Food Chemistry-X
·
2026
·
IF 9.2
Xiaoxue Lu,Jingna Liu,Yuanhong Zhuang,Bingli Wang,Peng Fei,Wenqiang Lai
A series of thermo-responsive PNIPAAm-CS/SA composite hydrogel films were synthesized via radical polymerization and ionic cross-linking. FTIR, XPS, and NMR confirmed the successful covalent grafting of PNIPAAm onto the chitosan (CS) backbone. XRD and SSNMR analyses revealed that the grafting disrupted the CS crystalline regions, inducing an amorphous structural transition. The PNIPAAm-CS copolymer solutions exhibited LCST values in the range of 30–32 °C. Notably, compared with the corresponding precursor systems, the hydrated films exhibited an apparent thermo-responsive transition onset approximately 1 °C higher in temperature-dependent optical measurements, suggesting that film-network formation influenced the thermal response behavior of the PNIPAAm-containing system. Grafting modification significantly improved optical and mechanical properties: PNIPAAm-CS/SA-4 achieved a peak transmittance of 82.81% (vs. 50.78% for pure CS/SA), while PNIPAAm-CS/SA-2 reached an optimal balance with 22.6 MPa tensile strength and ∼ 100% elongation. Furthermore, antibacterial evaluation of the PNIPAAm-CS copolymers showed that, although the inhibitory activity decreased with increasing PNIPAAm incorporation, measurable antibacterial effects against E. coli and S. aureus were retained. Together with the preliminary package-integrated visual response demonstration, these results suggest that the hydrated films may serve as candidate temperature-responsive indicator materials for further development in intelligent packaging.
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DOI
PubMed
高影响因子
ChemPlusChem
·
2026
·Vol. 91
·期 10
·e70252
·
IF 3.1
Yue-Jie Li,Ran Chen,Shao-Bo Li,Jin Zeng,Jing-Wen Chen,Hong-Yuan Wang,Chang-Wei Xu,Li Li,Jing Liu
Dye-containing wastewater remains an important environmental concern because many synthetic dyes are persistent and potentially harmful to aquatic organisms and human health. In this work, a biomass-based adsorbent was evaluated together with a separate post-desorption photo-oxidative treatment step. Cellulose (CL) and chitosan (CS) were used to prepare cross-linked CS/CL (C-CS/CL) microspheres for dye removal from water, with glutaraldehyde (GA) used to improve the structural stability of the microspheres. The synthesized C-CS/CL microspheres exhibited improved mechanical stability and pH-dependent dye adsorption, with preferential uptake of anionic dyes (acid blue 93 and acid black 1) and lower uptake of cationic dyes (methyl violet and methyl green). After adsorption, the dyes were eluted, allowing the C-CS/CL microspheres to be reused for repeated dye removal. The dye-containing eluate was subsequently subjected to UV/H 2 O 2 treatment, resulting in partial degradation of the model dyes. Overall, the C-CS/CL microspheres enabled preferential adsorption and repeated reuse, while the separate UV/H 2 O 2 step provided subsequent treatment of the dye-containing eluate. Graphical Crosslinked chitosan/cellulose microspheres provide stable, pH-responsive adsorption of anionic and cationic dyes and retain most adsorption capacity through ten reuse cycles. Adsorption is maintained in electrolyte, binary-dye, and real-water matrices. Regeneration releases dye-containing eluate for separate UV/H 2 O 2 treatment, which provides partial dye degradation as a complementary downstream oxidation step after desorption.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yunhao Liu,Zuyu He,Yinghang Zhang,Chuang Zhou,Chao Wang,Lingxue Kong,Puwang Li,Shaohua Chen,Lu Yang,Wenwen Chen,Ziming Yang
