Food Chemistry-X
·
2023
·
IF 6.1
Yao Li,Hongjia Lu,Chao Liao,Xiong Liu
In this 13-week study, the potential effects of oxidized konjac glucomannan (OKGM) on ICR mice's metabolic health and gut microbiota were investigated and contrasted with enzyme-hydrolyzed KGM (EKGM) at a same molecular weight. Mice were fed diets containing 0 %, 2.5 %, 5.0 %, and 7.5 % of OKGM for 13 weeks. Results indicated that OKGM induced no adverse effects, with overall health, body weight gain, food consumption, and clinical pathology parameters being comparable to the control group. The no-observed-adverse-effect-level for OKGM was determined at 7.5 % in the diet, corresponding to 10.21 and 12.01 g/kg/day for male and female mice, respectively. OKGM intake positively regulated gut microbiota, characterized by a reduction in the relative abundance of Firmicutes , an increase in Bacteroidetes , and an enhanced presence of Lactobacillus , particularly Lactobacillus reuteri . In comparison, EKGM differently modulated the microbiota, notably increasing Muribaculaceae . These findings suggest that OKGM has the potential to be a functional food additive.
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Advanced Healthcare Materials
·
2026
·
IF 11
Shanan Chen,Kaiwen Wu,Mengzhuo Li,Yoav D. Livney,Xing Li,Wei Shang,Zhicheng Wei,Qiming Li,Rongmei Liu,Jie Xiao,Yuan Li
The in vivo functionality of oral probiotics is often compromised by their susceptibility to environmental and gastrointestinal stressors, coupled with limited mucosal retention. To overcome these challenges, we developed a smart, pH-responsive biomaterial platform based on shellac microgels (SCM), derived from a natural, biocompatible insect resin. Combining experimental characterization with finite element analysis, we verified that the densified molecular network of SCM functions as a potent physical barrier that effectively hinders the diffusion of O 2 , moisture, and UV radiation, as well as physiological assaults (H + and bile salts), protecting the viability of probiotics throughout storage and gastrointestinal transit. Crucially, the pK a -dependent phase transition of SCM enabled precise colon-targeted bio-interface, where its abundant functional groups facilitated strong mucosal anchoring via non-covalent interactions. In a DSS-induced colitis mouse model, this precision-release strategy significantly improved therapeutic outcomes by suppressing the inflammation, restoring gut homeostasis, and repairing the epithelial barrier. This study presents a sustainable, potent, and naturally derived biomaterial strategy for the controlled delivery of sensitive bacterial therapeutics.
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Food & Function
·
2023
·Vol. 14
·期 23
·10520-10534
·
IF 6.1
Jiachen Ma,Tian Yuan,Yuqi Gao,Xiaoming Zeng,Zhigang Liu,Jinming Gao
The oil of Torreya grandis (TGO), a common nut in China, is considered to be a bioactive edible oil and has a great value in functional food development. In this study, the neuroprotective effects of TGO were investigated on a scopolamine (SCOP)-induced C57BL/6J mouse model. The mice were pretreated with TGO for 30 days (1000 mg per kg per day and 3000 mg per kg per day, i.g.). Behavioral tests showed that the supplementation of TGO could prevent the cognitive deficits induced by SCOP. TGO rebalanced the disorder of the cholinergic system by upgrading the level of acetylcholine. TGO also alleviated the over-activation of microglia and inhibited neuroinflammation and oxidative stress. Additionally, TGO could regulate the composition of gut microbiota, increase the production of short-chain fatty acids, and decrease the content of lipopolysaccharides in the serum. In conclusion, TGO has the potential to prevent loss of memory and impairment of cognition, which may be related to its regulation of the gut microbiota–metabolite–brain axis.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2014
·
IF 3.432
Yuxin Fang,Wenjing Zhong,Yue Wang,Tianrong Xun,Dongguo Lin,Wenjun Liu,Jingyu Wang,Lin Lv,Shuwen Liu,Jian He
Tryptophan and arginine rich antimicrobial peptides (AMPs) possess high potencies against both gram positive and gram negative bacteria , while lipopeptides represent another family of promising antimicrobial agents to combat invading pathogens. In the present study, we have synthesized a series of very short arginine, lysine and tryptophan containing lipopeptides and evaluated their antimicrobial activities against a panel of pathogenic microorganisms including Staphylococcus aureus , Escherichia coli , and Candida albicans . The results showed that most of these peptides were effective against tested strains with MIC values ranging from 3.9 to 62.5 μg/mL. In addition to the small size, potent bactericidal activity , low to moderate hemolytic toxicity and membrane disruption ability, several peptides such as C10-RIKWWK and C10-RKWWK apparently retarded the migration of DNA on agarose gel in the DNA-binding assay, which implied the multiple modes of action in their bacteria-killing mechanism. These peptides revealed a promising therapeutic potential to develop as new antimicrobial agents.
