Nanomaterials
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2024
·Vol. 14
·期 10
·838
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IF 4.4
Hangyu Yan,Guowei Li,Fengyuan Zhang,Jingsong Liu,Mengdai Luoshan
Noble metal nanomaterials with a localized surface plasmon resonance effect exhibit outstanding advantages in areas such as photothermal therapy and photocatalysis. As a unique plasmonic metal nanostructure, gold nanobipyramids have been attracting much interest due to their strong specific local electric field intensity, large optical cross sections, and high refractive index sensitivity. In this study, we propose a novel three-component hetero-nanostructure composed of rough gold nanobipyramids (R-Au NBPs), Pt, and CdS. Initially, purified gold nanobipyramids are regrown to form R-Au NBPs that have a certain degree of roughness. These R-Au NBP substrates with a rough surface provide more hotspots and strengthen the intensity of localized electric fields. Subsequently, Pt and CdS nanoparticles are selectively deposited onto the surface of R-Au NBPs. Pt nanoparticles can provide more active sites. Each component of this hetero-nanostructure directly contacts others, creating multiple electron transfer channels. This novel design allows for tunable localized plasmon resonance wavelengths ranging from the visible to near-infrared regions. These factors contribute to the final superior photothermal conversion performance of the R-Au/Pt-CdS nanohybrids. Under the irradiation of near-infrared light (1064 nm), the photothermal conversion efficiency of R-Au/Pt-CdS reached 38.88%, which is 4.49, 1.5, and 1.22 times higher than that of Au NBPs, R-Au NBPs, and R-Au NBPs/Pt, respectively.
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ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Bin Guo,Xiaofei Sun,Shan Tao,Tian Tian,Haozhi Lei
As medical advancements turn most cancers into manageable chronic diseases, new challenges arise in cancer recurrence monitoring. Detecting circulating tumor cells (CTCs) is crucial for monitoring cancer recurrence, but the current methods are cumbersome and costly. This study developed a new CTC detection system combining DNA aptamer recognition, hybridization chain reaction (HCR) technology, and DNA logic devices, enabling the one-step recognition of CTCs by identifying multiple membrane proteins. After catalytically active Au nanoparticles were attached through reduction synthesis in situ onto the DNA hybridization strands of the CTCs surface, a 3,3′,5,5′-tetramethylbenzidine (TMB) colorimetric reaction was used to detect CTCs concentration via peroxidase-like catalysis. With this CTCs detection reporting system, we achieved an LOD of 4 cells/mL using an ultraviolet–visible (UV–vis) spectrophotometer. At certain concentrations, CTCs could even be detected visually without the need for an instrument. The development of this CTCs detection reporting system provided a convenient, reliable, and cost-effective detection strategy for widespread CTCs-based cancer recurrence monitoring.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Qiaozhi Yang,Weiyun Chen,Jiaxin Shi,Xin Huang,Luwei Zhang,Yunhan Zhang,Yixuan Wang,Yudong Wu,Xin Li,Kebin Xu,Qi Wang
Myoglobin (Myo) is the earliest biomarker for the diagnosis of acute myocardial infarction (AMI). Sensitive and reliable Myo assays are essential for timely diagnosis of AMI. In this work, a label-free electrochemical immunosensor was prepared by modifying a glassy carbon electrode (GCE) with a nanocomposite material combining a two-dimensional metal-organic framework (Co-BDC,1,4-benzenedicarboxylate is abbreviated as BDC) hybridized with molybdenum disulfide (MD) nanosheets and loaded with gold nanoparticles (Au NPs). The Au/Co-BDC@MD-modified electrode exhibits good electrochemical properties and biocompatibility, contributing to excellent sensor performance. Under optimal conditions, the linear range of the proposed electrochemical sensor was from 10 fg/mL to 10 ng/mL with a limit of detection (LOD) of 10.03 fg/mL (S/N = 3). In addition, the sensor possessed good specificity, reproducibility and stability. Meanwhile, the amount of Myo in serum was detected with recoveries of 96.9–98.5 % (RSD, 0.31–1.02 %). Therefore, the constructed immunosensor is important for the sensitive and accurate detection of Myo and the early diagnosis of AMI.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jiaojiao Li,Lei Chen,Boliang Zhou,Xin Yang,Xingyu Chen,Zhiwei Lu,Jiangling Wan,Qing Du,Chuansheng Zheng,Yanbing Zhao,Xiangliang Yang