Chitosan modified with quaternary phosphonium salt and sorbic acid was synthesized. • The TEO Pickering emulsions stabilized by CNC and MCS were prepared, which exhibited excellent stability. • A multifunctional film with good mechanical and barrier properties was designed. • The composite film against C. gloeosporioides can prolong the shelf life of mangoes. Mango is a popular tropical fruit valued for its flavor and nutritional richness. However, its postharvest shelf life is limited because of its climacteric nature, which leads to rapid softening and spoilage. Chitosan-based coatings suffer from limited mechanical strength and single-function antimicrobial activity. To address these limitations, a bifunctional modified chitosan (MCS) was synthesized by grafting quaternary phosphonium salts and sorbic acid onto the chitosan backbone. This MCS was then combined with a thyme essential oil (TEO) Pickering emulsion stabilized by cellulose nanocrystals (CNC) to fabricate an active composite coating (MCS-PE). The chemical structure, thermal stability, mechanical properties, and barrier properties of the composite films were characterized. The results indicated that the composite film loading with TEO at 3 μL/mL exhibited favorable tensile strength (10.94 MPa) and elongation at break (41.12%). Antibacterial assays revealed that the MCS-PE film-forming solution had excellent activity against Escherichia coli , Staphylococcus aureus and C.gloeosporioides . The coating films effectively extended the storage life of mangoes at 25 °C, as indicated by assessments of peel color, firmness, weight loss, and other physiological indices. Consequently, mangoes coated with the optimal MCS-PE3 coating film (3 μL/mL TEO) had a shelf-life extension of at least 10 days compared to the uncoated control group. The sensory acceptability of the coated mangoes, particularly regarding potential flavor alteration, should be evaluated in future studies prior to commercial application. This work demonstrates that the synergistic integration of bifunctional chemical modification and Pickering emulsion stabilization offers a promising strategy for designing next-generation fruit preservation coatings.
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DYES AND PIGMENTS
·
2026
·
IF 3.9
Guangxuan Zhu,Chuang Shang,Jiayang Niu,Aiai Gao,Yusen Zhao,Xuegang Chen
The novel furan-modified fluorene-based fluorescent small molecules were synthesized. • A catalyst-free Diels–Alder cycloaddition is utilized to crosslink chitosan, affording a mild fabrication strategy. • The as-prepared fluorescent hydrogel exhibits fluorescence color change behavior under ultraviolet light irradiation. • The fluorescent hydrogel achieve dual detection of Fe 3+ and Hg 2+ in aqueous solutions. In this study, a fluorescent furan-modified fluorene molecule ( F-Fu ) was first synthesized via a Stille coupling reaction. Using F-Fu as a cross-linker, a novel chitosan-based fluorescent hydrogel was successfully prepared through a Diels-Alder reaction between furan-functionalized F-Fu and maleimide-modified chitosan derivatives. The SEM results revealed the hydrogel has a porous network structure with pore sizes ranging from 60 to 100 μm. Rheological characterizations reveal dominant elastic responses (G′>G″), and the elastic modulus is elevated upon increasing crosslinking density. The hydrogel emits blue-violet fluorescence. The main emission peak at 385-386 nm originates from the π-π* transition of the fluorene core, and the shoulder peak at 398-402 nm is attributed to intramolecular charge transfer (ICT). Upon ultraviolet irradiation, the hydrogel exhibits green fluorescence, with its emission peaks merging and undergoing a blue shift to 378-382 nm. In aqueous dispersion, the fluorescence is readily quenched by Fe 3+ and Hg 2+ ions, enabling their sensitive detection. Owing to the paramagnetic or heavy-atom effect upon coordination, the LOD values for Fe 3+ and Hg 2+ are 0.064 ppm and 0.199 ppm, respectively. Download: Download high-res image (304KB) Download: Download full-size image
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Biomaterials Advances
·
2026
·
IF 6.7
Yutao Feng,Wenxin Zhou,Lai Chang,Chaoying Wang,Yanxu Li,Xuqing Cai,Fuyang Yu,Wei Wu
