Food Bioscience
·
2024
·
IF 4.8
Linhui Feng,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The Amadori rearrangement product (GR-ARP) derived from glutathione/ribose mixture (GSH/Rib) was prepared through spray drying characterized by short-term high temperature dehydration. The water activity of spray-dried samples containing GR-ARP decreased continuously with an intensified degree of dehydration. Lower water activity (from 0.23 to 0.13) and higher GR-ARP yield (from 46.56% to 64.02%) in the spray-dried products were found with the increase of inlet temperature, the slowdown of feed speed, and the alkalization of stock solution. Moreover, during the spray drying and formation of powders, the intensified dissipation of bound water to free water promoted intermolecular condensation that compensated bound water, favoring the directed conversion of GSH/Rib into GR-ARP. Compared to rotary evaporation at 80 °C, spray drying enabled a stronger restraint of amide cleavage and sulfhydryl oxidation in GSH, which reduced the yield of GSH-derived byproducts by 16.39%. Thus, GR-ARP was achieved a peak yield of 64.02% at an initial pH of 7.00 based on more efficient intermolecular condensation and controlled side reactions of GSH when the inlet temperature was set at 170 °C. The spray-dried sample containing richer GR-ARP and other flavor precursors showed a more similar flavor profile to the heated GSH/Rib mixture (complete Maillard reaction products) than other GR-ARP-related thermal processing samples, such as vacuum-dehydrated, GR-ARP, GR-ARP + GSH, and GR-ARP + Rib samples, revealing a great potential of the ARP mixture prepared by spray drying for flavor enhancement.
研究领域:
食品科学
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生物化学
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产品关联
DOI
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2025
·
IF 6.3
Yunxiang Du,Zhuoyue Lan,Wanting Yang,Xiong Li,Yunchuan Li,Hang Li,Zhiyu Pu,Letian Hu
Background Conventional chalcopyrite depressants face environmental and selectivity challenges in copper-molybdenum separation. This study introduces 1-thioglycerol (1-TG), an eco-friendly organic depressant, demonstrating exceptional selectivity for chalcopyrite. Methods The depression performance of 1-TG was evaluated through flotation experiments. Its selective adsorption mechanism was elucidated using surface characterization techniques, including contact angle, SEM-EDS, LEIS, FTIR, XPS and molecular dynamics simulations. Significant findings 1-TG achieved efficient separation of molybdenite from chalcopyrite. For the synthetic mixed ore at pH 5 with 25 mg/L 1-TG, recoveries of Cu and Mo were 6.01% and 89.53%. Mechanistic studies demonstrated that 1-TG selectively chemisorbs on chalcopyrite surfaces through coordinating with metal sites, effectively masking adsorption sites and reducing surface hydrophobicity. The -SH groups in 1-TG promoted selective adsorption, as confirmed by surface analyses. This non-toxic depressant functions effectively at low dosages, offering a sustainable alternative to conventional toxic inhibitors like cyanides. The findings provide fundamental insights into green reagent design and advance eco-friendly strategies for sulfide mineral separation, addressing critical environmental and efficiency challenges in copper-molybdenum processing.
