Advanced Therapeutics
·
2023
·Vol. 6
·期 4
·2200237
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IF 4.6
Yan-Mei Li,Xiang Zhou,Xin-Yu Li,Jia-Qi Huang,Zi-Wen Qiu,Ren-Jiang Kong,Ni Yan,Shi-Ying Li,Hong Cheng
Oxygen-dependent photodynamic therapy (PDT) holds unique advantages on tumor treatment by inducing cell apoptosis, but it is often limited owing to the unfavorable tumor microenvironments. In this study, a self-delivery O 2 -ecomonizer (designated as CeTam) is prepared to relieve hypoxia and reverse antiapoptotic pathway for enhanced photodynamic tumor therapy. Based on Chlorin e6 (Ce6) and Tamoxifen (Tam), CeTam is assembled through intermolecular hydrophobic interaction without any vehicles. Nanosized CeTam has an enhanced stability and improved drug delivery efficiency, which prefers to accumulate at tumor tissue for effective cellular uptake. More importantly, CeTam can effectively inhibit mitochondrial respiration to relieve hypoxia and reduce Bcl-2 expression to reverse antiapoptotic pathway. As a result, this self-delivery O 2 -ecomonizer successfully regulates the unfavorable tumor microenvironments to enhance the PDT efficacy on tumor elimination. Taken together, this work reports a multifunctional nanoplatform by a simple self-assembly strategy to remedy the deficiencies of PDT on hypoxic tumor treatment, which can advance the development of individualized biomedicine for precise tumor therapy.
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高影响因子
APPLIED CATALYSIS A-GENERAL
·
2022
·
IF 5.723
Feilin Zhao,Chizhong Wang,Dongdong Wang,Yimeng Yin,Jie Yu,Jinchi Han,Jie Zeng,Huazhen Chang
A series of Cd-doped NiO catalysts were prepared and tested in the N 2 O catalytic decomposition reaction. In comparison with NiO, it was found that the Cd 0.04 Ni catalyst showed higher N 2 O decomposition activity in the temperature range of 300–450 °C with or without O 2 , and lower activation energy (77.8 kJ mol −1 ). The incorporation of Cd into the NiO lattice was verified by X-ray diffraction (XRD) patterns and Raman spectra. This led to the distortion of the original NiO structure and weakened the Ni-O bond. X-ray photoelectron spectroscopy (XPS) results showed that compared with NiO and CdO, Cd 0.04 Ni possessed higher Ni 2+ and Cd (n+1)+ contents, which might have been induced by the electron transfer behavior between CdO and NiO. A possible mechanism for active site regeneration and O 2 desorption over Cd 0.04 Ni was proposed. The Cd 0.04 Ni catalyst also exhibited good resistance to NO and O 2 .
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Hanhao Huang,Yulian Shang,Haofei Li,Qi Feng,Yang Liu,Junlin Chen,Hua Dong
Pancreatic islets transplantation is an optimal alternative to exogenous insulin injection for long-term effective type 1 diabetes treatment. However, direct islets transplantation without any protection can induce cell necrosis due to severe host immune rejection. Insufficient O2 supply induced by the lack of capillary network at the early stage of islets transplantation is another critical constraint limiting islets survival and insulin-secretion function. In this paper, we design a novel co-transplantation system composed of islets-laden nanocomposite microgels and O2-generating microspheres. In particular, nanocomposite microgels confer the encapsulated islets with simultaneous physical protection and chemical anti-inflammation/immunosuppression by covalently anchoring rapamycin-loaded cyclodextrin nanoparticles to microgel network. Meanwhile, O2-generating microspheres prepared by blending inorganic peroxides in biodegradable polycaprolactone and polylactic acid can generate in situ O2 gas and thus avoid hypoxia environment around transplanted islets. In vivo therapeutic effect of diabetic mice proves the reversion of the high blood glucose level back to normoglycemia and superior glucose tolerance for at least 90 days post co-transplantation. In brief, the localized drug and oxygen codelivery, as well as physical protection provided by our co-transplantation system, has the potential to overcome to a large extent the inflammatory, hypoxia, and host immune rejection after islets transplantation. This new strategy may have wider application in other cell replacement therapies.