A CMCS-SA nanofiber biomembrane loaded with chlorogenic acid and astragalus polysaccharide was fabricated via electrospinning • The dual-active-loaded nanofiber biomembrane modulates oxidative stress and inflammatory response via NRF2/HO-1 signaling pathway • The nanofiber dressing accelerates diabetic wound repair by promoting collagen deposition and dermal tissue reconstruction • Natural-product-based electrospun nanofiber shows promising potential for diabetic wound healing application Background Chronic diabetic wounds are difficult to heal due to persistent oxidative stress, uncontrolled inflammation, cellular dysfunction, and impaired angiogenesis. Traditional dressings cannot actively regulate this complex microenvironment; thus, new active repair materials are urgently needed. Methods A dual-drug loaded nanofiber mat was constructed using carboxymethyl chitosan/sodium alginate (CMCS/SA) as the matrix, co -loaded with chlorogenic acid (CGA) and astragalus polysaccharide (APS) via electrospinning. Samples were characterized by SEM, etc. In vitro hemostatic, antibacterial, and cytocompatibility properties were evaluated. A full-thickness skin defect model in STZ-induced diabetic mice was used to evaluate healing efficacy. Mechanisms were explored using histology, immunofluorescence, Western blot, and flow cytometry. Results The nanofiber mat exhibited uniform structure, excellent hemostasis, water absorption, and antibacterial activity. In diabetic mice, it significantly accelerated wound closure, promoted granulation tissue formation, and enhanced re-epithelialization. Mechanistically, the material upregulated the NRF2/HO-1 pathway to eliminate ROS, inhibited NF-κB signaling to reduce TNF-α and IL-6, promoted macrophage polarization from M1 to M2, and enhanced angiogenesis and orderly collagen deposition. Conclusions This study successfully constructed a multifunctional nanofiber mat with synergistic effects of antioxidation, anti-inflammation, immune regulation, and tissue regeneration, providing a new strategy for diabetic wound treatment.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Qiuyue Huang,Ruoxuan Xu,Yanchen Liu,Na Li,Yuanyuan Sun,Rongxia Liu
Evo and Cur directly co-assembled into carrier-free nanoparticles • COS@EC NPs prolonged intestinal retention and increased systemic exposure • COS@EC NPs reduced ROS and VSMC proliferation with Nrf2/HO-1 upregulation • CETSA and DARTS supported HO-1 involvement in the cellular response • Oral COS@EC NPs reduced plaque burden in high-fat diet-fed ApoE −/− mice Oxidative stress and dysregulated vascular smooth muscle cell (VSMC) proliferation drive atherosclerotic (AS) progression and plaque development. Natural phytochemicals, including evodiamine (Evo) and curcumin (Cur), show anti-atherosclerotic potential, but poor aqueous solubility and insufficient intestinal absorption limit their oral use. Here, Evo and Cur were co-assembled into carrier-free Evo–Cur nanoparticles (EC NPs) and coated with chitosan oligosaccharide (COS) to obtain COS-coated EC nanoparticles (COS@EC NPs). Spectroscopic analyses and molecular dynamics simulations indicated that hydrophobic interactions, hydrogen bonding, and π–π stacking mediated Evo–Cur nanoassembly. Under simulated gastrointestinal conditions, COS@EC NPs reduced gastric Cur release and increased intestinal Cur release. After oral administration, COS@EC NPs prolonged intestinal residence and increased systemic exposure. In platelet-derived growth factor-BB (PDGF-BB)-stimulated VSMCs, COS@EC NPs suppressed excessive proliferation, reduced intracellular reactive oxygen species (ROS), elevated nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) expression, and restrained cell-cycle progression. This antiproliferative effect was partially reversed by the HO-1 inhibitor zinc protoporphyrin IX, suggesting HO-1 involvement. Cellular thermal shift assay (CETSA) and drug affinity responsive target stability (DARTS) analyses showed treatment-associated increases in the apparent thermal and proteolytic stability of HO-1, further supporting its involvement. In high-fat diet-fed ApoE −/− mice, oral administration of COS@EC NPs reduced plaque burden, improved lipid profiles, and alleviated oxidative stress without detectable systemic toxicity. Overall, these findings support COS@EC NPs as a potential carrier-free oral nanomedicine strategy for AS therapy and suggest that HO-1-associated redox regulation contributes to their vascular protective effects.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Jun Yang,Gulden Goksen,Di Wu,Guanghua Xia,Wanli Zhang
