the present work, we proposed a strategy by introducing mesoporous carbon (MPC) to obtain a FeS 2 /MPC composite electrode for LIBs. The FeS 2 /MPC composite was prepared by hydrothermal method. The results indicated that the FeS 2 /MPC composite electrode exhibited better electrochemical performance than pristine FeS 2 . Especially, the discharge capacity of composite electrode reached 650 mAh g −1 at 0.5 C current density, and this was significantly higher than that of pristine FeS 2 . Graphic abstract
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高影响因子
危险品化学品经营许可证（带存储）