JOURNAL OF NANOPARTICLE RESEARCH
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2024
·Vol. 26
·期 4
·1-10
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IF 2.1
Van Thuy Vu,Trang Vu Thao,Chun Sangeun,Thu Tran Viet
As a promising electrode material for electrochemical energy storage, iron hexacyanoferrate (FeHCF) possesses diverse structures and properties that strongly relate to synthetic conditions. In this work, we synthesized FeHCFs by co-precipitation route and studied the influence of two surfactants (sodium citrate and potassium bitartrate) on the material characteristics and K + storage properties of the resulting FeHCFs. Electrochemical measurements revealed that the FeHCF synthesized in the absence of surfactants exhibited superior performance to those synthesized in the presence of either surfactant due to reduced electrical resistivity and improved diffusion kinetics. The assembled all-solid-state symmetric device delivered an areal capacitance of 3.24 mF cm −2 , a wide potential window (1.4 V), an energy density of 3.17 μWh cm −2 , and a power density of 315.7 μW cm −2 at a current density of 0.5 mA cm −1 , indicating its potential application for energy storage.
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JOURNAL OF PLANT GROWTH REGULATION
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2024
·
IF 3.9
Luo Liping,Zhang Gaowei,Liang Wenjing,Wu Dong,Sun Qifang,Hao Yingbin
Broccoli microgreens represent a novel type of vegetable characterized by high levels of bioactive compounds. Here, we investigated the effects of light-emitting diode (LED) light quality on the development and nutritional uptake of broccoli microgreens. The plants were exposed to five distinct light treatments: white, single red, and red: blue at 5:1, 5:3, and 5:5 ratios. The soluble sugars, nutrients, and secondary metabolites of broccoli sprout extracts were examined using high-performance liquid chromatography and ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry under various light-quality conditions. In addition, the expression levels of genes encoding important enzymes in the glucosinolates (GLs) biosynthesis pathway were examined using quantitative real-time polymerase chain reaction. Overall, the findings demonstrated that mixed red-blue light, especially the 5:1 red: blue ratio, was beneficial for broccoli microgreens in terms of their hypocotyl length, fresh weight, edible rate, soluble proteins, vitamin C, total phenolics, total flavonoids, and GLs. Our findings provide a foundation and reference point for selecting the most appropriate LED light ratio in microgreens production.
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CELL DEATH AND DIFFERENTIATION
·
2024
·
IF 13.7
Wu Yachen,Zheng Wenzhong,Xu Guofeng,Zhu Lijun,Li Zhiqiang,Chen Jincao,Wang Lianrong,Chen Shi
Sterol regulatory element binding transcription factors (SREBPs) play a crucial role in lipid homeostasis. They are processed and transported to the nucleus via COPII, where they induce the expression of lipogenic genes. COPII maintains the homeostasis of organelles and plays an essential role in the protein secretion pathways in eukaryotes. The formation of COPII begins at endoplasmic reticulum exit sites (ERES), and is regulated by SEC16A, which provides a platform for the assembly of COPII. However, there have been few studies on the changes in SEC16A protein levels. The repetitive expansion of the hexanucleotide sequence GGGGCC within the chromosome 9 open reading frame 72 (C9orf72) gene is a prevalent factor in the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we found that the absence of C9orf72 leads to a decrease in SEC16A protein levels, resulting in reduced localization of the guanine nucleotide exchange factor SEC12 at the ERES. Consequently, the small GTP binding protein SAR1 is unable to bind the endoplasmic reticulum normally, impairing the assembly of COPII. Ultimately, the disruption of SREBPs transport decreases de novo lipogenesis. These results suggest that C9orf72 acts as a novel role in regulating lipid homeostasis and may serve as a potential therapeutic target for obesity.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
Bian Lijun,Su Xinglin,Wang Jialu
Carbon cloth (CC) was electrochemically activated using three electrochemical methods in different electrolytes. The gases released during the activation process etched the surface of the CC, thereby increasing its surface area of the activated CC (FCC). Moreover, functional groups such as oxygen-containing groups and N-doping have been introduced. The quantity and type of functional groups introduced during the activation process were related to the anions in the solution. FCC electrodes were used to construct electrochemical sensors for the simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The PFCC electrode activated by advanced cyclic voltammetry in (NH 4 ) 2 HPO 4 showed linear ranges for AA, DA, and UA concentrations of 0.1 to 2.1 mM, 0.5 to 11 µM, and 0.5 to 11 µM, respectively. The detection limits are 72.93, 0.22, and 0.42 µM, respectively. The good flexibility the PFCC electrode made it suitable for the preparation of flexible sensors. The simultaneous determination of AA, DA, and UA in fetal bovine serum showed a reliable recovery ratio. This study provides a simple and green approach for activating carbon cloth and constructing flexible electrochemical sensors with the potential to simultaneously detect AA, DA, and UA.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-26
·
IF 15.7
Li Kai,Yu Xuan,Xu Yanteng,Wang Haixia,Liu Zheng,Wu Chong,Luo Xing,Xu Jiancheng,Fang Youqiang,Ju Enguo,Lv Shixian,Chan Hon Fai,Lao Yeh-Hsing,He Weiling,Tao Yu,Li Mingqiang
Non-nucleotide stimulators of interferon gene (STING) agonists hold promise as immunotherapeutic agents for postsurgical adjuvant treatment of tumors. However, their limited effect duration hampers therapeutic effectiveness, necessitating prolonged administration of multiple doses that heightens infection risk and impacts patient compliance. Here, we develop an implantable dual-drug depot in a sandwich-like configuration, with a non-nucleotide STING agonist (MSA-2) in the outer layers of 3D-printed scaffolds and an immunogenic apoptosis inducer (doxorubicin, DOX) in the inner layer of electrospun fibers. We discover that MSA-2 can elicit endoplasmic reticulum stress-mediated and general immunogenic apoptosis of cancer cells. The stimulations with tumor-associated antigens and damage-associated molecular patterns from cancer cells, along with proinflammatory factors secreted by matured dendritic cells and M1-polarized macrophages, can depolymerize intracellular microtubules guiding activated STING trafficking towards lysosomes for degradation. Collectively, the dual-drug depots can initiate a long-lasting cascaded immunotherapy and chemotherapy, suppressing postsurgical tumor recurrence and metastasis.