Light-driven mesoporous polydopamine for controlled release of cinnamaldehyde. • Functionalized films show enhanced barrier properties and antibacterial performance. • Controlled antimicrobial release prolongs strawberry shelf-life by 2–4 days. • Smart light-responsive films integrate spatiotemporal release and postharvest preservation. Postharvest microbial contamination poses a significant challenge to fruit preservation. In this study, CMCTD films were fabricated by incorporating cinnamaldehyde-loaded mesoporous polydopamine nanocarriers with a phase-change shell into a chitosan matrix, producing a denser microstructure with enhanced mechanical strength and improved water vapor barrier properties. Upon near-infrared irradiation, the films rapidly induced photothermal temperature rise above 60 °C within 5 min, which simultaneously triggered controlled release of cinnamaldehyde at a cumulative amount of 4 mg/g over 24 h. At the microstructural level, the synergistic antibacterial effect arose from the combination of photothermal temperature rise and sustained cinnamaldehyde release, effectively inhibiting Escherichia coli and Staphylococcus aureus . The films exhibited high biocompatibility, with cell viability exceeding 96% and hemolysis rates below 5%, confirming their safety for food-contact applications. Application tests on strawberries demonstrated effective suppression of microbial growth, reduced moisture and nutrient loss, and prolonged shelf life by 2–4 days. These results illustrate how microstructural design and functional integration within CMCTD films can be harnessed to achieve controlled antimicrobial activity, providing a practical strategy for postharvest fruit preservation. Download: Download high-res image (150KB) Download: Download full-size image
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高影响因子
Polymers
·
2026
·Vol. 18
·期 9
·1114
·
IF 5.8
Phan Thi Minh Huyen,Luu Tien Hung,Phan Thi Hong Tuyet,Nguyen Huy Dan,Luu Thi Viet Ha,Tran Thi Nhu Quynh,Nguyen Xuan Dung
Antibiotic contamination of water, particularly tetracycline (TC), poses significant environmental risks and requires sustainable treatment solutions. This study reports a green and cost-effective synthesis of a ZnO/chitosan nanocomposite (ZnO/CS) for photocatalytic TC removal. ZnO nanoparticles were synthesized using lime juice as a natural stabilizing agent and subsequently incorporated into a chitosan matrix. The physicochemical properties of the composite were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), UV-Vis diffuse reflectance spectroscopy (UV-Vis DRS), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDX), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET) surface area analysis. The results confirmed the successful formation of hexagonal wurtzite ZnO and strong interfacial interactions between ZnO nanoparticles and the –NH 2 /–OH functional groups of chitosan. The incorporation of chitosan significantly increased the specific surface area from 10.7 to 21.7 m 2 g −1 and reduced the band gap from 3.18 to 3.03 eV, thereby improving visible-light absorption. The photocatalytic performance was evaluated under varying pH, initial TC concentration, and catalyst dosage, with optimal conditions identified at pH 6, 20 mg/L TC, and 1 g/L catalyst. Under these conditions, the ZnO/CS nanocomposite achieved 94.1% TC degradation within 120 min under visible-light irradiation. Scavenger experiments revealed that •OH and •O 2 − radicals are the dominant reactive species, and a possible degradation mechanism was proposed. These findings demonstrate the potential of the green-synthesized ZnO/CS nanocomposite for antibiotic removal from aqueous environments.
