RSC Advances
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2017
·Vol. 7
·期 77
·48894-48903
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IF 3.108
Ziyang Lu,Zehui Yu,Jinbo Dong,Minshan Song,Yang Liu,Xinlin Liu,Di Fan,Zhongfei Ma,Yongsheng Yan,Pengwei Huo
A stable core–shell imprinted Ag-(poly-o-phenylenediamine)/CoFe2O4 (imprinted Ag-POPD/CoFe2O4) was synthesized via the surface imprinting technique. Ag-POPD was introduced into an imprinted layer, which significantly enhanced the photocatalytic activity. Meanwhile, due to the existence of imprinted cavities in the imprinted layer, the imprinted Ag-POPD/CoFe2O4 exhibited the superior specific recognition capability for selective photodegradation of ciprofloxacin (CIP). This work puts forward a novel design idea for synthesizing imprinted photocatalysts.
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Molecular Medicine Reports
·
2025
·Vol. 31
·期 3
·1-12
·
IF 3.5
Xiangli Yan,Siqi Quan,Roujia Guo,Zibo Li,Ming Bai,Baoying Wang,Pan Su,Erping Xu,Yucheng Li
Calycosin‑7‑O‑β‑D‑glucoside (CG), a major active ingredient of Astragali Radix, exerts neuroprotective effects against cerebral ischemia; however, whether the effects of CG are associated with mitochondrial protection remains unclear. The present study explored the role of CG in improving mitochondrial function in a HT22 cell model of oxygen‑glucose deprivation/reperfusion (OGD/R). The Cell Counting Kit‑8 assay, flow cytometry, immunofluorescence and western blotting were performed to investigate the effects of CG on mitochondrial function. The results demonstrated that mitochondrial function was restored after treatment with CG, as indicated by reduced mitochondrial reactive oxygen species levels, increased mitochondrial membrane potential and improved mitochondrial morphology. Overactivated mitophagy was revealed to be inhibited by the regulation of proteins involved in fission [phosphorylated‑dynamin‑related protein 1 (Drp1) and Drp1] and mitophagy (LC3, p62 and translocase of outer mitochondrial membrane 20), and mitochondrial biogenesis was demonstrated to be enhanced by increased levels of sirtuin 1 (SIRT1) and peroxisome proliferator‑activated receptor γ coactivator‑1α (PGC‑1α). In addition, neuronal apoptosis was ameliorated by CG, as determined by a decreased rate of apoptosis, and levels of caspase‑3 and Bcl‑2/Bax. In conclusion, the present study demonstrated that CG may alleviate OGD/R‑induced injury by upregulating SIRT1 and PGC‑1α protein expression, and reducing excessive mitochondrial fission and overactivation of mitophagy.
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CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Shixian Chen,Gaohui Du,Yan Cheng,Di Han,Jiahao Deng,Yunting Wang,Huayu Li,Libing Yao,Dong Wang,Qingmei Su,Bingshe Xu
Lithium-sulfur (Li-S) batteries are poised to become the next-generation energy storage technology due to their ultra-high energy density of 2600 Wh kg −1 and the abundant reserves of sulfur on Earth. However, the practical use of Li-S batteries faces several challenges related to sulfur cathodes, including low sulfur loading, significant volumetric expansion, slow conversion kinetics, and the shuttle effect caused by polysulfides. To tackle these challenges, we have developed a hierarchical porous carbon co-doped with nitrogen, oxygen, and sulfur heteroatoms (NOSHPC) that is further loaded with monodispersed vanadium nitride quantum dots (VNQDs). This innovative combination serves as an efficient catalytic matrix to enhance charge transfer processes and facilitate the anchoring and conversion of lithium polysulfides. Moreover, we have fabricated dry-processed cathodes with ultrahigh sulfur loading by using fibrotic polytetrafluoroethylene (PTFE) as a binder, replacing the toxic solvent N-methyl-2-pyrrolidone and polyvinylidene fluoride. The dry-processed VNQDs/NOSHPC/S cathodes demonstrate a remarkable specific capacity of 1655mAh g −1 at 0.1C and achieve exceptional cycling stability, with a decay rate of only 0.0107 % per cycle over 1000 cycles at 1C with a sulfur loading of 5.2 mg cm −2 . Additionally, the pouch cells containing these dry-processed electrodes exhibit a practical areal capacity of 14.2mAh cm −2 (462 Wh kg −1 ) with a sulfur loading of up to 18.6 mg cm −2 and a low electrolyte-to-sulfur ratio of 5.3μL mg −1 . This work presents an innovative strategy for creating sulfur hosts and practical dry-processed Li-S electrodes, highlighting promising prospects for industrial application.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Shan Gao,Tinghong Lu,Xiaohan Zhu,Fengli Yu,Bing Yuan