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Food & Function
·
2023
·Vol. 15
·期 1
·387-400
·
IF 6.1
Chuanchuan Wang,Weixuan Chen,Yishan Jiang,Xiao Xiao,Qianhui Zou,Jiarui Liang,Yu Zhao,Qianxu Wang,Tian Yuan,Rui Guo,Xuebo Liu,Zhigang Liu
Autism Spectrum Disorder (ASD), a complex neurodevelopmental disorder marked by social communication deficits and repetitive behaviors, may see symptom amelioration through gut microbiota modulation. This study investigates the effects of a synbiotic – specifically a probiotic amplified by prebiotic supplementation – on ASD-like mouse model's social deficiencies. This model was established via valproic acid injection into pregnant females. Post-weaning, male progeny received daily synbiotic treatment, a combination of Lactobacillus reuteri (L. reuteri) and inulin, for four weeks. Results indicated that the synbiotic rectified social impairments and attenuated inflammatory cytokine expressions in the brain. Moreover, synbiotic intervention protected gut barrier integrity and altered the gut microbiota composition, enhancing the butyrate-producing Bifidobacterium abundance. The synbiotic elevated metabolites such as butyrate and 3-hydroxybutyric acid (3-HB), alongside upregulated genes associated with 3-HB synthesis in the colon and liver, and brain receptors. Conclusively, the synbiotic combination of L. reuteri and inulin mitigated ASD-related social impairments, partially via their regulatory effect on the gut–brain axis.
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CARBON
·
2023
·
IF 10.9
Yuan Li,Jing Gao,Yaxuan Shi,Yazhen Wang,Mengyang Li,Aizhao Pan,Mingyou Hu,Guanjun Zhang
Carbon quantum dots (CQDs) have been widely used in many fields due to their excellent optoelectronic properties. However, the impact of precursor on the structure, properties, and formation mechanism of CQDs under gas-liquid discharge process is poorly understood, which invites more detailed studies toward structure design and fluorescence regulation. In this study, the CQDs of blue fluorescence are successfully synthesized using only low-cost organic solvent such as ethanol, 1-butanol, and 1-hexanol as the precursors by gas-liquid discharges within 5 min. Entering argon gas into the liquid reactant greatly lowers the difficulty of discharges in the liquids and improves the discharge stability, and thereby produce a more uniform particle of the synthesized CQDs. The average size of CQDs synthesized by alcoholic organics is 2–3 nm, and the surfaces of the products are functionalized by various oxygen-containing groups. The CQDs present bright blue fluorescence with an excitation wavelength of 365 nm and exhibit an excitation-dependent property. In situ observations of optical emission spectrometry (OES) during discharges indicate that the precursors are break down into free radicals such as C 2 , CH and H, and then radicals recombine and grow continuously into CQDs. During the formation of CQDs, molecular fluorophores are produced concomitantly. In addition, changing the functional groups of the precursors significantly influences the fluorescence properties of the synthesized CQDs. For CQDs prepared from solvents containing heterogeneous elements such as nitrogen and sulfur show green fluorescence properties, i.e., fluorescence red-shift. This work provides a pathway for fabricating diversified CQDs by modulating the structure and functional groups of the selected precursors.