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高影响因子
LANGMUIR
·
2026
·
IF 4.4
You Zhou,Yunjin Li,Zhengkai Han,Shangqing Yang,Yun Xue,Aichen Zhu,Yang Liu,Zhen Liang,Rui Shi,Xinyue Zhang
Post-traumatic uncontrolled bleeding is a major cause of trauma-related mortality, especially in cases involving irregular and noncompressible wounds. Existing commercial hemostatic powders face limitations such as unstable clot formation, poor tissue adhesion, and suboptimal biocompatibility, which restrict their clinical applicability. To address this, we developed a chitosan (CS)/poly(acrylic acid) (polyacrylic acid (PAA))-based composite hemostatic powder (CP powder) for effective management of noncompressible bleeding. The CP powder was obtained by dehydrating and grinding the CS/PAA hydrogel. They could rapidly absorb a large volume of fluid at the bleeding site and undergo an in situ transformation into a hydrogel state only within 10 s. In vitro experiments verified its excellent antibacterial efficacy, hemocompatibility, immunoregulation, and coagulation performance. In vivo experiments confirmed its efficacy in achieving rapid hemostasis in noncompressible wounds and modulating the immune microenvironment to promote tissue regeneration. The CP powder combines the quick hemostasis and enhanced tissue regeneration, offering a promising strategy for managing severe bleeding in clinical and emergency settings.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Ting Wu,Qiwei Wang,Sihan Zhou,Hecheng Chen,Libing Zhang
pH-tunable, reversible bidirectional bending in the electro-responsive oppositely charged polyelectrolyte Janus hydrogel. • EHD printing-in-situ photopolymerization strategy resolves CS/SA hydrogel performance bottlenecks. • Excellent mechanics (808.9% strain) and high ionic conductivity (13.81 × 10 −3 S/cm) integrated in the hydrogel. • Practical devices (soft gripper, biomimetic flower) validate broad applications in soft robotics. Polyelectrolyte hydrogels are ideal for soft actuators, but conventional chitosan/sodium alginate (CS/SA) ionic hydrogels face a critical trade-off among flexibility, ionic content, and actuation speed, hindering their practical applications. Herein, dimethylaminoethyl methacrylate (DMAEMA) and sodium acrylate (AAS) were used to modify CS-based polycationic and SA-based polyanionic networks, respectively. A Janus polyelectrolyte hydrogel (PCDM/PSSM) with seamless interface was fabricated via one-pot synthesis, electrohydrodynamic (EHD) printing, and in-situ photopolymerization. Microstructural characterization verified successful monomer grafting, amorphous/low-crystallinity networks, and robust interlocked interfaces. The hydrogel exhibited superior mechanical properties (PSSM achieving a tensile stress of 78.6 kPa and a strain of 775.6%, and PCDM achieving a tensile stress of 52.2 kPa and a strain of 808.9%, respectively), high ionic conductivity (13.81 × 10 −3 S/cm for PSSM), and efficient electro-actuation (155° bending at 10 V). Its core advantage is pH-programmable reversible bidirectional bending: −145° toward the polyanionic layer at pH = 2 and + 151° toward the polycationic layer at pH ≥ 7, originating from pH-regulated asymmetric swelling of protonated/deprotonated functional groups and enhanced by electric-field-induced ion migration. Demonstrated applications included an underwater soft gripper for fragile object manipulation and a biomimetic flower for pH-responsive petal closure. This work resolves the longstanding trade-off of CS/SA hydrogels and provides a scalable strategy for high-performance stimuli-responsive soft actuators, promising broad use in soft robotics, bioinspired systems, and biomedical engineering.