A catalytic system of Ru nanoparticles (NPs), Ru@SLSaq, dispersed in water was developed by employing sodium lignosulfonate (SLS) to reduce and stabilize ruthenium(III) cation heptaacetate (Ru3O(OAc)7) in an aqueous solution. This Ru@SLSaq catalytic system enabled the efficient hydrogenation of diphenylmethane (DPM) and o-hydroxydiphenylmethane (o-HDPM), yielding dicyclohexylmethane (DCHM) and perhydrofluorene (PHF), respectively. Characterization using UV–vis, FT-IR, Raman spectroscopy, HR-TEM, CO chemisorption, DLS, XRD, and XPS demonstrated that SLS effectively replaces the axial acetate ligands of Ru3O(OAc)7, reduces Ru in situ through the phenolic hydroxyls in its macromolecular structure, and maintains the stability of its core structure, thereby preventing the aggregation of generated Ru NPs. The obtained Ru NPs, predominantly in the Ru0 state with a Ru (100) lattice plane, were uniformly dispersed in the aqueous phase, exhibiting an average particle size of 2–3 nm. Ru@SLSaq displayed excellent catalytic activity for the hydrogenation of DPM and o-HDPM, achieving yields of 96.6% and 97.0% for DCHM and PHF, respectively, under mild conditions (n(substrate)/n(Ru) = 750, hydrogen pressure of 1.5 MPa, at 80 °C for 4 h). The calculated apparent activation energies (Ea) for the two reactions were found to be 46.5 kJ·mol–1 and 75.3 kJ·mol–1, respectively, and the catalytic system demonstrated good cycling stability. Experimental results, supported by DFT calculations, indicate that the complete hydrogenation processes of DPM and o-HDPM occur on the surface of Ru NPs via monophenyl ring adsorption, exhibiting small energy barrier differences across various pathways.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Chuhan Zhang,Yanchang Chu,Linying Fu,Qiuyue Wang,Rui Ma,Donghai Xu,Le Yang
Lignin, a renewable resource rich in aromatic ring structures in nature, is an ideal natural source to produce aromatic compounds and cycloparaffin. Herein, we prepare MOF-derived Ni–MoxC/C and Co–MoxC/C as catalysts for the depolymerization of lignin and dimeric model compounds. Diphenyl ether (DPE) with 4-O-5 bond, benzyl phenyl ether (BPE) with α-O-4, and phenethyl phenyl ether (PPE) with β-O-4 are chosen as dimeric model compounds. Overall, Ni–MoxC/C and Co–MoxC/C show distinguished different activity toward product distribution. Ni–MoxC/C facilitates both C–O bond cleavage and hydrogenation of the benzene ring, and the main products are ethyl cyclohexane and cyclohexanol for all three model compounds. In contrast, Co–MoxC/C only facilitates C–O bond cleavage and obtains phenol and ethylbenzene as products. Similarly, for the depolymerization of lignin, cycloparaffins are obtained on Ni–MoxC/C, while phenol, guaiacol, 2,6-dimethoxyphenol, and their respective derivatives are obtained on Co–MoxC/C.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 14
·7760
·
IF 4.9
Churan Li,Boxiao Wu,Weihua Wang,Xiaoqin Yang,Yun Liu,Guolei Zhu,Sida Xie,Qian Jiang,Yong Ding,Yingjun Zhang,Ping Zhao,Lihua Zou
Arbutin and 6′-O-caffeoylarbutin (CA) fromVaccinium dunalianumWight are known for their ability to inhibit melanin synthesis. To boost the production of arbutin and CA, precursor feeding with hydroquinone (HQ) was studied inV. dunalianumsuspension cells. The effect of HQ on the biosynthesis of arbutin and CA in the suspension cells was investigated using high-performance liquid chromatography (HPLC), and possible molecular mechanisms were analyzed using metabolomics and transcriptomics analyses. HPLC analysis only showed that the addition of HQ significantly enhanced arbutin synthesis in cells, peaking at 15.52 ± 0.28 mg·g−1after 0.5 mmol·L−1HQ treatment for 12 h. Subsequently, metabolomics identified 78 differential expression metabolites (DEMs), of which arbutin and CA were significantly up-regulated metabolites. Moreover, transcriptomics found a total of 10,628 differential expression genes (DEGs). The integrated transcriptomics and metabolomics revealed that HQ significantly enhanced the expression of two arbutin synthase (AS) genes (Unigene0063512 and Unigene0063513), boosting arbutin synthesis. Additionally, it is speculated that CA was generated from arbutin and 3,4,5-tricaffeoylquinic acid catalyzed by caffeoyl transferase, with Unigene0044545, Unigene0043539, and Unigene0017356 as potentially associated genes with CA synthesis. These findings indicate that the precursor feeding strategy offers a promising approach for the mass production of arbutin and CA inV. dunalianumsuspension cells and provides new insights for CA biosynthesis inV. dunalianum.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Kaijia Wang,Ziwu Liu,Shiheng Mu,Huanqiang Shi,Mengmeng Zhou,Chao Yuan,Shijian Lu,Zhonghai Ni,Guoliang Tian