研究领域:
矿物加工工程
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资源与环境科学
·
表面化学
·
冶金工程
·
可持续技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xingguo Zhou,Hanghang Liu,Yanhui Zheng,Yaobao Han,Tingting Wang,Hao Zhang,Qiao Sun,Zhen Li
Radiotherapy has been extensively used to treat cancer patients because it can effectively damage most solid tumors without penetration limits. A hypoxic microenvironment in solid tumors leads to severe radioresistance and expression of hypoxic inducible factor-1 (HIF-1), which results in poor efficacy of radiotherapy alone. Herein, we report the excellent efficacy of radiotherapy achieved using a new type of yolk–shell Cu2–xSe@PtSe (CSP) nanosensitizer functionalized with the HIF-1α inhibitor acriflavine (ACF). We prepare the CSP nanosensitizer through the interfacial redox reactions between chloroplatinic acid and Cu2–xSe nanoparticles (CS) and then functionalize the nanosensitizer with ACF through their electrostatic interactions. We show that the synthesized CSP nanosensitizer can arrest the cell cycle (i.e., at the gap 2/mitosis (G2/M) phases) of tumor cells to enhance their sensitivity to X-rays and decompose endogenous H2O2 into O2 to reduce hypoxia and increase the production of reactive oxygen species, which leads to severe damage to DNA double strands and apoptosis of tumor cells. We also show that the ACF on the surface of CSP nanoparticles can effectively reduce the expression of HIF-1α. All these effects lead to a low vascular endothelial growth factor, low density of microvessels in tumor, decreased cell proliferation, and increased cell apoptosis, which synergistically and drastically enhance the efficacy of radiotherapy. This work provides insights and guidance for developing novel nanosensitizers to enhance the efficacy of radiotherapy.
研究领域:
肿瘤学
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纳米医学
·
放射生物学
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DOI
PubMed
高影响因子
ANALYST
·
2015
·Vol. 140
·期 13
·4662-4667
·
IF 4.107
Yaqi Hu,Chunyan Du,Yunchao Li,Louzhen Fan,Xiaohong Li
Direct and rapid detection of 1-hydroxypyrene (1-OHP) is of great importance owing to its high carcinogenicity, teratogenicity and toxicity. In this study, a simple colorimetric assay for rapid determination of 1-OHP is reported, which is based on non-crosslinking aggregation of gold nanoparticles (Au NPs) induced by 1-OHP in the presence of formic acid (FA). Initially, Au NPs were synthesized with citrate as the capping agent and exhibited red color. Subsequently, the addition of FA did not cause aggregation of Au NPs, but a proton transfer process occurred from FA to carboxylic anions on the surface of Au NPs with a decreased zeta potential. The subsequent addition of 1-OHP resulted in a further decreased zeta potential and an intensely hydrophobic environment, which led to a strong and rapid non-crosslinking aggregation of Au NPs within 5 min with the color changing from red to violet blue. Based on this principle, sensitive and selective detection of 1-OHP was achieved. The detection limit was 3.3 nM. Finally, the colorimetric assay was successfully applied to detect 1-OHP in a urine sample. This strategy provides new insights into developing colorimetric methods for on-site and real-time detection of polycyclic aromatic hydrocarbons.
研究领域:
环境科学
·
分析化学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
Metals
·
2025
·Vol. 15
·期 3
·299
·
IF 2.5
Feng Jiang,Shuai He,Wei Sun,Yuanjia Luo,Honghu Tang
The effective and environmental separation of chalcopyrite and molybdenite has long presented a challenge in mineral processing due to their similar floatability and close association at room temperature. This study explores the non-toxic 1-thioglycerol (1-TG) as a selective depressant for chalcopyrite–molybdenite flotation separation. An impressive separation effect was realized through single-mineral and mixed-mineral flotation experiments when using 1-TG as a depressant and kerosene as a collector. Contact angle measurements, zeta potential tests, and Fourier transform infrared spectroscopy (FT-IR) confirm the selective adsorption of 1-TG on the chalcopyrite surface, leading to enhanced surface hydrophilicity and the inhibition of collector adsorption. The depression mechanism is further elucidated through X-ray photoelectron spectroscopy (XPS), which demonstrates that it occurs via chemosorption between the thiol group in 1-TG and active iron sites on the chalcopyrite surface. These findings provide a potential efficient depressant for chalcopyrite–molybdenite flotation separation with low dosage, environmental friendliness, and human harmlessness.