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高影响因子
Small
·
2022
·Vol. 18
·期 15
·2107467
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IF 15.153
Jia-Qi Huang,Lin-Ping Zhao,Xiang Zhou,Ling-Shan Liu,Rong-Rong Zheng,Fu-An Deng,Yi-Bin Liu,Xi-Yong Yu,Shi-Ying Li,Hong Cheng
Abnormal tumor metabolism causes the hypoxic microenvironment, which greatly limits the efficacy of photodynamic therapy (PDT). In this work, a strategy of metabolic reprogramming is proposed to economize O 2 for enhanced PDT against hypoxic tumors. The carrier-free O 2 -economizer (designated as LonCe) is prepared based on the metabolic antitumor drug of Lonidamine (Lon) and the photosensitizer of chlorin e6 (Ce6). By virtue of intermolecular interactions, Lon and Ce6 self-assemble into nanosized LonCe with favorable stability and high drug contents. Compared with Ce6, LonCe exhibits an improved cellular uptake and photodynamic property for tumor treatment. Moreover, LonCe is capable of inhibiting cell metabolism and mitochondrial respiration to remit the tumor hypoxia, which would promote reactive oxygen species (ROS) production and elevate the PDT efficacy on tumor suppression. In vivo experiments indicate that intravenously injected LonCe prefers to accumulate at the tumor site for highly efficient PDT regardless of the hypoxic environment. Besides, the self-delivery LonCe is fabricated without any carriers, which avoids the excipients induced system toxicity and immunogenicity in vivo. This carrier-free nanomedicine with cell respiratory inhibition mechanism would expedite the development and clinical translation of photodynamic nanoplatforms in tumor treatment.
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高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Mengmeng Ni,Lihong Wang,Yao Chai,Bing Wang,Dongmiao Li,Jinni Shen,Zizhong Zhang,Xuxu Wang
The photocatalytic conversion of CO 2 and H 2 O into a series of value-added products is regarded as an important way to mimic natural photosynthesis for solar harvesting. Herein, we prepared CsBi 2 Ta 5 O 16 with a cubic pyrochlore structure via high-temperature molten salt method as a photocatalyst for the first time. The NiO-loaded CsBi 2 Ta 5 O 16 composites could efficiently photocatalyze the conversion of CO 2 into CH 4 and CO, and oxidize H 2 O to O 2 . With 10 wt% NiO loading, the highest yield of CH 4 (7.24 μmol g −1 h −1 ) and O 2 (3.59 μmol g −1 h −1 ) could be achieved. The adsorption and activation of CO 2 molecule on NiO can be attributed to the enhanced CO 2 photocatalytic conversion by the NiO-loaded CsBi 2 Ta 5 O 16 composites. This work provides a design idea of photocatalyst for the full reaction of CO 2 with H 2 O.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Zhongwei Li,Guochang Song,Xingyu Yang,Qiang Song
Activated carbon can be used to control NO x emissions in low-temperature flue gas, while improving its performance is challenging. NO adsorption on activated carbon was found significantly promoted with the presence of O 2 . Based on the analysis of NO adsorption characteristics under different atmospheres and corresponding desorption characteristics, NO oxidation, NO 2 migration and further conversion on activated carbon are proposed to cause the significant increase in NO adsorption capacity. Quantum chemical calculations conducted on the adsorption and reaction pathways of NO, O 2 , and NO 2 on different carbonaceous models clarified that the pathway of O 2 -promoted NO adsorption on activated carbon can be divided into two stages. In the first stage, O 2 adsorbs on active carbon atoms near the hydroxyl functional group and undergoes an oxidation reaction with gaseous NO to generate NO 2 . In the second stage, the desorbed NO 2 is re-absorbed on the saturated carbon atoms; the N-down adsorption configuration of NO 2 will not convert, while the O-down adsorption configuration of NO 2 will oxidize the active site to form C-O and release NO; the C-O further reacts with the gaseous NO 2 to form NO 3 - which stably remains. There are two types of active sites involved in the pathway. The active carbon atoms near the hydroxyl functional groups mainly play a catalytic role in the oxidation of NO, while the saturated carbon atoms mainly store nitrogen-containing components. The results can help improve the performance of activated carbon in adsorbing NO in low-temperature flue gas.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2021
·
IF 5.316
Pengfei Wang,Qing Xia,Yuncheng Zhou,Xueqian Ji,Hailan Feng,Yuxing Xu,Jun Yang,Qiangqiang Tan
The nickel-rich cathode materials (LiNi 0.8 Co 0.15 Al 0.05 O 2 , NCAs) in Lithium ion batteries often suffer from oxygen loss problems under partially overcharged conditions (>4.3 V), leading to capacity fading and safety problem. Herein, we utilize a facile ball-milling method to coat the NCAs with a shell of cerium aluminum composite oxide (CeO 2 -Al 2 O 3 ), which is commonly used as oxygen storage material. Proved by in situ X-ray diffraction results, the coating CeO 2 -Al 2 O 3 layer is capable to suppress the lattice volume change and irreversible phase transition of NCAs. The CeO 2 -Al 2 O 3 coating layer can adsorb released oxygen under overcharged conditions and replenish lattice oxygen of NCAs under oxygen-leaned conditions. The protective layer can also prevent dissolution of the transition metals caused by HF attack in electrolytes. As a result, the as prepared electrode presents high specific capacity of 186.4 mA h g −1 and excellent cycle stability with capacity retention of 94.1% after 300 cycles at a rate of 0.5 C under overcharged conditions (3.0–4.5 V). Coating CeO 2 -Al 2 O 3 is an efficient strategy to solve capacity fading problem and safety problem caused by partially overcharge, and such strategy shows significant promise for practical applications.