A significant challenge in comprehensive interventional liver cancer therapy based on radiofrequency ablation and multifunctional microsphere embolization lies in enhancing therapeutic efficacy. Addressing this challenge, an innovative coaxial electrospray technology has been developed. This technology distinguishes between the processes of droplet dispersion and microsphere solidification by utilizing the stability of Pickering emulsions. Consequently, it broadens the range of materials that can be synthesized via the electrospray method and enables the incorporation of diverse functional substances to prepare multifunctional embolic microspheres. This process successfully constructs Au@PAM microspheres that combine embolization, radiopaque imaging, and radiofrequency thermal response functions. The radiopacity of the Au@PAM was comparable to the 41 mg I/mL iohexol, indicating its potential as a radiopaque embolic agent. In vitro embolization simulation experiments have indicated that the Au@PAM microspheres exhibit excellent elasticity, deformation, filling capacity, and thermal response adhesion characteristics. Furthermore, in vitro radiofrequency response experiments have demonstrated that the Au@PAM microspheres exhibit significant radiofrequency thermal effects. The integration of embolization with radiofrequency treatment in VX2 tumor-bearing rabbits suggests that Au@PAM microspheres substantially enhance the synergistic anti-tumor effects of transcatheter arterial embolization and radiofrequency ablation on liver cancer. Additionally, they positively influence the regulation of the postoperative tumor microenvironment.
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Catalysts
·
2025
·Vol. 15
·期 6
·544
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IF 4
Tingting Hu,Baozeng Ren,Liang Zhao
Hydrogen peroxide (H2O2) is an important industrial chemical that is widely applied in many areas. The direct synthesis of H2O2from H2and O2has proved to be a green and economic pathway. Pd-based bimetallic catalysts, due to their superior catalytic performances in this reaction, have attracted intensive attention. Herein, Tetrakis(hydroxymethyl)phosphonium chloride (THPC) was adopted as the protective ligand to immobilize Pd-Au alloy nanoparticles onto activated carbon (AC). The varied Pd/Au molar ratios demonstrated homogeneously distributed Pd-Au nanoalloys with average particle sizes ranging from 3.51 to 5.75 nm. The optimal ratio was observed over the Pd3Au1/AC-THPC catalyst with a maximum H2O2productivity of 165 mol/(kgPd·h) and selectivity of 82.3% under ambient pressure. The relationship between the electronic structure and catalytic activity indicated Pd0was the active site, while the presence of Au inhibited H2O2degradation rate. This research could help in the design efficient bimetallic catalysts for the direct synthesis of H2O2.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
·
IF 6.3
Ye Wang,Yulong Ying,Lvlv Ji,Wei Li,Yuan Wei,Tao Wang,Sheng Wang
The concurrent generation of clean hydrogen fuel and value-added organic compounds through photocatalysis offers a promising pathway for solar-to-chemical conversion. Here, we present a ternary Au-mediated S-scheme heterostructure comprising hollow TiO 2 nanobowls (HTNB), vertically aligned ZnIn 2 S 4 (ZIS) nanosheets, and interfacially confined Au nanoparticles. The hollow TiO 2 scaffold, fabricated via a green and scalable electrospray method, shortens carrier diffusion paths, while the direct S-scheme junction preserves strong redox potentials. Embedded Au nanoparticles at the HTNB/ZIS interface act as directional electron mediators, enabling cascade charge transfer (TiO 2 → Au → ZIS) and suppressing recombination. The optimized HTNB/Au@ZIS achieves a remarkable H 2 evolution rate of 42.27 mmol g −1 h −1 with an apparent quantum efficiency of 59.5 % at 380 nm under simulated solar light, among the highest reported for TiO 2 /ZIS systems. In a sacrificial-free system, it simultaneously produces 4.48 mmol g −1 h −1 H 2 and 4.05 mmol g −1 h −1 N-benzylidenebenzylamine with > 99 % selectivity. Comprehensive spectroscopic, electrochemical, and EPR analyses confirm the Au-mediated S-scheme charge-transfer mechanism. This work demonstrates a generalizable interfacial-engineering strategy for coupling oxidative and reductive photocatalysis, advancing the design of efficient dual-functional photocatalysts for solar-to-chemical energy conversion.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yifan Liu,Yiyu Yang,Minjie Peng,Wen Zang,Chaozhen Wang,Yuenan Zhang,Changyong Gao,Aiguo Wu,Yujie Zhang