研究领域:
矿物加工工程
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2012
·Vol. 4
·期 6
·2150-2156
·
IF 5.914
Na Li,Jin-Gui Wang,Jian-Xiong Xu,Jin-Yu Liu,Hui-Jing Zhou,Ping-Chuan Sun,Tie-Hong Chen
Hydrothermally stable mesoporous aluminosilicates Al-SBA-1 with hierarchical pore structure have been successfully synthesized under alkaline condition at 120 °C by employing organic mesomorphous complexes of polyelectrolyte (poly(acrylic acid) (PAA)) and cationic surfactant (hexadecyl pyridinium chloride (CPC)) as template. The Si/Al ratio could be as high as 5 and the incorporation of Al into the silica framework did not disturb the well-ordered cubic Pmn mesostructure. Meanwhile, the incorporation of Al could greatly increase the specific surface area and pore volume of the samples. The Al-SBA-1 materials exhibited a high hydrothermal stability and remained stable even after being treated in boiling water for 10 days. The catalytic activity of the Al-SBA-1 materials was investigated by employing the Friedel–Crafts alkylation of toluene with benzyl alcohol as a model reaction and they exhibited excellent catalytic property due to the incorporated acid sites and the hierarchically mesoporous structure.
研究领域:
材料科学
·
催化化学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tiankai Bai,Zhilong Shi,Shuguang Bao,Xiaorong Hou,Yuping Zhao,Wai L.W. Leung,Yuhui Li,Sirigunqiqige Pan,Ying Xin,Ye Luo,Xiaohe Xiao,Laxinamujila Bai,Huifang Li
Radix Fici Hirtae (RFH), a traditional Chinese medication, is said to be useful in controlling immunity. However, it remained unclear whether its polysaccharides components are associated with these immunomodulatory properties. Herein, two polysaccharides, designated RFHP-1 and RFHP-2, were isolated from RFH using water-soluble alcohol precipitation and column chromatography. Structural characterization by monosaccharide content analysis, methylation, and nuclear magnetic resonance spectroscopy (NMR) revealed that the main chain of RFHP-1 was formed by the interconnection of →4)-α-D-Glc p -(1→, →3,6)-β-D-Glc p -(1→, →3)-β-D-Glc p -(1→, and →4,6)-α-D-Glc p -(1→, and the main chain of RFHP-2 was formed by the interconnection of →4)-α-D-Glc p -(1→, →3,6)-β-D-Gal p -(1→, →3)-β-D-Gal p -(1→, →4,6)-α-D-Glc p -(1→ and →6)-β-D-Gal p -(1→. Both RFHP-1 and RFHP-2 raised the CD4/CD8 ratio and improved the expression of immune factors in immunocompromised mice. By activating the NF-κB pathway (promote phosphorylation of p65 and IκB), RFHP-1 and RFHP-2 both promoted release cytokines (NO, TNF-a, IL-6, and IFN-γ) at RAW 264.7 macrophages. The results of molecular docking (−8.4 kcal/mol vs. -6.0 kcal/mol) and isothermal titration calorimetry (ITC) (−7.75 kcal/mol vs. -7.46 kcal/mol) demonstrated that RFHP-1 exhibited stronger binding affinity with MD2, suggesting greater immunoactivating potential. These findings indicate that RFHP polysaccharides, particularly RFHP-1, may serve as promising candidates for development as dietary supplements for individuals with compromised immune systems.