As a remarkable alternative anode to commercial graphite for the next-generation high-performance lithium-ion batteries (LIBs), silicon (Si) has attracted tremendous attention due to its high specific capacity. However, the enormous volume expansions/contractions during the charge/discharge limited its practical application in LIBs greatly. To solve these issues, herein, we fabricated a low-cost FeSi intermetallic compound (FeSi 2 ) by the ball milling with photovoltaic industrial waste micron-sized Si and Fe powders as raw materials and encapsulated it by N, S, O-doped mesoporous carbon with polyvinylpyrrolidone as C, N, O precursor and (NH 4 ) 2 SO 4 as template and pore-introducing agent. Owing to the presence of FeSi 2 , abundant meso-pores for mitigating Si and FeSi 2 expansion and the N, S, O-doped mesoporous carbon for facilitating lithium-ion transport and electron conduction, one as-prepared FeSi 2 /N, S, O-doped mesoporous carbon composite anode (FeSiA 1 @C) showed a high specific capacity of 401.7 mAh g −1 even at 1.0 A g −1 after 1600 cycles. More impressively, the assembled LiFePO 4 || 20 % FeSiA 1 @C/80 % commercial graphite full cell presented a high energy density of ca. 312.0 Wh kg −1 and a capacity retention of ca. 80 % after 500 cycles, demonstrating a promising practical applicability of FeSiA 1 @C anode, and showing a new way for the high-value utilization of industrial waste micron-sized Si for LIBs.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Wang Lixiang,Ren Qiang,Wang Xiaoli
Through a facile sol-gel method, a novel Z-scheme heterojunction BTMO was synthesized by combining Bi-modified TiO 2 with oxygen-modified graphitic carbon nitride. Bi serves as an electron mediator in the catalyst, facilitating the transfer of excited electrons to MCN-O. Infrared characterization reveals that the doping of O increases the adsorption of peroxymonosulfate by the catalyst, promoting the reaction between electrons on the conduction band of MCN-O and PMS. The as-prepared BTMO Z-scheme heterojunction significantly improved the degradation rate of trichloroethylene was in BTMO/PMS system. TCE degradation efficiency in BTMO/PMS photocatalytic system could reach 99.8 % within 1 hour. According to the results of electron paramagnetic resonance and quenching experiments, sulfate radical and holes are the main reactive species in BTMO/PMS system. This novel photocatalyst also exhibited excellent durability. This work provides a new method for solving environmental problems through visible light photocatalysis.
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ENERGY & FUELS
·
2024
·
IF 5.2
Lan Li,Tingxue Fang,Fuming Lai,Xinyue Li,Tingting Qu,Lin Wang,Xiaoshi Lang,Kedi Cai
Vanadium pentoxide (V2O5) is regarded as a promising sulfur-wrapped matrix for high-performance lithium–sulfur batteries, owing to its desirable structural and functional characteristics. In this paper, a large number of defective sites arise in the vanadium pentoxide structure via a codecoration strategy of the V, O sites, which is more beneficial to improving the electroconductivity and allows for the uniform loading of sulfur on the surface, thereby reducing the polarization resistance and elevating the kinetic rates during the electrochemical reaction. Electrochemical test results indicate that Mg2+/S-codecorated V2O5/S composite cathodes have 1131.15, 942.39, and 804.71 mAh·g–1 of discharge-specific capacities at 0.1, 0.2, and 0.5 C rates, respectively, with the lowest charge/discharge plateau voltage difference, and the capacity retention rate after 140 cycles can be 57.95%. Besides that, the multidefect V2O5 can effectively promote the adsorption strength of lithium polysulfide and catalytically accelerate the rate of liquid-phase conversion between lithium polysulfide so as to achieve the stable electrochemical properties for sulfur composite cathodes.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Rui Li,Wenhui Ruan,Rui Hao,Jue Chen,Chu Xu,Liyan Lu,Yingli Wang