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PubMed
高影响因子
Materials Today Nano
·
2026
·
IF 7.6
Yexia Xiao,Yuxin Guo,Bingyang Wang,Yongdong Zhao,Huifang Wang,Xianghua Gao,Baolong Niu,Wenfeng Li
Caffeic acid-modified chitosan (CCS) was successfully prepared as a dispersant and reducing agent for nanosilver. • AgNPs@CCS has excellent antimicrobial activity and biocompatibility. • APCCS composite films exhibit strong antioxidant properties. • The APCCS-2 composite film achieves long-lasting antimicrobial activity and can inhibit bacterial reproduction within 60 h. • APCCS composite films extended the shelf life of strawberries to the 9th day under 4 °C storage conditions. The massive release of silver nanoparticles poses a cumulative toxicity threat to the environment and living organisms. In this study, we have for the first time utilized the strong chelating effect of catechol groups in caffeic acid-modified chitosan (CCS) toward Ag + to achieve the immobilization and reduction of nanosilver (AgNPs@CCS) via a green synthesis method. This approach enables controlled Ag + release and enhances the biocompatibility of AgNPs@CCS: Ag + release was only 0.298 ± 0.004 μg/mL after 72 h. Hemolysis rates remained below 5% at 1024 μg/mL, and cell viability exceeded 80% at 250 μg/mL. Furthermore, to investigate the application of AgNPs@CCS in fruit preservation, we incorporated it as an antimicrobial filler into CCS and polyvinyl alcohol matrices to prepare composite films with excellent antimicrobial and preservation properties. Results demonstrated that the incorporation of AgNPs@CCS significantly enhanced the composite the mechanical properties, antioxidant capacity, and barrier performance of film. The APCCS-2 composite film exhibited antibacterial inhibition rates exceeding 97% against both E . coli and S . aureus , effectively suppressing bacterial proliferation for up to 60 h. Finally, the APCCS composite film extended the shelf life of strawberries stored at 4 °C to 9 days. And the weight loss rate of all APCCS composite films was greater than 19% on the 28th day, indicating that they have excellent degradation performance. It is a highly promising freshness-preserving packaging film. Download: Download high-res image (346KB) Download: Download full-size image
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Pei Wu,Yilin Che,Rui Zhou,Yixin Tang,Lei Guo,Baiqiao Chen,Xinran Yan,Shanli Wu,Chang Liu,Mujie Kan,Jizhou Zhang,Xi Yang,Xin Jiang,Zhanxin Wang,Erlei Wang,Tianhao Yan,Caina Xu
Novel chitosan-based composite film with Luteolin-SOD nano-micelles via nano-encapsulation for food preservation. • This composite film outperforms conventional packaging: superior inhibition of oxidation, delays spoilage, biodegradable. • Natural-ingredient film: promising substitute for traditional packaging, meeting eco-friendly and sustainable demands. Chitosan-based films are promising alternatives to petroleum-based food packaging materials but suffer from insufficient mechanical strength, poor water resistance, and limited antioxidant capacity. To address these issues, we synthesized chitosan-based nano-polymers loaded with luteolin (Lut) and superoxide dismutase (SOD) (CLS nano-micelles). We then incorporated these nano-micelles into a chitosan-based film to produce a CLS film. The results showed that, compared with the pure chitosan film, the mechanical properties of CLS film significantly improved, with tensile strength increasing from 6.14 MPa to 37.50 MPa and elongation at break increasing from 17.4% to 34.6%. The barrier properties of the CLS film were also enhanced, as both water vapor permeability and solubility decreased. Notably, the CLS film also exhibited excellent antioxidant properties (with DPPH inhibition rates increasing from 4.4% to 48.3% and ABTS inhibition rates rising from 7.2% to 74.6%) and demonstrated potent antibacterial activity against E. coli , S. aureus , and B. subtilis . It also exhibited excellent biocompatibility and demonstrated favorable biodegradability in soil. Grape preservation assays further confirmed its efficacy in maintaining fruit freshness. These results demonstrate that integrating CLS nano-micelles into a chitosan matrix significantly improves its mechanical, barrier, antioxidant, and antibacterial properties. This makes the CLS film a promising eco-friendly alternative for sustainable food packaging applications, offering an efficient and environmentally friendly solution. Download: Download high-res image (125KB) Download: Download full-size image
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高影响因子
危险品化学品经营许可证（带存储）