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Catalysts
·
2021
·Vol. 11
·期 1
·82
·
IF 4.146
Chuang Li,Dan Wang,Jiangli Gu,Yichun Liu,Xintong Zhang
Surface electron traps on semiconductor photoanodes mediate surface recombination and deteriorate the photoelectrochemical (PEC) water oxidation performance of the photoanode. Developing convenient methods to reduce surface electron traps is therefore essential for high efficiency PEC water oxidation on semiconductor photoanodes, particularly for nanostructured photoanodes with large surface area. Herein, we employ a O2plasma treatment to boost the PEC water oxidation performance of Ti-doped Fe2O3(Ti-Fe2O3) nanowires photoanodes, aiming to reduce surface oxygen vacancies, the dominant electron traps on Ti-Fe2O3surface. X-ray diffraction (XRD), scanning electron microscopy and spectroscopic analyses show that the oxygen plasma treatment changes the structural, morphological and optical properties negligibly, but it does reduce the content of surface oxygen vacancies, as estimated from O1s X-ray photoelectron spectroscopy spectra. An optimal O2plasma treatment (200 W, 70 s) increases the photocurrent density of the Ti-Fe2O3nanowire photoanode to 2.14 mA·cm−2(1.23 V vs. RHE) under air mass 1.5G simulated solar light, which is 1.95 times higher than the pristine Ti-Fe2O3nanowire photoanode. The surface hole transfer efficiency is also improved by 1.66 times due to the reduced surface recombination. The work suggests that O2plasma treatment is a convenient but effective method to boost the PEC water oxidation performance of Ti-Fe2O3photoanode and might be applicable to other semiconducting oxide photoanodes for high efficiency PEC water splitting.Keywords:photoelectrochemical water splitting;O2plasma treatment;surface oxygen vacancies;Ti-doped hematite nanowire arrays
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高影响因子
Journal of Environmental Sciences
·
2020
·
IF 4.302
Runping Wu,Qing Ye,Kai Wu,Hongxing Dai
To improve the removal capacity of NO + O 2 effectively, the alkaline earth metal-doped order mesoporous carbon (A-C-FDU-15(0.001) (A = Mg, Ca, Sr and Ba)) and Mg-C-FDU-15( x ) ( x = 0.001−0.003) samples were prepared, and their physicochemical and NO + O 2 adsorption properties were determined by means of various techniques. The results show that the sequence in (NO + O 2 ) adsorption performance was as follows: Mg-C-FDU-15(0.001) (93.2 mg/g) > Ca-C-FDU-15(0.001) (82.2 mg/g) > Sr-C-FDU-15(0.001) (76.1 mg/g) > Ba-C-FDU-15(0.001) (72.9 mg/g) > C-FDU-15 (67.1 mg/g). Among all of the A-C-FDU-15(0.001) samples, Mg-C-FDU-15(0.001) possessed the highest (NO + O 2 ) adsorption capacity (106.2 mg/g). The species of alkaline earth metals and basic sites were important factors determining the adsorption of NO + O 2 on the A-C-FDU-15( x ) samples, and (NO + O 2 ) adsorption on the samples was mainly chemical adsorption. Combined with the results of (NO + O 2 )-temperature-programmed desorption ((NO + O 2 )-TPD) and in situ diffused reflectance infrared Fourier transform spectroscopy (DRIFTS) characterization, we deduced that there were two main pathways of (NO + O 2 ) adsorption: one was first the conversion of NO and O 2 to NO 2 and then part of NO 2 was converted to NO 2 − and NO 3 − ; and the other was the direct oxidation of NO to NO 2 − and NO 3 − .