Cannabidiol (CBD) is a natural cannabinoid with anti-epileptic, anti-inflammatory, and other biological activities. However, CBD is highly lipophilic, and its oral bioavailability is only 6%, which greatly limits its efficacy. Here, we aimed to overcome the poor solubility and low oral bioavailability of CBD by formulating O-carboxymethyl chitosan-grafted cholesterol succinate monoester-loaded cannabidiol nanomicelles (CBD/CCMC NMs). The particle size, polydispersity index, and zeta potential of the optimised CBD/CCMC NMs were 230.61 ± 1.82 nm, 0.17 ± 0.05, and -13.52 ± 1.24 mV, respectively. And it showed a spherical structure under scanning electron microscopy, exhibited stability at 25 °C and 37 °C, with pH-dependent release in vitro . There was improved the solubility of CBD in water by 568.67-fold and exhibited excellent biocompatibility. There was also improved bioavailability of CBD. Therefore, CBD/CCMC NMs can be used as delivery systems for improving the solubility and intestinal absorption of hydrophobic drugs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yun Hu,Jingru Sun,Cuige Zhang,Chunmiao Xia,Liuyan Zhu,Maodong Xu,Rongli Zhang,Yinsheng Fang
Hollow carbon spheres (HCSs) have attracted broad attention in aqueous zinc-ion hybrid supercapacitors (ZIHSCs) owing to their distinctive properties. However, traditional methods for fabricating HCSs face limitations, including complex multistep procedures, the use of corrosive chemicals, and stringent reaction conditions. In this work, biomass-based poly(γ-glutamic acid)/Ni 2+ /melamine/chitosan nanoparticles were used as the precursors to fabricate N/O co-doped hollow graphite carbon spheres (HGCSs). Thanks to the appropriate hydrophilic characteristic, specific surface area, pore size distribution, and electrical conductivity, the fabricated HGCSs cathode exhibited superior electrochemical properties. The assembled HGCSs-based ZIHSCs device showed a satisfactory specific capacitance of 133.2 mAh·g −1 at a current density of 1.0 A·g −1 , high energy densities of 75.2 Wh·kg −1 at 10,000 W·kg −1 and 107.9 Wh·kg −1 at 1000 W·kg −1 , respectively. Additionally, the assembled HGCSs-based ZIHSCs device displayed an exceptional cycling stability, enduring up to 10,000 cycles at 0.5 A·g −1 with a capacity retention rate of 98.1 %. This work provides a facile and novel strategy to prepare superior electrochemical performance biomass-based HGCSs cathode for ZIHSCs.
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PHYTOMEDICINE
·
2024
·
IF 6.7
Tingwen Zhang,Yue Zhong,Yan Shi,Chengcheng Feng,Lu Xu,Zheng Chen,Xin Sun,Yan Zhao,Xialin Sun
Background The pathogenesis of acute liver injury (ALI) has been a pressing issue in the medical scientific community. We previously found that 5-O-methylvisammioside (MeV) from Saposhnikovia divaricata (Turcz.) Schischk has excellent anti-inflammatory properties. However, the mechanism by which MeV protects against ALI still needs to be deeply investigated. Purpose In the present study, we established an acetaminophen (APAP) -induced ALI mouse model and pre-protected the mice with MeV. Methods & Results Our findings indicate that MeV (5 and 10 mg/kg) lowered the blood levels of alanine aminotransferase and aspartate aminotransferase and reduced the infiltration of inflammatory cells in the liver. MeV initially showed an inhibitory effect on ALI. We then analyzed the molecular mechanisms underlying the effects of MeV by transcriptomic and metabolomic analyzes. Through transcriptomic analysis, we identified 4675 differentially expressed genes between the APAP+MeV group and the APAP-induced ALI group, which were mainly enriched in the MAPK pathway, the TNF pathway, and the NF-κB pathway. Through metabolomic analysis, we found that 249 metabolites in the liver were differentially regulated between the APAP+MeV group and the APAP- induced ALI group, which were mainly enriched in the arachidonic acid pathway. The mRNA expression levels of key genes (encoding TNF-α, p38, AP-1, RelB, IL-1β, and Ptges), as determined by RT-PCR analysis, were consistent with the RNA-seq data. The ELISA results indicate that MeV markedly decreased the serum levels of TNF-α and IL-1β in mice. Finally, the key proteins in the NF-κB and MAPK pathways were examined using immunoblotting. The results showed that MeV decreased IκB-α phosphorylation and inhibited the nuclear translocation of NF-κB. In addition, MeV reduced the hepatic inflammatory burst mainly by inhibiting the phosphorylation of p38 and JNK in the MAPK pathway. Conclusion The present study demonstrated (i) that MeV could ameliorate APAP-induced ALI by inhibiting arachidonic acid metabolism and the TNF, MAPK, and NF-κB pathways, and (ii) that MeV is a promising drug candidate for the prevention of ALI.
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