研究领域:
中药学
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免疫学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Keming Zhang,Xianye Luo,Sihui Li,Xiaohe Tian,Qingnan Wang,Chenlu Liu,Yanting Tang,Xiaoting Feng,Rui Zhang,Shuangfeng Yin,Shaofei Wang
Developing high-performance H 2 /CH 4 separation membranes is of great potential for H 2 production in the petroleum industry. Incorporating nanofillers into a polymer matrix to form mixed matrix membranes (MMMs) can elevate selectivity and permeability, but poor polymer-filler interfacial compatibility and filler aggregation are formidable problems. Targeting this, we propose a novel approach by incorporating a metal–organic framework (MOF) gel, ZIF-8 gel, as the versatile filler to a high free volume polymer PIM-1 and investigate the H 2 /CH 4 separation capabilities of the MMMs. Benefiting from the gel network morphology of ZIF-8, they were dispersed evenly in the PIM-1 matrix. The interconnected gel network structure of ZIF-8 gel helped to construct continuous gas transport pathways in the polymer. As a result, the H 2 /CH 4 separation performance was notably improved, demonstrating a substantial increase in H 2 permeability by 78.9% (exceeding 6800 Barrer) and a 38.0% enhancement in H 2 /CH 4 selectivity at a ZIF-8 gel loading of 31.0 wt%. These improvements surpassed the upper bound established in 2008. The Maxwell and Lewis-Nielsen models were developed to clarify gas transport mechanisms across membranes, and the experimental data of ZIF-8 gel/PIM-1 was well-matched with the calculated results of the Lewis-Nielsen models. Adopting MOF gel as fillers may pave a new approach to design high-performance MMMs with interconnected transport pathways.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Guojun Lv,Tao Wang,Yan Chen,Jiangzhang Wang,Xuyang Zou,Jun Lu,Fumin Wang,Xubin Zhang,Yi Zhai
Design of catalyst particles bearing excellent diffusion performance and suitable surface wettability is of great importance to the successful application of Pickering interfacial catalysis. In this study, selective oxidation reactions over hydrophobized hollow TS-1 zeolite were applied as probe reactions to investigate the influence of catalyst diffusion performance closely related to mesopore size on its catalytic activity. Hydrophobized hollow TS-1 zeolite particles were prepared via a post desilication treatment accompanied with precrystallization treatment. The synthesized hydrophobized hollow TS-1 zeolite was characterized by Scanning electron microscopy, Transmission electron microscopy , X-ray diffraction, UV–vis absorption spectrometry , Fourier-transform infrared spectroscopy and Nitrogen adsorption-desorption. Stable Pickering emulsions including 1-hexene-hydrogen peroxide, cyclohexene-hydrogen peroxide and cyclohexanone-water were prepared with hydrophobized hollow TS-1 zeolite particles as emulsifier . HTS-1–393(2)-S zeolite synthesized with precrystallization at 393 K for 2 h presented the maximum values of 43.9 mol/(Ti-mol·h) for 1-hexene epoxidation , 15.7 mol/(Ti-mol·h) for cyclohexene epoxidation and 247.3 mol/(Ti-mol·h) for cyclohexanone ammoximation. In addition, HTS-1–393(2)-S zeolite particles displayed good reusability for more than five cycles.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
WATER RESEARCH
·
2014
·
IF 5.323
Chao Shan,Zhiyao Ma,Meiping Tong,Jinren Ni
Fe 3 O 4 @SiO 2 magnetic nanoparticles modified by grafting poly(1-vinylimidazole) oligomer (FSPV) was fabricated as a novel adsorbent to remove Hg(II) from water. Fourier transform infra-red spectroscopy confirmed the successful grafting of oligomer , and thermogravimetric analysis showed FSPV had a high grafting yield with organic content of 22.8%. Transmission electron microscopy image displayed that FSPV particles were polymer-coated spheres with size of 10–20 nm. With saturation magnetization of 44.7 emu/g, FSPV particles could be easily separated from water with a simple magnetic process in 5 min. The Hg(II) adsorption capacity of FSPV was found to be 346 mg/g at pH 7 and 25 °C in 10 mM NaCl. Moreover, the removal of Hg(II) by FSPV was not obviously affected by solution pH (from 4 to 10) or humic acid (up to 8 mg/L as TOC). The presence of seven common ions including Na + , K + , Ca 2+ , Mg 2+ , Cl − , NO 3 − , and SO 4 2 − (up to 100 mM ionic strength) slightly increased the adsorption of Hg(II) by FSPV. X-ray photoelectron spectroscopy analysis revealed that the N atom of the imidazole ring was responsible for the bonding with Hg(II), whereas the bonding of Hg with N did not result in cleavage of Hg–Cl bond in HgCl 2 and HgClOH. The regeneration of Hg(II)-loaded FSPV could be achieved with 0.5 M HCl rapidly in 10 min, and the removal of Hg(II) maintained above 94% in five consecutive adsorption–desorption cycles. Therefore, FSPV could serve as a promising adsorbent for Hg(II) removal from water.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2024