Heparin, as a glycosaminoglycan with multiple physiological functions, performs important roles in clinical practice. The core function of heparin is its anticoagulant effect, which is commonly used to prevent and treat thrombotic diseases. However, when the heparin content in human blood exceeds the standard, it can result in thrombocytopenia, thereby posing threat to human health. Therefore, rapid, sensitive and accurate detection of heparin is of great practical importance in assessing the anticoagulant effect, prevention of thrombophilia, guidance on personalized medication, and avoiding side effects caused by excessive use. A new colorimetric sensor for detecting the anticoagulant heparin is introduced in this work. The sensor is low cost, fast, and simple. In the absence of heparin, protamine protects copper‑gold nanoparticles from the etching of iodide ions through electrostatic interaction, and the solution's color and spectral properties remain essentially the same as those of pure copper‑gold nanoparticles. When heparin is present, due to the strong electrostatic adsorption between heparin and protamine, protamine preferentially binds heparin and forms a complex. Cu-Au NPs are not protected and are etched into spherical Au NPs by iodide ions. The solution's color shifted from dark gray and purple to pink, thus colorimetric detection of heparin is realized rapidly based on the etching mechanism. The detection time is 15 min, and the detection limit is as low as 1 ng/mL. Compared with HPLC detection method, the colorimetric detection of heparin in serum samples has the recovery rate of 98.8–108.8 %, which has good prospects for application.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Qian Lan Li,Da Yong Miao,Zhong Wei Jiang,Kun Lin Huang,Chang Xia,Yi Wang
Dark-field microscopy (DFM) as a single particle analysis (SPA) technique has been developed rapidly in recent years because of its high signal-to-noise ratio, enhanced sensitivity, and sufficient spatial and temporal resolution. Here, an in situ single Au@Cu2O core–shell nanoparticle (Au@Cu2O NP) light scattering imaging analysis was reported to realize the ultrasensitive detection of biothiols–cysteine (Cys) and glutathione (GSH). Based on the specific binding of Cu(I) with –SH to the formation of the Cu–S bond, it triggered the decomposition of the Cu2O shell and exposure of the Au nanorods (Au NRs) in the presence of biothiols. Moreover, the process of Cu2O shell dissolution has been observed in real time under DFM, which indicated that the scattering color changed from bright green to dark red and the scattering intensity decreased, correspondingly. Compared with ex situ SPA, in situ SPA exhibited significantly high sensitivity due to the effect of concentration polarization, which exhibited linear correlations over broad concentration ranges (Cys: 0.05–3 nM, GSH: 0.1–10 nM), with low detection limits of 15.52 pM (Cys) and 75.07 pM (GSH). Therefore, this work provides a smart strategy to find promising applications for the ultrasensitive detection of biomolecules through SPA.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Ying Zhou,Senfeng Liu,Xinlei Yan,Yunying Wei,Liang Ma,Ruo Yuan
The convenient detection of tetracycline (TC) residues has attracted considerable attention because irrational use of TC causes food pollution damaging the human health. Herein, a point-of-care testing (POCT) platform is established for the sensitive and specific determination of TC in a polydopamine-functionalised Eppendorf tube. In particular, TC can be efficiently recognised by an aptamer–antibody chimera to trigger visual fluorescence (FL) and electrochemiluminescence (ECL) ‘dual-signal’ response of gold nanoclusters. Consequently, the biosensor exhibits a wide detection range spanning from 5 fM to 1 μM, with low detection limits of 73 fM (visual FL) and 2.3 fM (ECL). Hence, it can be said that the POCT platform is superior to the enzyme-linked immunosorbent assay. The strategy utilises the strength of FL, i.e. visualisation, and that of ECL, i.e. high sensitivity, providing a guiding approach for the development of POCT in food security and environmental monitoring.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Jing Wen,Jiayi Wang,Jiamin Sun,Baichao Zhang,Chao Suo,Jing Cui,Xuchuan Cao,Yaxin Yang,Yuexian Hao,Shaohui Guo,Xiaojian Bai,Xian-Ming Zhang