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Foods
·
2023
·Vol. 12
·期 22
·4176
·
IF 5.2
Linlin Wang,Shurong Yang,Chunxia Mei,Nan Tang,Jialiang Wang,Qiangqing Yu,Gang Wang,Gaojue Wu,Jianxin Zhao,Wei Chen
Constipation is a major health concern worldwide and requires effective and safe treatment options. In this study, we selected ten strains of two species of lactobacilli to identify whether they were effective against constipation induced by loperamide administration in BALB/c mice. Monitoring of constipation-related indicators indicated thatLactobacillus paracasei(L. paracasei) mainly acted on the whole intestinal peristalsis to relieve constipation. Furthermore, through the detection of biological, chemical, mechanical, and immune barriers in mice, it was discovered thatL. paracaseichanged the relative abundance of bacteria related to the levels of acetic acid and 5-hydroxytryptamine (5-HT) (such as by increasing the relative abundance ofOdoribacterandClostridium, and reducing the relative abundance ofMucispirillum,Ruminococcus,Coprobacillus, andDorea), increased the concentration of acetic acid in the intestine, which stimulated enterochromaffin cells, promoted 5-HT synthesis in the colon, enhanced intestinal motility, and relieved constipation. In conclusion, this study provides a theoretical foundation for the development of personalized products for the treatment of constipation.Keywords:lactobacilli;constipation;intestinal microbiota;acetic acid;5-HT;gastrointestinal regulatory peptide;inflammatory factors
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Lifang Zou,Xia Yu,Kezhou Cai,Baocai Xu,Conggui Chen,Guiran Xiao
Consuming a high‑sodium diet carries serious health risks and significantly influences the activation state of the renin-angiotensin system (RAS). This study evaluates the protective effect of angiotensin-converting enzyme (ACE) inhibitory peptide IVGFPAYGH on a high‑sodium diet–induced liver injury. IVGFPAYGH supplementation increased the activities of liver antioxidase and decreased the levels of liver inflammatory factor in mice fed a high‑sodium diet (8 % NaCl). IVGFPAYGH supplementation also reduced liver fatty acid synthesis and promoted fatty acid oxidation, increased the expression of low-density lipoprotein receptor, and improved liver dyslipidemia. Furthermore, IVGFPAYGH supplementation inhibited the activation of the liver RAS via inhibiting ACE activity and reducing angiotensin II levels in mice fed a high‑sodium diet. Moreover, IVGFPAYGH supplementation could alter the gut microbiota composition toward a normal gut microbiota composition and increase the abundance of the Lactobacillus genus. IVGFPAYGH supplementation also increased the expression levels of small intestinal tight junction protein and cecum short-chain fatty acids. Thus, IVGFPAYGH supplementation may maintain intestinal homeostasis and improve high‑sodium diet–induced liver injury by altering the gut microbiota composition and inhibiting the RAS. IVGFPAYGH is a promising functional ingredient for protecting liver damage caused by a high‑sodium diet.
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TRIBOLOGY INTERNATIONAL
·
2023
·
IF 6.2
Guanai Qu,Hongling Fang,Lei Liu,Yi Li,Songwei Zhang,Huimin Yang,Litian Hu
Although ionic liquids (ILs) have proven to be multifunctional and universal lubricant additives , their solubility in different polar lubricating oils varies greatly. This variability restrains their widespread use as general-purpose lubricating additives. To address this issue, three protic ionic liquids (PILs) with high solubility in lubricating oils with differing polarities were selected as additives, and their tribological performances in polyethylene glycol (PEG) and synthetic pentaerythritol carboxylic ester oil (5750) were systematically investigated. These findings were interesting, as PILs effectively improved the lubrication properties of PEG but impaired those of 5750. Additionally, a variety of surface analysis techniques and MD simulation were employed to further explore the lubrication mechanisms of PILs, and results indicated that they exhibited distinct tribological performance.