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Biomass Conversion and Biorefinery
·
2025
·
IF 4.1
Cao Shuangming,Sun Jianguo,Liu Qian,Gu Yonghua
Crab shells, as the waste from seafood processing, are emerging as a valuable resource for recycling and environmental protection. By combusting the organic components of crab shells, the high-calcium crab shell ash (CSA) is produced. This ash serves as a promising raw material for CO 2 mineralization, contributing to energy conservation and emission reduction. In this study, the systematic mineralization experiment of CSA was conducted using wet carbonation, focusing on the effects of reaction temperature, liquid–solid ratio, particle size, and stirring speed on CO 2 mineralization. The optimal mineralization conditions were achieved at a temperature of 60 °C, a liquid–solid ratio of 10 mL/g, a stirring speed of 700 rpm, and a CSA particle size exceeding 200 mesh, resulting in a carbonation efficiency of 66.10%. Furthermore, we improved the mineralization process by modifying the CSA with Na 2 CO 3 and employing microwave treatment. The carbonation efficiency significantly increased to 71.80% with a Na 2 CO 3 concentration of 1.75 mol/L. Notably, microwave drying further enhanced the carbonation efficiency of CSA to 73.01%. Our findings contribute to a deeper understanding of CSA mineralization and establish a theoretical foundation and research direction for enhancing the carbon sequestration capacity and subsequent application performance of crustacean biomass ash.
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Science China-Chemistry
·
2024
·
IF 10.4
Li Ting,Chen Lin,Xue Yunxin,Xiao Xiangyu,Dai Wenjun,Tan Kaiyuan,Chen Tiantian,Tao Yingfang,Mao Chun,Shen Jian,Wan Mimi
Glioblastoma (GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier (BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase (GOx) and carboxylated cisplatin (Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide (NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 32
·1-13
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IF 2.8
Tang Guohui,Ren Qian,Chen Zheng,Ding Zixuan,Zhu Changtian,Chen Jin,Xu Gaojie,Liu Fenghua
In this study, an economical graphene-based electrothermal composite slurry was synthesized via a facile liquid-phase ball milling technique, employing mechanically exfoliated graphene as the conductive filler, aluminum dihydrogen phosphate as the binding agent and span85 as a dispersing agent. The resultant slurry was utilized to fabricate electrothermal coatings through screen printing technology. A comprehensive investigation was conducted to evaluate the influence of graphene concentration on the physical appearance, microstructure, electrothermal characteristics, and mechanical adherence of the electrothermal coatings. The findings indicate a positive correlation between graphene content and the electrical conductivity of the coatings, with a concurrent increase in the attainable heating temperature. Specifically, a coating comprising an equal ratio of graphene to aluminum dihydrogen phosphate exhibited a diminished square resistance of 16.10 Ω sq −1 and was capable of swiftly elevating to a temperature of 431 °C under an applied voltage of 36 V. Moreover, the coatings demonstrated robust adhesion to borosilicate glass, quartz glass, and stainless steel substrates, with particularly noteworthy adhesion strength of up to 49,160 mN on borosilicate glass. These attributes suggest a broad spectrum of high-temperature applications for the developed electrothermal coatings.