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高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Fan Yamei,Li Rongtan,Wang Beibei,Feng Xiaohui,Du Xiangze,Liu Chengxiang,Wang Fei,Liu Conghui,Dong Cui,Ning Yanxiao,Mu Rentao,Fu Qiang
Sintering of active metal species often happens during catalytic reactions, which requires redispersion in a reactive atmosphere at elevated temperatures to recover the activity. Herein, we report a simple method to redisperse sintered Cu catalysts via O 2 -H 2 O treatment at room temperature. In-situ spectroscopic characterizations reveal that H 2 O induces the formation of hydroxylated Cu species in humid O 2 , pushing surface diffusion of Cu atoms at room temperature. Further, surface OH groups formed on most hydroxylable support surfaces such as γ-Al 2 O 3 , SiO 2 , and CeO 2 in the humid atmosphere help to pull the mobile Cu species and enhance Cu redispersion. Both pushing and pulling effects of gaseous H 2 O promote the structural transformation of Cu aggregates into highly dispersed Cu species at room temperature, which exhibit enhanced activity in reverse water gas shift and preferential oxidation of carbon monoxide reactions. These findings highlight the important role of H 2 O in the dynamic structure evolution of supported metal nanocatalysts and lay the foundation for the regeneration of sintered catalysts under mild conditions.
研究领域:
催化
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材料科学
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化学工程
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2024
·
IF 8.4
Ting He,Shuang Yao,Dejian Chen,Zhaoyun Sun,Xiaoyun Wang,Keyi Wang,Jiangwei Chen,Qingguo Li,Rizhi Chen,Yawei Wang,Zhaoliang Cui
Membrane oxygenator performs lung function in the Extra-corporeal Membrane Oxygenation (ECMO) system. In the clinical use, to ensure the balance of gas exchange of patient’s body, the gas-blood exchange membrane is required to possess CO 2 /O 2 selectivity, which is suggested to be in the range of 10-12. In our work, the molecular dynamics simulation results displayed that the amino-functionalized Zr-MOFs provides fast transport channels for CO 2 molecules because of the enhancement of the adsorption and diffusion ability for CO 2 . Therefore, we chose organic ligands with abundant CO 2 -philic groups to synthesize target amino-functionalized Zr-MOFs, and then dispersed them into medical-grade PDMS solution to study the separation performance of CO 2 /O 2 . On the basis of constructing anti-leakage coating layer, biomimetic gas channels were designed to increase the clearance rate of CO 2 . Experimental results exhibited that the CO 2 /O 2 selectivity of (NH 2 ) 2 -UiO-66/PDMS MMM was as high as 11.19, which was basically consistent with the simulation results. The obtained amino-functionalized Zr-MOF/PDMS coating layer displayed favorable biocompatibility and biosafety. Meanwhile, the construction of biomimetic channel solves the difficult problem of CO 2 removal in PMP membrane, which verifies the feasibility of applying porous materials to gas-blood exchange membranes in the ECMO system.
研究领域:
材料科学
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生物医学工程
·
分子动力学模拟
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膜技术
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高影响因子
Science Advances
·
2017
·Vol. 3
·期 6
·
IF 0
Pengwei Wang,Guofeng Zhao,Yu Wang,Yong Lu
Oxidative coupling of methane (OCM) is a promising method for the direct conversion of methane to ethene and ethane (C2 products). Among the catalysts reported previously, Mn2O3-Na2WO4/SiO2 showed the highest conversion and selectivity, but only at 800° to 900°C, which represents a substantial challenge for commercialization. We report a TiO2-doped Mn2O3-Na2WO4/SiO2 catalyst by using Ti-MWW zeolite as TiO2 dopant as well as SiO2 support, enabling OCM with 26% conversion and 76% C2-C3 selectivity at 720°C because of MnTiO3 formation. MnTiO3 triggers the low-temperature Mn2+↔Mn3+ cycle for O2 activation while working synergistically with Na2WO4 to selectively convert methane to C2-C3. We also prepared a practical Mn2O3-TiO2-Na2WO4/SiO2 catalyst in a ball mill. This catalyst can be transformed in situ into MnTiO3-Na2WO4/SiO2, yielding 22% conversion and 62% selectivity at 650°C. Our results will stimulate attempts to understand more fully the chemistry of MnTiO3-governed low-temperature activity, which might lead to commercial exploitation of a low-temperature OCM process.
研究领域:
化学工程
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催化
·
能源化学
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