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Friction
·
2023
·
IF 6.8
Wang Hanwen,Wang Ying,Wen Ping,Ma Lin,Fan Mingjin,Dong Rui,Zhang Chunhua
Development of energy-efficient lubricants is a way to reduce energy consumption for transportation, with the tendency to design molecules that are beneficial in reducing the viscosity of synthetic oils. Oligoether esters (OEEs), as a low-viscosity ester base oil, have characteristics such as simple synthesis and excellent lubrication effect, however, the application of OEEs in tribology field has rarely been investigated. The objective of the present study is to investigate the effect of structure on the lubricating performance of OEEs and to develop a predictive model for OEEs based on quantitative structure-property relationship (QSPR) through a combination of experiment and statistical modeling. Results showed that glycol chains contribute positively to lubrication with the ether functional groups increasing the sites of adsorption. Compared to branched-chain OEEs, straight-chain OEEs exhibited reduced wear, which was mainly due to the thicker adsorption film formed by the straight-chain structure. Furthermore, carbon films were detected on lightly worn surfaces, indicating that OEEs underwent oxidation during the friction process. Based on the results of principal component analysis (PCA) and partial least squares (PLS), it could be found that the predictive models of viscosity–temperature performance, thermal stability performance, coefficient of friction (COF), and wear volume (WV) performed well and robustly. Among them, COF and WV can be best predicted with an R 2 of about 0.90.
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Foods
·
2023
·Vol. 12
·期 21
·4002
·
IF 5.2
Jing Wang,Sheng Ke,Padraig Strappe,Ming Ning,Zhongkai Zhou
Three mannan polysaccharides and their oligosaccharides were investigated in terms of physicochemical characteristics and effects on gut microbiota. Oligosaccharides from guar gum had the fastest fermentation kinetics for SCFAs generation at the initial stage, while the locust bean of both polymers and oligosaccharides demonstrated the lowest SCFAs through the whole fermentation process. In contrast, konjac gum steadily increased SCFAs and reached its maximum level at 24 h fermentation, indicating its fermentation character may be associated with its rheological properties. Compared to their corresponding polysaccharides, all the oligosaccharides demonstrated a faster fermentation kinetics, followed by an enriched abundance of propionate-producing bacterialPrevotellaand a decreased abundance ofMegamonasandCollinsella. Meanwhile, oligosaccharides reduced theFirmicutes/Bacteroidotaratio as well as the abundance ofBacteroidetesandEscherichia-Shigella. The fermentation of konjac substrate significantly promoted the abundance of butyrate-producing bacterialFaecalibacterium. In contrast, although the fermentation of locust bean and guar gum substrates benefitedBifidobacteriumabundance due to their similar structure and monosaccharides composition, the fermentation of locust bean gum led to greaterBifidobacteriumthan the others, which may be associated with its higher mannose composition in the molecules. Interestingly, the partial hydrolysis of the three polysaccharides slightly reduced their prebiotic function.Keywords:mannan polysaccharides;oligosaccharides;short-chain fatty acids;rheological property;gut microbiota;prebiotic function
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Polymers
·
2023
·Vol. 15
·期 20
·4165
·
IF 5
Haining Zhuang,Huayue Dong,Xiaowei Zhang,Tao Feng
In this study, the digestion and fermentation properties of the bioactive water-soluble polysaccharide (HEP-W), and alkali-soluble polysaccharide (HEP-A) fromHericium erinaceusand the impact on the human colonic microbiota were determined using simulated saliva–gastrointestinal digestion and human fecal fermentation models in vitro. The basic physicochemical properties of HEP-W and HEP-A were determined at the same time. The results showed that the in vitro simulated digestion had almost no effect on the physicochemical properties of HEP-W and HEP-A, indicating that HEP-W and HEP-A were partially degraded. During fermentation, HEP-W and HEP-A increased the relative abundance of the dominant butyric acid-producing genera, the microbial community structure was significantly regulated, the gas production and short-chain fatty acid production in the fermentation broth were significantly increased, and the pH of the fermentation broth was reduced. There were structural and other differences in HEP-W and HEP-A due to different extraction methods, which resulted in different results. These results suggest that HEP-W and HEP-A may be potential gut microbial manipulators to promote gut health by promoting the production of beneficial metabolites by intestinal microorganisms using different butyric acid production pathways.Keywords:Hericium erinaceuspolysaccharides;extraction method;antioxidant;in vitro fermentation;gut microbiome
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