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AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 1
·1-14
·
IF 4
Fan Fan,Zhou Feng,Zhang Jiayu,Yang Junhui,Zhuang Kai,Shan Yudong,Jiang Lei,Zhang Jiantao
Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble drugs, but ASDs often have low drug loadings, thereby necessitating larger dosage sizes. This study intended to create Soluplus® (SOL)-based microparticle ASDs with high drug loading (up to 60 w/w%) and long-term stability (at least 16 months) using electrospraying to enhance the dissolution of poorly water-soluble celecoxib (CEL). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analyses showed that the electrosprayed SOL-CEL microparticles were amorphous, and Fourier transform infrared spectroscopy (FTIR) data indicated the presence of hydrogen bonding between SOL and CEL in the microparticles, which helped stabilize the ASDs. In vitro dissolution studies demonstrated that these ASDs improved the CEL dissolution rate by up to 8.2-fold compared to the crystalline form. Electrospraying presents a promising alternative to conventional methods like hot-melt extrusion (HME) and spraying drying (SD) for the production of ASDs, providing simplicity, high drug loading capability and long-term stability, thus catering to a variety of poorly water-soluble drugs. Graphical
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-14
·
IF 14.7
Xie Liangyiqun,Cai Yanming,Jiang Yujing,Shen Meikun,Lam Jason Chun-Ho,Zhu Jun-jie,Zhu Wenlei
Direct converting low concentration CO 2 in industrial exhaust gases to high-value multi-carbon products via renewable-energy-powered electrochemical catalysis provides a sustainable strategy for CO 2 utilization with minimized CO 2 separation and purification capital and energy cost. Nonetheless, the electrocatalytic conversion of dilute CO 2 into value-added chemicals (C 2+ products, e.g., ethylene) is frequently impeded by low CO 2 conversion rate and weak carbon intermediates’ surface adsorption strength. Here, we fabricate a range of Cu catalysts comprising fine-tuned Cu(111)/Cu 2 O(111) interface boundary density crystal structures aimed at optimizing rate-determining step and decreasing the thermodynamic barriers of intermediates’ adsorption. Utilizing interface boundary engineering, we attain a Faradaic efficiency of (51.9 ± 2.8) % and a partial current density of (34.5 ± 6.4) mA·cm −2 for C 2+ products at a dilute CO 2 feed condition (5% CO 2 v/v), comparing to the state-of-art low concentration CO 2 electrolysis. In contrast to the prevailing belief that the CO 2 activation step ( \({{CO}}_{2}+{e}^{-}+\, * \,\to {}^{ * }{CO}_{2}^{-}\) ) governs the reaction rate, we discover that, under dilute CO 2 feed conditions, the rate-determining step shifts to the generation of *COOH ( \({}^{ * } {{CO}}_{2}^{-}+{H}_{2}O\to {}^{ * } {COOH}+{{OH}}^{-}({aq})\) ) at the Cu 0 /Cu 1+ interface boundary, resulting in a better C 2+ production performance.
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JOURNAL OF POROUS MATERIALS
·
2024
·
IF 2.5
Xue Changhao,Hou Xiaohui,Sun Weijie,Yuan Xia
The acidic molecular sieve carrier Hβ supported non-noble metal catalyst Ni/Hβ was prepared by equal volume impregnation method and applied to the hydroalkylation of benzene to cyclohexylbenzene. The effects of calcination procedures on the particle size of Ni and the dispersion degree of metal on the carrier were investigated. Compared with the samples reduced by hydrogen after calcination, the active site Ni of Ni/Hβ obtained by direct thermal reduction in hydrogen is mainly dispersed on the surface of the carrier, with better metal dispersion and smaller particle size of Ni. Under the optimized reaction conditions, the initial pressure of H 2 is 2.5 MPa, the amount of catalyst is 4% of the total reaction liquid, and at the reaction temperature 190 °C for 3 h, the conversion of benzene is 38.4%, the selectivity of cyclohexylbenzene is 72.8%, the selectivity of cyclohexane is 5.2%, the selectivity of dicyclohexylbenzene is 16.5%, and the selectivity of other by-products decreased to 5.5%. After the catalyst was reused for 5 times, the conversion of benzene and selectivity of cyclohexylbenzene were both have a slight decrease. Characterization results showed that the structure of the recovered catalyst was stable, but the specific surface area and pore volume decreased significantly, the resulted problem of catalyst pore blockage can be restored through calcination treatment.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-13
·
IF 5.3
Hu Anqi,Chen Guoqing,Li Lei,Ma Chaoqun,Yang Taiqun,Gao Hui,Gu Jiao,Zhu Chun,Wu Yamin
Nitrogen, boron co-doped carbon quantum dots (gCQDs), and a coloration probe (PPD-NPs) with response to cobalt ions (Co 2+ ) were prepared by using 4-hydroxyphenylboric acid as the common precursor, with ethylenediamine and p-phenylenediamine (PPD) adopted as nitrogen-doped reagents, respectively. A noticeable brown-to-purple color change can be observed with the addition of Co 2+ , and a broad absorption band emerges at 535 nm. At the same time, gCQDs, which is introduced as the fluorescence signal source, will be significantly quenched due to the enhanced inner filtration effect, induced by the overlap between the emission spectrum of gCQDs and the emerging absorption band. Therefore, a colorimetric/fluorescent dual-mode sensing probe for Co 2+ is constructed by combining the recognition unit PPD-NPs and the fluorescent gCQDs into PPD-NP/gCQD. Under the optimized experimental conditions, the calculated limits of detection are 1.51 × 10 −7 M and 3.75 × 10 −7 M for the colorimetric mode and the fluorescence mode, respectively, well qualified for the determination of Co 2+ maximum permitted level in drinking water. The feasibility of the proposed method has been verified in tap water, lake water, and black tea samples. Graphical Abstract
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