Non-extra-artificial destructive detection of trace residual detached wall painting pigments is an important prerequisite for wall paintings restoration work. As the amount available for detection of artifacts is relatively small, the relevant information must be derived through microanalysis. To this end, the trace molecules can be concentrated and enriched for surface-enhanced Raman scattering (SERS). In this work, the ZIF-67 was Ni 2 + -acid etched into Co–Ni layered double hydroxide (LDH) hollow nanocages. After introducing Au nanoparticles (NPs), Au NPs@Co–Ni LDH core–shell structured composites with a very low detection limit for RhB (10 –10 mol L −1 ) were formed. The composites were applied to non-extra-artificial destructive detection of green, red, and blue trace mural mineral pigments, in which the main components were identified as chlorocopperite, vermilion and ultramarine, respectively. This result proves the universality of the composites to mural pigments of different types in different regions. Experimental data and finite element simulation results show that the etching treatment endowed the SERS substrate materials with a concentration effect, which led to more molecules of the substances to be measured aggregating around the Au NPs, enhanced the detection signals of the molecules, and achieved the concentration in the plasmonic field, which in turn improved their adsorption capacity and enrichment function of the target molecules. This work realizes the innovative application of the concentration effect in the SERS detection of ancient mural pigments, which is important for the analysis, identification, and restoration of mural paintings and other cultural relics.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zhi Chen,Jian Sun,Guoliang Cheng,Yifan Wang,Huanhuan Liu,Hui Lin
Fluorescence assay for in situ and on-site monitoring of pyrethroid pesticides residues from plants is of great value but remains little research. In this study, a fluorescence biosensor Au NCs@BSA, is designed and constructed by embedding Au nanoclusters (Au NCs) in bovine serum albumin (BSA) to transmit on-the-scene cypermethrin pesticide residues messages. Harnessing orange emission and stimuli-responsive performance of Au NCs, as well as the specific strong binding ability of BSA to cypermethrin molecules, Au NCs@BSA is endowed with quantitative response to cypermethrin at μM level within 20 s through promoting fluorescence recovery in conjunction with the transformation of fluorescence images into digital signals. In addition, the interference experiment using common ions and other types of pesticides as coexisting interference substances demonstrated that the sensing system possesses brilliant selectivity and anti-interference ability. By combining the smartphone-based platform and convolutional neural network (CNN-model), different concentrations levels of cypermethrin were accurately identified in real samples. This study opens up a new avenue to engineer simple fluorescence assay for in situ and on-site capturing of the pyrethroid pesticide residue information, favoring the rapid development of agriculture food monitoring.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Jinyong Hu,Yu Zhao,Bohao Liu,Yong Zhang
The exploitation of visible-light-activated gas sensors based on molybdenum disulfide (MoS 2 ) has been extensively investigated and is expected to hold tremendous potential in emerging fields of indoor gas sensing applications activated by daylight lamp. Enlightened by the localized surface plasmon resonance (LSPR) effect of Au nanoparticles in visible light spectrum and the abundant active sites of SnS quantum dots, an indoor white light activated gas sensor based on Au@MoS 2 /SnS nanocomposites is rationally developed for the high sensitive detection of nitrogen dioxide (NO 2 ). Under the white light irradiation, the as-proposed gas sensor demonstrates an enhanced response exceeding 25-folds toward 1 ppm of NO 2 compared with the pristine MoS 2 gas sensor. Moreover, the white light-activated Au@MoS 2 /SnS gas sensor manifests excellent repeatability, rapid response/recovery speed (7/8 s), ppb-level detection limit, favorable long-term stability, and remarkable selectivity toward NO 2 . These enhanced gas sensitive performances principally stem from the interfacial charge transfer effect within the Au@MoS 2 /SnS composite material and the multiplied gas-sensitive pathways facilitated by the LSPR effect originating from the Au nanoparticle cores. This work paves an efficacious avenue for the development of high-performance gas sensitive devices operable at room temperature, thereby facilitating innovative advancements of gas sensing technology in various Internet of Things (IoTs) applications.
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