·
IF 4.5
Yi Chen,Shasha Song,Yongfang Wang,Lili Wu,Jianbing Wu,Zhengmeng Jiang,Xinyu Li
Psoriasis (PSO) is a common inflammatory skin disease caused by multiple factors. Magnolia officinalis is an important medicinal plant in China, with various values such as ecology, medicine, food, and daily chemicals. However, its diverse application potential has not been fully explored. Magnolol (MGO) is the main active compound of Magnolia officinalis with significant anti-inflammatory effect. To investigate the application potential of MGO in inflammatory skin disease, the effects and underlying mechanisms of topical MGO treating psoriasis were explored in this study. Network pharmacology and molecular docking firstly predicted that topical MGO may treat psoriasis by regulating pyroptosis pathway and acting on caspase-1 (CASP1). In vitro experiments then demonstrated that MGO could inhibit the level of inflammatory cytokines and the key protein expression of NOD-like receptor protein 3 (NLRP3)/Caspase-1 pathway in lipopolysaccharide (LPS)-stimulated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 cells. Meanwhile, MGO could inhibit CuSO 4 -induced neutrophils migration in Tg (mpx:EGFP) zebrafish by suppressing inflammation and pyroptosis. This study further indicated that topical application of MGO ameliorated imiquimod (IMQ)-induced psoriasis-like dermatitis by reducing the release of inflammatory factors and decreasing the key protein expression of pyroptosis-related NLRP3/Caspase-1 pathway. Metabolomics analysis revealed that topical application of MGO could significantly regulate tryptophan metabolism and affect the level of tryptophan in skin lesions. Tryptophan could also regulate inflammation-related genes and inhibit pyroptosis-related NLRP3/Caspase-1 pathway in LPS-stimulated PMA-differentiated THP-1 cells. In conclusion, this study suggested that topical MGO may ameliorate psoriasis-like dermatitis by inhibiting NLRP3/Caspase-1 pathway and regulating tryptophan metabolism.
研究领域:
药理学
·
皮肤科
·
分子生物学
·
代谢组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wenyu Luo,Binhua Huang,Minzhen Lei,Zhijian Wu,Qian Yu,Dawei Zhang,Chunyan Yan
Throughout the history of traditional Chinese medicine, Angelica pubescens has been extensively employed to treat inflammatory arthritis. However, little is known about the anti-rheumatoid arthritis (RA) effects of A. pubescens polysaccharides. In this study, four crude polysaccharides (APR50, APR70, APR90, and APRB) were isolated from A. pubescens radix, and the rat model of collagen-induced arthritis (CIA) was established to evaluate the anti-RA effects of A. pubescens polysaccharides. A. pubescens polysaccharides could effectively reduce the degree of paw swelling in CIA rats, among which the effect of APR50 was comparable to that of methotrexate. A homogenous polysaccharide APRP50-2-1 was purified from APR50. Structural characterization indicated that APRP50-2-1 was primarily composed of glucose, mannose, galactose, and arabinose. The main skeleton of APRP50-2-1 consisted of →4)- α - d -Glc p -(1→, →6)- α - d -Glc p -(1→, and →6,4)- α - d -Gal p -(1→ residues. The branched chains of →4)- α - d -Glc p -(1→ and →3)- β - d -Man p -(1→ were substituted at O -4 of →4,6)- α - d -Gal p -(1→. APRP50-2-1 inhibited the proliferation and promoted the apoptosis of MH7A cells by down-regulating the expression of the anti-apoptotic protein B-cell lymphoma-2 (BCL-2) and up-regulating the expression of the pro-apoptotic protein BCL2-associated X (BAX). In conclusion, A. pubescens polysaccharides had significant anti-RA effects in rat CIA model, among which APR50 and APRP50-2-1 possessed the promising prospects of ameliorating RA.
研究领域:
中药学
·
免疫学
·
结构生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）